Article
Biochemistry & Molecular Biology
Boyu Tang, Yu Chen, Pei Zhao, Wenlong Yan, Xiao Huang, Weiqian Jiang, Mingjie Sun, Hongrui Zhang, Dulei Xiang, Tingmei Chen, Chengjie Lian, Jian Zhang
Summary: This study revealed that cellular senescence is a major cause of imbalanced differentiation of bone marrow mesenchymal stem cells (BMSCs) and the progression of steroid-induced osteonecrosis of the femoral head (SONFH). MiR-601 and SIRT1 were identified to play important roles in BMSCs senescence, and metformin was shown to alleviate BMSCs senescence and SONFH progression. These findings provide a new perspective for the prevention and treatment of SONFH.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Francesca Bartoli-Leonard, Fiona L. Wilkinson, Andrew Schiro, Ferdinand Serracino Inglott, M. Yvonne Alexander, Ria Weston
Summary: This study found that in diabetic calcified arteries, SIRT1 levels are reduced and DNA damage marker expression is increased. Vascular smooth muscle cells isolated from diabetic patients show elevated DNA damage and senescence. In vitro, hyperglycaemic conditions induced DNA damage and enhanced senescence in vascular smooth muscle cells.
CARDIOVASCULAR RESEARCH
(2021)
Article
Nutrition & Dietetics
Kamil Skowron, Magdalena Kurnik-Lucka, Michal Jurczyk, Veronika Aleksandrovych, Paulina Stach, Emil Dadanski, Beata Kusnierz-Cabala, Krzysztof Jasinski, Wladyslaw P. Weglarz, Paulina Mazur, Piotr Podlasz, Krzysztof Wasowicz, Krzysztof Gil
Summary: The study assessed the effects of the activity-based anorexia animal model on daily life in male and female rats of different ages and body weights, revealing significant gonadal and cardiovascular dysfunctions, further validating the reliability of ABA as a research tool.
Article
Clinical Neurology
Erik Schele, Iris Stoltenborg, Anders Xie, Fiona Peris-Sampedro, Roger A. H. Adan, Suzanne L. Dickson
Summary: This study aims to investigate the activation of orexin neurons during severe anorectic state and the potential of suvorexant, a dual orexin receptor antagonist, in reducing excessive physical activity. The findings indicate that a large population of orexin neurons are activated in the ABA mouse model and that peripheral administration of suvorexant decreases food anticipatory activity. Orexin may be a suitable target for treating hyperactivity in AN, and further research is recommended to examine the efficacy of suvorexant in aiding AN patients in controlling excessive activity.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Andras Attila Horvath, Aniko Papp, Janos Zsuffa, Anna Szucs, Janos Luckl, Ferenc Radai, Ferenc Nagy, Zoltan Hidasi, Gabor Csukly, Gabor Barcs, Anita Kamondi
Summary: Subclinical epileptiform activity is more common in Alzheimer's disease patients than in healthy elderly individuals, and is associated with lower memory performance. Alzheimer's patients with epileptiform discharges show a faster decline in global cognitive scores, with a strong correlation between cognitive decline and spike frequency.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Biology
Celia Souque, Jose Antonio Escudero, R. Craig MacLean
Summary: Integrons accelerate resistance evolution by rapidly generating combinatorial variation in cassette composition while maintaining genomic integrity.
Article
Biochemistry & Molecular Biology
Sicheng Wan, Chaolong Liu, Chongyang Li, Zhi Wang, Gaichao Zhao, Jingui Li, Wenhao Ran, Xi Zhong, Yongsen Li, Li Zhang, Hongjuan Cui
Summary: A protein called AKIP1 was found to be overexpressed in various human cancers and linked to worse prognosis. It has been shown to play a role in tumor metastasis, angiogenesis, and resistance to chemotherapy and radiotherapy. However, its specific mechanism in accelerating the progression of glioblastoma (GBM) remains unknown.
Article
Biochemistry & Molecular Biology
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lu, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Emerging observational data suggest that vitamin D deficiency is associated with knee osteoarthritis. However, the relationship between vitamin D level and osteoarthritis, as well as the role of vitamin D supplementation in prevention, are still controversial. This study found that 1,25(OH)2D3 deficiency accelerated the development of knee osteoarthritis in mice, while supplementation with 1,25(OH)2D3 rescued the phenotypes of osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Abigail Dove, Anna Marseglia, Ying Shang, Giulia Grande, Davide Liborio Vetrano, Erika J. Laukka, Laura Fratiglioni, Weili Xu
Summary: This study investigated the combined impact of cardiometabolic diseases (CMDs) on cognitive function. An increasing number of CMDs dose-dependently accelerated cognitive decline and increased the risk of cognitive impairment and dementia. Co-morbid CMDs could be ideal targets for interventions to protect cognitive health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Pauline Tirelle, Colin Salaun, Alexandre Kauffmann, Christine Bole-Feysot, Charlene Guerin, Marion Hure, Alexis Goichon, Asma Amamou, Jonathan Breton, Jean-Luc do Rego, Pierre Dechelotte, Najate Achamrah, Moise Coeffier
Summary: The role of microbiota in eating disorders has been found to be significant. Previous research has shown that lipopolysaccharides induce anorexia and body weight decrease through the activation of toll-like receptor 4 (TLR4). In the activity-based anorexia (ABA) mouse model, an increase of TLR4 expression in intestinal epithelial cells (IEC) has been observed. This study aimed to investigate the role of TLR4 in IEC in the ABA model in male and female mice.
Article
Biochemistry & Molecular Biology
Wen Peng, Shuang Shi, Jiacheng Zhong, Hanghua Liang, Jianbin Hou, Xiaosong Hu, Feng Wang, Jiayi Zhang, Shengjun Geng, Xiaochuan Sun, Dong Zhong, Hongjuan Cui
Summary: CBX3, also known as HP1 gamma, is upregulated in glioblastoma multiforme (GBM) and promotes cell proliferation, invasion, and tumorigenesis. It regulates the malignant progression of GBM through an EGFR-dependent mechanism. CBX3 directly suppresses the transcriptional levels of PARK2 and STUB1, reducing the ubiquitination of EGFR.
Article
Engineering, Environmental
Weiwei Wang, Jie Zhang, Ze Li, Jie Gu, Jingyu Qin, Jiali Li, Xiaona Zhang, Shaoguo Ru
Summary: BPS exposure accelerates the progression of ASCVD, inducing characteristic symptoms in zebrafish embryo-larvae model, such as inflammation, macrophage recruitment, and oxLDL accumulation in blood vessels.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biology
Xiao-Min Luo, Sin Man Lam, Yuan Dong, Xiao-Juan Ma, Cen Yan, Yue-Jie Zhang, Yu Cao, Li Su, Guotao Lu, Jin-Kui Yang, Guanghou Shui, Ying-Mei Feng
Summary: Metabolomics analysis reveals that inosine monophosphate (IMP) promotes myelopoiesis and contributes to severe acute pancreatitis. These findings provide a potential therapeutic target for the control of vascular complications in diabetes.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Manjiri P. P. Jalgaonkar, Urvi M. M. Parmar, Yogesh A. A. Kulkarni, Manisha J. J. Oza
Summary: The prevalence of diabetes is increasing, leading to microvascular and macrovascular complications. The interaction between SIRT1 and FOXOs plays an important role in controlling and alleviating diabetic complications, suggesting them as potential therapeutic targets.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biology
Carla L. Pietrucci, Laura K. Milton, Erika Greaves, Aneta Stefanidis, Maarten van den Buuse, Brian J. Oldfield, Claire J. Foldi
Summary: Genetic animal models are a valuable tool for understanding human pathologies, with the choice of model being crucial for uncovering specific effects. Contrary to previous findings in mice, the BDNF Val66Met polymorphism does not appear to influence susceptibility to weight loss or energy balance in a rat model of anorexia nervosa. These discrepancies highlight the importance of considering species-specific differences in research on animal models of human diseases.
Article
Clinical Neurology
Alberto Benussi, Antonella Alberici, Kiran Samra, Lucy L. Russell, Caroline Greaves, Martina Bocchetta, Simon Ducharme, Elizabeth Finger, Giorgio Fumagalli, Daniela Galimberti, Lize C. Jiskoot, Isabelle Le Ber, Mario Masellis, Benedetta Nacmias, James B. Rowe, Raquel Sanchez-Valle, Harro Seelaar, Matthis Synofzik, Jonathan D. Rohrer, Barbara Borroni
Summary: The presymptomatic stages of frontotemporal dementia (FTD) have not been clearly defined, indicating a need for a consensus lexicon to comprehensively describe the stages that anticipate dementia and to formulate a better strategy for characterizing these disease stages.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Ermelinda De Meo, Emilio Portaccio, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Angelo Bellinvia, Mattia Fonderico, Antonio Giorgio, Maria Laura Stromillo, Massimo Filippi, Sandro Sorbi, Nicola De Stefano, Maria Pia Amato
Summary: The BDNF Val66Met polymorphism may have a protective role in multiple sclerosis patients against both hippocampal atrophy and cognitive impairment.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Matilde Nerattini, Federica Rubino, Annachiara Arnone, Cristina Polito, Salvatore Mazzeo, Gemma Lombardi, Giulia Puccini, Benedetta Nacmias, Maria Teresa De Cristofaro, Sandro Sorbi, Alberto Pupi, Roberto Sciagra, Valentina Bessi, Valentina Berti
Summary: The study aims to interpret discrepancies between amyloid PET and CSF biomarkers in Alzheimer's disease diagnosis, utilizing a combination of different imaging and biomarker analysis techniques to improve diagnostic accuracy.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Giulia Giacomucci, Salvatore Mazzeo, Sonia Padiglioni, Silvia Bagnoli, Laura Belloni, Camilla Ferrari, Laura Bracco, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
Summary: The study found that women with SCD were younger and had less education, lower intelligence test scores, and more cognitive complaints compared to men. Intelligence tests were directly related to age of onset for both genders, while years of education were only inversely related to age of onset in women. Gender independently affected intelligence tests, with intelligence tests being directly related to cognitive complaints in men.
NEUROLOGICAL SCIENCES
(2022)
Article
Psychiatry
Andrea Patti, Gabriele Santarelli, Giulio D'Anna, Andrea Ballerini, Valdo Ricca
Summary: Aberrant salience plays a major role in psychotic proneness. Cannabis use, personality traits, psychotic-like symptoms, and self-transcendence dimensions are closely related to aberrant salience. Among cannabis users, subthreshold psychotic experiences are predominant, while personality traits are more relevant among nonusers.
Article
Environmental Sciences
Giovanni Castellini, Alessio Pellegrino, Livio Tarchi, Maria Calabrese, Maria Boddi, Valdo Ricca, Gianfranco Costanzo, Pietro Amedeo Modesti
Summary: The study found that first-generation Chinese migrants in Italy had a lower level of body-size perception compared to native Italians. In the Chinese cohort, factors like female gender, BMI, and years spent in Italy contributed to a desire to be thinner, while age showed a negative impact. The study suggests the importance of prevention programs specifically targeted towards men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
E. Limoncin, G. Ciocca, G. Castellini, A. Sansone, F. Cavalieri, F. Cavallo, T. Cocchiaro, V Ricca, G. di Lorenzo, A. Rossi, A. D. Fisher, V Rochira, G. Corona, E. A. Jannini
Summary: Hypersexual behavior has been broadly studied due to its unclear etiology, nature, and manifestation in relation to organic and psychopathological conditions. This position statement aims to provide evidence that hypersexuality should be considered as a symptom of an underlying condition and to offer specific statements for assessment and diagnosis based on recent literature. The importance of evaluating comorbid psychopathological and organic conditions and considering the impact of pharmacological treatments is emphasized.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Neuroimaging
Livio Tarchi, Stefano Damiani, Teresa Fantoni, Tiziana Pisano, Giovanni Castellini, Pierluigi Politi, Valdo Ricca
Summary: Eigenvector centrality has shown potential in the field of psychiatry, particularly in relation to ADHD. This study explored aberrant connectivity in ADHD using Voxel-Mirrored Homotopic Connectivity (VMHC) and found no differences between diagnostic groups. However, significantly higher eigenvector centrality values were observed in the ADHD group in specific brain regions. The findings suggest that eigenvector centrality may be more relevant to ADHD psychopathology, while VMHC is consistently linked to age.
BRAIN IMAGING AND BEHAVIOR
(2022)
Editorial Material
Clinical Neurology
Nils Peters, Benedetta Nacmias
Article
Neurosciences
Andrea Patti, Gabriele Santarelli, Ottone Baccaredda Boy, Isotta Fascina, Arianna Ida Altomare, Andrea Ballerini, Valdo Ricca
Summary: This study translated the Embodied Sense-of-Self Scale (ESSS) into Italian and examined its factor structure, reliability, and validity in an Italian sample. The three-factor structure of the ESSS was confirmed, although three different factors emerged in the Italian sample. The measure demonstrated good reliability and validity, showing consistent relationships with other variables. The 19-item Italian version of the ESSS is a suitable measure for assessing embodiment abnormalities in Italian samples.
Article
Health Care Sciences & Services
Giulia Giacomucci, Cristina Polito, Valentina Berti, Sonia Padiglioni, Giulia Galdo, Salvatore Mazzeo, Enrico Bergamin, Valentina Moschini, Carmen Morinelli, Claudia Nuti, Maria Teresa De Cristofaro, Assunta Ingannato, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Valentina Bessi
Summary: The study aimed to assess empathy deficit and neuronal correlates in patients with logopenic primary progressive aphasia (lv-PPA) and compare it with amnesic Alzheimer's disease (AD). The findings showed that both lv-PPA and AD patients had decreased cognitive empathy and increased personal distress over time. The study also found that specific brain regions with metabolic dysfunction were associated with empathy deficits.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Multidisciplinary Sciences
Miguel Angel Brieno-Enriquez, Mariela Faykoo-Martinez, Meagan Goben, Jennifer K. Grenier, Ashley McGrath, Alexandra M. Prado, Jacob Sinopoli, Kate Wagner, Patrick T. Walsh, Samia H. Lopa, Diana J. Laird, Paula E. Cohen, Michael D. Wilson, Melissa M. Holmes, Ned J. Place
Summary: Female naked mole rats have a long reproductive lifespan with no significant decline in fertility. The study found that these rats have a large ovarian reserve and undergo postnatal oogenesis. The presence of germ cells and pluripotency markers suggest a unique strategy of maintaining a small population of germ cells that can expand upon reproductive activation.
NATURE COMMUNICATIONS
(2023)
Review
Psychology, Multidisciplinary
Giuseppe Pierpaolo Merola, Ottone Baccaredda Boy, Isotta Fascina, Vincenzo Pecoraro, Andrea Falone, Andrea Patti, Gabriele Santarelli, David Colin Cicero, Andrea Ballerini, Valdo Ricca
Summary: This study evaluated the psychometric properties and screening potential of the Aberrant Salience Inventory (ASI), finding that ASI is a feasible screening tool for mental disorders and proposing a new three-factor model to explain the subscale structure of ASI.
SCANDINAVIAN JOURNAL OF PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Eleonora Rossi, Emanuele Cassioli, Lucia Cecci, Francesca Arganini, Michela Martelli, Carolina Alberta Redaelli, Simona Anselmetti, Sara Bertelli, Isabel Fernandez, Valdo Ricca, Giovanni Castellini
Summary: Adding EMDR to CBT-E may be beneficial for patients with AN reporting moderate/severe CM. Patients with trauma history showed improvements in BMI and ED-specific psychopathology after treatment, with the CBT + EMDR group demonstrating greater improvements. Dissociation played a mediating role in the reduction of ED symptoms in traumatised patients.
EUROPEAN EATING DISORDERS REVIEW
(2023)