Article
Orthopedics
Yueh-Hsiu Lu, Hsi-Hsien Lin, Hsuan-Ying Chen, Po-Hsin Chou, Shih-Tien Wang, Chien-Lin Liu, Ming-Chau Chang
Summary: Calcium pyrophosphate dihydrate deposition disease involving the cervical ligamentum flavum is rare, with specific clinical and imaging characteristics differentiating it from other conditions such as ossification of ligamentum flavum. Different image signs, including acute on chronic phenomenon, can help distinguish this condition from others.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Clinical Neurology
Yoshinori Ishikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Daisuke Kudo, Chiaki Sato, Yoichi Shimada
Summary: This case report presents successful treatment of coexisting cervical OLF and OPLL in a 70-year-old male patient. Surgical intervention led to significant improvement in symptoms and maintenance of cervical alignment. Surgeons should carefully evaluate the severity of adhesion, muscle damage, and necessity of posterior corrective surgery, as well as consider the patient's comorbidities and potential postoperative complications.
WORLD NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Jiabao Chen, Qingsong Yu, Haidong Wang, Huangda An, Chenhao Dou, Zhe Lu, Aoran Ding, Lei Ma
Summary: In this retrospective study, 91 patients with thoracic ossification of the ligamentum flavum (OLF) were included. It was found that the non-DO group had significantly higher residual area ratio (RAR) and short shaft ratio (SSR) compared to the DO group. SSR had a higher accuracy in predicting DO and could be a better predictor.
Article
Genetics & Heredity
Baoliang Zhang, Guanghui Chen, Xiaoxi Yang, Tianqi Fan, Xi Chen, Zhongqiang Chen
Summary: Pathological changes in the ligamentum flavum, including hypertrophy and ossification, have unclear pathogenesis. MicroRNAs play a crucial role in regulating gene expression and revealing the pathological mechanisms of these changes. Studies have shown the importance of miRNAs in regulating ligamentum flavum pathology.
FRONTIERS IN GENETICS
(2021)
Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Eren O. Kuris
Summary: Ossification of the ligamentum flavum (OLF) is a spinal condition that can potentially cause compression of the spinal canal and neurological damage. The exact cause is debated but is likely related to gene overexpression and signaling pathways. Progressive myelopathy is the most common symptom, and radiographic analysis can show ossification in different areas. Surgical treatment options exist but may result in complications and postoperative neurological deficits.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Surgery
Canada T. Montgomery, Stephen P. Miranda, Ernest Nelson, Katie Louka, MacLean Nasrallah, Paul J. Zhang, Joel Stein, Dmitriy Petrov
Summary: This report discusses a rare case of spinal osteoblastoma with associated OLF and myelopathy. The patient's neurological symptoms completely resolved after surgical treatment, highlighting the effectiveness of surgery in such cases.
FRONTIERS IN SURGERY
(2022)
Article
Multidisciplinary Sciences
Kuankuan Liu, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, Chi Zhang
Summary: This study identified the increased expression of PTGR1 in thoracic ossification of the ligamentum flavum (TOLF) and demonstrated its involvement in cell proliferation, possibly through activating the expression of c-Myc and CyclinD1 via the JNK pathway.
Review
Medicine, Research & Experimental
Yeqiu Xu, Yuanzhuang Zhang, Yinzhou Luo, Guanzhen Qiu, Yize Liu, Wei Zhao, Yong Wang
Summary: This article reports a case of incomplete Brown-Sequard syndrome (BSS) caused by ossification of the ligamentum flavum (OLF), which responded well to conservative treatment. However, further research is needed to determine if this can be considered as the standard of care.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Clinical Neurology
Guanghui Chen, Zhongqiang Chen, Weishi Li, Yu Jiang, Xinhu Guo, Baoliang Zhang, Liyuan Tao, Chunli Song, Chuiguo Sun
Summary: Dural ossification (DO) is a common condition in patients with ossification of the ligamentum flavum (OLF), leading to dural tears. However, current methods for diagnosing DO are limited. This study proposed a novel CT-based imaging sign, called the Banner cloud sign (BCs), and investigated its clinical characteristics and correlations with DO.
EUROPEAN SPINE JOURNAL
(2022)
Article
Surgery
Qiangqiang Pan, Zhenhui Zhang, Yanyu Zhu, Wentao Jiang, Kai Su, Peilin Liu, Yongsheng Kang, Zhe Shao, Wei Mei, Qingde Wang
Summary: This study proposed a zoning laminectomy to reduce the incidence of nerve injury during spinal surgery for thoracic ossification of the ligamentum flavum (TOLF). Retrospective analysis of 45 TOLF patients who underwent zoning laminectomy showed that it was a safe and effective surgical option.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Orthopedics
Yue Deng, Mingzhi Yang, Chao Xia, Yong Chen, Zhong Xie
Summary: This study evaluated the efficacy and safety of unilateral biportal endoscopic decompression treatment in patients with thoracic ossification of the ligamentum flavum (OLF). The results showed that this treatment significantly improved the neurological status of the patients and had a low complication rate.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Chemistry, Multidisciplinary
Norihiro Nishida, Muzammil Mumtaz, Sudharshan Tripathi, Amey Kelkar, Takashi Sakai, Vijay K. Goel
Summary: Cervical laminoplasty may cause ligament damage during surgery, leading to increased biomechanical stresses in the cervical spine, especially during flexion motion.
APPLIED SCIENCES-BASEL
(2021)
Article
Clinical Neurology
Jialiang Lin, Fei Xu, Shuai Jiang, Longjie Wang, Zhuoran Sun, Zhongqiang Chen, Zhaoqing Guo, Qiang Qi, Yan Zeng, Chuiguo Sun, Weishi Li
Summary: The study investigates the relationship between BMI and thoracic ossification of the ligamentum flavum (TOLF), finding that BMI is a crucial risk factor for TOLF. Prompt detection and treatment of TOLF progression are necessary for asymptomatic TOLF patients with high BMI.
EUROPEAN SPINE JOURNAL
(2022)
Article
Medicine, Research & Experimental
Kinshi Kato, Kenichi Otoshi, Michiyuki Hakozaki, Shin-Ichi Konno
Summary: This case study suggests that thoracic OLF may increase in size and become exacerbated in certain individuals, such as professional pitchers, who experience repeated, localized, mechanical stress on the thoracic spine, regardless of age.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Clinical Neurology
Yin Zhao, Bo Yuan, Li Cheng, Shengyuan Zhou, Yifan Tang, Zhichao Zhang, Yanqing Sun, Zheng Xu, Fengning Li, Xinyuan Liao, Xiongsheng Chen
Summary: This study induced ossification of ligamentum flavum (OLF) in rats using cyclic tensile stress, showing that longer duration of stress led to more visible osteogenesis. Western blot and RT-PCR analyses revealed increased expression of seven osteogenesis-related molecules in the experimental groups.
