Review
Immunology
Hongjiang Liu, Yundong Zou, Chen Chen, Yundi Tang, Jianping Guo
Summary: Systemic lupus erythematosus (SLE) is a common autoimmune disease that affects multiple organs and its pathogenesis is still unclear. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with closed loop structure that may play essential roles in gene expression, cell function, and the development of autoimmune diseases, including SLE. CircRNAs exhibit tissue-specific expression patterns and have implications in immune responses and autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Feng Chen, Ying Zheng, Xinying Chen, Zhanfa Wen, Youjia Xu, Jinghua Yang, Kaisi Xu
Summary: Belimumab is an important medication for the treatment of cSLE. However, there is a lack of sufficient research on its efficacy and safety, and further studies are needed to validate its clinical value.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zongxin Ling, Yiwen Cheng, Jie Gao, Wenhui Lei, Xiumei Yan, Xiaogang Hu, Li Shao, Xia Liu, Runfang Kang
Summary: This study aimed to investigate whether the fecal and vaginal microbiomes are disrupted in SLE patients and whether they are correlated, as well as their associations with immunological features. The results showed that although both the intestinal and vaginal microbiomes of SLE patients were altered, the changes in the vaginal microbiome were more pronounced and were associated with the patients' immunological features.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Wenqian Wang, Chenran Yue, Sheng Gao, Shuting Li, Jianan Zhou, Jiaqing Chen, Jiahong Fu, Weijian Sun, Chunyan Hua
Summary: Exosomal miRNAs show potential as biomarkers in SLE/LN patients for renal injury diagnosis. Exosomes are considered optimal delivery vehicles due to their high stability, minimal toxicity, low immunogenicity, and specific target effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jinyan Guo, Guangying Cui, Wei Huang, Zhaohui Zheng, Tianfang Li, Guanmin Gao, Zhen Huang, Yuwei Zhan, Suying Ding, Shengyun Liu, Zujiang Yu, Zhigang Ren
Summary: This study compared the characteristics of the oral microbiome between patients with systemic lupus erythematosus (SLE) and healthy controls, and developed an SLE classifier based on the oral microbiota. The results showed that SLE patients had increased oral microbial diversity and a different microbial community compared to healthy controls. Specific microbial changes were identified and used to construct a classifier for diagnosing SLE.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Wuquan Li, Xiaoran Guan, Yong Wang, Yan Lv, Yuyong Wu, Min Yu, Yeying Sun
Summary: This study investigated cuproptosis-related molecular clusters in systemic lupus erythematosus (SLE) and constructed a predictive model. The optimal machine learning model was selected based on gene expression and immune features, and a CeRNA network based on 5 core diagnostic markers was established. Drugs targeting core diagnostic markers were identified through molecular docking.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Morgane Humbel, Florence Bellanger, Alice Horisberger, Madeleine Suffiotti, Natalia Fluder, Mariko Makhmutova, Amandine Mathias, Renaud Du Pasquier, Craig Fenwick, Camillo Ribi, Denis Comte
Summary: This study identified an immune signature for systemic lupus erythematosus (SLE) based on the expression of signaling lymphocytic activation molecule family (SLAMF) receptors on peripheral blood mononuclear cells (PBMC). The frequency of SLAMF1+ B cells, SLAMF4+ monocytes, and SLAMF4+ NK showed correlations with disease activity. Consensus clustering analysis also identified two cell clusters, SLESMB and SLEcTFH, which were significantly increased in SLE compared to controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Yingzhuo Wang, Feng Guo, Donglin Hao, Yunke Guo, Tingting Xu, Qiuxiang Shen, Youjuan Zhu, Jinfeng Su, Lu Wang, Shijia Liu
Summary: By analyzing metabolite profiles in serum samples using a metab-olomics method, this study identified 14 significant metabolites that distinguish patients with SLE from healthy controls. Potential biomarkers such as arabitol, asparagine, and stearic acid were identified, with altered pathways including aspartate metabolism, glycine and serine metabolism, and purine metabolism.
MICROCHEMICAL JOURNAL
(2021)
Article
Medical Laboratory Technology
Zhicheng Ye, Tao Zhang, Menghua Xu, Jin Xu
Summary: This study evaluated sST2 as a potential biomarker in pediatric systemic lupus erythematosus (SLE) patients, and found that sST2 levels were associated with disease activity and other laboratory test results.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Lu Xiao, Feng Zhan, Shudian Lin
Summary: This study identified biomarkers and mechanisms associated with systemic lupus erythematosus (SLE) at a transcriptome level, demonstrating their clinical value in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Konstantinos Parperis, Nikolaos Velidakis, Elina Khattab, Evangelia Gkougkoudi, Nikolaos P. E. Kadoglou
Summary: Pulmonary hypertension is commonly seen in patients with systemic lupus erythematosus, presenting with non-specific symptoms and negatively affecting survival. It can result from immune system dysregulation, as well as various other conditions. Early diagnosis and identification of underlying pathogenetic mechanisms are crucial for introducing targeted therapy and preventing irreversible pulmonary vascular damage. The management of pulmonary hypertension in SLE patients is similar to that of idiopathic PAH, but specific diagnostic tools for early diagnosis seem to be unavailable yet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Guobao Wang, Liling Wu, Huanjuan Su, Xiaodan Feng, Meng Shi, Lingwei Jin, Manqiu Yang, Zhanmei Zhou, Cailing Su, Bihui Yang, Yajing Li, Wei Cao
Summary: This study found that elevated urinary MMP-7 levels are correlated with renal histologic activity in LN patients, and a higher level detected after long-term renal disease remission is associated with an increased risk of incident renal flare in patients with LN.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Rheumatology
Linnea Karlsson, Agneta Zickert, Elisabet Svenungsson, Jan Schmidt-Mende, Francesca Faustini, Iva Gunnarsson
Summary: This study retrospectively analyzed the histopathological findings of first-time kidney biopsies in 139 SLE patients. The results showed that 88.5% of the patients had histopathological findings consistent with lupus nephritis, while 11.5% had other renal diseases. These findings highlight the importance of kidney biopsy in diagnosing and managing inflammatory renal diseases.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Maxence Tailliar, Joost P. Schanstra, Tim Dierckx, Benjamin Breuil, Guillaume Hanouna, Nicolas Charles, Jean-Loup Bascands, Bertrand Dussol, Alain Vazi, Laurent Chiche, Justyna Siwy, Stanislas Faguer, Laurent Daniel, Eric Daugas, Noemie Jourde-Chiche
Summary: The study found that urinary peptidome analysis could not effectively differentiate between active and non-active lupus nephritis (LN) or predict early response to therapy. The validated CKD273 and LN172 classifiers have some diagnostic and differential value, but cannot replace kidney biopsy. The value of urinary peptidome in predicting long-term chronic kidney disease (CKD) or renal flares in systemic lupus erythematosus (SLE) remains to be evaluated.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Daniel Li, Kazuki Yoshida, Candace H. Feldman, Cameron Speyer, Medha Barbhaiya, Hongshu Guan, Daniel H. Solomon, Brendan M. Everett, Karen H. Costenbader
Article
Rheumatology
Cameron B. Speyer, Daniel Li, Hongshu Guan, Kazuki Yoshida, Emma Stevens, April M. Jorge, Brendan M. Everett, Candace H. Feldman, Karen H. Costenbader
RHEUMATOLOGY INTERNATIONAL
(2020)
Article
Rheumatology
Candace H. Feldman, Cameron Speyer, Rachel Ashby, Bonnie L. Bermas, Shamik Bhattacharyya, Eliza Chakravarty, Brendan Everett, Elizabeth Ferucci, Aimee O. Hersh, Francisco M. Marty, Joseph F. Merola, Rosalind Ramsey-Goldman, Brad H. Rovin, Mary Beth Son, Laura Tarter, Sushrut Waikar, Jinoos Yazdany, Joel S. Weissman, Karen H. Costenbader
Summary: The study aimed to define a set of SLE-specific adverse outcomes that could be prevented with timely, effective ambulatory care. Through a modified Delphi process, 25 SLE-specific conditions were identified as potentially preventable and important on a population level, falling into categories of vaccine-preventable illnesses, medication-related complications, reproductive health-related complications, and SLE-related complications.
ARTHRITIS CARE & RESEARCH
(2021)
Editorial Material
Medicine, General & Internal
Caren G. Solomon
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Rheumatology
Alessandra Zaccardelli, Xinyi Liu, Julia A. Ford, Jing Cui, Bing Lu, Su H. Chu, Peter H. Schur, Cameron B. Speyer, Karen H. Costenbader, William H. Robinson, Jeremy Sokolove, Elizabeth W. Karlson, Carlos A. Camargo, Jeffrey A. Sparks
Summary: Elevated anti-citrullinated protein antibodies (ACPA) before diagnosis of rheumatoid arthritis (RA) in women were associated with increased risk of chronic obstructive pulmonary disease (COPD), while women who later developed RA were more likely to develop asthma compared to non-RA controls.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Su H. Chu, Jing Cui, Jeffrey A. Sparks, Bing Lu, Sara K. Tedeschi, Cameron B. Speyer, LauraKay Moss, Marie L. Feser, Lindsay B. Kelmenson, Elizabeth A. Mewshaw, Jess D. Edison, Kevin D. Deane, Clary Clish, Jessica Lasky-Su, Elizabeth W. Karlson, Karen H. Costenbader
Article
Rheumatology
Chio Yokose, April Jorge, Kristin D'Silva, Naomi Serling-Boyd, Mark Matza, Mazen Nasrallah, Sarah Keller, Amar Oza, Hyon Choi, Marcy B. Bolster, Deborah Collier
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2020)
Article
Rheumatology
Kristin M. D'Silva, Chio Yokose, Na Lu, Natalie McCormick, Hwajeong Lee, Yuqing Zhang, Hyon K. Choi
Summary: The study found no long-term excess mortality risk among American women with SU levels as low as <3 mg/dl, but observed a 28% higher mortality risk in men with SU levels <4 mg/dl. This suggests a potential causal relationship between hypouricemia and mortality in men, particularly from diabetes mellitus.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Kristin M. D'Silva, April Jorge, Andrew Cohen, Natalie McCormick, Yuqing Zhang, Zachary S. Wallace, Hyon K. Choi
Summary: The study found that COVID-19 patients with systemic autoimmune rheumatic diseases may have a higher risk of hospitalization, ICU admission, acute renal failure, and venous thromboembolism compared to those without systemic ARDs. These risks may be largely influenced by comorbidities, except for the risk of venous thromboembolism.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Oncology
Ioana A. Dobre, Angela J. Frank, Kristin M. D'Silva, David C. Christiani, Daniel Okin, Amita Sharma, Sydney B. Montesi
Summary: This study found that patients with ILD receiving PD-1 inhibitors more frequently died from cancer-related causes than from ILD. Further research is needed to determine the safety of ICIs in patients with ILD and if ILD subtype may help to refine ICI-associated risks.
CLINICAL LUNG CANCER
(2021)
Article
Rheumatology
Kristin M. D'Silva, Zachary S. Wallace
Summary: Baseline glucocorticoid use is associated with severe COVID-19 outcomes in autoimmune disease patients, but DMARDs categories do not appear to increase risk. Randomized clinical trials show glucocorticoids reduce mortality in severe COVID-19, while other agents like baricitinib may improve outcomes in certain populations. More research is needed to guide DMARD management in autoimmune disease patients during the pandemic and their role in COVID-19 treatment.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Health Care Sciences & Services
Sara Jane Cromer, Kristin M. D'Silva, Elaine W. Yu, Joan Landon, Rishi J. Desai, Seoyoung C. Kim
Summary: The study found that the use of denosumab has surpassed all other bone-directed therapies over the past decade, especially since its approval in 2010. The use of denosumab also showed increasing trends among patients with osteoporosis, malignancies, and recent fractures. However, it is noteworthy that the proportion of using any bone-directed therapy after fractures is low and has declined over time.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Rheumatology
Kristin M. D'Silva, Iazsmin Bauer Ventura, Marcy B. Bolster, Flavia Castelino, Amita Sharma, Brent P. Little, Ayodeji Adegunsoye, Mary E. Strek, Hyon Choi, Sydney B. Montesi
Summary: A multicentre observational study examined the use of rituximab (RTX) in interstitial pneumonia with autoimmune features (IPAF) patients. The majority of IPAF patients treated with RTX at two medical centres demonstrated improvement or stability at 1 year, calling for prospective studies to determine the risks, benefits and cost effectiveness of RTX in IPAF.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2021)