Biochemical pathways to α-ketoglutarate, a multi-faceted metabolite

Metabolic manipulation by Pseudomonas fluorescens: a powerful stratagem against oxidative and metal stress

(2020) Alex MacLean et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

(2019) Yuan Su et al.   Aging-US

Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens

(2019) Azhar A. Alhasawi et al.   Frontiers in Microbiology

Metabolic adaptation and NADPH homeostasis evoked by a sulfur-deficient environment in Pseudomonas fluorescens

(2019) Félix Legendre et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Alpha ketoglutarate nanoparticles: A potentially effective treatment for cyanide poisoning

(2018) Shaheen Sultana et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications

(2018) Shaojuan Liu et al.   Biomed Research International

Metabolic defence against oxidative stress: the road less travelled so far

(2017) J. Lemire et al.   JOURNAL OF APPLIED MICROBIOLOGY

Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing

(2017) Vance L Albaugh et al.   JOURNAL OF NUTRITION

In vitro metabolic engineering for the production of α-ketoglutarate

(2017) Barbara Beer et al.   METABOLIC ENGINEERING

Ethylene production in Synechocystis sp. PCC 6803 promotes phototactic movement

(2017) Ekaterina Kuchmina et al.   MICROBIOLOGY-SGM

Phospho-transfer networks and ATP homeostasis in response to an ineffective electron transport chain in Pseudomonas fluorescens

(2016) V.P. Appanna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Alpha-Ketoglutarate: Physiological Functions and Applications

(2016) Nan Wu et al.   Biomolecules & Therapeutics

Therapies targeting lipid peroxidation in traumatic brain injury

(2016) Tamil Selvan Anthonymuthu et al.   BRAIN RESEARCH

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs

(2015) Lei Wang et al.   AMINO ACIDS

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Alpha-ketoglutarate attenuates toxic effects of sodium nitroprusside and hydrogen peroxide in Drosophila melanogaster

(2015) Maria M. Bayliak et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Brain metabolism and Alzheimer’s disease: The prospect of a metabolite-based therapy

(2015) S. C. Thomas et al.   Journal of Nutrition Health & Aging

Ethylene-forming enzyme and bioethylene production

(2014) Carrie Eckert et al.   Biotechnology for Biofuels

Mitochondrial lactate metabolism is involved in antioxidative defense in human astrocytoma cells

(2014) Joseph Lemire et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation

(2014) John S. Scotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the α-ketoglutarate overproduction from raw glycerol by overexpression of the genes encoding NADP+-dependent isocitrate dehydrogenase and pyruvate carboxylase in Yarrowia lipolytica

(2013) Venelina Yovkova et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mitochondrial Biogenesis and Energy Production in Differentiating Murine Stem Cells: A Functional Metabolic Study

(2013) Sungwon Han et al.   Cellular Reprogramming

Hydrogen peroxide stress provokes a metabolic reprogramming in Pseudomonas fluorescens: Enhanced production of pyruvate

(2013) Adam Bignucolo et al.   JOURNAL OF BIOTECHNOLOGY

Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis

(2013) H. Eoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of bacterial ethylene-forming enzyme gene in Trichoderma reesei enhanced the production of ethylene

(2012) Xi Chen et al.   International Journal of Biological Sciences

Artefacts in cell culture: α-Ketoglutarate can scavenge hydrogen peroxide generated by ascorbate and epigallocatechin gallate in cell culture media

(2011) Lee Hua Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic response to aluminum toxicity: Dyslipidemia and liver diseases

(2011) Ryan J. Mailloux et al.   EXPERIMENTAL CELL RESEARCH

Aluminum toxicity and astrocyte dysfunction: A metabolic link to neurological disorders

(2011) Joseph Lemire et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Metabolic Reprogramming Evoked by Nitrosative Stress Triggers the Anaerobic Utilization of Citrate in Pseudomonas fluorescens

(2011) Christopher Auger et al.   PLoS One

The disruption of l-carnitine metabolism by aluminum toxicity and oxidative stress promotes dyslipidemia in human astrocytic and hepatic cells

(2011) Joseph Lemire et al.   TOXICOLOGY LETTERS

Metabolic engineering for ethylene production by inserting the ethylene-forming enzyme gene (efe) at the 16S rDNA sites of Pseudomonas putida KT2440

(2010) Jian-Ping Wang et al.   BIORESOURCE TECHNOLOGY

Histidine is a source of the antioxidant, α-ketoglutarate, in Pseudomonas fluorescens challenged by oxidative stress

(2010) Joseph Lemire et al.   FEMS MICROBIOLOGY LETTERS

d-Galacturonic acid catabolism in microorganisms and its biotechnological relevance

(2009) Peter Richard et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

 -Ketoglutarate Dehydrogenase and Glutamate Dehydrogenase Work in Tandem To Modulate the Antioxidant  -Ketoglutarate during Oxidative Stress in Pseudomonas fluorescens

(2009) R. J. Mailloux et al.   JOURNAL OF BACTERIOLOGY

α-Ketoglutarate abrogates the nuclear localization of HIF-1α in aluminum-exposed hepatocytes

(2008) Ryan J. Mailloux et al.   BIOCHIMIE

A novel metabolic network leads to enhanced citrate biogenesis in Pseudomonas fluorescens exposed to aluminum toxicity

(2008) Ryan J. Mailloux et al.   EXTREMOPHILES

Identifying the direct effects of ammonia on the brain

(2008) Cristina R. Bosoi et al.   METABOLIC BRAIN DISEASE

Effect of dietary alpha‐ketoglutarate on blood lipid profile during hypercholesterolaemia in rats

(2008) Radoslaw P. Radzki et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION