Article
Cell Biology
Ji-Hye Lee, Min-Gee Oh, Sang-Hwan Kim
Summary: The present study investigated the morphological changes in the endometrium of cows during early pregnancy, and found that there were changes in cell apoptosis and gene expression in the uterine and caruncle tissues. Furthermore, the stimulation of 20 alpha-HSD and Casp-3 promoted the reorganization of the uterine and caruncle tissues.
Review
Cell Biology
Lucas Sagrillo-Fagundes, Thais Casagrande Paim, Luiza Pretto, Isadora Bertaco, Carla Zanatelli, Cathy Vaillancourt, Marcia R. Wink
Summary: Purinergic signaling plays a crucial role in regulating nutrient exchange, immune control, and hormonal exchange between embryo and mother during pregnancy. The modulation of ATP and adenosine on the embryo-maternal interface depends on maternal health status and is increasingly recognized for its role in modulating suboptimal pregnancy conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Physiology
Viviane C. L. Gomes, Jenny L. Sones
Summary: Preeclampsia is a life-threatening pregnancy complication with incompletely understood causes, possibly due to a complex interaction at the maternal-fetal interface. Inadequate trophoblast invasion, insufficient uterine vascular remodeling, and poor placental perfusion are key events leading to this syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Immunology
Sijia Zhao, Ting Xie, Li Shen, Hong Liu, Liling Wang, Xixiang Ma, Jianli Wu, Shuiqiao Yuan, Gil Mor, Aihua Liao
Summary: The COVID-19 pandemic has raised concerns about the potential impact of SARS-CoV-2 on pregnant women and fetuses. This study found changes in immune cell subsets in the peripheral blood of pregnant women recovering from COVID-19, but no significant differences in the immune cell subsets in umbilical cord blood. Placental inflammation in late recovery stage patients may be related to the antiviral response, with minimal impact on the fetus due to rare infection through the placenta.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Lorenzo G. T. M. Segabinazzi, Brandy N. Roberts, Erik W. Peterson, Rachael Ambrosia, Don Bergfelt, Juan Samper, Hilari French, Robert O. Gilbert
Summary: This study characterized early embryo development and changes in corpus luteum development and progesterone profiles in pregnant and non-pregnant jennies. The findings contribute to our understanding of the reproductive processes in donkeys.
Review
Veterinary Sciences
Paola Toschi, Mario Baratta
Summary: Maternal undernutrition in early pregnancy can impact placental development and subsequently affect fetal health and growth. Various placental adaptation strategies and the involvement of autophagy as a response mechanism play crucial roles in the placental response to nutritional deficiency.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Neurosciences
Riikka J. Lund, Minna Kylaniemi, Nina Pettersson, Riina Kaukonen, Mikko Konki, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson, Eeva Ekholm
Summary: Maternal depressive symptoms during pregnancy can influence placental DNA methylation, particularly in genes related to neuronal development, which may impact the longterm health of the developing brain. The study found that maternal depressive symptoms are associated with DNA methylation marks in placenta, which are enriched for developmental genes and linked to mental disease traits. Further research is needed to determine if similar marks can be detected in exposed children.
NEUROBIOLOGY OF STRESS
(2021)
Article
Environmental Sciences
Hui Liu, Wenyu Jiang, Yafen Ye, Bei Yang, Xin Shen, Siying Lu, Jun Zhu, Mengling Liu, Chuanzhen Yang, Haibin Kuang
Summary: Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well-documented toxicity to reproductive functions in aquatic organisms. Studies on pregnant mice showed that TBT exposure led to an increase in absorbed embryos and abnormal placental development.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anya Lara Arthurs, Tanja Jankovic-Karasoulos, Claire Trelford Roberts
Summary: This review highlighted the risks of COVID-19 infection during pregnancy, where maternal infection may lead to miscarriage, preterm birth, and stillbirth.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Reinaldo Marin, Flor H. Pujol, Deliana Rojas, Luis Sobrevia
Summary: SARS-CoV-2 infection in pregnant women leads to alterations in maternal and placental function, increasing the risk of preterm birth and caesarean delivery. Placentas of infected mothers show signs of vasculopathy and inflammation. The impact of maternal infection on the fetus and postnatal health is still unclear.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Anatomy & Morphology
S. Mohammad, J. Bhattacharjee, T. Vasanthan, C. S. Harris, S. A. Bainbridge, K. B. Adamo
Summary: Metabolomics, the application of analytical chemistry methodologies to survey the chemical composition of a biological system, is valuable for studying the maternal-fetal interface and has shown moderate usefulness in pregnancy complications. However, the placental metabolome in a healthy pregnancy remains poorly characterized and understood, with potentials for future opportunities in this emerging field.
Review
Cell Biology
Li Qing Wang, Iciar Fernandez-Boyano, Wendy P. Robinson
Summary: This review provides an overview of the impact of genetic variation on placental development and function, emphasizing its association with fetal growth and pregnancy outcomes. Early epidemiology studies, cytogenetic studies of the placenta, and advancements in molecular techniques have contributed to significant progress in understanding genetic variation in the field of placenta.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jorge Moreno-Fernandez, Julio J. Ochoa, Catalina De Paco Matallana, Africa Cano, Estefania Martin-Alvarez, Javier Sanchez-Romero, Juan M. Toledano, Maria Puche-Juarez, Sonia Prados, Susana Ruiz-Duran, Lucia Diaz-Meca, Maria Paz Carrillo, Javier Diaz-Castro
Summary: COVID-19 infection during pregnancy can lead to decreased serum antioxidant capacity in mothers and alterations in placental iron metabolism. Further research is required to understand the pathogenic mechanisms and outcomes in maternal and infant health.
Article
Endocrinology & Metabolism
George M. Butterstein, Colin Hirst, V. Daniel Castracane
Summary: This study investigated the role of the placenta in regulating maternal serum leptin levels in pregnant rats. The results showed that the number of fetal-placental implants impacted maternal serum leptin levels, with lower implant numbers associated with higher leptin levels. Additionally, progesterone appears to suppress maternal serum leptin levels.
Article
Immunology
Jacqueline Guettler, Desiree Forstner, Gerhard Cvirn, Sabine Maninger, Beatrice A. Brugger, Olivia Nonn, Nadja Kupper, Elisabeth Pritz, Stefan Wernitznig, Gottfried Dohr, Heinz Hutter, Herbert Juch, Berend Isermann, Shrey Kohli, Martin Gauster
Summary: In early human gestation, trophoblast plugs in uterine spiral arteries obstruct maternal arterial blood flow into the developing placenta. Maternal platelets are localized in vessel-like channels and intercellular gaps of extravillous trophoblasts, contributing to trophoblast differentiation into the invasive phenotype. However, HLA-G does not affect platelet adhesion and aggregation in this context.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
