Article
Infectious Diseases
Hulya Gamze Celik, Siran Keske, Ulker Sener, Muge Tekbas, Mahir Kapmaz, Sukru Taylan Sahin, Asli Ozyildirim, Saide Aytekin, Vedat Aytekin, Onder Ergonul
Summary: This study aimed to describe QTc prolongation and related adverse cardiac events during the treatment of COVID-19 with HCQ. Critical QTc prolongation was detected in 12% of patients, and diabetes mellitus and the use of oseltamivir were found to be associated with this complication.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
History & Philosophy Of Science
Farid Zahnoun
Summary: Despite the widespread belief in contemporary cognitive science that approaches eschewing representation are limited in explanatory scope, there is still no compelling reason to assume that non-representationalist theories are inherently limited. The influential argument regarding 'representation-hungry' cognition by Clark and Toribio is flawed due to inconsistent notion of representation and conflation of explanandum with explanans. The appeal of the argument from representation-hunger seems to stem primarily from the unscientific principle of like causes like upon closer inspection.
Article
Psychiatry
Jose A. Puertas-Gonzalez, Carolina Marino-Narvaez, Maria Isabel Peralta-Ramirez, Borja Romero-Gonzalez
Summary: The study found that the COVID-19 pandemic has psychological effects on pregnant women, particularly in terms of depression, phobic anxiety, and perceived stress. Insomnia and recent loss of a loved one are important factors affecting depression, while fear of COVID-19 infection leads to an increase in phobic anxiety.
PSYCHIATRY RESEARCH
(2021)
Editorial Material
Obstetrics & Gynecology
Ezgi Darici, Christophe Blockeel, Shari Mackens
Summary: Chronic endometritis is an infectious or inflammatory process that disrupts the correct implantation of embryos. Its prevalence ranges from 2% to almost 60%, with a higher suspicion in women with recurrent early pregnancy loss and recurrent implantation failure. The impact of chronic endometritis on reproductive outcomes following IVF is uncertain due to the lack of convincing data showing improvement after diagnosis and treatment. This article critically evaluates current diagnostic methods, treatments, and patient populations for chronic endometritis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Pediatrics
Danilo Buonsenso, Walter Malorni, Arianna Turriziani Colonna, Sofia Morini, Martina Sbarbati, Alessandro Solipaca, Antonio Di Mauro, Brigida Carducci, Antonio Lanzone, Umberto Moscato, Simonetta Costa, Giovanni Vento, Piero Valentini
Summary: This study aimed to assess the impact of the COVID-19 pandemic on the mental health, type of delivery, and neonatal feeding of pregnant women with or without SARS-CoV-2 infection. The survey results showed that pregnant women with SARS-CoV-2 infection had a higher probability of being separated from the newborn and a lower probability of breastfeeding. Additionally, these women were more likely to experience symptoms suggestive of postnatal depression.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Justine Chinn, Shaina Sedighim, Katharine A. Kirby, Samuel Hohmann, Afshan B. Hameed, Jennifer Jolley, Ninh T. Nguyen
Summary: This study compared characteristics and outcomes of women who underwent childbirth with vs without COVID-19 in a large US cohort, and found that women with COVID-19 during childbirth had higher rates of mortality, intubation, ICU admission, and preterm birth.
Article
Health Care Sciences & Services
Ruxandra-Gabriela Cigaran, Radu Botezatu, Elma-Maria Mineca, Corina Gica, Anca Maria Panaitescu, Gheorghe Peltecu, Nicolae Gica
Summary: The COVID-19 pandemic had significant impact on the lifestyle and mental health of pregnant women in Romania. Majority of participants were emotionally affected by the pandemic and were concerned about the possibility of virus affecting their pregnancies. Trust in healthcare services decreased during the pandemic, with private hospitals perceived as safer option than public ones.
Article
Psychiatry
Hernan Lopez-Morales, Macarena Veronica del Valle, Lorena Canet-Juric, Maria Laura Andres, Juan Ignacio Galli, Fernando Poo, Sebastian Urquijo
Summary: During the quarantine period of 50 days, all women showed a gradual increase in psychopathological indicators and a decrease in positive affect, with pregnant women exhibiting a more pronounced increase in depression, anxiety, and negative affect than non-pregnant women did. Additionally, pregnant women experienced a more pronounced decrease in positive affect compared to non-pregnant women.
PSYCHIATRY RESEARCH
(2021)
Article
Computer Science, Information Systems
Floris Devriendt, Jeroen Berrevoets, Wouter Verbeke
Summary: Uplift modeling has gained attention in predictive analytics, with the introduction of a new evaluation metric called the maximum profit uplift that helps assess the potential profit of uplift models. This measure allows for comparison of customer churn prediction models and uplift models, and has been applied in a case study in the financial industry.
INFORMATION SCIENCES
(2021)
Article
Infectious Diseases
Sanaz Nargesi, Felix Bongomin, Mohammad T. Hedayati
Summary: Fungal neglected tropical diseases (FNTDs) such as mycetoma, chromoblastomycosis, and paracoccidioidomycosis have a similar geographical distribution to diseases like tuberculosis and malaria, but receive less attention. AIDS-related mycoses are also highlighted, with inadequate funding being a challenge despite advancements in antiretroviral therapy.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Ethics
Daniel Rodger
Summary: The use of animal-derived medical products on patients without their informed consent undermines respect for autonomy and may cause psychological harm. It is morally inconsistent to respect patients' dietary preferences and then use animal-derived medicines or medical devices without their informed consent. Addressing this ethical blind spot by consistently applying the principles of respect for autonomy and informed consent is necessary.
JOURNAL OF MEDICAL ETHICS
(2022)
Article
Immunology
Jane Williams, Chris Degeling, Jodie McVernon, Angus Dawson
Summary: Vaccination plays a crucial role in pandemic planning and response, but the effectiveness of vaccines for novel pandemic viruses is uncertain. Ethical considerations and uncertainties must be taken into account when distributing vaccines.
Article
Ecology
Conrad van den Ende, Mark N. Puttick, Araxi O. Urrutia, Matthew A. Wills
Summary: Indices of morphological and molecular disparity are used to summarize variation within species groups, and the former is more influenced by subjective character selection. Molecular disparity is found to be less influenced by sampling biases and can be obtained in a more objective and automated manner than morphological data. Comparisons between morphological and molecular disparity can provide a fuller picture of subclade evolution.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Nicolas Berthelot, Julia Garon-Bissonnette, Christine Drouin-Maziade, Vanessa Bergeron, Thibaut Series
Summary: This study evaluated the effects of an online mentalization-based prenatal group program, STEP-COVID, on psychological distress in pregnant women during the COVID-19 pandemic. The results showed a significant decrease in distress and post-traumatic symptoms, and an increase in positive affectivity in the intervention group, compared to the control group where only post-traumatic symptoms improved. Women in the intervention group also reported greater changes in resilience-promoting factors during pregnancy. These findings suggest that brief online interventions like STEP-COVID can help mitigate the impact of the pandemic on the mental health of pregnant women.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Niloufar Arzamani, Shiva Soraya, Fatemeh Hadi, Sara Nooraeen, Mahdieh Saeidi
Summary: Addressing the impact of the COVID-19 pandemic on mental health in pregnant women is crucial, and providing recommendations can guide health professionals and policymakers in improving their mental well-being.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Anna Kajdy, Dorota Sys, Artur Pokropek, Steven W. Shaw, Tung-Yao Chang, Pavel Calda, Ganesh Acharya, Maya Ben-Zion, Tal Biron-Shental, Dariusz Borowski, Bartosz Czuba, Adolfo Etchegaray, Stepan Feduniw, Rosario Garcia-Mandujano, Monica Garcia Santacruz, Maria M. Gil, Sonia Hassan, Sebastian Kwiatkowski, Arancha Martin-Arias, Raigam Jafet Martinez-Portilla, Federico Prefumo, Michal Rabijewski, Laurent J. Salomon, Heidi Tiller, Stefan Verlohren, Hian Yan Voon, Omar Fernando Yanque-Robles, Soon Leong Yong, Liona C. Poon
Summary: This study examines risk factors for anxiety and depression among pregnant women during the COVID-19 pandemic. The results indicate that pregnant women in high-income economies experience higher levels of anxiety and depression. Factors such as the need for psychiatric treatment before pregnancy, restrictions in social distancing and access to leisure activities, pregnancy-related complications, fear of adverse outcomes in children related to COVID-19, and financial burden are associated with increased risk of anxiety and depression during pregnancy.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Guixue Hou, Ya Gao, Liona C. Poon, Yan Ren, Chunwei Zeng, Bo Wen, Argyro Syngelaki, Liang Lin, Jin Zi, Fengxia Su, Weiwei Xie, Fang Chen, Kypros H. Nicolaides
Summary: This study defined the lipidomic profile in plasma during pregnancy and identified lipid biomarkers for the prediction of gestational diabetes mellitus (GDM) in early pregnancy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sani Tsz Kei Wong, So Ling Lau, Christopher Pak Hey Chiu, Patricia Nga Ping Ip, Lo Wong, Dorota Sys, Anna Kajdy, Liona Chiu Yee Poon
Summary: This study assessed the anxiety and depression levels of pregnant women in Hong Kong during the COVID-19 pandemic and examined the influence of demographic, economic, and social factors on these levels. The findings showed that pregnant women with psychiatric illness had higher scores in anxiety and depression. Factors such as financial difficulty, education, and in-vitro fertilization were associated with higher levels of depression, while partner support was associated with reduced levels of depression and anxiety. Therefore, addressing the needs of pregnant women with psychiatric illness and providing partner support are crucial during the COVID-19 pandemic.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Fouzia Farooq, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A. Tippett Barr, Elisa Bevilacqua, Justin S. Brandt, Nathalie Broutet, Irene Fernandez Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Valerie J. Flaherman, Chris Gale, Maria M. Gil, Sami L. Gottlieb, Eduard Gratacos, Olivia Hernandez, Stephanie Jones, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Valentina Laurita Longo, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Elizabeth M. McClure, Tori D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Soderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E. Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M. Tielsch
Summary: Despite heterogeneity in study design and quality, a sequential, prospective meta-analysis found that SARS-CoV-2 infection during pregnancy increases the risk of maternal mortality, severe maternal morbidity, and neonatal morbidity. However, there is no association with stillbirth or intrauterine growth restriction. The findings highlight the importance of preventing and managing SARS-CoV-2 infection in pregnant women. Overall, the study is rated 8 out of 10 in terms of importance.
Review
Biochemistry & Molecular Biology
Jan Modzelewski, Iga Siarkowska, Justyna Pajurek-Dudek, Stepan Feduniw, Katarzyna Muzyka-Placzynska, Arkadiusz Baran, Anna Kajdy, Magdalena Bednarek-Jedrzejek, Aneta Cymbaluk-Ploska, Ewa Kwiatkowska, Sebastian Kwiatkowski
Summary: This systematic review collected evidence on preeclampsia occurring before the 20th week of gestation and investigated the role of PLGF and sFlt-1 in its development. In the analyzed cases, all pregnancies with preeclampsia before the 20th week resulted in intrauterine fetal demise, and elevated SFlt-1/PLGF ratios were observed in all women. The review identified 37 reported cases worldwide, emphasizing the need for further research to establish revised definitions or new ones for this very early onset preeclampsia, which is rare but possible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anna Lorenz, Sebastian Lenkiewicz, Mateusz Kozlowski, Sebastian Kwiatkowski, Aneta Cymbaluk-Ploska
Summary: Neuroendocrine tumours of the gastrointestinal and reproductive tracts are rare and have a poor prognosis. Surgical resection is the main treatment, but non-surgical treatments are also used. This article focuses on identifying risk factors, including genetic mutations, and comparing the effectiveness of different non-surgical treatments, such as chemotherapy, radiotherapy, peptide receptor radionuclide therapy, somatostatin analogues, and immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Pediatrics
Lai Ling Hui, Karene H. T. Yeung, Ka Ming Chow, Liona C. Poon, Patricia L. S. Ip, E. Anthony S. Nelson
Summary: Barriers to breastfeeding during the COVID-19 pandemic in Hong Kong include mother-baby separations in hospitals and vaccine safety concerns. However, the pandemic has also created new opportunities to support breastfeeding, such as receiving post-natal care from family doctors, online antenatal classes, work-from-home policies, and telemedicine.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Obstetrics & Gynecology
Sani T. K. Wong, Daljit S. Sahota, Natalie K. L. Wong, Isabella Y. M. Wah, Xueqin Wang, S. L. Lau, C. P. H. Chiu, Patricia N. P. Ip, Liona C. Poon
Summary: This study evaluated the diagnostic performance and clinical utility of the urine Congo red dot test (CRDT) in predicting preeclampsia (PE) within 7, 14, and 28 days. The results showed that urine CRDT had high specificity but low sensitivity in predicting PE in women with suspected PE. Further studies are needed to evaluate its clinical utility.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Article
Surgery
Xinrui Yang, Weiran Zheng, Xiaoyu Wei, Jingmei Ma, Jie Yan, Liona C. Poon, Huixia Yang
Summary: This study aims to evaluate the importance of gestational age and types of cesarean scar pregnancy (CSP) in treatment outcomes and identify the optimal treatment based on both factors. The results show that ultrasound-guided vacuum aspiration is an effective treatment method for CSPs regardless of gestational age and type, with minimal intraoperative bleeding.
FRONTIERS IN SURGERY
(2023)
Article
Obstetrics & Gynecology
Jun Guo, Qiaoli Feng, Piya Chaemsaithong, Kubi Appiah, Daljit S. Sahota, Bo Wah Leung, Jacqueline P. Chung, Tin Chiu Li, Liona C. Poon
Summary: This study aimed to identify potential markers for miscarriage at 6 weeks' gestation among women following IVF/ET and evaluate their predictive performance. The combination of maternal age, fetal heart activity, mUTPI, and serum glycodelin-A achieved high accuracy in identifying IVF/ET pregnancies at risk of first trimester miscarriage.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Ana M. Fidalgo, Raquel Miguel, Irene Fernandez-Buhigas, Asuncion Aguado, Marcos J. Cuerva, Elisa Corrales, Valeria Rolle, Belen Santacruz, Maria M. Gil, Liona C. Poon
Summary: After appropriate training, attending midwives and obstetricians have a level of agreement in ultrasound measurements to evaluate fetal head position and progress of labor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Adriana Aquise, Nieves Rayo, Irene Fernandez-Buhigas, Ana Alfonso, Natalia Pagola, Miguel Rodriguez, Laura de Miguel, Irene Santacruz, Santiago Valor, Liona C. Poon, Maria M. Gil, Belen Santacruz
Summary: The seroprevalence of SARS-CoV-2 among first-trimester pregnant women was 8.2% between January 1 and May 15, 2020. Seropositive women did not show significant differences in complications.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Biochemistry & Molecular Biology
Anna Golara, Mateusz Kozlowski, Pawel Guzik, Sebastian Kwiatkowski, Aneta Cymbaluk-Ploska
Summary: Selenium and manganese are essential micronutrients that play important roles in cell metabolism. They are involved in enzyme systems and regulate enzyme activity. Disturbances in their homeostasis can lead to diseases and carcinogenesis due to increased oxidative stress and impaired antioxidant properties. Selenium maintains immune-endocrine, metabolic, and cellular homeostasis, while manganese is important in development, digestion, reproduction, antioxidant defense, energy production, immune response, and regulation of neuronal activity. This review highlights their roles in tumor growth, metastasis, and microenvironment remodeling, and their potential as biomarkers for diagnosis and treatment of reproductive organ cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Lin Gao, Vrinda Mathur, Sabrina Ka Man Tam, Xuemeng Zhou, Ming Fung Cheung, Lu Yan Chan, Guadalupe Estrada-Gutierrez, Bo Wah Leung, Sakita Moungmaithong, Chi Chiu Wang, Liona C. Poon, Danny Leung
Summary: Recent studies have found that COVID-19 infection can cause disruptions in the maternal-fetal interface, potentially leading to pregnancy complications. By analyzing transcriptomic and epigenomic data from COVID-19 patients and control samples, researchers discovered abnormal immune activation and angiogenesis patterns in specific cells, as well as dysregulation of retrotransposons. In particular, they found that reduced enhancer activities of LTR8B elements were linked to downregulation of pregnancy-specific glycoprotein genes in syncytiotrophoblasts.
NATURE CELL BIOLOGY
(2023)
Review
Obstetrics & Gynecology
Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Ling Wu, Liona C. Poon, Chi Chiu Wang
Summary: This meta-analysis confirmed that platelet count was significantly lower in preeclamptic women, irrespective of severity and presence or absence of associated complications, even before the onset of preeclampsia and in the second trimester of pregnancy. Our findings suggest that platelet count may be a potential marker to identify and predict preeclampsia.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
