Article
Neurosciences
Sandesh Panthi, Beulah Leitch
Summary: PV+ interneurons play an inhibitory role within the CTC network, preventing runaway excitation in the brain and contribute to the generation of absence seizures. Activating these interneurons can prevent or reduce the severity of absence seizures.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Veronique Riban, Isabelle Heulard, Lucie Reversat, Hakim Si Hocine, Marc Verleye
Summary: Stiripentol has a significant antiseizure effect on absence seizures by inhibiting T-type calcium channels. This finding contributes to a better understanding of the mechanism of action of stiripentol and its specificity in the treatment of Dravet syndrome.
Article
Biochemistry & Molecular Biology
Muhammad Hassan, David R. R. Grattan, Beulah Leitch
Summary: Childhood absence epilepsy seizures arise from multiple cellular and molecular mechanisms in the cortico-thalamocortical network, which are still being investigated. Understanding these mechanisms is crucial due to the high treatment failure rate and common adverse neurological sequelae.
Article
Neurosciences
Maryam Jafarian, Sayed Mostafa Modarres Mousavi, Sadegh Rahimi, Firuze Ghaderi Pakdel, Ahmad Ali Lotfinia, Mahmoud Lotfinia, Ali Gorji
Summary: The study investigated alterations of the GABAergic system in the LDN and SC in an experimental model of absence seizure. Results showed changes in GABA receptor subunit expressions in the LDN and SC were associated with the occurrence of SWD. Pharmacological manipulations of GABA receptors in the LDN had varying effects on SWD generation.
Article
Neurosciences
Collin D. Teague, Joseph A. Picone, William J. Wright, Caleb J. Browne, Gabriella M. Silva, Rita Futamura, Angelica Minier-Toribio, Molly E. Estill, Aarthi Ramakrishnan, Freddyson J. Martinez-Rivera, Arthur Godino, Eric M. Parise, Kyra H. Schmidt, Nathalia V. Pulido, Zachary S. Lorsch, Jee Hyun Kim, Li Shen, Rachael L. Neve, Yan Dong, Eric J. Nestler, Peter J. Hamilton
Summary: During chronic drug use, brain transcriptional neuroadaptation contributes to changes in drug use behavior. The transcription factor CREB has been shown to counteract the rewarding properties of drugs, and zinc finger protein 189 (Zfp189) is identified as a target gene of CREB in the nucleus accumbens (NAc) of mice. By manipulating the CREB-Zfp189 interaction, researchers found that it can increase Zfp189 expression and decrease the reinforcing responses to cocaine. The induction of Zfp189 by CREB in different types of medium spiny neurons also affects their electrophysiological activity and diminishes cocaine-conditioned behaviors.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Veterinary Sciences
F. Wielaender, F. M. K. James, M. A. Cortez, G. Kluger, J. N. Nessler, A. Tipold, H. Lohi, A. Fischer
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2018)
Article
Neurosciences
Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L. Collingridge, Zhengping Jia
NATURE NEUROSCIENCE
(2018)
Article
Clinical Neurology
Krutika Joshi, Lily Shen, Feng Cao, Susan Dong, Zhengping Jia, Miguel A. Cortez, O. Carter Snead
Editorial Material
Clinical Neurology
Puneet Jain, Robyn Whitney, Miguel A. Cortez
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Neurosciences
Rui Dang, Junxia Qi, An Liu, Qiaoyun Ren, Dandan Lv, Lifang Han, Zikai Zhou, Feng Cao, Wei Xie, Zhengping Jia
Article
Clinical Neurology
Shiro Baba, Vasily A. Vakorin, Sam M. Doesburg, Chizuko Nagamori, Miguel A. Cortez, Ryoko Honda, Tomonori Ono, Keisuke Toda, Hanako Nishimoto, Toshihiro Ebihara, Kana Sakai, Ayako Ochi, O. Carter Snead, Hiroshi Baba, Hiroshi Otsubo
Article
Veterinary Sciences
Thomas Parmentier, Gabrielle Monteith, Miguel A. Cortez, Franziska Wielaender, Andrea Fischer, Tarja S. Jokinen, Hannes Lohi, Sean Sanders, Veronique Sammut, Tricia Tai, Fiona M. K. James
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2020)
Article
Veterinary Sciences
Masayasu Ukai, Thomas Parmentier, Miguel A. Cortez, Andrea Fischer, Luis Gaitero, Hannes Lohi, Stephanie Nykamp, Tarja S. Jokinen, Danielle Powers, Veronique Sammut, Sean Sanders, Tricia Tai, Franziska Wielaender, Fiona James
Summary: Many veterinary studies on epilepsy rely on subjective caregiver-derived histories to determine seizure frequency, while in human medicine objective EEG data are used. This study found a weak correlation between reported seizures and EEG-confirmed ictal paroxysmal discharges in dogs, suggesting potential underreporting of seizures. Confirmation of this phenomenon in dogs through prospective studies is recommended.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Cell Biology
Susan Zhou, Zhengping Jia
Summary: The study found that normal PAK signaling in cFos-positive cells activated during social interaction is critical for social memory.
Article
Clinical Neurology
Ipsita Goswami, Bryan Maguire, Vann Chau, Emily W. Tam, Elana Pinchefsky, Robyn Whitney, Diane Wilson, Steven P. Miller, Miguel A. Cortez
Summary: This study investigates the association between heart rate variability (HRV) in infants at risk of Infantile Epileptic Spasm Syndrome (IESS) and the clinical onset of IESS. The study found that early HRV patterns may be potential predictors for the development of IESS, providing valuable prognostic information.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Nihan Carcak, Melike Sahiner, Ozlem Akman, Medine Gulcebi Idrizoglu, Miguel A. Cortez, O. Carter Snead, Esat Eskazan, Filiz Onat
NORTHERN CLINICS OF ISTANBUL
(2020)
Meeting Abstract
Clinical Neurology
O. Snead, Susan Dong, Krutika Joshi, Miguel Cortez