Journal
VIRAL IMMUNOLOGY
Volume 33, Issue 9, Pages 594-599Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/vim.2020.0039
Keywords
picornavirus; type 1 diabetes; bio breeding rat; antiviral treatment
Categories
Funding
- Karolinska University Hospital
- Karolinska Institutet [91201100915]
- Family Erling Persson Foundation
- Strategic Research Program in Diabetes at Karolinska Institutet
- Stichting af Jochnick Foundation
Ask authors/readers for more resources
A Picornavirus (Ljungan virus [LV]) originally found in bank voles has been associated with type 1 diabetes (T1D) in its wild rodent reservoir, but also associated with T1D in a laboratory rat model for the disease, the diabetes prone (DP) Bio Breeding (BB) rat. Successful treatment of diabetes in this rat model, using experimental antiviral compounds directed against picornavirus, has been reported. In the present study we show significant clinical response in DP-BB rats using antiviral compounds available for human use (Pleconaril, Efavirenz, and Ribavirin). Presence of LV picornavirus antigen has been detected in islets of Langerhans from both human and the T1D rat model with clear morphological similarity. Based on these data it would be of interest to test antiviral treatment in patients with newly diagnosed T1D. Successful outcome will offer both proof of concept regarding the role of virus involvement in the disease and possibly a first generation treatment interrupting a persistent infection and stopping beta-cell destruction.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available