Article
Oncology
Dan Song, Ziqi Ye, Fangyu Chen, Liangliang Zhan, Xinchen Sun
Summary: This study reveals that circFNDC3B is upregulated in ESCC and promotes ESCC progression by regulating the miR-370-3p/miR-136-5p/MYO5A signaling pathway. circFNDC3B could potentially serve as a diagnostic marker for ESCC.
Article
Biochemistry & Molecular Biology
Shalini Das Gupta, Robert Ciszek, Mette Heiskanen, Niina Lapinlampi, Janne Kukkonen, Ville Leinonen, Noora Puhakka, Asla Pitkanen
Summary: The study identified plasma miR-9-3p and miR-136-3p as promising biomarker candidates for mTBI, showing potential for distinguishing mTBI patients with high sensitivity and specificity. Further validation in a larger patient population is needed to confirm their diagnostic utility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jinpeng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen, Gang Luo, Jinkun Xu, Hao Li, Dongmei Pei, Xiang Zhao, Zhengting Guo, Xinqiao Li, Shengliang Zong, Yang Jiang, Zhitao Jing
Summary: This study identifies a novel circular RNA, circGNB1, which is upregulated in glioma and closely associated with poor prognosis. Functional assays reveal that circGNB1 overexpression promotes the viability, proliferation, invasion, and neurosphere formation of glioma stem cells. Mechanistically, circGNB1 upregulates the expression of oncogene XPR1 by sponging miR-515-5p and miR-582-3p. XPR1, in turn, promotes the malignant phenotype of glioma stem cells through upregulating IL6 expression and activating JAK2/STAT3 signaling. Additionally, the RNA binding protein IGF2BP3 binds to and stabilizes circGNB1, thus enhancing its effects on glioma stem cells. This study uncovers the crucial role of circGNB1 in tumorigenesis and malignant progression of glioma, providing a promising cancer biomarker.
CANCER CELL INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Madeleine Wheatley, Niantao Deng, Sarah Alexandrou, Thomas P. Davis, Maria Kavallaris, C. Elizabeth Caldon, Joshua McCarroll, Katleen De Preter, Pieter Mestdagh, Glenn M. Marshall, Kaylene J. Simpson, Jamie Fletcher, Alexander Swarbrick
Summary: This study discovered that miR-99b-5p, miR-380-3p, and miR-485-3p enhance the chemotherapeutic effects of doxorubicin in high-risk neuroblastoma. These miRNAs are often lost in patients and their low expression predicts poor survival outcomes.
Review
Cell Biology
Xingyu Chen, Yongyun Li, Tengteng Yao, Renbing Jia
Summary: Zebrafish are widely used in cancer research due to their low cost, quick establishment, and small sample size required. The zebrafish patient-derived xenograft (zPDX) models show promising evidence for short-term clinical treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Haiyang Wang, Haoran Li, Qianqian Jiang, Xuchen Dong, Suwen Li, Shan Cheng, Jia Shi, Liang Liu, Zhiyuan Qian, Jun Dong
Summary: Recent studies have shown that Glioma Stem-like Cells (GSCs) can induce malignant transformation of fibroblasts (t-FBs) in the tumor microenvironment through the HOTAIRM1/miR-133b-3p/TGF beta axis. This finding could potentially provide a new target for treating gliomas.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng
Summary: The study identified hsa_circ_0110389 as a novel upregulated circRNA in malignant-transformed gastric cancer cells, and found that it promotes gastric cancer progression via the miR-127-5p/miR-136-5p-SORT1 pathway. This circRNA may serve as a diagnostic/prognostic biomarker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Chenlong Li, Yan Liu, Zhonghua Lv, Hongshan Zheng, Zhenzhe Li, Jixing Zhang, Hongbo Bao, Sibin Zhang, Jinsheng Xiong, Hua Jin, Lei Yu, Siqi Ai, Yingjie Wang, Xu Xiao, Tianqi Su, Peng Liang
Summary: This study identified the novel biomarker panel consisting of the circHECTD1/miR-296-3p/SLC10A7 axis, which is critical for glioma tumorigenesis and invasiveness, representing a potential therapeutic target for intervening in glioma progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Xuepei Li, Junwen Guan, Zhou Jiang, Shuting Cheng, Wang Hou, Junjie Yao, Zhengrong Wang
Summary: The study revealed that M2 microglial exosomes promote the proliferation and migration of gliomas by regulating tumor-related protein expression and reducing apoptosis. miR-7239-3p is recruited to glioma cells by exosomes and inhibits Bmal1 expression in the glioma microenvironment.
NEUROSCIENCE BULLETIN
(2021)
Article
Endocrinology & Metabolism
Melanie S. S. Hulshoff, Isabel N. N. Schellinger, Xingbo Xu, Jolien Fledderus, Sandip K. K. Rath, Fang Cheng Wong, Sabine Maamari, Josephina Haunschild, Guido Krenning, Uwe Raaz, Elisabeth M. M. Zeisberg
Summary: Diabetes patients exhibit accelerated aortic stiffening which contributes to cardiovascular diseases. This study demonstrates that EndMT plays a role in the development of aortic stiffening in type 2 diabetes. miR-132-3p and KLF7 are identified as novel regulators of EndMT.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Cell Biology
Lingzhi Jiang, Mingshan Wang, Renhua Sun, Zongbin Lin, Renyang Liu, Hanhui Cai, Zhiyun Tang, Run Zhang
Summary: miR-19b-3p protects cells from sepsis-induced inflammation injury by inhibiting the NF-κB signaling pathway, with KLF7 confirmed as a potential target.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biology
Yanguo Peng, Wei Li, Shuiyu Chen, Wangchun Wu, Zhanfang Shang
Summary: The study revealed that miR-494-3p expression was reduced while KLF7 expression was enhanced in a peripheral nerve injury model. MiR-494-3p negatively regulates KLF7 in Schwann cells, affecting cell proliferation and apoptosis processes.
Article
Neurosciences
Jiakai Chen, Handong Wang, Junjun Wang, Wenhao Niu, Chulei Deng, Mengliang Zhou
Summary: Accumulated evidence suggests that NEAT1 promotes glioma progression by acting as a sponge for miR-128-3p. The NEAT1/miR-128-3p/ITGA5 axis is involved in glioma initiation and progression, offering a potential novel strategy for treatment. NEAT1 competitively binds to miR-128-3p to enhance ITGA5 expression, activating the FAK signaling pathway and promoting cell growth in glioma.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ping Xue, Saihua Huang, Xiao Han, Caiyan Zhang, Lan Yang, Wenfeng Xiao, Jinrong Fu, Hao Li, Yufeng Zhou
Summary: Exosomal miRNAs, such as miR-101-3p and miR-423-5p, play important roles as tumor suppressors in mediating the progression of medulloblastoma by inhibiting proliferation, migration, and invasion of tumor cells, and promoting apoptosis. These exosomal miRNAs can be delivered to tumor cells via exosomes and directly target genes like FOXP4 and EZH2, reinforcing their tumor inhibitory effects. Overexpression of miR-101-3p and miR-423-5p has been shown to inhibit tumorigenesis in vivo in a xenograft mouse model, indicating a potential therapeutic approach for the treatment of children with medulloblastoma.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Zhenxing Sun, Naili Wei, Shenglian Yao, Guihuai Wang, Yaxing Sun, Zhenze Wang, Dan Yuan
Summary: LINC01158 is overexpressed in glioma and enhances CENPK expression by sponging miR-6734-3p, promoting glioma development and inhibiting apoptosis.
CANCER CELL INTERNATIONAL
(2021)