Article
Surgery
Ya-Lin Kong, Hong-Yi Zhang, Cheng-Li Liu, Xiao-Jun He, Gang Zhao, Cheng Wang, Ling-Hong Kong, Jing Zhao
Summary: The study evaluated the efficacy and safety of endobiliary radiofrequency ablation (RFA) combined with self-expandable metal stents (SEMS) placement for unresectable malignant obstructive jaundice. The results showed that this combined treatment was technically safe and feasible in improving quality of life and prolonging survival for these patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Mingxing Xia, Wenhao Qin, Bing Hu
Summary: Endobiliary radiofrequency ablation (RFA) is a promising technique for palliating malignant biliary strictures (MBS) that cannot be surgically resected. Clinical studies have shown that RFA can effectively prolong the survival of extrahepatic cholangiocarcinoma (CCA) and ampullary cancer, especially without distant metastasis. However, it does not confer a survival benefit in patients with nonprimary bile duct malignancies. Biliary RFA combined with systemic chemotherapy may have a synergistic effect on inoperable CCA, particularly in patients with locally advanced tumors.
DIGESTIVE ENDOSCOPY
(2023)
Article
Oncology
Tadahisa Inoue, Hiromu Kutsumi, Mayu Ibusuki, Masashi Yoneda
Summary: This study aimed to evaluate the efficacy and safety of endobiliary radiofrequency ablation (RFA) for ingrowth occlusion using bovine liver. The results showed that the ablation effect was diminished when the electrode came into contact with the stent-wire.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomas Andrasina, Tomas Rohan, Jiri Panek, Petra Kovalcikova, Lumir Kunovsky, Lenka Ostrizkova, Vlastimil Valek
Summary: The study found that endobiliary radiofrequency ablation prior to metal stent insertion can increase stent patency in patients with cholangiocarcinoma, but no improvement in survival was observed in other types of malignant biliary stenosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Oncology
M. Feretis, Y. Wang, B. Zhang, S. -S. Liau
Summary: Biliary cooling during RFA appears to reduce biliary complications, but further evidence is needed to assess its impact on tumor recurrence rates.
Review
Surgery
Shaoming Song, Haojie Jin, Qinghao Cheng, Shiyi Gong, Kun Lv, Ting Lei, Hongwei Tian, Xiaofei Li, Caining Lei, Wenwen Yang, Kehu Yang, Tiankang Guo
Summary: This study conducted a meta-analysis to compare the efficacy and safety of radiofrequency ablation combined with stent (RFA + Stent) and stent alone for unresectable malignant biliary obstruction (MBO). The results showed that RFA + Stent was associated with better overall survival, longer mean survival time, longer mean stent patency time, and higher stent patency at 6 months compared to stent alone. The incidence of adverse effects was similar between the two interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Dongwook Oh, Junyong Chong, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Summary: This study retrospectively assessed the feasibility, efficacy, and safety of EB-RFA for malignant hilar obstruction (MHO). The results showed that SEMS placement after EB-RFA in MHO was not associated with improvement in the stent patency and patient survival. Further prospective randomized studies are necessary to establish the effectiveness of EB-RFA with stents in MHO.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Sung Ill Jang, Sungsoon Fang, Ji Hae Nahm, Jae Hee Cho, Min Young Do, Su Yeon Lee, Seok Jeong, Don Haeng Lee, Dong Ki Lee
Summary: This study investigated the safety and efficacy of corticosteroid-eluting fully covered self-expandable metal stents (FCSEMS) in an animal model and found that they had the potential to reduce fibrotic tissue. Further research is needed to confirm their safety and efficacy in humans with refractory benign biliary strictures (BBS).
SCIENTIFIC REPORTS
(2022)
Article
Surgery
A. K. Uribe Rivera, B. Seeliger, C. A. Saldivar, E. Houghton, F. Rodriguez, P. Acquafresca, M. Palermo, M. E. Gimenez
Summary: This retrospective observational study evaluated the use of a dedicated percutaneous short single-operator cholangioscope (PSSOC) for the diagnosis and treatment of benign or malignant biliary diseases. The PSSOC enabled direct visualization of the biliary tract and relevant procedures. In 40 patients, the clinical use of the PSSOC was safe and effective, optimizing the diagnosis and treatment of complex biliary diseases.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Multidisciplinary Sciences
Nonthalee Pausawasdi, Panotpol Termsinsuk, Phunchai Charatcharoenwitthaya, Julajak Limsrivilai, Uayporn Kaosombatwattana
Summary: This study developed and validated a predictive score for clinical success after stent placement in patients with unresectable malignant biliary obstruction. The scoring system, which includes parameters such as biliary obstruction level, liver biochemistry, and stent type, can predict the probability of total bilirubin resolution within 2 weeks and bilirubin normalization within 6 weeks after stenting. The score may help endoscopists identify patients suitable for palliative stenting.
Article
Gastroenterology & Hepatology
Tae Hoon Lee, Jong Ho Moon, Yun Nah Lee, Seok Jung Jo, Jae Keun Park, Jae Kook Yang, Sang-Woo Cha, Young Deok Cho, Sang-Heum Park
Summary: Temporary placement of a modified intraductal short FCSEMS improved perihilar BBS in patients that primarily failed by plastic stents, with successful removal of combined biliary stones after stricture resolution.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Oncology
Jana Jarosova, Peter Macinga, Alzbeta Hujova, Jan Kral, Ondrej Urban, Julius Spicak, Tomas Hucl
Summary: Cholangiocarcinoma and pancreatic cancer are common causes of malignant biliary obstruction, which often cannot be surgically resected at late stages. For these cases, Radiofrequency ablation (RFA) may offer a promising modality for treatment, with potential positive impacts on survival and stent patency. Further studies with well-characterized patient populations are needed for routine clinical practice acceptance.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Koji Takahashi, Hiroshi Ohyama, Yuichi Takiguchi, Motoyasu Kan, Mayu Ouchi, Hiroki Nagashima, Izumi Ohno, Naoya Kato
Summary: This study compared the use of SBS and PSIS in the treatment of unresectable hilar malignant biliary stricture. The results showed no significant differences in clinical success rate, adverse event rate, time to recurrent biliary obstruction, or overall survival between the SBS and PSIS groups, except for the significantly longer procedure time in the PSIS group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tomas Rohan, Tomas Andrasina, Peter Matkulcik, Vladan Bernard, Vlastimil Valek
Summary: This study demonstrates the feasibility and safety of percutaneous endoluminal radiofrequency ablation (eRFA) using a monopolar approach in the recanalization of occluded biliary metal stents.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming-Xing Xia, Shu-Ping Wang, Ji-Gang Yuan, Dao-Jian Gao, Xin Ye, Tian-Tian Wang, Jun Wu, Dong-Xun Zhou, Bing Hu
Summary: This study investigated the long-term outcomes of endoscopic radiofrequency ablation (RFA) for malignant biliary strictures in a large cohort of patients. Results showed that RFA could prolong overall survival for some patients, but the survival benefits were limited to patients with extrahepatic cholangiocarcinoma without distant metastasis.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Se Woo Park, Kyong Joo Lee, Moon Jae Chung, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seung Woo Park, Si Young Song, Huapyong Kang, Eui Joo Kim, Yeon Suk Kim, Jae Hee Cho, Seungmin Bang
Summary: This study compared the clinical outcomes of UCDBS and PCDBS for distal MBO. The results showed that PCDBS had a longer stent patency, but there were no significant differences between the two groups in overall survival and stent dysfunction.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Biophysics
N. G. Gurudatt, Hogyeong Gwak, Kyung-A Hyun, Se-Eun Jeong, Kyungyeon Lee, Sunyoung Park, Moon Jae Chung, Seong-Eun Kim, Jung Hyun Jo, Hyo-Il Jung
Summary: Tumor-derived extracellular vesicles (tdEVs) have great potential as biomarkers for liquid biopsy-based cancer diagnostics due to the specific membrane proteins they express. This study developed an indium-tin-oxide (ITO) sensor integrated microfluidic device for the sensitive detection and quantification of tdEVs. The device successfully captured tdEVs on specific antibody modified ITO surfaces and showed excellent linear response in the clinically relevant tdEVs-concentration range for pancreatic cystic neoplasms. This system holds promise for liquid biopsy-based cancer prognostics and diagnostics.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Endocrinology & Metabolism
Hee Seung Lee, Wonjeong Chae, Min Je Sung, Jiyoung Keum, Jung Hyun Jo, Moon Jae Chung, Jeong Youp Park, Seung Woo Park, Si Young Song, Eun-Cheol Park, Chung Mo Nam, Sung-In Jang, Seungmin Bang
Summary: This study aimed to investigate the differences in incidence of pancreatic cancer between new-onset diabetes mellitus (NODM) and long-standing DM (LSDM). The results showed that the risk of pancreatic cancer was higher in the group with diabetes compared to the non-diabetes group, and the risk was higher in the NODM group than in the LSDM group, especially in men and patients in their 50s.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Huapyong Kang, Bora Lee, Jung Hyun Jo, Hee Seung Lee, Jeong Youp Park, Seungmin Bang, Seung Woo Park, Si Young Song, Joonhyung Park, Hajin Shim, Jung Hyun Lee, Eunho Yang, Eun Hwa Kim, Kwang Joon Kim, Min-Soo Kim, Moon Jae Chung
Summary: A GBM ensemble model and LR model were developed and showed good potential for predicting and preventing hypoxaemia during ERCP under MAC.
YONSEI MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho, Soo Been Park, Chanyang Kim, Galam Leem, Dawoon E. Jung, Soon Sung Kwon, Chul Hoon Kim, Jung Hyun Jo, Hye Won Lee, Si Young Song, Jun Yong Park
Summary: The study developed organoids for two ICC subtypes, which revealed distinct transcriptional profiles and potential therapeutic targets.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Mi Ho Jeong, Taehwang Son, Yoo Keung Tae, Chan Hee Park, Hee Seung Lee, Moon Jae Chung, Jeong Youp Park, Cesar M. M. Castro, Ralph Weissleder, Jung Hyun Jo, Seungmin Bang, Hyungsoon Im
Summary: Cholangiocarcinoma (CCA) is a fatal disease often diagnosed at advanced stages. There is a lack of effective diagnostic methods or biomarkers for early detection of CCA. A nanoplasmonic sensing technology called FLEX is developed for sensitive and robust single extracellular vesicle (EV) analysis, which detected a wide heterogeneity of CCA-derived EVs and identified tumor markers in clinical bile samples. The FLEX assay showed better diagnostic performance than current clinical markers, offering a potential tool for early CCA diagnosis.
Article
Gastroenterology & Hepatology
Jae Hee Cho, Jaihwan Kim, Hee Seung Lee, Su Jeong Ryu, Sung Ill Jang, Eui Joo Kim, Huapyong Kang, Sang Soo Lee, Tae Jun Song, Seungmin Bang
Summary: Repeat EUS-FNA/B is crucial for patients with an inconclusive initial diagnosis of solid pancreatic lesions without rapid on-site evaluation (ROSE). Factors such as tumor location, number of needle passes, needle type, needle size, and suction method are associated with improved diagnostic performance of repeat EUS-FNA/B.
Article
Health Care Sciences & Services
Jung Hyun Jo, Zhan Gao, Inkyung Jung, Si Young Song, Geert Ridder, Hyungsik Roger Moon
Summary: This article discusses a survival function estimation method for clinical trials of poor prognosis cancer treatments, specifically pancreatic cancer. The copula-graphic estimation is used to handle dependent censoring, and a novel method for choosing the copula parameter is proposed. The method is applied to a clinical trial of GV1001 as a treatment for pancreatic cancer, and the results show statistically significant differences in median survival times between the treatment and control groups.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wonjeong Chae, Hee Seung Lee, Jung Hyun Jo, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Sung-In Jang, Jeong Youp Park
Summary: Gallbladder stones (GS) are associated with an increased risk of cardiovascular disease, but the relationship between cholecystectomy for GS and acute coronary syndrome (ACS) is unclear. In this study, the ACS risk in patients with GS and its association with cholecystectomy were investigated. The risk of ACS was higher in the GS group compared to the control group, and individuals without cholecystectomy in the GS group had a higher risk of ACS development. Cholecystectomy was associated with increased ACS risk in the gallstone group, especially in patients without metabolic disorders.
SCIENTIFIC REPORTS
(2023)