Review
Oncology
Louise Marie Beelen, Anne-Margreet van Dishoeck, Elena Tsangaris, Michelle Coriddi, Joseph H. Dayan, Andrea L. Pusic, Anne Klassen, Dalibor Vasilic
Summary: Lymphedema is a chronic and debilitating condition affecting many cancer survivors. Patient-reported outcome measures (PROMs) can provide valuable insight into the impact of lymphedema on quality of life, but none of the existing lymphedema-specific PROMs met all quality standards for development. A well-developed PROM based on patient input is needed to better understand and measure the impact of this condition and evaluate treatment effects.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Alba Nicolas-Boluda, Anne Oppenheimer, Jerome Bouaziz, Arnaud Fauconnier
Summary: Patient Reported Outcome Measures (PROM) allow capturing patients' perspectives on their condition in the context of endometriosis care. Despite their extensive use in research and clinical trials, PROMs are rarely used in clinical practice. The development of digital tools can help facilitate the integration of PROMs into routine endometriosis care, improving patient-centered communication and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Donald C. Moore, Joseph B. Elmes, Scott A. Strassels, Jai N. Patel
Summary: Patient-reported outcomes (PROs) are not consistently utilized and lack harmonization in oncology drug clinical trials leading to initial accelerated approval.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Pediatrics
Madeline R. Horan, Jin-ah Sim, Kevin R. Krull, Justin N. Baker, I-Chan Huang
Summary: This review describes the generic and cancer-specific PRO measures for pediatric cancer populations and summarizes their characteristics, translations, content coverage, and measurement properties. It highlights the importance of considering psychometric properties and content coverage before implementing PRO measures in childhood cancer research or clinical care. Routine PRO assessment in pediatric cancer care can improve clinical decision-making and quality of care.
Article
Rehabilitation
Allen W. Heinemann, Kristian P. Nitsch, Kristen Gracz, Linda Ehrlich-Jones, Edeth Engel, Meghan Wilson, Colleen Zale, Ian D. Graham
Summary: This article discusses a project that aimed to implement patient-reported outcome measures (PROMs) based on electronic health records (EHRs) in a large inpatient spinal cord injury rehabilitation program. The project took longer than expected, but the report provides valuable lessons, successes, and challenges encountered during the process. The article emphasizes the importance of detailed planning, cooperation with the institution's Information Systems department, and identifying key players for successful implementation.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Health Care Sciences & Services
Brittany R. Lapin, Ryan Honomichl, Nicolas Thompson, Susannah Rose, Abby Abelson, Chad Deal, Irene L. Katzan
Summary: Most patients reported positive experiences with completing PROMs, finding the questions easy to understand, useful, and improving communication with their physician. Younger age, non-white race, lower income, and being a new patient were associated with better experiences with PROMs.
QUALITY OF LIFE RESEARCH
(2021)
Review
Medical Informatics
Finlay J. Pearce, Samantha Cruz Rivera, Xiaoxuan Liu, Elaine Manna, Alastair K. Denniston, Melanie J. Calvert
Summary: This systematic evaluation examines the use of patient-reported outcome measures (PROMs) in clinical trials for artificial intelligence (AI) technologies. The study found that although there is an increase in the number of clinical trials for AI health technologies, the use of PROMs is still lacking. The most common clinical areas where PROMs are used include digestive system health and musculoskeletal health.
LANCET DIGITAL HEALTH
(2023)
Review
Medicine, General & Internal
Pervez Sultan, Nadir Sharawi, Lindsay Blake, Kazuo Ando, Ellile Sultan, Nima Aghaeepour, Brendan Carvalho, Nishant Sadana
Summary: This study evaluated patient-reported outcome measures (PROMs) for outpatient postpartum recovery and found that the best-performing PROMs currently available are the Maternal Concerns Questionnaire, the Postpartum Quality of Life tool, and the World Health Organization Quality of Life-BREF. Future research should focus on developing and validating a new comprehensive PROM for evaluating outpatient postpartum recovery.
Editorial Material
Dentistry, Oral Surgery & Medicine
Dhelfeson Willya Douglas-de-Oliveira, Kitty Jieyi Chen
Summary: Patient reported outcomes (PROs) are significant in evaluating treatment effectiveness and patient satisfaction. This editorial introduces the context of dental PROMs and invites submissions for a special collection in BMC Oral Health on PROs in dentistry.
Review
Dermatology
Eric Xia, Sara J. Li, Lara Drake, Sophia Reyes-Hadsall, Carol Mita, Aaron M. Drucker, Arash Mostaghimi
Summary: Despite progress, there is still a lack of standardization in the use of outcome measures for AA. A scoping review revealed heterogeneity in the outcome measures used in assessing and treating AA. Only a small number of ClinROMs were frequently used in research studies and clinical trials, indicating the need for consensus and standardization in this field.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Health Care Sciences & Services
Rasa Ruseckaite, Claire Bavor, Lucy Marsh, Joanne Dean, Oliver Daly, Dora Vasiliadis, Susannah Ahern
Summary: This study aimed to assess the feasibility and acceptability of incorporating patient-reported outcome measures (PROMs) into the Australian Pelvic Floor Procedure Registry (APFPR). The study found that most women and clinicians supported the incorporation of PROMs in the APFPR, believing that PROMs have the potential for use in individual care and provide useful aggregate health-related quality of life (HRQoL) data.
QUALITY OF LIFE RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Ran Kornowski
Summary: In today's medical ecosystem, measuring the outcomes most important to patients is crucial. Patient-reported outcome measures (PROMS) can serve as essential metrics for delivering high-quality cardiovascular care, but a lack of standardization makes it challenging to compare outcomes across treatments. By leveraging information technology, sophisticated data analysis using patient-derived data and randomization can generate impactful metrics to inform decision-making.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Review
Multidisciplinary Sciences
James Reeves Mbori Ngwayi, Jie Tan, Ning Liang, Emmanuel Gildas Eric Sita, Kenedy Uzoma Obie, Daniel Edward Porter
Summary: A systematic literature search identified Chinese cross culturally adapted and new designed Patient Reported Outcome Measures (PROMs) for hip assessment. Evaluation using the EMPRO tool showed that none of the Chinese adapted versions are currently rated acceptable for clinical use, with only OAKHQOL and HAGOS reaching acceptability threshold. Further research on cross-cultural adaptation, interpretability, and burden assessment is needed.
Article
Surgery
Viren Patel, Jesse Y. Hsu, Robyn B. Broach, Marty P. Morris, Adrienne N. Christopher, Shelby N. Nathan, Jessica R. Cunning, Benjamin K. Poulose, John P. Fischer
Summary: A novel and accurate method for converting scores between AHQ and HerQLes is presented, facilitating the unification of QoL data from different PROMs. This supports the broader integration of PROMs in surgery and enhances understanding of patient-defined measures of success.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Neurosciences
Alison R. Snyder Valier, Jessica Rogo, R. Curtis Bay, Tamara C. Valovich Mcleod
Summary: This study aimed to estimate scale scores for patient-reported outcome measures in order to classify the improvement level of patients after concussion. The results provide cut-point scores for interpreting outcome measures in concussion patients, aiding clinicians in making informed decisions.
Letter
Rheumatology
Robert B. M. Landewe, Sofia Ramiro, Remy L. M. Mostard
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Juergen Braun, Robert B. M. Landewe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Robert B. M. Landewe, Juergen Braun
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
T. Rusman, M. A. C. van der Weijden, M. T. Nurmohamed, C. J. van Denderen, R. B. M. Landewe, P. M. Bet, C. M. A. van der Bijl, C. J. Van der Laken, I. E. van der Horst-Bruinsma
Summary: The study found that 16 weeks of etanercept treatment did not have an impact on disease activity, the chance of biological treatment, or radiographic progression in patients with suspected non-radiographic axial spondyloarthritis.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Victoria Navarro-Compan, Anne Boel, Annelies Boonen, Philip J. Mease, Maxime Dougados, Uta Kiltz, Robert B. M. Landewe, Xenofon Baraliakos, Wilson Bautista-Molano, Praveena Chiowchanwisawakit, Hanne Dagfinrud, Lara Fallon, Marco Garrido-Cumbrera, Lianne Gensler, Bassel Kamal ElZorkany, Nigil Haroon, Yu Heng Kwan, Pedro M. Machado, Walter Maksymowych, Anna Molto, Natasha de Peyrecave, Denis Poddubnyy, Mikhail Protopopov, Sofia Ramiro, In-Ho Song, Salima van Weely, Desiree van der Heijde
Summary: This study aims to define the instruments for the Assessment of SpondyloArthritis international Society-Outcomes Measures in Rheumatology core domain set for axial spondyloarthritis (axSpA). The study selected core outcome instruments through a systematic literature review and assessment of the instruments' psychometric properties. Additionally, the study endorsed additional instruments to enhance the evaluation of axSpA trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Sofia Ramiro, Elena Nikiphorou, Alexandre Sepriano, Augusta Ortolan, Casper Webers, Xenofon Baraliakos, Robert B. M. Landewe, Filip E. Van den Bosch, Boryana Boteva, Ann Bremander, Philippe Carron, Adrian Ciurea, Floris A. van Gaalen, Pal Geher, Lianne Gensler, Josef Hermann, Manouk de Hooge, Marketa Husakova, Uta Kiltz, Clementina Lopez-Medina, Pedro M. Machado, Helena Marzo-Ortega, Anna Molto, Victoria Navarro-Compan, Michael J. Nissen, Fernando M. Pimentel-Santos, Denis Poddubnyy, Fabian Proft, Martin Rudwaleit, Mark Telkman, Sizheng Steven Zhao, Nelly Ziade, Desiree van der Heijde
Summary: The ASAS-EULAR recommendations provide updated guidance on the management of axial spondyloarthritis, including treatment targets, non-pharmacological interventions, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) as the first-line pharmacological treatment. For patients with comorbidities, the use of biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) is recommended. The recommendations also cover the management of extramusculoskeletal manifestations, tapering of bDMARDs, and surgical interventions.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Augusta Ortolan, Casper Webers, Alexandre Sepriano, Louise Falzon, Xenofon Baraliakos, Robert B. M. Landewe, Sofia Ramiro, Desiree van der Heijde, Elena Nikiphorou
Summary: This study updated the evidence of non-biological treatments for axSpA, providing a basis for the 2022 ASAS-EULAR recommendations. The results showed that education, exercise, and NSAIDs were efficacious in axSpA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Josef S. Smolen, Robert B. M. Landewe, Sytske Anne Bergstra, Andreas Kerschbaumer, Alexandre Sepriano, Daniel Aletaha, Roberto Caporali, Christopher John Edwards, Kimme L. Hyrich, Janet E. Pope, Savia de Souza, Tanja A. Stamm, Tsutomu Takeuchi, Patrick Verschueren, Kevin L. Winthrop, Alejandro Balsa, Joan M. Bathon, Maya H. Buch, Gerd R. Burmester, Frank Buttgereit, Mario Humberto Cardiel, Katerina Chatzidionysiou, Catalin Codreanu, Maurizio Cutolo, Alfons A. den Broeder, Khadija El Aoufy, Axel Finckh, Joao Eurico Fonseca, Jacques-Eric Gottenberg, Espen A. Haavardsholm, Annamaria Iagnocco, Kim Lauper, Zhanguo Li, Iain B. McInnes, Eduardo F. Mysler, Peter Nash, Gyula Poor, Gorica G. Ristic, Felice Rivellese, Andrea Rubbert-Roth, Hendrik Schulze-Koops, Nikolay Stoilov, Anja Strangfeld, Annette van der Helm-van Mil, Elsa van Duuren, Theodora P. M. Vliet Vlieland, Rene Westhovens, Desiree van der Heijde
Summary: This study provides an update on the management recommendations for rheumatoid arthritis (RA) based on the latest developments in the field. The recommendations cover various aspects including medication use, combination therapy, treatment strategies, and dose reduction. The consensus was reached on 5 overarching principles and 11 specific recommendations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Alexandre Sepriano, Andreas Kerschbaumer, Sytske Anne Bergstra, Josef S. Smolen, Desiree van der Heijde, Roberto Caporali, Christopher J. Edwards, Patrick Verschueren, Savia de Souza, Janet Pope, Tsutomu Takeuchi, Kimme Hyrich, Kevin L. Winthrop, Daniel Aletaha, Tanja Stamm, Jan W. Schoones, Robert B. M. Landewe
Summary: This study conducted a systematic literature review (SLR) to evaluate the safety of synthetic and biological disease-modifying antirheumatic drugs (DMARDs) for the management of rheumatoid arthritis (RA). The results indicated that bDMARDs were associated with an increased risk of serious infections compared to csDMARDs, while JAK inhibitors (JAKi) showed higher risk of herpes zoster infections. The risks of malignancies, major adverse cardiovascular events (MACE), and venous thromboembolism (VTE) were similar among different treatments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Sytske Anne Bergstra, Alexandre Sepriano, Andreas Kerschbaumer, Desiree van der Heijde, Roberto Caporali, Christopher John Edwards, Patrick Verschueren, Savia de Souza, Janet E. Pope, Tsutomu Takeuchi, Kimme L. Hyrich, Kevin L. Winthrop, Daniel Aletaha, Tanja A. Stamm, Jan W. Schoones, Josef S. Smolen, Robert B. M. Landewe
Summary: This systematic literature review examines the efficacy, duration of use, and safety of glucocorticoids (GCs) in the management of rheumatoid arthritis (RA). The study confirms the effectiveness of GCs in treating RA, with most patients able to stop GCs within 12-24 months. However, the use of GCs also carries well-known safety risks, including osteoporotic fractures, serious infections, diabetes, and mortality.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Gizem Ayan, Sofia Ramiro, Fernando M. Pimentel-Santos, Wim van Lankveld, Levent Kilic
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Diego Benavent, Dafne Capelusnik, Sofia Ramiro, Victoria Navarro-Compan
Summary: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that affects the spine and sacroiliac joints, potentially leading to irreversible structural damage. Early detection and intervention are crucial for preventing long-term damage and improving outcomes. However, it is unclear if the concept of a window of opportunity applies to axSpA. Recent advances in management, including diagnostic techniques and advanced therapies, show promise in improving outcomes.
Article
Rheumatology
Xenofon Baraliakos, Atul Deodhar, Desiree van der Heijde, Marina Magrey, Walter P. Maksymowych, Tetsuya Tomita, Huji Xu, Ute Massow, Carmen Fleurinck, Alicia M. Ellis, Thomas Vaux, Julie Shepherd-Smith, Alexander Marten, Lianne S. Gensler
Summary: Bimekizumab (BKZ), a monoclonal antibody that inhibits IL-17F and IL-17A, demonstrated sustained efficacy in patients with axial spondyloarthritis (axSpA) at Week 52. The dual inhibition of IL-17A and IL-17F resulted in significant improvements compared to placebo and the safety profile was consistent with previous findings.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Santiago Rodrigues-Manica, Alexandre Sepriano, Sofia Ramiro, Robert Landewe, Pascal Claudepierre, Anna Molto, Maxime Dougados, Miranda van Lunteren, Desiree van der Heijde
Summary: This study aimed to investigate the association between bone marrow edema (BME) and the development of structural lesions at the same anatomical location of the sacroiliac joints (SIJ) in patients with early axial spondyloarthritis (axSpA). The results showed that BME in each quadrant of the SIJ was associated with sclerosis, erosions, and fatty lesions, and the persistent BME pattern was associated with higher structural damage.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Rheumatology
Rosalinde Stal, Sofia Ramiro, Desiree van der Heijde, Floris A. van Gaalen, Xenofon Baraliakos, Pedro M. Machado, Manouk de Hooge, Rosaline van den Berg, Monique Reijnierse, Juergen Braun, Robert Landewe, Alexandre Sepriano
Summary: In patients with radiographic axial spondyloarthritis, vertebral corner inflammation can lead to the development of syndesmophytes, but only a small portion of this effect is explained by vertebral corner fat deposition.