Article
Neurosciences
Marina Sagud, Matea Nikolac Perkovic, Anja Dvojkovic, Nenad Jaksic, Bjanka Vuksan-Cusa, Maja Zivkovic, Zorana Kusevic, Alma Mihaljevic-Peles, Nela Pivac
Summary: Higher baseline plasma BDNF levels might be associated with improvements in verbal fluency and working memory in vortioxetine-treated patients. Vortioxetine treatment was superior in simple attention efficiency compared to escitalopram. Moderate positive correlation was found between pretreatment plasma BDNF levels and improvement in cognitive performance in vortioxetine-treated patients.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Motohiro Okada, Ryusuke Matsumoto, Yoshimasa Yamamoto, Kouji Fukuyama
Summary: This study investigated the effects of lurasidone, vortioxetine, and escitalopram on 5-HT7R function and found that chronic administration of these drugs leads to downregulation of 5-HT7R in the thalamus. Furthermore, it was observed that vortioxetine and lurasidone induce more rapid downregulation of 5-HT7R through direct inhibition, while escitalopram's downregulation is slower due to its indirect elevation of extracellular serotonin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Takashi Shiroyama, Kouji Fukuyama, Motohiro Okada
Summary: The study investigated the effects of antidepressants on astrocyte transmission, showing that 5-HT1A receptor and 5-HT7 receptor play different roles in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Leon Jesus German-Ponciano, Gilberto Uriel Rosas-Sanchez, Jonathan Cueto-Escobedo, Rafael Fernandez-Demeneghi, Gabriel Guillen-Ruiz, Cesar Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: Depressive disorders are a highly disabling global disease, with increasing incidence in recent decades. Flavonoids hold promise as potential antidepressants, with mechanisms that are not fully understood. Individuals with depression have low levels of serotonin and BDNF, which can be reversed by flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Annette Johansen, Sophia Armand, Pontus Plaven-Sigray, Arafat Nasser, Brice Ozenne, Ida N. Petersen, Sune H. Keller, Jacob Madsen, Vincent Beliveau, Kirsten Moller, Alexandra Vassilieva, Christelle Langley, Claus Svarer, Dea S. Stenbaek, Barbara J. Sahakian, Gitte M. Knudsen
Summary: This study investigated the effects of the SSRI escitalopram on synaptic plasticity. The findings suggest that daily intake of escitalopram for 3-5 weeks can lead to changes in brain synaptic plasticity, providing a biological explanation for the delayed treatment response commonly observed in patients treated with SSRIs.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Vanessa H. Brait, Katherine A. Jackman, Terence Y. Pang
Summary: Stroke is a major cause of mortality, and the treatment process is complicated by the emergence of secondary psychological symptoms. Selective serotonin reuptake inhibitors (SSRIs) have been effective in treating poststroke depression (PSD), but alternative treatment options need to be explored due to the associated risks. Exercise has shown mood benefits in neurological conditions, but the effects of physical exercise post-stroke are not well-known.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
George M. Anderson, Christine M. Ramsey, Kevin G. Lynch, Joel Gelernter, David W. Oslin
Summary: This study investigated the distribution of baseline platelet serotonin (5-HT) levels in depression patients seeking treatment and defined subgroups based on drug exposure. The bioeffect of 5-HT reuptake inhibitors (SRIs) and the relationship between demographic variables and platelet 5-HT concentration were also assessed. Data from a cross-sectional study of 1433 Veterans Administration (VA) patients were analyzed, revealing a bimodal distribution of platelet 5-HT levels and significant differences in population, sex, and age.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Cell Biology
Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli, Federico Sicca
Summary: Serotonergic dysfunction is believed to be a major cause of depression, although other dysfunctional mechanisms may also be involved. The astrocytic inward rectifier potassium channel 4.1 (Kir4.1) may play an important role in neuronal excitability and glutamate metabolism, with its dysfunction potentially related to depression.
Article
Behavioral Sciences
Isabel Cristina Bandeira, Lucas Giombelli, Isabel Cristina Werlang, Ana Lucia Abujamra, Thais Leite Secchi, Rosane Brondani, Jose Augusto Bragatti, Jorge Wladimir Junqueira Bizzi, Sandra Leistner-Segal, Marino Muxfeldt Bianchin
Summary: The study evaluated the methylation profile of BDNF and SLC6A4 genes in patients with temporal lobe epilepsy and found significantly decreased methylation associated with mood disorders.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Younjung Lee, Kye-Hyun Kim, Bun-Hee Lee, Yong-Ku Kim
Summary: The study found that pregnancy and postpartum depression can affect BDNF concentration, and the BDNF concentration in the postpartum depression-recovery group significantly increased at 6 weeks postpartum.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
N. Simple Santi, Sashi Bhusan Biswal, Birendra Narayan Naik, Jyoti Prakash Sahoo, Bhabagrahi Rath
Summary: This study compares the efficacy and adverse effects of vilazodone, escitalopram, and vortioxetine. The results show that vortioxetine significantly reduces the Hamilton Depression Rating Scale (HDRS) and Montgomery-Asberg Depression Rating Scale (MADRS) scores compared to vilazodone and escitalopram after 12 weeks of follow-up. This suggests that vortioxetine may have potential antidepressant effects.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Robin Carhart-Harris, Bruna Giribaldi, Rosalind Watts, Michelle Baker-Jones, Ashleigh Murphy-Beiner, Roberta Murphy, Jonny Martell, Allan Blemings, David Erritzoe, David J. Nutt
Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Behavioral Sciences
Ofelia Limon-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jimenez, Marco Cerbon, Herlinda Bonilla-Jaime
Summary: Depressive illness is associated with cognitive impairment, reduced levels of neurotrophins, and dysfunctions in the serotonergic system. The study found that neonatal treatment with clomipramine caused molecular changes in brain regions related to learning and memory.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Psychiatry
John-Jose Nunez, Yang S. Liu, Bo Cao, Benicio N. Frey, Keith Ho, Roumen Milev, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Valerie H. Taylor, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam
Summary: Depression is a complex disorder with a heterogeneous response to treatment. This study used machine learning to cluster patients with depression and found three distinct response patterns. The subjective mood state/anhedonia was identified as the core feature of response to escitalopram, but there were also other patterns related to neurovegetative symptoms, activation, and cognition.
PSYCHIATRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mirjana Babic Leko, Matej Mihelcic, Jasna Jurasovic, Matea Nikolac Perkovic, Ena Spanic, Ankica Sekovanic, Tatjana Orct, Klara Zubcic, Lea Langer Horvat, Nikolina Pleic, Spomenka Kidemet-Piskac, Zeljka Vogrinc, Nela Pivac, Andrea Diana, Fran Borovecki, Patrick R. Hof, Goran Simic
Summary: Several metals, including heavy metals and essential metals, are associated with the pathogenesis of Alzheimer's disease. Further research is needed to understand the mechanisms of toxicity. This study found positive associations between levels of certain metals and AD biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Matea Nikolac Perkovic, Morana Jaganjac, Lidija Milkovic, Tea Horvat, David Rojo, Kamelija Zarkovic, Marijana Coric, Tvrtko Hudolin, Georg Waeg, Biserka Orehovec, Neven Zarkovic
Summary: This study found that 4-hydroxynonenal (4-HNE) exists as protein adducts in the plasma of prostate cancer patients and is associated with specific changes in plasma metabolites. Metabolomics revealed a positive correlation between long-chain and medium-chain fatty acids and the presence of prostate cancer. Furthermore, 4-HNE significantly affected the biosynthesis pathway of unsaturated fatty acids.
Article
Biochemistry & Molecular Biology
Marina Sagud, Zoran Madzarac, Gordana Nedic Erjavec, Ivona Simunovic Filipcic, Filip Luka Mikulic, Dunja Rogic, Zoran Bradas, Maja Bajs Janovic, Nela Pivac
Summary: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR) and systemic immune-inflammation index (SII index) are commonly used to indicate inflammation. Their relationship with negative symptoms, including anhedonia, in patients with schizophrenia is not well understood. This study found that there were weak to moderate positive correlations between various negative symptoms and blood cell inflammatory ratios in male patients, and weaker correlations in female patients. However, social anhedonia showed a negative correlation with the SII index in females, suggesting a possible different mechanism. Further exploration is needed to understand the relationship between anhedonia and inflammatory markers.
Article
Biochemistry & Molecular Biology
Katarina Kouter, Matea Nikolac Perkovic, Gordana Nedic Erjavec, Tina Milos, Lucija Tudor, Suzana Uzun, Ninoslav Mimica, Nela Pivac, Alja Videtic Paska
Summary: Due to the increasing number of progressive dementias, studies are being conducted to determine risk factors, biomarkers, and mechanisms for differentiating between normal aging, MCI, and dementia. This study investigated the association of BDNF and COMT gene expression and methylation with the development of AD. The results showed higher BDNF expression in MCI subjects compared to AD individuals, suggesting its potential as a marker for distinguishing between MCI and AD. No difference in COMT gene expression was found.
Review
Pathology
Matea Nikolac Perkovic, Martin Gredicak, Marina Sagud, Gordana Nedic Erjavec, Suzana Uzun, Nela Pivac
Summary: This mini review presents recent evidence on the association between brain-derived neurotrophic factor (BDNF) concentration/levels, BDNF Val66Met (rs6265) polymorphism, and major depressive disorders. It focuses on the changes in peripheral BDNF levels before and after treatment with antidepressant drugs or different therapeutic strategies, as well as the association between different antidepressants/therapeutic strategies and BDNF Val66Met genotypes. The expert opinion suggests that BDNF plays an important role in the pathophysiology and treatment response in depression, and peripheral BDNF levels may serve as potential biomarkers of therapeutic response.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Biochemistry & Molecular Biology
Lucija Tudor, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Marcela Konjevod, Suzana Uzun, Oliver Kozumplik, Ninoslav Mimica, Gordan Lauc, Dubravka Svob Strac, Nela Pivac
Summary: The molecular mechanisms behind PTSD, including the role of glycosylation and the FUT8 gene, were investigated in this study. Associations between plasma N-glycan levels and FUT8-related polymorphisms were observed in both PTSD patients and control participants. The findings suggest that FUT8-related polymorphisms play a regulatory role in glycosylation, which may contribute to the development and clinical manifestation of PTSD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcela Konjevod, Katherina B. B. Sreter, Sanja Popovic-Grle, Marina Lampalo, Lucija Tudor, Irena Jukic, Gordana Nedic Erjavec, Jasna Bingulac-Popovic, Hana Safic Stanic, Matea Nikolac Perkovic, Jasenka Markeljevic, Miroslav Samarzija, Nela Pivac, Dubravka Svob Strac
Summary: The study investigated platelet serotonin levels and platelet monoamine oxidase B activity in healthy individuals and asthma patients, as well as gene polymorphisms related to serotonin receptors and monoamine oxidase. The results showed that asthma patients had lower platelet serotonin concentration and higher platelet monoamine oxidase B activity. However, there were no differences in these parameters between patients with different asthma severity or phenotypes. Further analysis revealed that certain gene polymorphisms were associated with platelet monoamine oxidase B activity and asthma severity. More studies are needed to understand the involvement of the serotonergic system in asthma pathophysiology.
Article
Biochemistry & Molecular Biology
Matea Nikolac Perkovic, Fran Borovecki, Igor Filipcic, Barbara Vuic, Tina Milos, Gordana Nedic Erjavec, Marcela Konjevod, Lucija Tudor, Ninoslav Mimica, Suzana Uzun, Oliver Kozumplik, Dubravka Svob Strac, Nela Pivac
Summary: The aim of this study was to evaluate the potential difference in plasma brain-derived neurotrophic factor (BDNF) concentrations between subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients and to determine the possible association between BDNF plasma levels and the degree of cognitive decline in these individuals. The results showed significantly higher plasma BDNF concentrations in AD patients compared with MCI subjects. Additionally, there was a negative correlation between cognitive functions and BDNF plasma concentrations, suggesting higher BDNF levels in subjects with more pronounced cognitive decline.
Article
Genetics & Heredity
Marina Sagud, Lucija Tudor, Gordana Nedic Erjavec, Matea Nikolac Perkovic, Suzana Uzun, Ninoslav Mimica, Zoran Madzarac, Maja Zivkovic, Oliver Kozumplik, Marcela Konjevod, Dubravka Svob Strac, Nela Pivac
Summary: This study investigated the association of COMT rs4680 and rs4618 polymorphisms with the severity of cognitive and other clinical symptoms in patients with schizophrenia. The results showed that male carriers of rs4818 G allele had more abstract thinking difficulties, whereas male carriers of rs4680 A allele had worse abstract thinking scores. Male carriers of rs4818-rs4680 GA haplotype had higher somatic concern scores, while GG haplotype carriers had lower anxiety and depression scores. Female patients with severe disturbance of volition had less COMT GG haplotype and more CG haplotype.
Article
Biochemistry & Molecular Biology
Biljana Kosanovic Rajacic, Marina Sagud, Drazen Begic, Matea Nikolac Perkovic, Anja Dvojkovic, Lana Ganoci, Nela Pivac
Summary: Brain-derived neurotrophic factor (BDNF) plays a crucial role in the etiology and treatment response of major depressive disorder (MDD). This study found that all MDD patients had lower peripheral BDNF levels compared to healthy controls (HC). However, no significant differences were observed in BDNF levels between different stages of MDD. Patients who responded well to bright light therapy (BLT) had higher post-treatment BDNF concentrations, suggesting that changes in plasma BDNF levels may serve as potential biomarkers for treatment response in TRD patients.
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
