Review
Oncology
Ruizhe Huang, Yizhen Li, Haowen Wu, Boyi Liu, Xuanjun Zhang, Zhongxi Zhang
Summary: The aim of this study was to compare the diagnostic efficacy of Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI in patients with biochemically recurrent prostate cancer. A meta-analysis and systematic review were conducted, analyzing 37 studies involving 8409 patients. The results showed that Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI had similar detection rates for biochemically recurrent prostate cancer. However, larger prospective studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yining Wang, Zijun Chen, Yinjie Zhu, Haitao Zhao, Lianghua Li, Gang Huang, Wei Xue, Ruohua Chen, Jianjun Liu
Summary: The purpose of this study was to assess whether total-body [(68) Ga]Ga-PSMA-11 PET/CT could improve the detection rate compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer. The results showed that total-body [(68) Ga]Ga-PSMA-11 PET/CT had better objective evaluation in terms of background noise, lesion prominence, liver SD, SNR, and lesion SUVmax compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT. Overall, total-body [(68) Ga]Ga-PSMA-11 PET/CT had a significantly higher detection rate for biochemical recurrent prostate cancer compared to conventional [(68) Ga]Ga-PSMA-11 PET/CT. Rating: 9/10.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaomei Gao, Yongxiang Tang, Minfeng Chen, Jian Li, Hongling Yin, Yu Gan, Xiongbin Zu, Yi Cai, Shuo Hu
Summary: This study compared [Ga-68]Ga-RM26 PET/CT and [Ga-68]Ga-PSMA-617 PET/CT for diagnosing prostate cancer, and found that [Ga-68]Ga-PSMA-617 PET/CT had superior accuracy in detecting clinically significant PCa, while [Ga-68]Ga-RM26 PET/CT showed an advantage for imaging low-risk PCa.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Wen, Yinjie Zhu, Lianghua Li, Jianjun Liu, Yumei Chen, Ruohua Chen
Summary: Dynamic total-body PET imaging in patients with prostate cancer showed that 6 minutes post-injection was the optimal time for imaging, avoiding interference from bladder activity and detecting lesions with relatively low PSMA uptake. Additionally, imaging at 35-59 minutes post-injection could also yield similar results to imaging at 60 minutes post-injection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuheng Liu, Lianghua Li, Yanyu Qin, Zijun Chen, Haitao Zhao, Xinlu Wang, Ruohua Chen
Summary: The objective of this study was to compare the diagnostic performance and image quality of total-body PET/CT imaging using half-dose of [(68) Ga]Ga-PSMA radiotracer to conventional PET/CT imaging using full dose of [(68) Ga]Ga-PSMA. The results showed that total-body PET/CT with half-dose of [(68) Ga]Ga-PSMA yielded comparable image quality and diagnostic performance to conventional PET/CT, while reducing radiation exposure for the subjects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Wenxiao Yu, Ming Zhao, Yingjun Deng, Shengjing Liu, Guanchao Du, Bin Yan, Ziwei Zhao, Ning Sun, Jun Guo
Summary: This study compared the diagnostic value of (18) F-PSMA-1007 PET/CT, (18) F-FDG PET/CT, and Ga-68-PSMA PET/CT in prostate cancer. The results showed that both (18) F-PSMA-1007 PET/CT and Ga-68 PSMA PET/CT demonstrated higher diagnostic efficacy compared to (18) F-FDG PET/CT.
Article
Clinical Neurology
Arunav Kumar, Sreedharan Thankarajan ArunRaj, Khush Bhullar, K. P. Haresh, Subhash Gupta, Sanjana Ballal, Madhav Yadav, Manmohan Singh, Nishikant Avinash Damle, Ajay Garg, Madhavi Tripathi, Chandrasekhar Bal
Summary: In this prospective study, Ga-68 PSMA showed potential for evaluating recurrence in high-grade gliomas, with a high level of concordance between PET and MRI.
Article
Oncology
Fuquan Deng, Xiaoyuan Li, Fengjiao Yang, Hongwei Sun, Jianmin Yuan, Qiang He, Weifeng Xu, Yongfeng Yang, Dong Liang, Xin Liu, Greta S. P. Mok, Hairong Zheng, Zhanli Hu
Summary: This study used deep learning methods to perform low-dose image restoration on PSMA PET/MRI and found that synthesizing full-dose PET images based on MRI priors using 50% dose PET images did not affect the clinical diagnosis of prostate cancer. Prostate cancer patients can undergo 68Ga-PSMA prostate PET/MRI scans with radiation doses reduced by up to 50% through the use of deep learning methods to synthesize FDPET images.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wojciech Cytawa, Stefan Kircher, Hubert Kuebler, Rudolf A. Werner, Simon Weber, Philipp Hartrampf, Tomasz Bandurski, Piotr Lass, Wojciech Polom, Marcin Matuszewski, Hans-Juergen Wester, Constantin Lapa, Andreas Rosenwald, Anna Katharina Seitz, Andreas K. Buck
Summary: The purpose of this study was to validate the expression of primary tumor PSMA in prostate cancer patients using [Ga-68]Ga-PSMA PET/CT imaging. The results showed that among PSMA-positive patients, about one-third had lymph node metastases, which were associated with PSMA expression and tumor volume. In contrast, only 1 out of 7 PET-negative patients had lymph node involvement. These results suggest that PSMA-positive prostate cancer may have a higher risk of aggressiveness and distant metastasis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Pattison, Maciej Debowski, Brook Gulhane, Evyn G. Arnfield, Anita M. Pelecanos, Peter L. Garcia, Melissa J. Latter, Charles Y. Lin, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas
Summary: This study aimed to compare the concordance of [F-18]PSMA-1007 and [(68)Ga]Ga-PSMA-11 in TNM diagnosis and tracer uptake. The results showed differences in tracer uptake in most physiological sites, but high consistency in overall AJCC prognostic stage.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yee Ling Ng, Xinlan Yang, Yinjie Zhu, Lianghua Li, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Total-body parametric imaging of [(68) Ga]Ga-PSMA-11 improved lesion contrast and detectability compared to SUV images, which may serve as an imaging biomarker and theranostic tool for precise diagnosis and treatment evaluation in prostate cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guochang Wang, Linlin Li, Jie Zang, Haiyan Hong, Lin Zhu, Hank F. Kung, Zhaohui Zhu
Summary: This study compared the diagnostic performance of Ga-68-P16-093 and Ga-68-PSMA-617 PET/CT in primary prostate cancer patients. The results showed that Ga-68-P16-093 PET/CT detected more positive tumors and had higher tumor uptake and better tumor detection capability than Ga-68-PSMA-617 PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Manuela A. Hoffmann, Jonas Mueller-Huebenthal, Florian Rosar, Nicolas Fischer, Finn Edler von Eyben, Hans-Georg Buchholz, Helmut J. Wieler, Mathias Schreckenberger
Summary: This study compared the performance of [F-18]PSMA-1007 and [Ga-68]Ga-PSMA-11 positron emission tomography/computed tomography in the initial staging of prostate cancer patients. The results showed that both methods were able to detect PSMA-avid lesions with high concordance to histopathologically proven cancer. There was no superior advantage of either method in diagnosing prostate cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Samuele Ghezzo, Ilaria Neri, Paola Mapelli, Annarita Savi, Ana Maria Samanes Gajate, Giorgio Brembilla, Carolina Bezzi, Beatrice Maghini, Tommaso Villa, Alberto Briganti, Francesco Montorsi, Francesco De Cobelli, Massimo Freschi, Arturo Chiti, Maria Picchio, Paola Scifo
Summary: This study proposes a new workflow for accurate co-registration of prostate PET images with histopathological images using a dual-tracer PET/MRI study. The method allows a deeper understanding of PET tracer distribution and enables advanced analyses. The co-registration workflow involves five steps and the precision was evaluated using target registration error (TRE) and DICE score.
BIOENGINEERING-BASEL
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jiayu Cai, Weizhi Xu, Tinghua Meng, YiZhen Pang, Haojun Chen
Summary: Mixed neuroendocrine carcinoma-acinar carcinoma is a rare type of neuroendocrine prostate cancer and has rarely been reported in de novo cases. In this case, we present the PET/CT findings of Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG in the de novo form of mixed large-cell neuroendocrine carcinoma-acinar adenocarcinoma of the prostate. Different levels of radiotracer uptake were observed in metastatic sites on Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG PET/CT. This case demonstrates the potential use of a multitracer PET/CT strategy for noninvasive detection of intermetastatic heterogeneity in metastatic neuroendocrine prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk, Ismail Dogu Kilic
Letter
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk, Ahmet Baki Yagci
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk, Tuncay Hazirolan
Summary: A cardiac outpouching (CO) is a protrusion in a heart chamber's internal anatomical lining. Most COs are clinically insignificant, but some are of vital importance, requiring immediate surgery. Cross-sectional imaging findings of COs, such as location, morphology, size, and accompanying wall motion abnormalities, play an essential role in determining the correct diagnosis and appropriate clinical management. Therefore, radiologists should be familiar with them. This article reviews the key cross-sectional imaging findings and differential diagnoses of COs.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Pediatrics
Muhammed Tekinhatun, Furkan Ufuk, Munevver Yilmaz, Dolunay Gurses, Argun Kis, Gokhan Ozturk
Summary: A previously healthy 12-year-old girl presented to the emergency department with severe chest pain and dyspnea. She had short-term syncope just before the emergency admission. Physical examination revealed a respiratory rate of 26 breaths per minute at rest and a blood pressure of 92/56 mmHg. Laboratory tests showed elevated C-reactive protein and white blood cell count, while other test results were within normal limits. An electrocardiogram showed ST-segment elevation, and echocardiography revealed a complicated pericardial effusion and a suspicious mass adjacent to the left ventricle.
PEDIATRIC PULMONOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Merve Oguz, Dolunay Gurses, Furkan Ufuk, Munevver Yilmaz, Olcay Gungor
Summary: This case report describes a DMD patient presenting with ACP and elevated troponin, diagnosed with acute myocardial injury and successfully treated with corticosteroids. It suggests that ACP with troponin elevation in DMD patients may indicate acute myocardial injury.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Letter
Pediatrics
Furkan Ufuk, Hakki Peker, Munevver Yilmaz, Dolunay Gurses
PEDIATRIC PULMONOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk, Ismail Dogu Kilic
Summary: A 58-year-old man with intermittent chest pain and palpitations presented to the cardiology clinic. His medical history revealed the presence of a cardiac mass detected 3 years ago, and he had a family history of sudden cardiac death. Physical examination was unremarkable except for increased blood pressure. Laboratory findings were within normal limits. ECG showed sinus rhythm and ST depression in the left precordial leads. Transthoracic echocardiography revealed an irregular left ventricle mass.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk
Article
Pharmacology & Pharmacy
Ayse Ugur, Olga Yaylali, Doganguen Yuksel
Summary: This study aimed to successfully label [Ga-68]GaPSMA-HBED-CC and [Ga-68]GaDOTA-TATE using TEA buffer without chemical impurities, and ensure the suitability of the final products for clinical use through quality control testing. High purity DOTA-TATE peptide suitable for clinical use was obtained by adding 363K temperature and radical scavenger in the reaction. This method is suitable for clinical use and can be adapted for routine use in nuclear medicine laboratories.
CURRENT RADIOPHARMACEUTICALS
(2023)
Article
Oncology
Tarik Sengoz, Yeliz Arman Karakaya, Aziz Gueltekin, Sevda Yilmaz, Ergun Erdem, Burcu Yapar Taskoylu, Zehra Kesen, Olga Yaylali, Dogangun Yuksel
Summary: This study retrospectively evaluated the role of baseline and post-treatment SUVmax values in predicting pathological response in breast cancer patients after neoadjuvant chemotherapy. The results showed that post-treatment SUVmax and dSUVmax can be used to predict the response of the tumor to treatment.
EUROPEAN JOURNAL OF BREAST HEALTH
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Furkan Ufuk, Ismail Dogu Kilic
Article
Rheumatology
Serdar Kaymaz, Murat Yigit, Furkan Ufuk, Burak Sarilar, Ugur Karasu, Veli Cobankara, Nuran Sabir, Hakan Alkan
Summary: This study evaluated the stiffness and cross-sectional area of the tibial nerve in patients with systemic sclerosis using shear wave elastography and ultrasound. The results showed that disease activity in patients with systemic sclerosis was associated with tibial nerve involvement, which could be detected using ultrasound and shear wave elastography.
ARCHIVES OF RHEUMATOLOGY
(2023)
