Review
Oncology
Zijian Wang, Jiarui Liu, Jingri Xie, Xingxing Yuan, Bingyu Wang, Wenjuan Shen, Yang Zhang
Summary: This review discusses the role of autophagy in gastric cancer and the regulatory mechanisms of ncRNAs in autophagy. Increasing evidence suggests that ncRNAs have dual roles in the initiation and progression of gastric cancer. This review aims to provide insights for the development of potential therapeutic strategies for gastric cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Mina Karimpour, Reyhaneh Ravanbakhsh, Melika Maydanchi, Ali Rajabi, Faezeh Azizi, Ali Saber
Summary: Brain metastasis is a common occurrence in lung cancer patients and is associated with poor prognosis and mortality. Understanding the mechanisms involved in lung cancer brain metastasis is crucial for improving overall survival. Various cancer-related genes and non-coding RNAs are proposed as potential predictors and biomarkers for lung cancer brain metastasis. Several clinical studies have focused on determining the mechanisms involved in lung cancer brain metastasis and their impact on diagnosis, prognosis, and treatment outcomes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Xiao Yu, Qingyuan Zheng, Qiyao Zhang, Shuijun Zhang, Yuting He, Wenzhi Guo
Summary: MCM3AP-AS1, a novel lncRNA aberrantly expressed in human cancers, is significantly associated with clinical characteristics of tumors and modulates tumor progression by controlling cellular functions. It shows promise as a biomarker for cancer diagnosis, prognosis evaluation, and treatment, with potential clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chao Wang, Yiyang Hu, Huan Yang, Sumin Wang, Bo Zhou, Yulu Bao, Yu Huang, Qiang Luo, Chuan Yang, Xia Xie, Shiming Yang
Summary: Gastric cancer, a common malignant tumor of the digestive system, is influenced by genetic, environmental, and microbial factors. Infection of Helicobacter pylori is closely related to the occurrence of gastric cancer, while non-coding RNA plays a crucial role in tumor progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shantanu Gupta, Ronaldo F. Hashimoto
Summary: This study investigated the role of long non-coding RNAs in non-small cell lung cancer (NSCLC). Using a Boolean model, the authors identified ANRIL and UFC1 as important gene regulators in NSCLC and confirmed the significance of the miR-34a/Myc pathway in lung cancer cells.
Review
Medicine, General & Internal
Joanna Jarosz-Popek, Marta Wolska, Aleksandra Gasecka, Pamela Czajka, Daniel Jakubik, Lucia Sharif, Taqwa Adem, Wei-Ling Liu, Dagmara Mirowska-Guzel, Marek Postula, Ceren Eyileten
Summary: Diabetes mellitus is a complex and global health problem, with increasing complications affecting the nervous system. Studies suggest that miRNAs and lncRNAs play crucial roles in modulating signaling pathways, making them potential biomarkers and treatment options for neurodegenerative diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Genetics & Heredity
Liqiao Chen, Jingyu Deng
Summary: Noncoding RNAs play important roles in regulating the immune microenvironment of gastric cancer, with potential implications for improving patient prognosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Pharmacology & Pharmacy
Binliang Gan, Youwu He, Yonggang Ma, Linfeng Mao, Chuanjie Liao, Ganlu Deng
Summary: This study identified 32 differentially expressed long non-coding RNAs (lncRNAs), of which 12 were associated with the prognosis of hepatocellular carcinoma (HCC) patients. A prognostic signature comprising 6 prognostic lncRNAs was developed and showed excellent predictive ability. Additionally, a differential m6A regulator, RBMX, was found to be negatively correlated with the hub lncRNA AC115619.1. AC115619.1 was downregulated in HCC tissues compared to normal tissues, and its expression was significantly related to clinicopathological features, survival rate, and drug sensitivity. Overexpression of AC115619.1 inhibited proliferation, migration, and invasion of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Ying Liu, Xiang Ao, Yu Wang, Xiaoge Li, Jianxun Wang
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jianming Wei, Ye Zeng, Xibo Gao, Tong Liu
Summary: In this study, a prognostic ferroptosis-related lncRNA signature was constructed for gastric cancer, with the low-risk group showing significantly better prognosis than the high-risk group. The risk score was identified as an independent prognostic factor. This risk model provides a novel method for predicting prognosis in gastric cancer patients.
Review
Biochemistry & Molecular Biology
Seyedeh Tayebeh Ahmadpour, Charlotte Orre, Priscila Silvana Bertevello, Delphine Mirebeau-Prunier, Jean-Francois Dumas, Valerie Desquiret-Dumas
Summary: This review highlights the importance of long noncoding RNAs (lncRNAs) in breast cancer chemoresistance. LncRNAs regulate multiple pathways involved in breast cancer development and treatment response. Understanding these mechanisms in detail may improve the clinical outcomes for breast cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bei Wang, Wen Xu, Yuxuan Cai, Jinlan Chen, Chong Guo, Gang Zhou, Chengfu Yuan
Summary: This article summarizes the role of lncRNA DUXAP8 in the occurrence and progression of tumors. It is found that DUXAP8 regulates the growth, invasion, and metastasis of tumors by affecting the activity of miRNAs, signaling pathways, and proteins. The research results suggest that DUXAP8 may be a potential therapeutic target for treating tumors.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Julia Bohosova, Adela Kubickova, Ondrej Slaby
Summary: PVT1 plays a crucial role in RCC development and there is a significant amount of research trying to uncover its cellular mechanisms. This review summarizes the current knowledge on the role of PVT1 in RCC development and its association with clinical behavior. 17 scientific papers analyzed in this review provide robust support for the importance of PVT1 in RCC development and personalized therapy.
Article
Cell Biology
Shuangquan Li, Yiran Wang, Caiyun Wen, Mingxi Zhu, Meihao Wang, Guoquan Cao
Summary: This study investigates the 5hmC modifications at lncRNA loci in pancreatic adenocarcinoma (PAAD) and identifies PAAD-specific lncRNAs with abnormal 5hmC modifications compared to healthy individuals. Machine-learning and Cox regression approaches are used to develop diagnostic and prognostic models using these 5hmC-modified lncRNAs. The models show excellent performance in discriminating PAAD patients from healthy controls and effectively stratify PAAD patients into high-risk and low-risk groups.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Radu Pirlog, Rares Drula, Andreea Nutu, George Adrian Calin, Ioana Berindan-Neagoe
Summary: CCAT2 is a highly studied lncRNA with diverse functions in cancer regulation, including interactions with various RNA binding proteins and transcription factors. It has been shown to play a role in promoting chromosome instability and altering glutamine metabolism, potentially affecting cancer therapy resistance and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Maryam Khayamzadeh, Vahid Niazi, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard, Mohammad Samadian
Summary: Brain tumors, particularly glioblastoma, are aggressive and often fatal due to inadequate treatment and late detection. Recent studies have found that glioblastoma cells produce extracellular vesicles containing miRNAs and other components that enhance their malignant behavior and impact neighboring cells. Understanding the molecular composition of these extracellular vesicles is crucial in developing effective therapies against this type of tumor.
METABOLIC BRAIN DISEASE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: Long intergenic non-protein coding RNA 173 (LINC00173) is a long non-coding RNA that plays a significant role in tumorigenesis. While most studies support its oncogenic role in various cancers, exceptions exist in B-cell precursor acute lymphoblastic leukemia, cervical cancer, pancreatic cancer, and gastric cancer. In breast and lung cancers, LINC00173 has been reported to have both oncogenic and tumor suppressor roles. It acts as a molecular sponge for miRNAs, regulating various miRNA/mRNA axes involved in cancer progression. This review summarizes the current understanding of LINC00173 in these cancers.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Mohammad Taheri, Arash Safarzadeh, Arefe Bahranian, Solat Eslami, Nader Akbari Dilmaghani, Soudeh Ghafouri-Fard, Guive Sharifi
Summary: In this study, the expression levels of six lncRNAs were evaluated in Iranian patients with NFPA. MAPKAPK5-AS1, PXN-AS1, and URB1-AS1 were found to be overexpressed in NFPA tissues. Furthermore, the relative expression levels of PXN-AS1 were associated with tumor subtype, while MAPKAPK5-AS1 and LIFR-AS1 were associated with patient gender. These findings suggest a potential role of MAPKAPK5-AS1, PXN-AS1, and URB1-AS1 in the pathogenesis of NFPAs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Cell Biology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammad Taheri, Arda Kiani
Summary: Sarcopenia is a disease characterized by muscle atrophy and frailty in older adults, with the underlying molecular mechanisms still unclear. Noncoding RNAs, particularly microRNAs and long noncoding RNAs, have been identified as playing a role in the development and progression of sarcopenia. This manuscript reviews the current understanding of their involvement and discusses their potential as therapeutic targets.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Kimia Behzad Moghadam, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Arda Kiani
Summary: NCK1-AS1 is a lncRNA that promotes carcinogenesis and has been verified in multiple types of cancer. It acts as a sponge for several microRNAs. In this review, we summarize the functions of NCK1-AS1 in malignant conditions and atherosclerosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Atefeh Harsij, Bashdar Mahmud Hussen, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Small nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that plays vital roles in epithelial and muscle satellite cells and is over-expressed in various cancer cell lines. It acts as a molecular sponge for multiple miRNAs, regulating the expression of their target genes in cancer and influencing the pathogenesis of several disorders, including atherosclerosis, chronic cerebral ischemia, acute gouty arthritis, ischemic stroke, and myocardial infarction. This review aims to summarize the role of SNHG8 in diverse human disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Bashdar Mahmud Hussen, Hazha Jamal Hidayat, Snur Rasool Abdullah, Sayran Mohamadtahr, Mohammad Fatih Rasul, Majid Samsami, Mohammad Taheri
Summary: This review focuses on the functional properties of lncRNAs and the role of dysregulated TGF-β signaling in BC. Both lncRNAs and the TGF-β pathway play important roles in BC diagnosis, prognosis, and drug resistance.
Review
Pathology
Soudeh Ghafouri-Fard, Hamed Shoorei, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Yadollah Poornajaf, Mohammad Taheri, Majid Samsami
Summary: SNHG12, a lncRNA, plays a role in various human pathologies. It acts as a molecular sponge for multiple miRNAs, affecting the activity of several signaling pathways. It has been implicated in the pathogenesis of different diseases, particularly cancer, and could be a potential diagnostic and prognostic marker.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Elena Jamali, Arash Safarzadeh, Bashdar Mahmud Hussen, Thomas Liehr, Soudeh Ghafouri-Fard, Mohammad Taheri
Summary: Using a systems biology approach, we analyzed single cell RNA-seq data to identify differentially expressed genes in PDAC samples compared to adjacent non-cancerous samples. We discovered 1462 DEmRNAs and 27 DElncRNAs, along with dysregulated signaling pathways, abnormally expressed genes, and aberrant cellular functions. These findings have implications for the development of biomarkers and therapeutic targets in PDAC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Bashdar Mahmud Hussen, Ahmad Eghbali, Soudeh Ghafouri-Fard
Summary: MINCR is a lncRNA with a significant correlation with the MYC gene and plays important roles in carcinogenesis. It acts as a molecular sponge for miR-28-5p, miR-708-5p, miR-876-5p, and miR-146a-5p. Dysregulated expression of MINCR has been observed in various cancers, particularly hepatocellular carcinoma. It is also associated with dysregulation of expression patterns in schizophrenia and neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis. This review outlines the molecular mechanisms of MINCR in different disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Sara Ahmadi Teshnizi, Bashdar Mahmud Hussen, Mohammad Taheri, Hakimeh Zali
Summary: This review summarizes recent studies on the expression of GHET1, its in vitro functions, and its impact on the beginning and progression of cancer based on xenograft models, highlighting the correlation between up-regulation of GHET1 and poor prognosis in various malignancies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Peixin Dong, Yadollah Poornajaf, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: Exosomes are extracellular vesicles that transfer biomolecules and facilitate cell-cell communication. The content, particularly miRNA, in exosomes reflects disease-specific patterns and can be used as diagnostic and prognostic markers. Exosomal miRNAs enter recipient cells and regulate gene expression. They have great potential in detecting disorders, especially cancers. However, standardization, large-scale clinical studies, and consistent experimental settings are challenges that need to be addressed.
NON-CODING RNA RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Mahdi Gholipour, Solat Eslami, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian, Mir Davood Omrani
Summary: Multiple sclerosis (MS) has been suggested to be influenced by the dysregulation of Mitogen-activated protein kinase 14 (MAPK14) and its associated long non-coding RNA (lncRNA). This study measured the expression levels of MAPK14 and its associated lncRNAs in the circulation of MS patients. The results showed abnormal expression levels of NORAD, RAD51-AS1, and ZNRD1ASP in MS patients compared to controls, but these expression levels were not correlated with clinical factors.
NON-CODING RNA RESEARCH
(2023)
Article
Biochemical Research Methods
Bashdar Mahmud Hussen, Safeen Jasim Saleem, Snur Rasool Abdullah, Sayran Mohamadtahr, Hazha Jamal Hidayat, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Summary: Lung cancer is the leading cause of cancer-related deaths globally, and the TGF-beta family of growth factors and miRNA play critical roles in its development. Recent research suggests that TGF-beta signaling directly affects the synthesis of miRNA, ultimately influencing the fate of cancer cells. Understanding the key functions of miRNA in lung cancer progression and its impact on the TGF-beta signaling pathway can help identify potential therapeutic targets for improving lung cancer treatment.
MOLECULAR AND CELLULAR PROBES
(2023)
Review
Biochemistry & Molecular Biology
Mohammad Taheri, Reyhane Eghtedarian, Soudeh Ghafouri-Fard, Mir Davood Omrani
Summary: Certain miRNAs and lncRNAs play important roles in the pathogenesis of type 2 diabetes and can be used as markers or therapeutic molecules.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)