Journal
ACS CATALYSIS
Volume 10, Issue 15, Pages 8277-8284Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.0c01958
Keywords
photobiocatalysis; peroxyzymes; halogenation; hydroxylation; H2O2 generation
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Funding
- Young Talent Support Plan of Xi'an Jiaotong University [7121191208]
- National Natural Science Foundation of China [21706205]
- China Postdoctoral Science Foundation [2018M633518]
- Natural Science Foundation of Shaanxi Province [2018JQ2062]
- European Research Commission (ERC) [648026]
- Netherlands Organisation for Scientific Research (VICI grant) [724.014.003]
- Spanish Government Project [BIO2016-79106-R-Lignolution]
- Comunidad de Madrid Synergy CAM project [Y2018/BIO-4738-EVOCHIMERA-CM]
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Peroxyzymes simply use H2O2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H2O2 can be addressed by a controlled supply of H2O2, ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organo-photocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H2O2 generation. Very promising turnover numbers for the biocatalysts of up to 318 000 have been achieved.
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