Journal
CLINICAL SCIENCE
Volume 130, Issue 11, Pages 843-852Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20150780
Keywords
metabolic disease; microRNAs; mitochondria; obesity; skeletal muscle
Categories
Funding
- Netherlands Organization for Scientific Research (NWO) [918.96.618, 917.14.358]
- Dutch Diabetes Research Foundation [2013.82.1639]
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The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity and obesity-related metabolic disease. In recent years, novel aspects in the regulation of mitochondrial metabolism, such as mitochondrial dynamics, mitochondrial protein quality control and post-transcriptional regulation of genes coding for mitochondrial proteins, have emerged. In this review, we discuss the recent findings concerning the dysregulation of these processes in skeletal muscle in obesogenic conditions.
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