Article
Cardiac & Cardiovascular Systems
Omer Gendelman, Ariel J. Feifel, Avishai M. Tsur, Doron Comanhester, Arnon D. Cohen, Howard Amital
Summary: This study found an association between Familial Mediterranean Fever (FMF) and venous thromboembolism (VTE). FMF patients had a higher risk of VTE, which may be due to the chronic inflammatory state. Physicians should be aware of this association and take measures to control the unbalanced disease.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Review
Biochemistry & Molecular Biology
Maddalena Lancieri, Marta Bustaffa, Serena Palmeri, Ignazia Prigione, Federica Penco, Riccardo Papa, Stefano Volpi, Roberta Caorsi, Marco Gattorno
Summary: This study provides an updated overview on the main aspects of pathophysiology, genetics, diagnosis, and treatment resistance of Familial Mediterranean Fever (FMF), a prototypal autoinflammatory disease. It also emphasizes the importance of FMF in understanding the functioning of the innate immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Article
Pediatrics
Elif Kilic Konte, Fatih Haslak, Mehmet Yildiz, Neslihan Gucuyener, Ipek Ulkersoy, Aybuke Gunalp, Esma Aslan, Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
Summary: This study aimed to investigate the demographic and clinical characteristics of children with both FMF and PFAPA syndromes and their response to colchicine and tonsillectomy. The results showed that patients with tonsillopharyngitis, aphthous stomatitis, and PFAPA family history were more likely to be colchicine-resistant and tonsillectomy responsive, while those with exon 10 MEFV gene mutations were more prone to have a favorable response to colchicine.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Genetics & Heredity
Eugenio Sangiorgi, Alessia Azzara, Roberto Rumore, Ilaria Cassano, Elena Verrecchia, Luciano Giaco, Maria Alessandra Tullio, Fiorella Gurrieri, Raffaele Manna
Summary: Periodic fever syndromes are autoinflammatory disorders characterized by recurrent fevers and inflammation without T or B cell involvement. The genetic basis of many of these disorders is complex, with only a few having a known monogenic origin. Current molecular diagnostic tests for these disorders have limited success rates, and it is thought that other genetic factors may be responsible for the remaining cases. This study performed exome sequencing on familial cases of periodic fever syndromes and identified potential candidate genes that may play a role in the pathogenesis of these disorders.
Article
Rheumatology
Yoel Levinsky, Liat Azani, Vered Shkalim Zemer, Gabriel Chodick, Rotem Tal, Liora Harel, Gil Amarilyo
Summary: This study aimed to compare the adherence to colchicine between FMF patients treated with IL-1 inhibitors and FMF patients treated only with colchicine. The results showed that both groups had poor adherence to colchicine, highlighting the importance of patient and caregiver education.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
S. Ozen, H. L. Lutz, V. M. Rivera, A. Reiff, E. D. Batu, E. Anderson, M. Salas Garcia, G. Aldrovandi, T. H. Akbaba, I. Pazarbasi, Y. Bilginer, A. Balat, B. Balci-Peynircioglu, J. A. Gilbert, F. Dedeoglu, J. S. Hausmann
Summary: This study found significant differences in gut microbiota composition between children with FMF from Turkey and the USA, but this composition did not have a strong impact on disease severity. FMF patients and controls exhibited microbiota differences in different geographic regions, but gut microbiota composition was not a major influencing factor in the development of FMF.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Seza Ozen, Erdal Sag, Eldad Ben-Chetrit, Marco Gattorno, Ahmet Gul, Philip J. Hashkes, Isabelle Kone-Paut, Helen J. Lachmann, Elena Tsitsami, Marinka Twilt, Fabrizio de Benedetti, Jasmin B. Kuemmerle-Deschner
Summary: A set of evidence-based core statements defining colchicine resistance/intolerance in patients with FMF were developed to guide clinicians and health authorities in the management of patients with FMF.
Article
Rheumatology
Avishai M. Tsur, Abdulla Watad, Omer Gendelman, Daniel Nissan, Arnon D. Cohen, Howard Amital
Summary: The study found a positive association between FMF and asthma through a cross-sectional study. Further research is needed to validate and explore possible explanations for this association. These findings challenge previous studies that suggested FMF as a protective factor against asthma.
Article
Rheumatology
Deniz Gezgin Yildirim, Pelin Esmeray Senol, Oguz Soylemezoglu
Summary: This study investigated the predictors of persistent inflammation in children with familial Mediterranean fever (FMF). The results showed that M694V homozygosity, colchicine resistance, positive family history, and other factors may be independent predictors of persistent inflammation in FMF. These predictors can help clinicians suspect subclinical inflammation and improve disease management in FMF.
MODERN RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Mustafa capraz, Muhammed Emin Duz
Summary: This study examines the genotypes of FMF patients from Amasya, Turkey, and finds that the R202Q genotype is commonly observed. The study suggests that the R202Q genotype should be included in routine molecular screenings of patients and calls for functional studies of the R202Q variant pyrin protein.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Vikash Jaiswal, Zouina Sarfraz, Trissa Paul, Furqan Ahmad Jarullah, Christine Zakhary
Summary: This case report discusses a 12-year-old Egyptian boy with familial Mediterranean fever (MEFv) confirmed by genetic testing, despite the absence of fever as a symptom. Treatment with steroids and colchicine-salicylate has proven effective in reducing symptom frequency, although the risk-to-benefit ratio should be carefully considered. Further research is needed for better long-term treatment options, and the key takeaway is that fever is not a necessary symptom for diagnosing FMF.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Rheumatology
Limor Marko, Asaf Shemer, Merav Lidar, Chagai Grossman, Amit Druyan, Avi Livneh, Shaye Kivity
Summary: Treatment with anakinra is beneficial for the majority of colchicine-resistant FMF patients and is relatively safe, as evidenced by a significant improvement in the Global Assessment Score. However, some patients experienced adverse effects such as hospitalizations and injection site reactions.
Article
Pediatrics
Oren Biro, Alex Gileles-Hillel, Talia Dor-Wollman, Eli M. Eisenstein, Yackov Berkun
Summary: The study found a higher prevalence of ADHD, learning disabilities, headaches, and febrile seizures in children with FMF. Headaches and febrile seizures were significantly more common in children with FMF compared to their siblings. ADHD and learning disabilities were associated with poor adherence to colchicine treatment. Overall, it highlights the importance of addressing neurodevelopmental aspects in children with FMF for better disease management.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, General & Internal
Mhd Boshr Alesh, Didem Barlak Keti, Aysenur Pac Kisaarslan, Sabahattin Muhtaroglu, Sema Nur Taskin
Summary: This study investigated the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with familial Mediterranean fever (FMF) during an attack-free period. The results showed a negative association between subclinical inflammation/oxidative stress and vitamin D levels. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Rheumatology
Aslihan Avanoglu Guler, Tuba Yuce Inel, Timucin Kasifoglu, Cansu Coskun, Hazan Karadeniz, Derya Yildirim, Reyhan Bilici, Hasan Satis, Hamit Kucuk, Seminur Haznedaroglu, Berna Goker, Mehmet Akif Ozturk, Ismail Sari, Abdurrahman Tufan
Summary: The features of familial Mediterranean fever (FMF) do not have a negative impact on the prognosis of COVID-19. Non-adherence to colchicine treatment is a risk factor for requiring hospitalization for respiratory support. The rate of FMF attacks increases significantly after COVID-19, with some of them being prolonged and destructive.
MODERN RHEUMATOLOGY
(2023)
Article
Immunology
Berkan Armagan, Ebru Atalar, Serdar Can Guven, Bahar Ozdemir, Hatice Ecem Konak, Pinar Akyuz Dagli, Abdulsamet Erden, Kevser Gok, Yuksel Maras, Ismail Dogan, Orhan Kucuksahin, Sukran Erten, Ahmet Omma
Summary: The study aimed to evaluate the impact of sulfasalazine therapy on COVID-19 outcomes in patients with Axial Spondyloarthritis. The results suggest that sulfasalazine may be associated with more severe COVID-19 in AxSpA patients. Therefore, these patients should be closely followed in the presence of COVID-19, and discontinuation of sulfasalazine should be considered.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Rheumatology
Ozlem Karakas, Abdulsamet Erden, Berkan Armagan, Serdar Can Guven, Ebru Atalar, Bunyamin Polat, Ahmet Omma, Orhan Kucuksahin
Summary: The aim of this study was to evaluate the development of side effects and complications in APS patients after COVID-19 vaccination. The study included 35 APS patients who had received at least 1 dose of either CoronaVac or BNT162b2 vaccines. The most common adverse events reported were myalgia and malaise. No vaccine-related thrombotic events or disease flares were observed. Larger-scale studies are needed for more accurate evaluation of side effects in APS patients after COVID-19 vaccination.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
M. Kiraci, E. Bilgin, E. Duran, B. Farisogullari, E. C. Bolek, G. K. Yardimci, Z. Ozsoy, G. Ayan, G. S. Uzun, T. H. Akbaba, B. Balci-Peynircioglu, O. Karadag, A. Akdogan, S. A. Bilgen, S. Kiraz, A. Ertenli, U. Kalyoncu, L. Kilic
Summary: Comparing the features of patients with familial Mediterranean fever (FMF) accompanying axial spondyloarthritis (axSpA) to patients with each condition alone, it was found that patients with FMF + axSpA had earlier onset of axSpA, more severe hip involvement, and higher prevalence of amyloidosis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Arzu Taghiyeva, Levent Kilic, Murat Cagan, Ertugrul Cagri Bolek, Gozde Kubra Yardimci, Ozgur Ozyuncu, Sule Apras Bilgen, Omer Karadag
Summary: This study aimed to evaluate fertility, early menopause, and pregnancy outcomes of patients with Takayasu's arteritis (TA) before and after diagnosis. The results showed that TA patients had a higher infertility rate compared to the general population in Turkey (12.5% vs 8.6%) and a lower rate of early menopause (16.7% vs 36.1%). Pregnancy following a TA diagnosis had more maternal complications, and fetal complications were common both before and after diagnosis. Chronic inflammation may contribute to increased infertility and fetal complications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Immunology
Pinar Akyuez Dagli, Abdulsamet Erden, Serdar Can Gueven, Berkan Armagan, oeykue Tayfur Yuerekli, Yasemin oezderin oezin, Ahmet Omma, Orhan Kuecueksahin
Summary: This study evaluated the effectiveness of tofacitinib in the treatment of enteropathic arthritis. The results showed that after tofacitinib treatment, clinical and laboratory symptoms of both inflammatory bowel disease and arthritis improved in three patients.
Article
Immunology
Bahar Ozdemir Ulusoy, Abdulsamet Erden, Serdar Can Guven, Berkan Armagan, Oyku Tayfur Yurekli, Yasemin Ozderin Ozin, Ahmet Omma, Orhan Kucuksahin
Summary: Treatments targeting the IL-23 pathway have shown high efficacy in psoriasis, psoriatic arthritis, and inflammatory bowel diseases. This study investigated the effectiveness of ustekinumab, a biological agent blocking the IL-12/23 pathway, in patients with enteropathic arthritis. The results showed that ustekinumab effectively achieved clinical remission in inflammatory bowel disease and enteropathic arthritis, as well as regression of other extraintestinal findings.
Article
Rheumatology
Berkan Armagan, Hatice Ecem Konak, Bahar Ozdemir, Hakan Apaydin, Ebru Atalar, Pinar Akyuz Dagli, Serdar Can Guven, Abdulsamet Erden, Orhan Kucuksahin, Ahmet Omma, Sukran Erten
Summary: This study evaluated the frequency, risk factors, and re-infection rates of COVID-19 in patients with autoimmune rheumatic diseases receiving rituximab. The results showed that hypogammaglobulinemia was a significant risk factor for COVID-19 development, and advanced age was associated with more severe disease. Additionally, a high rate of COVID-19 re-infection was observed.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medical Laboratory Technology
Mehmet Kayaalp, Abdulsamet Erden, Hakan Apaydin, Serdar Can Gueven, Berkan Armagan, Merve Caglayan Kayaalp, Esma Andac Uzdogan, Seymanur Ala Enli, Ahmet Omma, Orhan Kucuksahin
Summary: The study aimed to evaluate the levels of Sema3A in patients with systemic sclerosis (SSc), particularly in major vascular involvements like digital ulcer (DU), scleroderma renal crisis (SRC), pulmonary arterial hypertension (PAH), and to compare Sema3A level with SSc disease activity. The study suggests that Sema3A may play a significant role in the pathogenesis of vasculopathy and can be used as a biomarker in SSc patients with vascular complications such as DU and PAH.
LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Onur Keskin, Bayram Farisogullari, Gozde Kubra Yardimci, Burcu Gurbuz, Melike Kole, Erkan Parlak, Omer Karadag, Taylan Kav, Umut Kalyoncu
Summary: This study aimed to determine the effectiveness of adding a simple questionnaire related to the musculoskeletal system to routine outpatient examination to detect undiagnosed axial and peripheral arthropathy in patients with inflammatory bowel disease (IBD). The study found that the DETAIL questionnaire is an effective tool for identifying missed cases of enteropathic arthritis in patients with IBD.
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Gozde Kubra Yardimci, Doruk Arslan, Berrin Babaoglu, Ertugrul Cagri Bolek, Levent Kilic, Arzu Saglam, Asli Tuncer, Figen Soylemezoglu, Rahsan Gocmen, Kader K. Oguz, Ersin Tan, Omer Karadag
Summary: In this study, the HUVAC database was used to evaluate cases of pachymeningitis in patients with IgG4-related disease. It was found that most of these patients had normal serum IgG4 levels, therefore not useful for diagnosis. Typical radiology and tentorial thickening should raise suspicion of IgG4-related disease and prompt early biopsy. With steroids+ rituximab treatment, there was no long-term relapse related to meningeal involvement.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
O. Deniz, C. Cavusoglu, H. Satis, R. B. Salman, O. Varan, N. Atas, S. Coteli, R. T. Dogrul, H. Babaoglu, A. Oncul, H. D. Varan, M. C. Kizilarslanoglu, A. Tufan, B. Goker
Summary: This study aimed to compare sleep quality and its associations with disease activity and quality of life between older patients with rheumatoid arthritis and age- and gender-matched controls. The findings showed that older RA patients had poor sleep quality and sleep quality is strongly associated with disease activity and quality of life. In the geriatric population with rheumatologic diseases such as rheumatoid arthritis, sleep quality should be kept in mind and evaluated in routine management.
EUROPEAN GERIATRIC MEDICINE
(2023)
Article
Rheumatology
Gullu Sandal Uzun, Arzu Taghiyeva, Ibrahim Y. Cakir, Kenan Moral, Gozde Kubra Yardimci, Ertugrul C. Bolek, Bayram Farisogullari, Emine Duran, Gizem Ayan, Zehra Ozsoy, Mustafa Ekici, Erdinc Unaldi, Serife A. Germe, Busra Firlatan, Gozde S. Kart-Bayram, Emre Bilgin, Levent Kilic, Omer Karadag, Ali Akdogan, Sule A. Bilgen, Sedat Kiraz, Ali Ihsan Ertenli, Umut Kalyoncu
Summary: The choice of b/ts-DMARDs, comorbidities, and disease activity control are important factors in the development of CKD in RA patients. The mortality rate did not significantly differ between CKD and non-CKD patients, but both groups experienced increased overall mortality after the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rehabilitation
Gonca Bumin, Alison Hammond, Remziye Akarsu, Yeliz Prior, Buesra Kaplan, Fatma Temizkan, Ozgun Belen, Yusuf Celik, Gozde Kubra Yardimci, Umut Kalyoncu
Summary: The EDAQ was translated into Turkish and tested for validity and reliability in people with RA in Turkey. The Turkish version showed good internal consistency, concurrent validity, and test-retest reliability, making it a reliable tool for assessing daily activity ability in Turkish speakers with RA.
DISABILITY AND REHABILITATION
(2023)