Article
Biology
Elisabeth Schirmer, Stefan Schuster, Peter Machnik
Summary: Bisphenols, important plasticizers released into the biosphere, have been found to have alarming and uncompensated effects on neuronal functioning in mature vertebrate brains. The study calls for the rapid development of alternative plasticizers and presents a new assay method to accelerate early testing phases for next-generation plasticizers.
COMMUNICATIONS BIOLOGY
(2021)
Article
Orthopedics
Tian-lin Li, He-dong Liu, Mao-xian Ren, Zhi Zhou, Wen-kai Jiang, Min Yang
Summary: This study investigated the difference in the protective effects of intraperitoneal injection of exogenous melatonin during daytime or nighttime on bone loss in ovariectomized rats. Results showed that daytime treatment significantly increased bone mass in ovariectomized rats compared to nighttime treatment. Microscopic and biomechanical experiments revealed improved bone parameters and strength in the daytime treatment group. Molecular biology experiments showed increased bone formation-related molecules and decreased bone resorption-related molecules. Cell experiments demonstrated higher cell viability and better inhibition of ROS production and apoptosis with low-dose melatonin treatment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Multidisciplinary Sciences
Douglas H. Boyes, Darren M. Evans, Richard Fox, Mark S. Parsons, Michael J. O. Pocock
Summary: The study found that artificial light at night significantly reduces moth caterpillar abundance and affects their development, with negative impacts more prominent under white LED street lights. This suggests that ALAN and the shift towards white LEDs will have substantial consequences for insect populations and ecosystem processes.
Article
Pharmacology & Pharmacy
Hao Tian, Tao Jiang, Kai Yang, Ruonan Ning, Tianqi Wang, Qi Zhou, Niandong Qian, Ping Huang, Lei Guo, Min Jiang, Xiaobing Xi, Xing Xu, Lianfu Deng
Summary: This study found that alpha-asarone (ASA), a compound derived from the traditional Chinese medicinal herb Acorus tatarinowii, can inhibit the activity of overactivated osteoclasts and reduce bone resorption. ASA's effects on osteoclastogenesis are dose-dependent and mediated through multiple signaling pathways. In an estrogen-deficiency-induced osteoporosis model, ASA also improved bone microstructure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ju-Mi Hwang, Jeong-Won Bae, Eun-Ju Jung, Woo-Jin Lee, Woo-Sung Kwon
Summary: Studies have shown that novaluron affects sperm functions, including sperm viability, motility, and motion kinematics. Additionally, it may lead to a reduction in acrosome reactions and suppress sperm function by altering PKA activity and tyrosine phosphorylation.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Andrology
Mojdeh Sabour, Azam Agha-Rahimi, Mahmood Dehghani Ashkezari, Seyed Morteza Seifati, Fatemeh Anbari, Ali Nabi
Summary: Polyvinylpyrrolidone (PVP) is commonly used in intracytoplasmic sperm injection (ICSI) for immobilization and manipulation of spermatozoa. However, this study found that prolonged exposure to PVP significantly affects sperm viability and morphology, leading to increased DNA fragmentation and abnormal chromatin structure.
Article
Immunology
Chao Ma, Liang Mo, Zhangzheng Wang, Deqiang Peng, Chi Zhou, Wei Niu, Yuhao Liu, Zhenqiu Chen
Summary: By modulating multiple signaling pathways, DTI can inhibit osteoclast formation and prevent estrogen-deficiency osteoporosis. This makes DTI a promising candidate for the treatment of osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ziqi Fang, Guangdong Cheng, Mengting He, Yanliang Lin
Summary: This study found that CYP27A1 deficiency promotes osteoclast differentiation and bone loss, indicating its potential as a therapeutic target for osteoclast-related diseases. Transcriptomic analysis revealed differential expression of multiple genes and their association with osteogenesis-related pathways. Further research is needed to explore the exact mechanisms involved.
Review
Endocrinology & Metabolism
Amy J. Warner, Jessica D. Hathaway-Schrader, Rena Lubker, Christopher Davies, Chad M. Novince
Summary: Tetracyclines, a class of broad-spectrum antibiotics, have unclear effects on bone metabolism and further research is needed to understand their impact on skeletal development and homeostasis.
Article
Nutrition & Dietetics
So Young Eun, Yoon-Hee Cheon, Gyeong Do Park, Chong Hyuk Chung, Chang Hoon Lee, Ju-Young Kim, Myeung Su Lee
Summary: Vigeo, a mixture of fermented extracts, showed protective effects against inflammatory bone loss and osteoclastogenesis induced by LPS and RANKL, respectively, by inhibiting various signaling pathways and gene expressions.
Review
Physiology
Scott Epsley, Samuel Tadros, Alexander Farid, Daniel Kargilis, Sameer Mehta, Chamith S. Rajapakse
Summary: Bone remodeling is a continual process involving osteoblasts and osteoclasts, where inflammation plays a crucial role in skewing the process towards resorption. Inflammatory mediators interact with bone cells to alter the expression of regulatory factors, leading to various bone-related pathologies. Further research is needed to advance early detection and treatments for bone diseases influenced by inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michele Iuliani, Sonia Simonetti, Giulia Ribelli, Andrea Napolitano, Umile Giuseppe Longo, Bruno Vincenzi, Paolo Orsaria, Vincenzo Denaro, Giuseppe Tonini, Daniele Santini, Pantano Francesco
Summary: This study compared the potential effects of three CDK4/6 inhibitors on the breast cancer bone microenvironment. The results showed that these inhibitors exerted similar inhibitory effects on the differentiation of bone resorption cells and the expression of bone resorption markers, without affecting cell viability. However, they did not affect the ability of bone formation cells to produce bone matrix, although higher doses of two inhibitors reduced the viability of these cells. In co-culture models of breast cancer and bone cells, palbociclib demonstrated a lower anti-tumor effect compared to the other two inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Barbara Kolodziejska, Natalia Stepien, Joanna Kolmas
Summary: This study summarizes the role of strontium in the treatment of osteoporosis, highlighting its multidirectional effects on bone tissue and its similarities to calcium. It discusses the unique mechanism of action of strontium ranelate and the increasing interest in using strontium ions in ceramics as bone replacement materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Geosciences, Multidisciplinary
Leonardo dos Santos Pereira, Aline Muniz Rodrigues, Maria do Carmo Oliveira Jorge, Antonio Jose Teixeira Guerra, Colin A. Booth, Michael A. Fullen
Summary: As tourist activities increase in natural havens of beauty, such as the Ubatuba Municipality in Brazil, soil erosion and runoff become destructive issues that impact soil processes and local geodiversity. This study analyzed the changes in soil properties and the measurements of runoff and soil loss on a trail in Ubatuba. The findings highlight the need for balance between tourist activities and the preservation of environmental functions, as well as the importance of sustainable tourism practices.
Article
Cell Biology
Alycia G. Berman, John G. Damrath, Jennifer Hatch, Alexis N. Pulliam, Katherine M. Powell, Madicyn Hinton, Joseph M. Wallace
Summary: The study found that the combination treatment of Raloxifene and targeted tibial loading can enhance bone architecture and mechanical integrity, leading to greater improvements than either treatment individually.
CONNECTIVE TISSUE RESEARCH
(2022)
Article
Endocrinology & Metabolism
Samantha P. Tippen, Corinne E. Metzger, Elizabeth A. Swallow, Spencer A. Sacks, Joseph M. Wallace, Matthew R. Allen
Summary: The study aimed to investigate the interaction between chronic kidney disease (CKD) and aging on bone structure and mechanical properties. The results showed that aging mice with CKD had significantly higher cortical porosity than young mice, and both structural and mechanical properties were poorer in aging mice.
Article
Endocrinology & Metabolism
Alyson L. Essex, Joshua R. Huot, Padmini Deosthale, Alison Wagner, Jorge Figueras, Azaria Davis, John Damrath, Fabrizio Pin, Joseph Wallace, Andrea Bonetto, Lilian Plotkin
Summary: This study reveals that the Trem2 variant associated with Alzheimer's disease risk may independently affect bone and skeletal muscle loss, regardless of central nervous system defects. These findings suggest a potential link between Trem2 signaling alterations and skeletal health.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Engineering, Biomedical
Nathaniel Lazorchak, M. Ryne Horn, M. Ivette Muzquiz, Landan M. Mintch, Ken Yoshida
Summary: This study investigates the sensitivity of the simulation models to electrical parameter estimates and volume conductor type. The results show that increasing the realism of the simulations leads to more accurate predictions.
Article
Engineering, Biomedical
Onna Marie Doering, Christian Vetter, Awadh Alhawwash, M. Ryne Horn, Ken Yoshida
Summary: The study developed an upgraded 3D printed cuff electrode design containing a novel intrinsically conductive polymer for stimulating and recording peripheral nerve fibers. Through the use of specific materials and structures, rapid optimization of neural interface performance is achieved.
Article
Engineering, Biomedical
M. Ryne Horn, Christian Vetter, Rizwan Bashirullah, Mike Carr, Ken Yoshida
Summary: This study aims to characterize the intrinsic electrical material properties of mammalian peripheral nerves, which are important for accurate simulation and design of neural interfaces. Experimental measurements and analysis were conducted to determine the resistive and reactive components of different layers in the nerve bundle. The results provide valuable insights for modeling and optimizing peripheral nerve models and neural interface devices.
Article
Endocrinology & Metabolism
John G. Damrath, Corinne E. Metzger, Matthew R. Allen, Joseph M. Wallace
Summary: Diabetes and chronic kidney disease can have detrimental effects on bone health, especially when both conditions are present. They can lead to decreased bone turnover, decreased trabecular bone volume, and lowered bone density. The combined effects of both diseases are even more severe.
Article
Engineering, Biomedical
Amin Joukar, Amy Creecy, Sonali Karnik, Hessam Noori-Dokht, Stephen B. Trippel, Joseph M. Wallace, Diane R. Wagner
Summary: The main objective of this study was to assess the relationship between the wear resistance of healthy articular cartilage and its biochemical composition and viscoelastic material properties. The findings suggest that stiffer cartilage with higher glycosaminoglycans, collagen, and water content has a higher wear resistance. Enzymatic collagen crosslinks also enhance the wear resistance of the collagen network.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Endocrinology & Metabolism
Andrea Jacobson, Carli A. Tastad, Amy Creecy, Joseph M. Wallace
Summary: Thermoneutral housing and Raloxifene treatment have the potential to improve bone properties. Housing mice within a specific temperature range improves bone quality, while Raloxifene treatment enhances bone strength and geometry. Considering the impact of temperature on mice is important for longer pre-clinical trials to improve the accuracy of the models.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Rachel K. Surowiec, Matthew R. Allen, Joseph M. Wallace
Summary: Water in bone plays an important role in its mechanical properties and tissue quality. Different compartments of water in bone have different effects. Current research focuses on understanding the changes in bone water under various conditions and improving mechanical properties through therapeutic targeting of water.
Article
Endocrinology & Metabolism
Elizabeth A. Swallow, Corinne E. Metzger, Neal X. Chen, Joseph M. Wallace, Samantha P. Tippen, Rachel Kohler, Sharon M. Moe, Matthew R. Allen
Summary: This study assessed the impact of different bisphosphonates and dosing regimens on cortical microstructure and bone mechanical properties in animal models of chronic kidney disease (CKD). The results showed that a single dose of zoledronate led to higher cortical porosity, while more frequent dosing of bisphosphonates had minimal effect on cortical bone microstructure.
Meeting Abstract
Endocrinology & Metabolism
John Damrath, Sharon Moe, Joseph Wallace
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Rachel K. Surowiec, Ratan K. Rai, John G. Damrath, Matthew R. Allen, Joseph M. Wallace
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Elizabeth A. Swallow, Corinne E. Metzger, Samantha P. Tippen, Rachel Kohler, Joseph M. Wallace, Matthew R. Allen
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
John G. Damrath, Neal X. Chen, Corinne E. Metzger, Shruthi Srinivasan, Kalisha O'Neill, Annabel Biruete, Keith G. Avin, Joseph M. Wallace, Matthew R. Allen, Sharon M. Moe
Summary: Chronic kidney disease-mineral and bone disorder (CKD-MBD) increases cardiovascular calcification and skeletal fragility. Treatments aimed at reducing oxidative stress and parathyroid hormone (PTH) levels can help prevent these complications.