Article
Oncology
Michael Pennock, Shouyi Wei, Chingyun Cheng, Haibo Lin, Shaakir Hasan, Arpit M. Chhabra, J. Isabelle Choi, Richard L. Bakst, Rafi Kabarriti, Charles B. Simone II, Nancy Y. Y. Lee, Minglei Kang, Robert H. Press
Summary: Bragg peak proton FLASH is a novel radiotherapy technique that combines ultra-high dose rates and conformal organ sparing for cancer treatment. By modifying the planning software and treatment delivery, Bragg peak FLASH can improve organ sparing and target coverage compared to conventional proton therapy. This study demonstrates the potential benefits of Bragg peak proton FLASH in head and neck reirradiation.
Article
Oncology
Chumin Zhou, Maria Rita Fabbrizi, Jonathan R. Hughes, Gabrielle J. Grundy, Jason L. Parsons
Summary: The study explored the impact of HPV infection on head and neck squamous cell carcinoma (HNSCC) response to radiotherapy, highlighting the increased radiosensitivity of HPV-positive cells compared to HPV-negative cells. PARP inhibitors were found to enhance the radiosensitivity of HPV-negative HNSCC spheroids to photons and protons, resulting in significant growth suppression.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sandra Nuyts, Heleen Bollen, Sweet Ping Ng, June Corry, Avraham Eisbruch, William M. Mendenhall, Robert Smee, Primoz Strojan, Wai Tong Ng, Alfio Ferlito
Summary: Proton therapy is a promising radiation therapy method for improving outcomes in head and neck cancer patients. It can minimize radiation dose to surrounding vital structures, reducing toxicity. However, current evidence on its effectiveness is limited, leading to scarce reimbursement indications in most countries. Despite this, there are approximately 100 proton therapy centers worldwide, and initial experiences for head and neck cancer are being reported. This review aims to summarize the early clinical experience and challenges of proton therapy for head and neck cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Asma Amjad, Jiaofeng Xu, Dan Thill, Colleen Lawton, William Hall, Musaddiq J. Awan, Monica Shukla, Beth A. Erickson, X. Allen Li
Summary: In this study, general and custom autosegmentation models were developed and evaluated for reducing workload and inconsistencies in organ segmentation for radiation treatment planning. The models, based on deep convolutional neural networks, achieved high accuracy using either diversified multi-institutional datasets or well-controlled single-institution datasets. Organ-based approaches were implemented to improve segmentation accuracy for small or complex organs. The autosegmentation models significantly reduced contouring time compared to manual contouring methods.
Article
Oncology
David J. Sher, Dominic H. Moon, Dat Vo, Jing Wang, Liyuan Chen, Michael Dohopolski, Randall Hughes, Baran D. Sumer, Chul Ahn, Vladimir Avkshtol
Summary: This prospective phase II study indicates that elective neck irradiation is no longer mandatory for head and neck squamous cell carcinoma treatment, and radiation therapy can effectively reduce tumor recurrence and improve patients' quality of life.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Arthur Lalonde, Mislav Bobic, Brian Winey, Joost Verburg, Gregory C. Sharp, Harald Paganetti
Summary: This study compared the impact of setup variations and anatomical changes on the quality of head and neck IMPT treatments. The results showed that daily online-adapted plans can achieve superior target coverage and lower dose to organs at risk compared to robust optimization methods.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Puja Upadhaya, Nathan Ryan, Peyton Roth, Travis Pero, Felipe Lamenza, Anna Springer, Pete Jordanides, Hasan Pracha, Darrion Mitchell, Steve Oghumu
Summary: This study demonstrates that tumor-targeted radiation therapy can generate tumor antigens that induce strong immune responses. These responses show comparable sensitivity but greater specificity for T cell activation compared to conventional antibodies. This information can be utilized to predict patient responses to radiation and immune therapy.
Article
Oncology
Christian Baeumer, Rezarta Frakulli, Jessica Kohl, Sindhu Nagaraja, Theresa Steinmeier, Rasin Worawongsakul, Beate Timmermann
Summary: The study aimed to evaluate the role of MRI-based adaptive proton therapy for children with tumors of the head and neck and base of skull. The method of transferring anatomical changes from MRIs to synthetic CTs was successfully implemented and validated. The results showed no clinically relevant deterioration in treatment planning for the studied cohort.
Article
Oncology
Elena Borderias-Villarroel, Vicki Taasti, Wouter Van Elmpt, S. Teruel-Rivas, X. Geets, E. Sterpin
Summary: This study compares the efficacy of non-adapted robust plans with two adaptive IMPT methods in head and neck cancer patients. The results show that dose restoration strategy improves target coverage and robustness, reducing the impact on critical organs. However, due to anatomical changes and inaccurate patient repositioning, some cases still require full offline adaptation to ensure optimal treatment quality.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Michelle L. Qiu, Austin J. Iovoli, Michael Khan, Mark K. Farrugia, Sung Jun Ma, Anurag K. Singh
Summary: Prophylactic high-dose gabapentin can reduce opioid use and delay the need for opioids in patients undergoing radiotherapy for head and neck cancer. In a study of 480 patients, those given high-dose gabapentin had lower opioid use and a longer time before requiring opioids.
Article
Materials Science, Multidisciplinary
Shichen Zhang, Zhengqiang Li, Zhimin Xu, Yixin Tang, Congcong Duan, Huanyan Dai, Xinyu Dai, Xin Wei, Yan Liu, Caina Xu, Bing Han
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of head and neck cancer. Traditional treatments can have negative effects on physiological functions and appearance. This article discusses the use of reactive oxygen species (ROS)-based cancer therapy and summarizes various nanotherapeutics for HNSCC, including photodynamic therapy, sonodynamic therapy, radiation therapy, and chemodynamic therapy. The challenges and future directions for these treatments are also discussed.
MATERIALS & DESIGN
(2022)
Article
Oncology
Justin Lee, Nhu Tram Nguyen, James Wright, Ka-Kit David Yeung, Stephen Sagar, Do-Hoon Kim, Orest Ostapiak, Lilian Doerwald-Munoz, Timothy Whelan
Summary: This study aims to evaluate the response rates to SBRT in older age patients with locally advanced HNSCC. It suggests that SBRT may offer a shorter and more effective treatment compared to the current standard of care palliative regimens.
Article
Medicine, General & Internal
Alexander Ruehle, Sebastian Marschner, Marlen Haderlein, Alexander Fabian, Maria Weymann, Max Behrens, Carolin Senger, Daniel R. Dickstein, Johannes Kraft, Jens von der Gruen, Eric Chen, Todd Aquino-Michaels, Justus Domschikowski, Amanda Bickel, Alev Altay-Langguth, Goda Kalinauskaite, Victor Lewitzki, Konstantinos Ferentinos, Constantinos Zamboglou, Soeren Schnellhardt, Erik Haehl, Simon K. B. Spohn, Eleni Gkika, Daniela Zoeller, Matthias Guckenberger, Volker Budach, Claus Belka, Richard Bakst, Arnulf Mayer, Heinz Schmidberger, Anca-Ligia Grosu, Panagiotis Balermpas, Carmen Stromberger, Nils H. Nicolay
Summary: This study aimed to investigate whether the addition of chemotherapy or cetuximab to radiotherapy improves survival in older adults with HNSCC. The results showed that chemoradiation, but not cetuximab-based bioradiotherapy, was associated with longer overall survival compared to radiotherapy alone. Additionally, the addition of chemotherapy also prolonged progression-free survival. Rating: 8/10.
Article
Oncology
Tenny Mudianto, Katie M. Campbell, Jason Webb, Paul Zolkind, Zachary L. Skidmore, Rachel Riley, Erica K. Barnell, Ibrahim Ozgenc, Tusar Giri, Gavin P. Dunn, Douglas R. Adkins, Malachi Griffith, Ann Marie Egloff, Obi L. Griffith, Ravindra Uppaluri
Summary: The study revealed a Yap1-dependent resistance to trametinib therapy in HNSCCs, with downstream effectors of the Hippo pathway being activated. Combined targeting of Yap1 and MEK may enhance the therapeutic response in head and neck squamous cell carcinoma. The findings suggest potential strategies to overcome resistance and improve treatment outcomes.
CLINICAL CANCER RESEARCH
(2021)
Review
Medicine, General & Internal
Zhaomeng Guo, Kang Li, Peng Liu, Xiangmin Zhang, Jie Lv, Xianhai Zeng, Peng Zhang
Summary: Head and neck squamous cell carcinoma (HNSCC) originates from different parts of the head and neck, and the causes and molecular basis can vary. The tumor microenvironment (TME) consisting of various cells and molecules is crucial for the survival and spread of cancer cells. Understanding the interaction between tumor cells and the TME is essential for developing effective anti-cancer therapies.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Arnaud Beddok, Leslie Guzene, Alexandre Coutte, David Thomson, Sue Yom, Valentin Calugaru, Eivind Blais, Olivier Gilliot, Severine Racadot, Yoann Pointreau, June Corry, Kenneth Jensen, Sandro Porceddu, Nazim Khalladi, Vianney Bastit, Audrey Lasne-Cardon, Pierre-Yves Marcy, Florent Carsuzaa, Christophe Nioche, Jean Bourhis, Julia Salleron, Thariat Juliette
Summary: This study evaluated the interobserver variability of common flaps used in head and neck cancer, showing that delineation of four main flaps was reproducible. However, close cooperation between radiologist, surgeon, and radiation oncologist is necessary for accurate delineation of the FAMM flap.
Article
Oncology
Makbule Tambas, Hans Paul van der Laan, Roel J. H. M. Steenbakkers, Jerome Doyen, Beate Timmermann, Ester Orlandi, Morten Hoyer, Karin Haustermans, Petra Georg, Neil G. Burnet, Vincent Gregoire, Valentin Calugaru, Esther G. C. Troost, Frank Hoebers, Felipe A. Calvo, Joachim Widder, Fabian Eberle, Marco van Vulpen, Philippe Maingon, Tomasz Skora, Damien C. Weber, Kjell Bergfeldt, Jiri Kubes, Johannes A. Langendijk
Summary: This study investigated the current practice of proton therapy in European adult cancer patients. The results showed that central nervous system tumors and head and neck cancer were the most frequently treated tumor types, and most centers used indication protocols for treatment. Lack of evidence and reimbursement issues were the main reasons for not treating certain tumor types.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Pavel Vitek, Jiri Kubes, Vladimir Vondracek, Michal Andrlik, Matej Navratil, Radek Zapletal, Alexandra Haas, Katerina Dedeckova, Barbora Ondrova, Alexander Grebenyuk, Jozef Rosina
Summary: This single-institution study demonstrated the high efficacy of PBS IMPT in the definitive chemoradiotherapy of anal cancer, achieving a high rate of complete regression with low haematological acute toxicity. The acute toxicities completely resolved in all patients without lethal outcomes. Longer follow-up is needed to assess the impact of PBT on chronic toxicity.
Article
Oncology
Georgios Ntentas, Katerina Dedeckova, Michal Andrlik, Marianne C. Aznar, Rebecca Shakir, Johanna Ramroth, Rubina Begum, Jiri Kubes, Sarah C. Darby, N. George Mikhaeel, David J. Cutter
Summary: In some patients with Hodgkin lymphoma, proton beam therapy may reduce the risk of radiation-related cardiovascular disease and second cancers compared with photon radiation therapy. The study aims to identify patients who benefit the most from proton beam therapy in terms of predicted 30-year absolute mortality risks from cardiovascular disease and second cancers. The results show that PBT can reduce the burden for certain categories of lymphoma patients with specific disease types.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Juliette Mainguene, Sophie Vacher, Maud Kamal, Abderaouf Hamza, Julien Masliah-Planchon, Sylvain Baulande, Sabrina Ibadioune, Edith Borcoman, Wulfran Cacheux, Valentin Calugaru, Laura Courtois, Carole Crozes, Marc Deloger, Elodie Girard, Jean-Pierre Delord, Antoine Dubray-Vautrin, Linda Larbi Cherif, Celia Dupain, Emmanuelle Jeannot, Jerzy Klijanienko, Sonia Lameiras, Charlotte Lecerf, Anouchka Modesto, Alain Nicolas, Roman Rouzier, Esma Saada-Bouzid, Pierre Saintigny, Anne Sudaka, Nicolas Servant, Christophe Le Tourneau, Ivan Bieche
Summary: The study found that HPV integration is associated with overexpression of certain cancer genes (such as PDL1 and MYC) in HNSCC patients. This may indicate a role of HPV integration in the carcinogenesis of HNSCC.
MOLECULAR ONCOLOGY
(2022)
Review
Oncology
Laurien De Roeck, Hiska L. van der Weide, Danielle B. P. Eekers, Miranda C. Kramer, Claire Alapetite, Malin Blomstrand, Neil G. Burnet, Valentin Calugaru, Ida E. M. Coremans, Dario Di Perri, Semi Harrabi, Alberto Iannalfi, Yvonne L. B. Klaver, Johannes A. Langendijk, Alejandra Mendez Romero, Frank Paulsen, Erik Roelofs, Dirk de Ruysscher, Beate Timmermann, Pavel Vitek, Damien C. Weber, Gillian A. Whitfield, Petra Witt Nystrom, Jaap Zindler, Esther G. C. Troost, Maarten Lambrecht
Summary: The purpose of this study is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. A consensus was reached among radiation-oncology experts using the Delphi method, resulting in a basic framework for consistent toxicity scoring and follow-up. These recommendations will enable the collection of uniform toxicity data and facilitate collaboration in the research field of radiation-induced toxicities.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Otorhinolaryngology
Arnaud Beddok, Caroline Saint-Martin, Samar Krhili, Catherine Ala Eddine, Laurence Champion, Anne Chilles, Farid Goudjil, Sofia Zefkili, Malika Amessis, Dominique Peurien, Olivier Choussy, Christophe le Tourneau, Remi Dendale, Irene Buvat, Gilles Crehange, Valentin Calugaru
Summary: This study analyzed the outcomes of curative reirradiation for recurrent head and neck squamous cell carcinoma, and found that the locoregional recurrence rate was high and there were risks of toxicity grade >= 2.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiri Kubes, Vladimir Vondracek, Michal Andrlik, Matej Navratil, Silvia Slavikova, Daniel Klika, Alexandra Haas, Katerina Dedeckova, Katerina Kopeckova, Barbora Ondrova, Eliska Rotnaglova, Stepan Vinakurau, Alexander Grebenyuk, Jozef Rosina
Summary: This study reported the feasibility and early clinical results of using proton therapy for the treatment of Glomus jugulare tumours (GJT). The results showed that proton therapy was able to effectively treat patients with mild acute toxicity and stabilize tumour size. Longer follow-up and larger patient cohorts are needed to further investigate the role of proton therapy for this indication.
JOURNAL OF MEDICAL RADIATION SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arnaud Beddok, Fanny Orlhac, Valentin Calugaru, Laurence Champion, Catherine Ala Eddine, Christophe Nioche, Gilles Crehange, Irene Buvat
Summary: The purpose of this study was to evaluate whether radiomics from [18F]-FDG PET and/or MRI before re-irradiation could predict the occurrence and location of a second locoregional recurrence in patients with recurrent head and neck cancer. Radiomic features extracted from pre-reRT PET and MRI were used to create prediction models. The results showed that the models based on MRI and PET could predict the occurrence and location of recurrence with accuracy rates ranging from 78.5% to 84.5%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Yungan Tao, Xu-Shan Sun, Yoann Pointreau, Christophe Le Tourneau, Christian Sire, Marie-Christine Kaminsky, Alexandre Coutte, Marc Alfonsi, Benoit Calderon, Pierre Boisselier, Laurent Martin, Jessica Miroir, Jean-Francois Ramee, Jean-Pierre Delord, Florian Clatot, Frederic Rolland, Julie Villa, Nicolas Magne, Olgun Elicin, Elisabeta Gherga, France Nguyen, Cedrik Lafond, Guillaume Bera, Valentin Calugaru, Lionnel Geoffrois, Bruno Chauffert, Lars Damstrup, Philippa Crompton, Abdallah Ennaji, Kathrin Gollmer, Heidi Nauwelaerts, Jean Bourhis
Summary: This study compared the long-term efficacy and overall survival of xevinapant plus standard chemoradiotherapy with placebo plus chemoradiotherapy in patients with unresected locally advanced squamous cell carcinoma of the head and neck. The results showed that xevinapant plus CRT significantly reduced the risk of locoregional failure, death or disease progression, and prolonged overall survival in patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jiri Kubes, Silvia Slavikova, Pavel Vitek, Alexandra Haas, Barbora Ondrova, Katerina Dedeckova, Michal Andrlik, Martin Domansky, Katerina Jirankova, Veronika Schlencova, Anh Harazimova, Barbora Turkova, Tomas Dolezal, Sarah Falah Abass Al-Hamami, Vladimir Vondracek
Summary: In this retrospective study, the clinical outcomes of prostate cancer patients treated with ultra-hypofractionated proton beam radiotherapy were analyzed. The results showed that ultra-hypofractionated proton beam radiotherapy is an effective treatment for low- and favorable intermediate-risk prostate cancer, with comparable long-term bDFS rates to other techniques. It also shows promise for unfavorable intermediate-risk prostate cancer and has acceptable long-term GI and favorable GU toxicity.
Article
Medicine, General & Internal
Jaromir Astl, Tomas Belsan, Ludmila Michnova, Jiri Kubes, Tomas Filipovsky, Jiri Blecha, Richard Holy
Summary: Sarcomas in the head and neck area are rare diseases, with osteosarcomas being the most common type. The exact diagnosis of sarcomas is determined through immunohistochemical investigation. We present a case of successfully treated malignant osteosarcoma in the ethmoids and maxillary sinus, and discuss the morbidity after treatment.
MEDICINA-LITHUANIA
(2022)
Review
Oncology
Arnaud Beddok, Chloe Lahaye, Valentin Calugaru, Ludovic De Marzi, Charles Fouillade, Samuel Salvador, Jean-Marc Fontbonne, Vincent Favaudon, Juliette Thariat
Summary: This study critically reviews the biological and clinical effects of dose rate (DR) variation in radiation therapy. Preclinical studies have shown that increasing DR can result in decreased survival of both normal and tumor cells due to unrepaired sublethal DNA damage. However, there are variations and inconsistencies in the models and conditions used in these studies, and the impact of beam microstructure is often overlooked.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Amelia Barcellini, Maurizio Massaro, Francesca Dal Mas, Johannes A. Langendijk, Morten Hoyer, Valentin Calugaru, Karin Haustermans, Beate Timmermann, Juliette Thariat, Daniele Scartoni, Sabina Vennarini, Petra Georg, Ester Orlandi
Summary: The survey findings show that European particle RT hubs have responded rapidly and effectively in managing the healthcare crisis. Despite challenges such as delayed cancer diagnosis and an increase in advanced diseases, clinical treatment choices remain aligned with scientific recommendations and patient-centered.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
