4.5 Review

SARS-CoV-2: characteristics and current advances in research

Journal

VIROLOGY JOURNAL
Volume 17, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12985-020-01369-z

Keywords

SARS-CoV-2; COVID-19; Cytokine storm; Cardiovascular disease; Myocardial injury; Venous thromboembolism; Treatment

Categories

Funding

  1. National Key RAMP
  2. D Program of China [2018YFC1602206]
  3. Yangjiang Science and Technology Program key projects [2019010]
  4. Guangzhou Science and Technology Program key projects [201803040006]
  5. Guangdong Science and Technology Program key projects [2018B020207006]

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Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection has spread rapidly across the world and become an international public health emergency. Both SARS-CoV-2 and SARS-CoV belong to subfamilyCoronavirinaein the familyCoronaviridaeof the orderNidoviralesand they are classified as the SARS-like species while belong to different cluster. Besides, viral structure, epidemiology characteristics and pathological characteristics are also different. We present a comprehensive survey of the latest coronavirus-SARS-CoV-2-from investigating its origin and evolution alongside SARS-CoV. Meanwhile, pathogenesis, cardiovascular disease in COVID-19 patients, myocardial injury and venous thromboembolism induced by SARS-CoV-2 as well as the treatment methods are summarized in this review.

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