Article
Cell & Tissue Engineering
L. L. E. Whitehouse, N. H. Thomson, T. Do, G. A. Feichtinger
Summary: Research in dental regeneration is focusing on dental-pulp capping, with natural biomimetic scaffolds showing potential advantages over manufactured materials. Further exploration of synergistic peptide use and tailored scaffold development is needed for the successful application in dental-pulp capping.
EUROPEAN CELLS & MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Ballal, H. F. Duncan, D. B. Wiedemeier, N. Rai, P. Jalan, V Bhat, V. S. Belle, M. Zehnder
Summary: In this study, it was found that the levels of neutrophil gelatinase 9 (MMP-9)/total protein (TP) and NaOCl lavage significantly influenced pulp survival in cariously exposed and directly capped teeth, while mild preoperative discomfort did not have an impact.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Medicine, General & Internal
Luisa Bandeira Lopes, Catarina Calvao, Filipa Salema Vieira, Joao Albernaz Neves, Jose Joao Mendes, Vanessa Machado, Joao Botelho
Summary: This umbrella review critically assesses the available systematic reviews on vital pulp therapy (VPT) and non-vital therapy (NPT) for dental caries in primary dentition. The review finds that the methodological quality of the included studies varies, and future high standard reviews and well-designed clinical trials are needed to better understand the clinical protocols and outcomes of VPT and NPT.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Optics
Samir Nammour, Marwan El Mobadder, Melanie Namour, Saad Houeis, Daniel Heysselaer, Paul Nahas, Carmen D. Todea, Jacek Matys, Kinga Grzech-Lesniak, Aneta Olszewska, Wassim El Mobadder, Ilaria Giovannacci, Markus Laky, Amaury Namour, Sabine Geerts
Summary: This study aimed to evaluate the success rate of different lasers and materials in direct pulp capping. The results showed that the CO2 laser group had the highest success rate, followed by the Er: YAG laser, 980 nm diode laser, and Ca(OH)2 group. Factors such as patient age, filling timing, size of exposure, tooth type, and exposure etiology significantly influenced the success rate.
Article
Dentistry, Oral Surgery & Medicine
Rafiqul Islam, Md Refat Readul Islam, Toru Tanaka, Mohammad Khursheed Alam, Hany Mohamed Aly Ahmed, Hidehiko Sano
Summary: The aim of direct pulp capping (DPC) is to promote pulp healing and mineralized tissue barrier formation by placing a dental biomaterial directly over the exposed pulp. Successful application of this approach avoids the need for further and more extensive treatment. This review focuses on the DPC procedure, the materials used, and their mechanisms of action to promote pulpal healing.
JAPANESE DENTAL SCIENCE REVIEW
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ruby Long, Arindam Dutta, Matthew M. B. Thomas, Morgana Eli Vianna
Summary: This study evaluated the complexity of root canal treatments accepted for treatment by postgraduate training grades at Cardiff University Dental Hospital using different scoring systems. The results showed that the complexity level varied when evaluated using different systems. Factors such as endodontic treatment history, post treatment disease, and quality of root filling contributed to the differences in scores among the systems.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Cell Biology
Milos Papic, Suzana Zivanovic, Tamara Vucicevic, Miona Vuletic, Mirjana V. Papic, Nevena Milivojevic, Ana Miric, Marina Miletic Kovacevic, Marko Zivanovic, Milan Stamenkovic, Vladimir Zivkovic, Slobodanka Mitrovic, Vladimir Jakovljevic, Biljana Ljujic, Milica Popovic
Summary: The study aimed to evaluate the dental pulp responses to rhEPO and/or MTA in pulp capping of inflamed dental pulp in vivo. Pulp capping with rhEPO or MTA + rhEPO resulted in lower inflammation and higher mineralization scores compared to untreated control. Capping with rhEPO or MTA + rhEPO resulted in a favorable effect that was similar or even superior to that of MTA.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Manal Matoug-Elwerfelli, Ahmed Abdou, Wejdan Almutairi, Malak Alhuthayli, Shaikhah Aloyaynaa, Rahaf Almohareb
Summary: This study compared the use of stainless steel hand instruments and engine-driven rotary instruments in endodontic treatment and found that rotary instrumentation techniques can reduce instrumentation and obturation related endodontic mishaps.
Review
Chemistry, Multidisciplinary
Alicia Almudever-Garcia, Leopoldo Forner, Jose Luis Sanz, Carmen Llena, Francisco Javier Rodriguez-Lozano, Julia Guerrero-Girones, Maria Melo
Summary: This systematic review highlights the potential application of pulse oximetry in diagnosing pulp vitality. While showing good sensitivity and specificity, its clinical use in dentistry is hindered by limitations such as the lack of a specific pulse oximeter for dental practice and insufficient evidence on the impact of different systemic and oral pathologies on pulp oxygen saturation levels.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Chao-An Chen, Xiaofei Zhu, Brian R. Morrow, Ukrit Thamma, Tia J. Kowal, Hassan M. Moawad, Matthias M. Falk, Himanshu Jain, George T-J Huang
Summary: The TAMP calcium silicate material showed good biocompatibility with human and swine DPSCs in vitro, and demonstrated positive outcomes for pulp regeneration in vivo, suggesting its potential application in dentin bridge regeneration after pulp exposure.
JOURNAL OF DENTISTRY
(2021)
Review
Environmental Sciences
Swadheena Patro, Agron Meto, Ankita Mohanty, Viresh Chopra, Sanjay Miglani, Antarikshya Das, Alexander Maniangat Luke, Dunia Al Hadi, Aida Meto, Luca Fiorillo, Mohmed Isaqali Karobari, Dian Agustin Wahjuningrum, Ajinkya M. Pawar
Summary: This systematic review and meta-analysis compares the diagnostic accuracy of pulp vitality and pulp sensibility tests in assessing pulpal health. The results suggest that pulse oximeter (PO) is the most accurate diagnostic method, with higher sensitivity and specificity compared to electric pulp tester (EPT), cold test (CT), and heat test (HT).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: The vitality of dental pulp is essential for maintaining the health and functionality of the tooth. Hydraulic calcium-silicate cements can stimulate reparative dentinogenesis in direct pulp capping procedures, leading to the formation of new dentin bridges. Different degrees of pulp inflammatory response and dentin bridge formation were observed during pulp healing, showing positive effects on tertiary dentin formation and pulp vitality preservation.
Article
Medicine, General & Internal
Pratima Panda, Shashirekha Govind, Sanjit Kumar Sahoo, Satabdi Pattanaik, Rachappa M. Mallikarjuna, Triveni Nalawade, Sanjay Saraf, Naseer Al Khaldi, Salma Al Jahdhami, Vinay Shivagange, Amit Jena
Summary: The study examined the effects of different pulp capping agents on human dental pulp stem cells. The results showed that platelet-rich fibrin (PRF) had the highest cell viability and the greatest potential to enhance cell proliferation and differentiation. On the other hand, Tetric N-Bond was found to be ineffective as a pulp capping agent. Overall, PRF was the most effective in maintaining the viability of human dental pulp stem cells compared to the other tested materials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
AlAnoud Almeshari, Rita Khounganian, Wael Mahdi, Fahd Aljarbou, Shilpa Bhandi, Sara Alsubait
Summary: The study evaluated the effects of using iloprost, MTA, and MTA-iloprost as pulp capping materials on pulpal inflammation and tertiary dentin formation in rat molars. Results showed similar pulpal responses in all groups, suggesting that mixing MTA with iloprost might not have significant clinical benefits.
APPLIED SCIENCES-BASEL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shaqayeq Ramezanzade, Tudor Laurentiu Dascalu, Bulat Ibragimov, Azam Bakhshandeh, Lars Bj
Summary: This study aimed to evaluate the impact of providing artificial intelligence (AI)-based radiographic information to dental students on their ability to predict pulp exposure compared to standard radiographic and clinical information. The results showed that the AI model outperformed the students in all groups, with an F1-score of 0.71 (P < 0.001). The students' F1-score in the groups with AI predictions (G(X-ray+AI) and G(X-ray+clinical data+AI)) was slightly higher than the groups without AI predictions (G(X-ray) and G(X-ray+clinical data)), but the difference was only marginally significant (P = 0.054).
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Michael Naumann, Patricia Scholz, Joachim Krois, Falk Schwendicke, Guido Sterzenbach, Arndt Happe
Summary: The objective of this study was to compare monolithic hybrid abutment crowns (screw-retained) versus monolithic hybrid abutments with adhesively cemented monolithic single-tooth crowns for implant-borne restorations. Twenty subjects were randomly assigned to receive either cement-retained or screw-retained monolithic restorations. The follow-up period was 36 months, and the results showed no significant difference between the two treatment options in terms of patient satisfaction and restoration outcomes.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Kuo Feng Hung, Andy Wai Kan Yeung, Michael M. Bornstein, Falk Schwendicke
Summary: Personalized medicine tailors diagnostics and therapeutics to individuals based on their biological, social, and behavioral characteristics. Advanced AI technologies have the potential to integrate diverse data and bring us closer to personalized dentistry, also known as P4 dentistry. AI applications in dentomaxillofacial imaging have shown promising results, but further research is needed to assess their impact on treatment decisions and outcomes.
DENTOMAXILLOFACIAL RADIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. R. Herbst
Summary: This study aimed to identify significant associations between preoperative risk factors and achieving optimal root filling length (RFL) during orthograde root canal treatments (RCT) and to predict successful RFL using machine learning. The results showed that the success of RFL during RCT is influenced by the operator and several risk factors. However, the predictive performance of machine learning algorithms for RFL was insufficient.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Akhilanand Chaurasia, Thomas Wiegand, Sergio E. Uribe, Margherita Fontana, Ilze Akota, Olga Tryfonos, Joachim Krois
Summary: This study aims to develop a core curriculum for oral and dental AI education, in order to improve healthcare providers' literacy and ability to critically evaluate and utilize AI applications in the field.
JOURNAL OF DENTISTRY
(2023)
Article
Nutrition & Dietetics
Ana C. Mafla, Geraldine De La Cruz-rosero, Hector W. Vallejo-Rosero, Jorge A. Argoty-Rodriguez, Falk Schwendicke
Summary: This study assessed the dietary patterns during lockdown in the Colombian population and found that people tend to consume more cariogenic food during this period. Being single, having children, and being in lockdown were significantly associated with higher frequency of cariogenic food consumption.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Review
Medicine, General & Internal
Marcus Cebula, Gerd Goestemeyer, Joachim Krois, Vinay Pitchika, Sebastian Paris, Falk Schwendicke, Susanne Effenberger
Summary: The present study conducted a meta-analysis to evaluate the certainty of evidence for resin infiltration of proximal carious lesions in primary and permanent teeth. The results showed that resin infiltration can effectively arrest caries lesions in both primary and permanent teeth. However, the certainty of evidence remains unclear due to the high or unclear risk of bias in the included trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Stella Danek, Martha Buettner, Joachim Krois, Falk Schwendicke
Summary: To reach more vaccine recipients, high-income countries have introduced mass vaccination centers for COVID-19. Understanding user experiences of these structures can help improve their design and increase patient satisfaction and vaccine uptake.
Article
Biology
Martin Baxmann, Lan Huong Timm, Falk Schwendicke
Summary: The key step prior to clear aligner therapy (CAT) is to examine and select suitable cases, which includes understanding the orthodontic problem and evaluating oral health. The characteristics of patients seeking CAT may differ among European countries. This study retrospectively analyzed anonymized data from a large CAT provider in five European countries. The results showed differences in gender distribution and motivations across countries, as well as low prevalence of oral conditions among patients seeking CAT.
Article
Dentistry, Oral Surgery & Medicine
W. Park, F. Schwendicke, J. Krois, J. -K. Huh, J. -H. Lee
Summary: This study evaluated the efficacy of deep learning in identifying and classifying different types of dental implant systems using a large-scale multicenter data set. Deep learning outperformed dental professionals in accuracy and required less reading and classification time. The results suggest that deep learning can be used successfully as a decision support aid for the identification and classification of dental implant systems encountered in clinical practice.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Hossein Mohammad-Rahimi, Rata Rokhshad, Sompop Bencharit, Joachim Krois, Falk Schwendicke
Summary: The objective of this study is to explain the basic concept of deep learning to dental researchers and professionals who may find it challenging to understand and interpret deep learning studies. The study provides an overview of deep learning models, approaches, and data management strategies, as well as a step-by-step guide for completing a real-world project.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lisa Schneider, Roman Rischke, Joachim Krois, Aleksander Krasowski, Martha Buettner, Hossein Mohammad-Rahimi, Akhilanand Chaurasia, Nielsen S. Pereira, Jae-Hong Lee, Sergio E. Uribe, Shahriar Shahab, Revan Birke Koca-Unsal, Gurkan Unsal, Yolanda Martinez-Beneyto, Janet Brinz, Olga Tryfonos, Falk Schwendicke
Summary: This study demonstrates the effectiveness of Federated Learning (FL) in dentistry, showing that it can train high-performance and generalizable deep learning models without sharing sensitive data. FL outperformed Local Learning (LL) in tooth segmentation on panoramic radiographs and proved to be a valuable alternative when data pooling is not feasible.
JOURNAL OF DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Falk Schwendicke, Lisa Bombeck
Summary: This study assessed the cost-effectiveness of near-infrared-light-transillumination (NILT) for school-based caries screening and found that NILT may provide limited effectiveness gains and cost savings in the modelled populations. However, in countries other than Germany, NILT may have higher cost-effectiveness.
JOURNAL OF DENTISTRY
(2023)
Article
Engineering, Biomedical
Philipp Messer-Hannemann, Henrik Bottcher, Sven Henning, Falk Schwendicke, Susanne Effenberger
Summary: The objective of this study was to apply the concept of ductile particle reinforcement to restorative dentistry and introduce an innovative glass ionomer material based on the dispersion of PEG-PU micelles. The results showed that reinforcing a conventional glass ionomer with PEG-PU micelles significantly improved the flexural strength and fracture toughness, enhancing the mechanical properties of the material.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gerd Goestemeyer, Mareike Preus, Karim Elhennawy, Falk Schwendicke, Sebastian Paris, Haitham Askar
Summary: In this study, the diagnostic accuracy of radiographic evaluation, visual-tactile assessment, laser-fluorescence, and near-infrared-light transillumination were evaluated for proximal root caries lesions. The results showed that near-infrared-light transillumination was not applicable for detecting proximal root caries, while laser-fluorescence and visual-tactile assessment were more accurate than radiographic evaluation for detecting these lesions.
CLINICAL ORAL INVESTIGATIONS
(2023)