Journal
ONCOTARGETS AND THERAPY
Volume 13, Issue -, Pages 7411-7422Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S258252
Keywords
prostate cancer; metastasis; alpha V beta 3; signal pathway
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In prostate cancer, distant organ metastasis is the leading cause of patient death. Although the mechanism of malignant tumor metastasis is unclear, studies have confirmed that integrin alpha V beta 3 plays an important role in this process. In prostate cancer, alpha V beta 3 mediates adhesion, invasion, immune escape and neovascularization through interactions with differ-ent ligands. Among these ligands and in addition to proteins that are directly related to tumor invasion, other proteins that contain the RGD structure could also bind to alpha V beta 3 and cause a number of biological effects. In this article, we summarized the ligand and downstream proteins related to alpha V beta 3-mediated prostate cancer metastasis as well as some diagnostic and therapeutic measures targeting alpha V beta 3.
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