Article
Pharmacology & Pharmacy
Radu A. Paun, Daciana C. Dumut, Amanda Centorame, Thusanth Thuraisingam, Marian Hajduch, Martin Mistrik, Petr Dzubak, Juan B. De Sanctis, Danuta Radzioch, Maryam Tabrizian
Summary: The study developed a stable and scalable formulation of CuET by encapsulating it in nanoliposomes, addressing the issues of poor solubility in water and low bioavailability. The formulation demonstrated excellent stability and controlled drug release, showing significant anticancer effects on melanoma cells in vivo.
Article
Pharmacology & Pharmacy
Monica C. Garcia, Jose Manuel Calderon-Montano, Manuela Rueda, Marcela Longhi, Antonio M. Rabasco, Miguel Lopez-Lazaro, Francisco Prieto-Dapena, Maria Luisa Gonzalez-Rodriguez
Summary: This study reports the development of pH/thermo-sensitive liposomes using nucleolipids and modified with gold nanoparticles. The results demonstrate that these liposomes can efficiently release anticancer drugs and exhibit significant toxicity against cancer cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Engineering, Biomedical
Rui Sang, Bradley Stratton, Alexander Engel, Wei Deng
Summary: Conventional treatments for colorectal cancer severely impact advanced patients' therapeutic effects. The development of nanomedicines has led to liposomal delivery systems being considered promising for CRC treatment. Recent reviews have focused on preclinical research and drug delivery, but our review provides the latest advances in liposome technology for CRC with strong potential for clinical translation.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Ariane Stucki, Petra Juskova, Nicola Nuti, Steven Schmitt, Petra S. Dittrich
Summary: Microfluidic methods for forming single and double emulsion droplets have greatly enhanced high-throughput screening capabilities for various applications. A new strategy is introduced for on-demand delivery of reactants in DEs using lipid vesicles as carriers, allowing synchronized release of content inside DEs to be triggered at any desired time.
Article
Medicine, Research & Experimental
Xiangjun Chen, Huayu He, Xinyu Guo, Mingyi Hou, Xinzhong Zhang, Shengnan Li, Changrong Wang, Guodong Zhao, Wenting Li, Xiuping Zhang, Wei Hong
Summary: This study developed highly effective pH-responsive and biodegradable nanoparticles that can deliver drugs to tumor sites through the enhanced permeability and retention effect. The nanoparticles showed a switchable charge and excellent drug loading efficiency. In vitro and in vivo experiments demonstrated the effectiveness and safety of this drug delivery system, resulting in a significant inhibition of tumor growth.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Lauren B. Grimsley, Phillip C. West, Callie D. McAdams, Charles A. Bush, Stacy S. Kirkpatrick, Joshua D. Arnold, Michael R. Buckley, Raymond A. Dieter, Michael B. Freeman, Michael M. McNally, Scott L. Stevens, Oscar H. Grandas, Deidra J. H. Mountain
Summary: The research has made progress in developing targeted liposomal nanocarriers for preferential collagen IV binding under static vascular flow conditions, showing potential for future clinical applications.
Review
Biochemistry & Molecular Biology
Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman
Summary: Recent advancements in drug delivery technologies have led to the emergence of nanotechnology as a potential tool in cancer therapeutics. Solid lipid nanoparticles (SLNs) have shown great potential for drug delivery, clinical medicine, and overcoming challenges in cancer therapy. Further research is needed to better understand the biological responses of SLNs and develop therapeutics with reduced side effects. This review focuses on the development, mechanisms, and applications of SLNs in cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Manman Xu, Xinpu Han, Hongtai Xiong, Yijie Gao, Bowen Xu, Guanghui Zhu, Jie Li
Summary: Cancer poses a severe threat to global health, making effective treatments crucial. Nanomedicine's application in cancer therapy holds immense potential for improving specificity, efficacy, and tolerability of treatments. This review explores nanoparticle-mediated drug delivery mechanisms, advantages, and transformative potential in different treatment modalities, while emphasizing the need to address toxicity concerns, improve drug delivery strategies, and simplify nano-design.
Article
Biotechnology & Applied Microbiology
Meng-Meng Song, Jing Chen, Shu-Ming Ye, Da-Peng Lu, Gui-Yang Zhang, Rui Liu, Yu-Xian Shen
Summary: This study aimed to develop an effective drug delivery system for acute ischemic stroke using EDV-LIPs. The results of biodistribution and therapeutic effect analysis showed that the nanoliposomes had a long circulation time and were able to accumulate in the brain lesion region. Furthermore, the EDV-LIPs could restore cerebral blood flow, reduce infarct volume, and decrease neuronal apoptosis.
Review
Chemistry, Medicinal
Richu Raju, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Summary: Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood-brain barrier (BBB). This review paper consolidates relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes, and discusses the challenges and potential of using liposomal systems to treat brain tumors.
Article
Biophysics
Sylwia Michlewska, Zuzana Garaiova, Veronika Subjakova, Marcin Holota, Ma lgorzata Kubczak, Marika Grodzicka, Elzbieta Okla, Nikolaos Naziris, Lucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska, Maksim Ionov
Summary: In this study, we combined dendritic and liposomal carriers and analyzed the biochemical and biophysical properties of these formulations. Lipid-coated dendritic carriers showed significantly improved transfection profiles and lower toxicity to erythrocyte membranes compared to noncomplexed components. The nanometric size, low polydispersity index, and reduced positive zeta potential of these complexes make them attractive for future drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Engineering, Biomedical
Dong Liu, Ting Wang, Yuan Lu
Summary: The article discusses the potential applications of untethered microrobots in medical treatment, particularly focusing on the advantages of active drug delivery systems compared to traditional passive systems. It introduces an integrated 5D radar chart analysis model and addresses the various factors that need to be considered before clinical application of microrobots.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Claudia Bonechi, Fariba Fahmideh Mahdizadeh, Luigi Talarico, Simone Pepi, Gabriella Tamasi, Gemma Leone, Marco Consumi, Alessandro Donati, Agnese Magnani
Summary: Glaucoma, a group of neurodegenerative diseases, is the second leading cause of irreversible blindness worldwide. The limited penetration of drugs through the ocular barrier reduces the systemic bioavailability, leading to the need for frequent drug administration and potential toxic effects. Liposomes and other novel drug-delivery systems can enhance the therapeutic efficacy of antiglaucomatous drugs by improving drug penetration, bioavailability, sustained release, tissue targeting, and reduction in intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Epiphane K. Silli, Mengfei Li, Yuting Shao, Yiran Zhang, Guilin Hou, Jiaqian Du, Jingdan Liang, Ying Wang
Summary: This review discusses the applications of liposomes in the treatment of pancreatic cancer. Pancreatic cancer is an incurable disease with a high death rate. By using different liposomal nanostructures, the effectiveness of chemotherapy drugs can be optimized and toxicity can be reduced.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Geriatrics & Gerontology
Jared M. Campbell, Saabah Mahbub, Abbas Habibalahi, Sharon Paton, Stan Gronthos, Ewa Goldys
Summary: The study used non-destructive multispectral assessment to investigate the metabolic mechanisms of in vitro mesenchymal stem cell (MSC) ageing. By analyzing spectral signals for different fluorophores in MSCs over serial passages, the researchers were able to develop a reliable model for categorizing the age of culture-expanded MSCs accurately.
Review
Biochemistry & Molecular Biology
Biyao Yang, Bo-Ping Song, Shaina Shankar, Anna Guller, Wei Deng
Summary: Liposomes, among various nanoparticle-based delivery platforms, have shown particular success in clinical applications, especially in cancer therapy like breast cancer. This review discusses liposome design with targeting and triggering functions, as well as recent advancements in liposome-based therapeutics for breast cancer since 2014. Challenges in the future clinical translation of liposome technology are also identified.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Correction
Multidisciplinary Sciences
Saabah B. Mahbub, Long T. Nguyen, Abbas Habibalahi, Jared M. Campbell, Ayad G. Anwer, Uzair M. Qadri, Anthony Gill, Angela Chou, Muh Geot Wong, Martin E. Gosnell, Carol A. Pollock, Sonia Saad, Ewa M. Goldys
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Saabah B. Mahbub, Long T. Nguyen, Abbas Habibalahi, Jared M. Campbell, Ayad G. Anwer, Uzair M. Qadri, Anthony Gill, Angela Chou, Muh Geot Wong, Martin E. Gosnell, Carol A. Pollock, Sonia Saad, Ewa M. Goldys
Summary: This study demonstrates the potential of multispectral assessment of cell autofluorescence in urinary exfoliated proximal tubule kidney cells as a sensitive, non-invasive diagnostic method for distinguishing healthy and diseased patients with CKD, showing significant differences in autofluorescence signals.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Vlada S. Rozova, Ayad G. Anwer, Anna E. Guller, Hamidreza Aboulkheyr Es, Zahra Khabir, Anastasiya Sokolova, Maxim U. Gavrilov, Ewa M. Goldys, Majid Ebrahimi Warkiani, Jean Paul Thiery, Andrei Zvyagin
Summary: The study used machine learning and image analysis to examine how individual breast cancer cells respond to substrates of varying stiffness, revealing significant changes in cell morphology and molecular expression. The results suggest that the stiffest microenvironment can induce MET, providing new insights into the process of metastasis.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Microbiology
Hari Kumar Peguda, Saabah B. Mahbub, Tashi Doma Sherpa, Dinesh Subedi, Abbas Habibalahi, Ayad G. Anwer, Zi Gu, Mark D. P. Willcox, Ewa M. Goldys, Nicole A. Carnt
Summary: This study investigated the effect of antibiotics and anesthetic drugs on the autofluorescence patterns of Acanthamoeba and bacteria that cause keratitis. Fluorescence spectroscopy was found to differentiate Acanthamoeba from bacteria in vitro, highlighting the potential for diagnostic use. Further research is needed to assess the fluorescence patterns of different strains and the effects of anti-amoebic drugs before in vivo testing.
Review
Medicine, General & Internal
You Zhou, Wenmin Deng, Mulan Mo, Dexu Luo, Houhe Liu, Yuan Jiang, Wenjie Chen, Chuanshan Xu
Summary: Bacterial infections are common and deadly diseases in clinical settings. Photodynamic therapy (PDT) has the potential to be an alternative antibacterial treatment, but faces challenges with the selectivity and specificity of photosensitizers. Stimuli-responsive nanoplatforms offer unique advantages in enhancing drug efficacy and providing new opportunities for the effective delivery of PS in PDT against bacterial infections.
FRONTIERS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Tiffany C. Y. Tan, Saabah B. Mahbub, Jared M. Campbell, Abbas Habibalahi, Carl A. Campugan, Ryan D. Rose, Darren J. X. Chow, Sanam Mustafa, Ewa M. Goldys, Kylie R. Dunning
Summary: The study successfully differentiated between euploid and aneuploid ICM cells in mouse blastocysts using hyperspectral autofluorescence microscopy. Further validation in human embryos is needed to confirm the approach's effectiveness.
HUMAN REPRODUCTION
(2022)
Article
Neurosciences
Martin E. Gosnell, Vasiliki Staikopoulos, Ayad G. Anwer, Saabah B. Mahbub, Mark R. Hutchinson, Sanam Mustafa, Ewa M. Goldys
Summary: This study successfully validated the feasibility of using hyperspectral autofluorescence imaging and deep learning techniques as a tool to differentiate tissues from nerve injured vs non-injured mice, providing important research and clinical applications prospects.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Analytical
Yi Li, Fei Deng, Ewa M. Goldys
Summary: The study demonstrates the use of CRISPR/Cas12a ribonucleoproteins to enhance the sensitivity of commercial ELISA systems by amplifying fluorescence signals. The approach, known as CES-Amplifier, involves integrating a hybrid single strand DNA oligo and antibody conjugate targeting the HRP enzyme into commercial ELISA kits, allowing for expansion of CRISPR/Cas-based biosensing to a wide range of non-nucleic acid analytes.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Multidisciplinary
Houhe Liu, Fanwen Yang, Wenjie Chen, Teng Gong, Yi Zhou, Xiaoyan Dai, Wingnang Leung, Chuanshan Xu
Summary: This paper reviews the application of ERM in PDT and discusses the challenges ERM faces as carriers for delivering PS, in order to further advance the development of PDT in the management of malignancies.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anna Guller, Inga Kuschnerus, Vlada Rozova, Annemarie Nadort, Yin Yao, Zahra Khabir, Alfonso Garcia-Bennett, Liuen (Olivia) Liang, Aleksandra Polikarpova, Yi Qian, Ewa M. Goldys, Andrei V. Zvyagin
Summary: The study established an in vitro/in vivo model to investigate organ-specific micrometastases of triple-negative breast cancer using a chick embryo experimental platform. The model demonstrated potential applications in cancer research, drug development, and nanomedicine, providing insights into the colonization process of TNBC cells in distant organs.
Article
Geriatrics & Gerontology
Jared M. Campbell, Saabah B. Mahbub, Michael J. Bertoldo, Abbas Habibalahi, Dale M. Goss, William L. Ledger, Robert B. Gilchrist, Lindsay E. Wu, Ewa M. Goldys
Summary: Increasing age has a negative impact on female fertility due to deteriorating quality of oocytes. The use of nicotinamide mononucleotide (NMN) has been shown to restore oocyte quality and fertility in aged animals. Identifying the multispectral profile of oocyte autofluorescence during aging could serve as a non-invasive and sensitive measure of oocyte quality.
Article
Oncology
Abbas Habibalahi, Alexandra Allende, Jesse Michael, Ayad G. Anwer, Jared Campbell, Saabah B. Mahbub, Chandra Bala, Minas T. Coroneo, Ewa M. Goldys
Summary: This study introduces an imaging-based method for screening ocular surface squamous neoplasia, which will reduce pressure on health resources and potentially eliminate the need for eye biopsy in suspected cases.
Article
Pharmacology & Pharmacy
You Zhou, Mulan Mo, Dexu Luo, Yi Yang, Jialin Hu, Chenqing Ye, Longxiang Lin, Chuanshan Xu, Wenjie Chen
Summary: This study comprehensively evaluated the scientific research on 5-aminolevulinic acid (5-ALA) and found that China published the highest number of articles in this field. SBI Pharmaceuticals Co., Ltd. emerged as the most productive institution. The analysis results highlighted the improvement of photodynamic efficacy as the current key direction in 5-ALA research. Additionally, the study focused on the involvement of nanotechnology in 5-ALA delivery and theranostics research.
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)
