4.6 Editorial Material

Cohesin Biology: From Passive Rings to Molecular Motors

Journal

TRENDS IN GENETICS
Volume 36, Issue 6, Pages 387-+

Publisher

CELL PRESS
DOI: 10.1016/j.tig.2020.03.001

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The loop extrusion hypothesis postulated that extrusion of DNA loops through cohesin rings organizes genomes. Recent findings suggest that cohesin itself is a molecular motor that extrudes DNA. This has important implications not only for the organization of interphase chromatin but also for other processes where cohesin plays vital roles.

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