☆ 4.7 Article

Key challenges in normal tissue complication probability model development and validation: towards a comprehensive strategy

RADIOTHERAPY AND ONCOLOGY (2020)

Journal

RADIOTHERAPY AND ONCOLOGY

Volume 148, Issue -, Pages 151-156

Publisher

ELSEVIER IRELAND LTD

DOI: 10.1016/j.radonc.2020.04.012

Keywords

Normal Tissue Complication Probability models; Normal tissue; Statistical methods; Head and neck

Categories

Oncology Radiology, Nuclear Medicine & Medical Imaging

Funding

Dutch Cancer Society (KWF) [RUG 2015-7899]

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Abstract

Normal Tissue Complication Probability (NTCP) models can be used for treatment plan optimisation and patient selection for emerging treatment techniques. We discuss and suggest methodological approaches to address key challenges in NTCP model development and validation, including: missing data, non-linear response relationships, multicollinearity between predictors, overfitting, generalisability and the prediction of multiple complication grades at multiple time points. The methodological approaches chosen are aimed to improve the accuracy, transparency and robustness of future NTCP-models. We demonstrate our methodological approaches using clinical data. (C) 2020 The Authors. Published by Elsevier B.V.

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Season of radiotherapy and outcomes of head & neck cancer patients in the MACH-NC & MARCH meta-analyses

Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin

Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Oncology

Meta-analysis of 5-day preoperative radiotherapy for soft tissue sarcoma (5D-PREORTS)

Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes

Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.

RADIOTHERAPY AND ONCOLOGY (2024)

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