Article
Chemistry, Multidisciplinary
Martina Cotena, Melanie Auffan, Virginie Tassistro, Noemie Resseguier, Jerome Rose, Jeanne Perrin
Summary: Exposure to combusted CeO2 NMs or BaP resulted in significantly higher DNA damage in all cell types considered, while co-exposure to CeO2 NMs-BaP mixture induced additive DNA damage in sperm and cumulus cells. The potential protective effects of cumulus cells on oocytes and the efficient DNA damage repair system of oocytes compared to cumulus and sperm cells may explain the lack of additive effect observed in rat oocytes.
Article
Environmental Sciences
Isaac Ayodele Ololade, Nurudeen Abiola Oladoja, Oluwaranti Olubunmi Ololade, Toyin Dunsin Saliu, Adenike Bosede Alabi, Samuel Babatunde Obadawo, Mayowa Monday Anifowose
Summary: This study analyzed the levels of polycyclic aromatic hydrocarbons (PAHs) in fish and shellfish samples collected from the Ogbese River in Nigeria, finding that fish had higher concentrations of PAHs compared to shellfish, with bottom dwellers showing more significant accumulation. The findings suggest the need for urgent remediation of the river to safeguard public health.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Katarzyna Mokra, Jaromir Michalowicz
Summary: Benzo[a]pyrene (B[a]P) is a representative polycyclic aromatic hydrocarbon (PAH) that is commonly found in the environment and human surroundings. It has been shown to have toxic effects on DNA, reproduction, neurology, and development. The metabolism of B[a]P is mediated by cytochrome P450 (CYP P450) and its polymorphism determines the sensitivity to B[a]P. Additionally, B[a]P may facilitate the replication of viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Humairat H. Rahman, Danielle Niemann, Stuart H. Munson-McGee
Summary: This study aimed to assess the relationship between urinary metals, arsenic compounds, polycyclic aromatic hydrocarbons (PAHs), and chronic obstructive pulmonary disease (COPD) in the adult US population. The results showed that urinary PAHs, cadmium, and tin were significantly associated with COPD, while other urinary metals did not show a significant association.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Food Science & Technology
Luana Schmidt, Osmar Damian Prestes, Paula Rossini Augusti, Jose Claudio Fonseca Moreira
Summary: Olive oil and olive pomace, as main components of the Mediterranean diet, contain phenolic compounds that contribute to various health benefits. These compounds, such as oleuropein, tyrosol, and hydroxytyrosol, are believed to prevent and control diseases like cardiovascular diseases and cancer. However, olives and their products can be contaminated by mycotoxins, pesticide residues, and polycyclic aromatic hydrocarbons. Phenolic compounds in olive oil and pomace can reduce the toxicity of these contaminants, but the pollutants may also affect the beneficial properties of these products. Further studies are needed to understand the interactions between bioactive and toxic compounds in olive oil and pomace for a better understanding of their health benefits.
Article
Environmental Sciences
Pavlina Simeckova, Katerina Pencikova, Ondrej Kovac, Josef Slavik, Martina Parenicova, Jan Vondracek, Miroslav Machala
Summary: The toxicity profiles of six environmentally relevant PAHs were evaluated, revealing their interactions with intracellular receptors and signaling pathways, as well as their impact on cellular metabolism, stress, and genotoxicity markers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Toxicology
Lynn Crosby, Berran Yucesoy, Carmine Leggett, Zheng Tu, Steven A. Belinsky, Jake McDonald, Shuguang Leng, Guodong Wu, Hammad Irshad, Luis G. Valerio, Hans Rosenfeldt
Summary: The study compared the smoke chemistry and toxicity of 10 conventional cigarettes and 10 cigarillos, finding that cigarillos exhibited higher cytotoxicity and genotoxicity compared to cigarettes, as well as higher levels of harmful tobacco constituents. These findings are crucial for understanding the health risks associated with cigarillos compared to cigarettes.
TOXICOLOGICAL SCIENCES
(2021)
Review
Environmental Sciences
Francisco Carlos da Silva Junior, Maria Beatriz Mesquita Cansancao Felipe, Denis Elvis Farias de Castro, Sinara Carla da Silva Araujo, Herbert Costa Nobrega Sisenando, Silvia Regina Batistuzzo de Medeiros
Summary: The systematic review found evidence of genotoxic, mutagenic, and carcinogenic endpoints in 13 US EPA non-priority PAHs. Some of the PAHs, such as 5-MC, 7,12-DMBA, CPP, and Db [al]P, have been extensively studied and shown to have mutagenic effects and potential carcinogenicity. More research is needed to improve future protocols for environmental analysis and risk assessment in populations with high exposure to these PAHs.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Rupa Rani, Abhidha Kela, Geeta Dhaniya, Kamini Arya, Amit K. Tripathi, Rajesh Ahirwar
Summary: Specific miRNAs have been identified as early warning biomarkers for health effects associated with exposure to PAHs in exposed populations, and they can serve as indicators of early health effects in response to chronic environmental exposure to PAHs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yusuke Nakakuki, Takashi Hirose, Hikaru Sotome, Min Gao, Daiki Shimizu, Ruiji Li, Jun-Ya Hasegawa, Hiroshi Miyasaka, Kenji Matsuda
Summary: Helically twisted conductive nanocarbon materials are suitable for optoelectronic and electromagnetic molecular devices on the nanometer scale, showing a large effective conjugation length and ultrafast decay dynamics. The extended π-helicenes achieved a large effective conjugation length through helical fusion, leading to an absorption edge in the near-infrared region.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Xiushang Xu, Amy L. Vonder Haar, Rengo Yoshioka, Qizheng Zhang, Serhii Vasylevskyi, Andrew J. Musser, Akimitsu Narita
Summary: A benzo[rst]pentaphene derivative, BPP-MeOPA, was synthesized and characterized by NMR and single-crystal X-ray analysis. Investigation of its photophysical properties, including transient absorption spectroscopy, revealed improved absorption and emission features from an S-1 state with excitonic and charge-transfer character by introducing MeOPA groups.
CHEMICAL COMMUNICATIONS
(2023)
Article
Food Science & Technology
Jing Xi, Yiyi Cao, Yanhua Wang, Xinyue You, Weiying Liu, Ting Wang, Jingjing Yin, Junxiang Ma, Zhenjie Wang, Nan Wu, Xinyu Zhang, Huawei Duan, Yang Luan
Summary: This study investigated the genetic damage in coke oven workers and found that their occupational exposure increased the risk of genetic damage. The PIG-A gene mutation frequency could potentially be used as a biomarker for assessing the risk of carcinogen exposure.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Correction
Environmental Sciences
Majid Kermani, Tahereh Rahmatinia, Vahide Oskoei, Samira Norzaee, Abbas Shahsavani, Mahdi Farzadkia, Mohammad Hossein Kazemi
Summary: A correction to this paper has been published.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Environmental Sciences
Meng Qiao, Weixiao Qi, Huijuan Liu, Jiuhui Qu
Summary: Oxygenated polycyclic aromatic hydrocarbons (OPAHs) have higher concentrations and toxicity in water environments, posing significant ecological risks to surface water ecosystems.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Organic
Yushi Ohno, Shogo Ando, Daisuke Furusho, Ryoyu Hifumi, Yuuya Nagata, Ikuyoshi Tomita, Shinsuke Inagi
Summary: Here, a facile and selective synthesis of cationic azatriphenylene derivatives was achieved through electrochemical intramolecular cyclization, where the key step involves atom-economical C-H pyridination without a transition-metal catalyst or an oxidant. This proposed strategy provides a practical approach for introducing cationic nitrogen (N (+)) into pi-electron systems, thus expanding the molecular design of N (+)-doped polycyclic aromatic hydrocarbons.
Article
Environmental Sciences
Audrey Catteau, Anne Bado-Nilles, Remy Beaudouin, Cleo Tebby, Sandrine Joachim, Olivier Palluel, Cyril Turies, Nina Chretien, Katherine Nott, Sebastien Ronkart, Alain Geffard, Jean-Marc Porcher
Summary: The study utilized three-spined sticklebacks as indicator organisms and a multi-biomarker approach to assess water quality in the Meuse basin in Europe. Results showed minimal effects of WWTP effluents on physiological parameters, but multivariate analysis successfully distinguished different study sites.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
S. Joachim, R. Beaudouin, G. Daniele, A. Geffard, A. Bado-Nilles, C. Tebby, O. Palluel, O. Dedourge-Geffard, M. Fieu, M. Bonnard, M. Palos-Ladeiro, C. Turies, E. Vulliet, V David, P. Baudoin, A. James, S. Andres, J. M. Porcher
Summary: This study found that diclofenac had significant adverse effects on aquatic organisms, including water plants, benthic animals, and fish, in a long-term freshwater mesocosm experiment. The effects observed in more natural conditions were more severe compared to those seen in laboratory settings. The implications of these findings for regulatory purposes were also discussed.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Corentin Regrain, Florence Anna Zeman, Mohammed Guedda, Karen Chardon, Veronique Bach, Celine Brochot, Roseline Bonnard, Frederic Tognet, Laure Malherbe, Laurent Letinois, Emmanuelle Boulvert, Fabrice Marliere, Francois Lestremau, Julien Caudeville
Summary: This study used an integrated exposure assessment approach to evaluate the exposure of pregnant women to chlorpyrifos in Picardy at a regional scale, finding that ingestion route was the main contributor to chlorpyrifos exposure. The study demonstrated the feasibility of comparing modeled predictions with biomonitoring data.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
News Item
Oncology
F. Belpoggi, R. C. Cattley, B. Reisfeld, P. Stewart, M. C. Turner, M. Audebert, J. Cox, C. Ge, P. Gustavsson, H. Kaefferlein, L. Lash, A. Lumen, M. Matsumoto, M. T. Munoz-Quezada, C. Peters, M. Purdue, C. Svendsen, A. Virji, M. G. Yakubovskaya, J. Yiin
Article
Environmental Sciences
Cleo Tebby, Julien Caudeville, Yasmil Fernandez, Celine Brochot
Summary: The decrease in lead levels in air and drinking water has resulted in a decrease in blood lead levels in children over the last 40 years, but there is still no known safe level of lead exposure for developmental effects. A study in France mapped predicted blood lead levels in children, finding that drinking water and food were the main sources of lead exposure, with the former being prominent in children over 2 years old. The study also showed discrepancies in predicted blood lead levels for infants and children aged 2 to 6, with the latter being more accurately predicted.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, Stephen Dertinger, Giel Hendriks, Mirjam Luijten, Francesco Marchetti, Sheroy Minocherhomji, Stefan Pfuhler, Daniel J. Roberts, Kristina Trenz, Carole L. Yauk
Summary: The Genetic Toxicology Technical Committee is developing adverse outcome pathways that describe modes of action leading to potentially heritable genomic damage. They present an AOP network that links oxidative DNA damage to mutations and chromosomal aberrations. This study identifies knowledge gaps that could be filled by targeted studies and provides building blocks for genotoxicity-associated AOPs.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Toxicology
Cleo Tebby, Wang Gao, Johannes Delp, Giada Carta, Wanda van der Stel, Marcel Leist, Paul Jennings, Bob van de Water, Frederic Y. Bois
Summary: This study used quantitative Adverse Outcome Pathways (qAOPs) and mathematical models to calibrate the mitochondrial toxicity of two chemicals in different cell lines. The results showed that there were practical difficulties in calibrating qAOPs in different cell types, and even when the same key event readouts were measured, the mathematical functions used may not be the same. Cross-validation also revealed underestimation of toxicity in LHUMES cells.
TOXICOLOGY IN VITRO
(2022)
Meeting Abstract
Toxicology
A. M. Vinggaard, M. Lamoree, B. I. Escher, J. -P. Antignac, M. Scholze, T. K. Jensen, M. Herzler, M. Audebert, T. Hamers, A. Kortenkamp, F. Busquet, M. Piumatti, G. Dervilly, M. J. Valente, R. Cariou, S. Moteau, M. Oelgeschlager, K. Renko, S. Schmeisser, D. Maier, L. L. Laursen
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
L. Evariste, B. Lamas, S. Ellero-Simatos, L. Khoury, C. Cartier, E. Gaultier, B. Chassaing, N. Feltin, L. Devoille, G. Favre, M. Audebert, E. Houdeau
TOXICOLOGY LETTERS
(2022)
Article
Environmental Sciences
Beate Escher, Marja Lamoree, Jean-Philippe Antignac, Martin Scholze, Matthias Herzler, Timo Hamers, Tina Kold Jensen, Marc Audebert, Francois Busquet, Dieter Maier, Michael Oelgeschlaeger, Maria Joao Valente, Henriette Boye, Sebastian Schmeisser, Gaud Dervilly, Matteo Piumatti, Solene Motteau, Maria Koenig, Kostja Renko, Maria Margalef, Ronan Cariou, Yanying Ma, Andreas Frederik Treschow, Andreas Kortenkamp, Anne Marie Vinggaard
Summary: The European Union's Green Deal aims to address the risk of chemical mixtures to human health by filling the existing gaps in risk assessment and implementing regulatory measures. To tackle this challenge, the PANORAMIX project suggests characterizing real-life mixtures, developing a high-throughput screening strategy, evaluating concern levels for children's development, and creating a web-based interface for risk estimation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Marc A. A. Beal, Marc Audebert, Tara Barton-Maclaren, Hannah Battaion, Jeffrey C. C. Bemis, Xuefei Cao, Connie Chen, Stephen D. D. Dertinger, Roland Froetschl, Xiaoqing Guo, George Johnson, Giel Hendriks, Laure Khoury, Alexandra S. S. Long, Stefan Pfuhler, Raja S. S. Settivari, Shamika Wickramasuriya, Paul White
Summary: Genotoxicity assessment plays a crucial role in chemical development and evaluation. Traditional assays have limitations in hazard classification and quantifying toxicity. Novel high-throughput in vitro assays offer a powerful approach for potency ranking and risk assessment. In this study, the use of in vitro to in vivo extrapolation models demonstrated protective dose levels for 20 out of 31 chemicals, indicating the potential of this testing strategy in enhancing prioritization and risk assessment of genotoxic chemicals.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Toxicology
Lauris Evariste, Bruno Lamas, Sandrine Ellero-Simatos, Laure Khoury, Christel Cartier, Eric Gaultier, Benoit Chassaing, Nicolas Feltin, Laurent Devoille, Georges Favre, Marc Audebert, Eric Houdeau
Summary: This study investigated the potential toxicity of edible gold (E175) by exposing mice to it for 90 days. The results showed that E175 caused sex-dependent alterations in the gut microbiota and intestinal immune response in mice. However, these changes remained low and mostly appeared to be non-toxic within the dose range of human exposure to E175.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Review
Toxicology
Thalia De Castelbajac, Kiara Aiello, Celia Garcia Arenas, Terje Svingen, Louise Ramhoj, Daniel Zalko, Robert Barouki, Tamara Vanhaecke, Vera Rogiers, Marc Audebert, Michael Oelgeschlaeger, Albert Braeuning, Etienne Blanc, Tamara Tal, Joelle Rueegg, Ellen Fritsche, Philip Marx-Stoelting, Gilles Riviere
Summary: New approach methodologies (NAMs) have the potential to significantly impact regulatory risk assessment, but their implementation faces challenges. The PARC project aims to address these challenges and develop innovative methods to improve chemical risk assessment. By focusing on essential regulatory data gaps, PARC intends to provide reliable assessment tools for next-generation risk assessment. Rating: 8 out of 10.
FRONTIERS IN TOXICOLOGY
(2023)
Review
Toxicology
Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Sylvie Bortoli, Peter Bouwman, Albert Braeuning, Tanja Burgdorf, Xavier Coumoul, Kloe Debizet, Maria Dusinska, Norman Ertych, Joerg Fahrer, Verena Fetz, Ludovic Le Hegarat, Adela Lopez de Cerain, Harm J. Heusinkveld, Kevin Hogeveen, Miriam N. Jacobs, Mirjam Luijten, Giuseppa Raitano, Cynthia Recoules, Elise Runden-Pran, Mariam Saleh, Iva Sovadinova, Martina Stampar, Lea Thibol, Celine Tomkiewicz, Ariane Vettorazzi, Bob van de Water, Naouale El Yamani, Bojana Zegura, Michael Oelgeschlaeger
Summary: Carcinogenic chemicals can be classified as genotoxic or non-genotoxic carcinogens. Genotoxic compounds cause DNA damage and can be detected through genotoxicity assays, while non-genotoxic compounds have diverse modes of action and do not have specific assays for detection. Evaluation of the carcinogenic potential of non-genotoxic compounds still relies on long-term studies in rodents, which are time-consuming, costly, and limited in their predictivity for human risk assessment. Therefore, there is an urgent need for new approach methodologies that integrate human-relevant in vitro assays and in silico tools to improve hazard assessment and risk assessment for chemical carcinogens.
FRONTIERS IN TOXICOLOGY
(2023)
Meeting Abstract
Environmental Sciences
Yasunobu Aoki, Jennifer Keir, Marc Audebert
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
