Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation

Bufalin induces apoptosis via mitochondrial ROS-mediated caspase-3 activation in HCT-116 and SW620 human colon cancer cells

(2019) Di Wu et al.   DRUG AND CHEMICAL TOXICOLOGY

β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma

(2019) Marina Ruiz de Galarreta et al.   Cancer Discovery

Multiple novel hepatocellular carcinoma signature genes are commonly controlled by the master pluripotency factor OCT4

(2019) Chao Ye et al.   CELLULAR ONCOLOGY

Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma

(2018) Hong Zhang et al.   HEPATOLOGY

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Inhibition of pMAPK14 Overcomes Resistance to Sorafenib in Hepatoma Cells with Hepatitis B Virus

(2018) Dvora Witt-Kehati et al.   Translational Oncology

Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase

(2018) Zhuo Yu et al.   Scientific Reports

Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy

(2018) Yinglu Feng et al.   OncoImmunology

Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin

(2018) Yong Zhang et al.   MOLECULAR CANCER THERAPEUTICS

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

(2018) Hanyong Sun et al.   Nature Communications

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bufalin induces apoptosis in vitro and has Antitumor activity against human lung cancer xenografts in vivo

(2016) Shin-Hwar Wu et al.   ENVIRONMENTAL TOXICOLOGY

Global strategies are required to cure and eliminate HBV infection

(2016) Peter Revill et al.   Nature Reviews Gastroenterology & Hepatology

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Hepatitis B Virus X Protein (HBx) Is Responsible for Resistance to Targeted Therapies in Hepatocellular Carcinoma: Ex Vivo Culture Evidence

(2015) P. Huang et al.   CLINICAL CANCER RESEARCH

The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway

(2015) JI QIN GAI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients

(2015) Hai Feng et al.   JOURNAL OF HEPATOLOGY

Mechanical strain induces E-cadherin-dependent Yap1 and  -catenin activation to drive cell cycle entry

(2015) B. W. Benham-Pyle et al.   SCIENCE

Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1

(2014) Y. Wang et al.   CANCER RESEARCH

The driving circuit of HBx and androgen receptor in HBV-related hepatocarcinogenesis

(2014) Sheng-Han Wang et al.   GUT

Cell cycle-related kinase mediates viral-host signalling to promote hepatitis B virus-associated hepatocarcinogenesis

(2014) Zhuo Yu et al.   GUT

Hepatitis B virus infection

(2014) Christian Trépo et al.   LANCET

Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells

(2013) Dong-Ze Qiu et al.   BMC Complementary and Alternative Medicine

Anticancer Effects of Bufalin on Human Hepatocellular Carcinoma HepG2 Cells: Roles of Apoptosis and Autophagy

(2013) Qing Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells

(2013) WEI GU et al.   ONCOLOGY REPORTS

Prospective randomised evaluation of traditional Chinese medicine combined with chemotherapy: a randomised phase II study of wild toad extract plus gemcitabine in patients with advanced pancreatic adenocarcinomas

(2012) Z Meng et al.   BRITISH JOURNAL OF CANCER

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Chronic hepatitis B infection in adolescents who received primary infantile vaccination

(2012) Tzu-Wei Wu et al.   HEPATOLOGY

Androgen Receptor Serine 81 Phosphorylation Mediates Chromatin Binding and Transcriptional Activation

(2012) Shaoyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial

(2012) Jordi Bruix et al.   JOURNAL OF HEPATOLOGY

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery

(2012) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis

(2011) Hai Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-hepatitis B Virus Activities of Cinobufacini and Its Active Components Bufalin and Cinobufagin in HepG2.2.15 Cells

(2010) Xiaoyan Cui et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor

(2010) Fanghua Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mechanisms of HBV-related hepatocarcinogenesis

(2010) Christine Neuveut et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3β kinase pathways

(2009) Wan-Jen Yang et al.   HEPATOLOGY

Recurrence of Hepatitis B-Related Hepatocellular Carcinoma Is Associated With High Viral Load at the Time of Resection

(2008) Ivan F. N. Hung et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY