Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 41, Issue 8, Pages 503-506Publisher
CELL PRESS
DOI: 10.1016/j.tips.2020.05.007
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Funding
- Swedish Research Council [2015-02760, 2016-01153, 2016-01154]
- EU's Horizon 2020 Research and Innovation Program U-PGx [668353]
- Swedish Research Council [2015-02760] Funding Source: Swedish Research Council
- H2020 Societal Challenges Programme [668353] Funding Source: H2020 Societal Challenges Programme
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A 2016 study proposed induction of the cytochrome P450 (CYP) enzyme CYP3A5 as a key mechanism for chemotherapy resistance and suggested CYP3A5 as a promising therapeutic target. However, in the context of the available literature we are skeptical that CYP3A5 contributes significantly to cancer drug resistance.
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