Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Daniel Pereira, Richard J. Cook, Vinod Chandran, Nigil Haroon, Robert D. Inman, Dafna D. Gladman
Summary: Isolated axial PsA and AS with psoriasis are relatively uncommon. HLA-B*27 positivity is associated with isolated axial PsA and may predict the development of peripheral disease. Isolated axial PsA is associated with better functional status. Isolated axial PsA appears clinically distinct from isolated axial AS with psoriasis.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Xabier Michelena, Clementina Lopez-Medina, Alba Erra, Xavier Juanola, Pilar Font-Ugalde, Eduardo Collantes, Helena Marzo-Ortega
Summary: This study compared the clinical and radiographical characteristics of axial psoriatic arthritis (PsA) with ankylosing spondylitis (AS) with psoriasis. It found that axial PsA is predominantly HLA-B27 negative and has different manifestations compared to AS with psoriasis. There is great heterogeneity in the definition of axial PsA from a clinical and imaging perspective.
Article
Rheumatology
Adrian Ciurea, Andrea Gotschi, Seraphina Kissling, Alexander Bernatschek, Kristina Burki, Pascale Exer, Michael J. Nissen, Burkhard Moller, Almut Scherer, Raphael Micheroli
Summary: This study compared the characteristics of patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA), and found differences in demographic and clinical features between the two groups, but a similar disease burden.
Article
Rheumatology
Emmerik Leijten, Weiyang Tao, Juliette Pouw, Tessa van Kempen, Michel Olde Nordkamp, Deepak Balak, J. Tekstra, Ernesto Munoz-Elias, Samuel DePrimo, Julia Drylewicz, Aridaman Pandit, Marianne Boes, Timothy Radstake
Summary: Novel serum proteins associated with the pathogenesis of PsA were identified by comparing PsA patients with healthy controls, psoriasis (Pso) patients, and ankylosing spondylitis (AS) patients. The study found 68 differentially expressed proteins in PsA compared to healthy controls, with the majority also dysregulated in Pso and/or AS. PsA and Pso patients shared a similar serum proteomic signature, suggesting a unified psoriatic disease spectrum.
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
David Hughes, Jose Ignacio Cuitun Coronado, Pieta Schofield, Zenas Yiu, Sizheng Steven Zhao
Summary: Cardiovascular risk prediction tools developed for the general population often underperform for individuals with RA, psoriatic disease (PsA and psoriasis), and AS, indicating the need for disease-specific risk prediction tools.
Article
Biochemistry & Molecular Biology
Chia-Jung Tsai, Yu-Chih Lin, Chung-Yu Chen, Chih-Hsing Hung, Yi-Ching Lin
Summary: This retrospective study analyzed the impact of biologics and non-biologics treatment on the development of hematologic malignancies in patients with AS, psoriasis, and PsA. The results showed that biologics significantly increased the risk of hematologic malignancies, specifically non-Hodgkin's lymphoma. Different treatment patterns, types of biologics, cumulative defined daily doses, comorbidities, and comedications did not have a significant effect on hematologic malignancy development.
Article
Rheumatology
Elana Meer, Telma Thrastardottir, Xingmei Wang, Maureen Dubreuil, Yong Chen, Joel M. Gelfand, Thorvardur J. Love, Alexis Ogdie
Summary: This study identified shared and different risk factors for PsA, PsO, RA, and AS, including obesity, alcohol intake, infections, and other factors. Smoking, anemia, inflammatory bowel disease, etc. also had an impact on the onset of RA and AS.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Clementina Lopez-Medina, Anna Molto, Joachim Sieper, Tuncay Duruoz, Uta Kiltz, Bassel Elzorkany, Najia Hajjaj-Hassouni, Ruben Burgos-Vargas, Jose Maldonado-Cocco, Nelly Ziade, Meghna Gavali, Victoria Navarro-Compan, Shue-Fen Luo, Sara Monti, Kim Tae-Jong, Mitsumasa Kishimoto, F. M. Pimentel-Santos, Jieruo Gu, Ruxandra Schiotis, Floris A. van Gaalen, Pal Geher, Marina Magrey, Sebastian E. Ibanez Vodnizza, Wilson Bautista-Molano, Walter Maksymowych, Pedro M. Machado, Robert Landew, Desiree van der Heijde, Maxime Dougados
Summary: This study included 4465 patients with SpA from 24 countries around the world, showing quantitative differences in peripheral manifestations among different subtypes but no significant qualitative differences. It was found that a high proportion of patients with SpA had both axial and peripheral manifestations coinciding.
Article
Rheumatology
G. E. Fragoulis, M. Pappa, G. Evangelatos, A. Iliopoulos, P. P. Sfikakis, M. G. Tektonidou
Summary: This study compared the demographic, radiologic, and clinical characteristics of PsA and AS with axial involvement. The results showed certain clinical and radiologic differences between the two groups, while comorbidities were comparable, except for a higher prevalence of depression in axial-PsA patients.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Review
Rheumatology
Ana De Vicente Delmas, Lara Sanchez-Bilbao, Vanesa Calvo-Rio, David Martinez-Lopez, Alba Herrero-Morant, Eva Galindez-Agirregoikoa, Inigo Gonzalez-Mazon, Nuria Barroso-Garcia, Natalia Palmou-Fontana, Miguel A. Gonzalez-Gay, Jose L. Hernandez, Ricardo Blanco
Summary: This study aimed to assess the frequency and clinical features of uveitis in psoriatic arthritis (PsA) patients, as well as its association with disease activity, functional disability, and biological treatment. The prevalence of uveitis in PsA patients was about 5%, and it was associated with a worse quality of life and greater functional disability. The incidence rate of uveitis varied depending on the type of biological treatment used.
Article
Rheumatology
Anne Constanze Regierer, Anja Weiss, Fabian Proft, Xenofon Baraliakos, Frank Behrens, Denis Poddubnyy, Georg Schett, Hanns-Martin Lorenz, Matthias Worsch, Anja Strangfeld
Summary: This study compared the differences between psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). The results showed that there were significant differences between patients with axial involvement in PsA (axPsA) and patients with axSpA accompanied by psoriasis (axSpA+pso), regardless of whether it was clinically or radiologically defined.
Article
Rheumatology
Christina Charles-Schoeman, Ernest Choy, Iain B. McInnes, Eduardo Mysler, Peter Nash, Kunihiro Yamaoka, Ralph Lippe, Nasser Khan, Anna K. Shmagel, Hannah Palac, Jessica Suboticki, Jeffrey R. Curtis
Summary: This study provides an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) events in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients treated with upadacitinib. The results show that the rates of MACEs and VTE events with upadacitinib are similar to those reported for conventional synthetic and biologic disease-modifying drugs, and comparable to adalimumab and methotrexate.
Article
Dermatology
Alice B. Gottlieb, Atul Deodhar, Iain B. Mcinnes, Xenofon Baraliakos, Kristian Reich, Stefan Schreiber, Weibin Bao, Kwaku Marfo, Hanno B. Richards, Luminita Pricop, Abhijit Shete, Vivek Trivedi, Deborah Keefe, Charis C. Papavassilis, Piotr Jagiello, Philemon Papanastasiou, Philip J. Mease, Mark Lebwohl
Summary: This study reports the long-term safety of Secukinumab in a large dataset, including patients with psoriasis, psoriatic arthritis, and ankylosing spondylitis. The results show that Secukinumab has a favorable safety profile for up to 5 years of treatment in these indications, and no new safety signals were identified.
ACTA DERMATO-VENEREOLOGICA
(2022)
Article
Immunology
Yu-Ping Zhang, Xing Wang, Li-Gang Jie, Yuan Qu, Xiao-Tong Zhu, Jing Wu, Qing-Hong Yu
Summary: This study explored the shared molecular mechanisms between psoriatic arthritis and ankylosing spondylitis, and identified potential diagnostic markers and therapeutic targets. The mRNA surveillance pathway and immune processes were found to be involved in the osteoarticular involvement of psoriasis and AS. PUM1 and ZFP91 were identified as potential biomarkers for diagnosing and treating AS and Ps patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Charles A. Hay, James A. Prior, John Belcher, Christian D. Mallen, Edward Roddy
Summary: There was no significant association found between all-cause mortality and the use of allopurinol in people with gout. However, the small number of included studies suggest that further research is necessary.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Sport Sciences
Yan Chen, Ying Chen, Baohua Geng, Yong Zhang, Rui Qin, Yamei Cai, Feng Bai, Dahai Yu
Summary: The study found that moderate-to-vigorous physical activity is inversely associated with abnormal liver function in Chinese adults, suggesting promoting such activities could be a cost-effective strategy in maintaining liver health.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2021)
Article
Rheumatology
James A. Prior, Zoe Paskins, Rebecca Whittle, Alyshah Abdul-Sultan, Carolyn A. Chew-Graham, Sara Muller, Ram Bajpai, Tom A. Shepherd, Athula Sumathipala, Christian D. Mallen
Summary: This study found that patients with fibromyalgia, osteoarthritis, or rheumatoid arthritis are at increased risk of self-harm, while patients with ankylosing spondylitis have a lower risk. Age and sex were found to be weak effect modifiers for these associations.
ARTHRITIS CARE & RESEARCH
(2021)
Review
Rheumatology
Charles A. Hay, Jon Packham, Sarah Ryan, Christian D. Mallen, Alexandros Chatzixenitidis, James A. Prior
Summary: The diagnosis of axial spondyloarthritis (axSpA) is challenging, resulting in delayed diagnosis for patients. A systematic review found that the average diagnostic delay for axSpA ranged from 2 to 6 years, with a third of studies reporting a median delay of only 2 to 2.3 years. Factors such as gender and family history did not significantly influence the delay.
CLINICAL RHEUMATOLOGY
(2022)
Article
Immunology
Jing Wang, Abram L. Wagner, Ying Chen, Etienne Jaime, Xinwen Hu, Shiqiang Wu, Yihan Lu, Yuhua Ruan, Stephen W. Pan
Summary: The study found that a Health Code-based vaccine mandate in China can increase willingness to vaccinate for COVID-19, especially among vaccine hesitators. Willingness to vaccinate significantly increased when vaccine efficacy was greater than 60%.
Review
Gastroenterology & Hepatology
Aymane Ajbar, Eleanor Cross, Simbarashe Matoi, Charles A. Hay, Libby M. Baines, Benjamin Saunders, Adam D. Farmer, James A. Prior
Summary: The delay in diagnosing pediatric inflammatory bowel disease (IBD) is common, and it takes several months for children to receive a final diagnosis. The diagnostic delay for ulcerative colitis (UC) tends to be shorter compared to Crohn's Disease (CD).
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kelvin P. Jordan, Trishna Rathod-Mistry, James Bailey, Ying Chen, Lorna Clarson, Spiros Denaxas, Richard A. Hayward, Harry Hemingway, Danielle A. van der Windt, Mamas A. Mamas
Summary: This study aimed to assess whether patients with unattributed chest pain presenting to primary care have an increased risk of cardiovascular events and to determine whether interventions are targeted at those at higher risk. The study found that patients with unattributed chest pain had an increased risk of cardiovascular events, and the primary prevention for those at higher risk was suboptimal.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Ying Chen, Lanwei Zhang, Tenglong Li, Li Li
Summary: This study used structural equation modeling to analyze the impact of COVID-19 vaccine allocation on health inequality. The study found that populations characterized by social vulnerabilities received less vaccination and were more affected by COVID-19. The unequal distribution of vaccines led to additional inequality in COVID-19 mortality.
Article
Biology
Xiangning Dong, Jingxian Huang, Yanze Yi, Lanwei Zhang, Tenglong Li, Ying Chen
Summary: Our study aimed to identify pathways from the source of information to the uptake of cancer genetic testing, with consideration of intermediate variables including perceptional, attitudinal, and psychosocial factors. Our findings suggest that only information from particular sources, such as healthcare providers and genetic counselors, had positive and significant effects on people's perceptions of cancer regarding its prevention, detection, and treatment. Attitudinal and psychosocial factors showed much smaller or insignificant effects on the uptake of genetic testing.
Review
Gastroenterology & Hepatology
Eleanor Cross, Benjamin Saunders, Adam D. Farmer, James A. Prior
Summary: This systematic review investigates the extent of diagnostic delay in inflammatory bowel disease (IBD) and its associations with patient or healthcare characteristics. The study finds that the median diagnostic delay for IBD is between 2 and 5.3 months, with UC patients experiencing a delay of 2 to 6 months and CD patients experiencing a delay of 2 to 12 months. However, the role of specific characteristics in diagnostic delay remains unclear.
INDIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Engineering, Environmental
Bingjie Qu, Shiqiang Wu, Peng Zhao, Zheng Feei Ma, Royston Goodacre, Linxi Yuan, Ying Chen
Summary: This study aimed to determine common patterns of geographic distribution of health-related minerals in the USA and evaluate their cumulative effects on overall population health. Using county-level data on concentrations of 14 minerals in stream sediments and overall health measurements, latent class analysis identified three clusters of life expectancy-related minerals. The 'infertile' cluster was associated with the shortest life expectancy, highest mortality risks at all ages, and highest mortality rates for various causes. The study provides novel insights into environmental geochemistry and its impact on health disparities in the USA.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Immunology
Tenglong Li, Zilong Wang, Shuyue He, Ying Chen
Summary: To evaluate the effectiveness of COVID-19 vaccination, it is important to separate the herd effect and marginal effect and parameterize them separately. Through studying the relationship between COVID-19 vaccination coverage and case fatality rate (CFR) at the county level in the U.S., we found three breakpoints where herd effects could potentially exist. Our results highlight the need for public-health researchers to differentiate and quantify the herd and marginal effects when analyzing vaccination data, to inform vaccination strategies and evaluate effectiveness.
Review
Primary Health Care
Fay M. Manning, Faraz Mughal, Hazem Ahmed Saad Mohamed Ismail, Libby M. Baines, Carolyn A. Chew-Graham, Zoe Paskins, James A. Prior
Summary: This study aimed to examine whether osteoporosis or fractures are risk factors for self-harm, suicidal ideation, and suicide. A systematic review of observational studies found a possible association between osteoporosis and fractures with self-harm, suicidal ideation, and suicide. However, limited study quality and mixed findings suggest that further examination is needed to understand these associations.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Rheumatology
James A. Prior, Edward Roddy, Ivonne Solis-Trapala, Nicola Cornwall, Clare Jinks, Abhishek Abhishek, Marwan Bukhari, James Galloway, Nicola Goodson, Sue Jowett, Samantha Hider
RHEUMATOLOGY ADVANCES IN PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Aymane Ajbar, Thomas A. Shepherd, Michelle Robinson, Christian D. Mallen, James A. Prior
Summary: Global Public Health Days have significant impact on online health information-seeking behavior in some countries, but the effects are short-lived with a sharp decrease in search volume after the peak of interest. Further research is needed to investigate the limitations of these interventions.
JOURNAL OF THE EGYPTIAN PUBLIC HEALTH ASSOCIATION
(2021)