Article
Pharmacology & Pharmacy
Yan Guangyu, Lou Jingfeng, Liu Xing, Yuan Hong, Lu Yao
Summary: Postoperative AKI in hypertensive patients undergoing noncardiac surgery is associated with a significantly higher risk of fatal stroke, fatal MI, and all-cause mortality within 5 years. The risk is even higher in patients receiving ACEI/ARB and CCB perioperatively.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Caelan Taggart, Ryan Wereski, Nicholas L. Mills, Andrew R. Chapman
Summary: The increased use of high-sensitivity cardiac troponins in clinical practice has raised awareness of non-ischaemic myocardial injury. While such injuries can be caused by various diseases, evidence suggests that patients' clinical outcomes are poor.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Kurt Ruetzler, Esra Kutlu Yalcin, Praveen Chahar, Nathaniel R. Smilowitz, Faith Factora, Xuan Pu, Elyad Ekrami, Kamal Maheshwari, Daniel I. Sessler, Alparslan Turan
Summary: The study retrospectively analyzed noncardiac surgical inpatients who experienced postoperative chest pain triggering a multidisciplinary Rapid Response System (RRS) activation. The results indicated that chest pain postoperatively may be a serious sign of myocardial infarction and should be taken seriously.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Multidisciplinary Sciences
Yong-Yeon Jo, Jong-Hwan Jang, Joon-myoung Kwon, Hyung-Chul Lee, Chul-Woo Jung, Seonjeong Byun, Han-Gil Jeong
Summary: This study developed deep learning models to predict intraoperative hypotension (IOH) using waveforms from arterial blood pressure (ABP), electrocardiogram (ECG), and electroencephalogram (EEG). The combination of ABP and EEG improved the model's performance and calibration.
Article
Anesthesiology
Kristin H. J. M. Mol, Victor G. B. Liem, Felix van Lier, Robert Jan Stolker, Sanne E. Hoeks
Summary: This study aimed to explore the incidence of intraoperative hypotension in patients with chronic beta-blocker therapy. The study found that chronic beta-blocker therapy was not associated with increased exposure to intraoperative hypotension. Furthermore, differences in patient subgroups and postoperative adverse cardiovascular events as a function of treatment regimen could not be demonstrated.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Medicine, General & Internal
Jeayoun Kim, Jungchan Park, Ji-Hye Kwon, Sojin Kim, Ah Ran Oh, Jae Ni Jang, Jin-Ho Choi, Jidong Sung, Kwangmo Yang, Kyunga Kim, Joonghyun Ahn, Seung-Hwa Lee
Summary: Elevated intraoperative lactate levels are associated with increased incidence of myocardial injuries after noncardiac surgery and higher 30-day mortality rates.
Article
Cardiac & Cardiovascular Systems
Johanna Gueckel, Christian Puelacher, Noemi M. Glarner, Danielle Gualandro, Ivo Strebel, Tobias Zimmermann, Ketina Arslani, Reka Hidvegi, Marcel Liffert, Alessandro Genini, Stella Marbot, Maria Schlaepfer, Luzius Steiner, Daniel Bolliger, Andreas Lampart, Lorenz Guerke, Christoph Kindler, Stefan Scharen, Stefan Osswald, Martin Clauss, Daniel Rikli, Giovanna Lurati Buse, Christian Mueller
Summary: This study evaluated the contributions of patient and procedure-related factors to perioperative myocardial infarction/injury (PMI) in noncardiac surgery. The results showed that procedure-related factors were more strongly associated with PMI occurrence, but patient factors also played a role in PMI development.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Ekaterine Popova, Pilar Paniagua-Iglesias, Jesus Alvarez-Garcia, Miquel Vives-Borras, Aranzazu Gonzalez-Osuna, Alvaro Garcia-Osuna, Mercedes Rivas-Lasarte, Gisela Hermenegildo-Chavez, Ruben Diaz-Jover, Gonzalo Azparren-Cabezon, Montserrat Barcelo-Trias, Abdel-Hakim Moustafa, Raul Aguilar-Lopez, Jordi Ordonez-Llanos, Pablo Alonso-Coello
Summary: Perioperative myocardial injury (PMI) is a common cardiac complication, and recent guidelines recommend systematic screening using high-sensitivity cardiac troponin (hs-cTn). We conducted a prospective study to evaluate the feasibility and outcomes of implementing PMI screening and found that it is recommendable, especially for high-risk patients. However, achieving optimal screening implementation is challenging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Paymon M. Azizi, Duminda N. Wijeysundera, Harindra C. Wijeysundera, Peter C. Austin, Angela Jerath, Lu Han, Maria Koh, Dennis T. Ko
Summary: International practice guidelines have different recommendations for postoperative troponin testing after noncardiac surgery. This study evaluated predictors of routine troponin testing after three commonly performed major noncardiac surgeries. The results showed significant variation in testing rates across hospitals, suggesting the need for a more standardized approach to troponin testing.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Article
Cardiac & Cardiovascular Systems
Carlos A. K. Nakashima, Luis A. O. Dallan, Luiz A. F. Lisboa, Fabio B. Jatene, Ludhmila A. Hajjar, Alexandre M. Soeiro, Remo H. M. Furtado, Talia F. Dalcoquio, Luciano M. Baracioli, Felipe G. Lima, Roberto R. C. Giraldez, Bianca A. Silva, Mateus S. S. Costa, Celia M. C. Strunz, Luis R. P. Dallan, Carlos J. D. G. Barbosa, Flavia A. B. Britto, Michael E. Farkouh, Paul A. Gurbel, Jose C. Nicolau
Summary: The platelet reactivity-based strategy is as effective as the standard of care in preventing post-CABG bleeding in ACS patients, while also reducing waiting time and hospital expenses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jianquan Liao, Meng Zhang, Rende Xu, Runda Wu, Huairui Shi, Qi Jin, Yi Fang, Jiarui Xu, Kang Yao, Yeqing Xie, Junbo Ge
Summary: This study aimed to evaluate the significance of elevated soluble interleukin 2 receptor (sIL-2R) levels in predicting acute kidney injury (AKI) and mortality in patients with acute myocardial infarction (AMI). The results showed that sIL-2R levels were independent risk factors and predictors for both AKI and in-hospital all-cause mortality in AMI patients. The findings suggest that sIL-2R may serve as a valuable tool for identifying high-risk patients regarding AKI and in-hospital mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe Sanchez Tijmes, Constantin A. Marschner, Joao Francisco Ribeiro Gavina de Matos, Camila M. Urzua Fresno, Jose Miguel Gutierrez Chacoff, Paaladinesh Thavendiranathan, Cristina Fuss, Kate Hanneman
Summary: COVID-19 and mRNA-based COVID-19 vaccination can lead to acute and longer-term cardiovascular manifestations, including myocardial injury and myocarditis. Noninvasive imaging such as cardiac MRI plays a key role in identifying cardiovascular diseases, evaluating mechanisms of injury, stratifying risk, and guiding treatment.
Article
Anesthesiology
Esther M. Wesselink, Sjors H. Wagemakers, Judith A. R. Van Waes, Jonathan P. Wanderer, Wilton A. Van Klei, Teus H. Kappen
Summary: Intraoperative hypotension appears to have a continuous association with postoperative myocardial injury and mortality, with depth of hypotension contributing more than duration.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Medicine, General & Internal
Lan-Ping Wu, Ke Pang, Bo Li, Yuan Le, Yong-Zhong Tang
Summary: This study aimed to explore the predictive value of pre-operative HbA1c for post-operative AKI in non-cardiac surgery patients. The results showed that elevated pre-operative HbA1c was independently associated with post-operative AKI risk and improved the predictive power of a logistic regression model based on traditional clinical risk factors for AKI.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jungchan Park, Ah Ran Oh, Seung-Hwa Lee, Jong-Hwan Lee, Jeong Jin Min, Ji-Hye Kwon, Jihoon Kim, Kwangmo Yang, Jin-Ho Choi, Sang-Chol Lee, Hyeon-Cheol Gwon, Kyunga Kim, Joonghyun Ahn, Sangmin Maria Lee
Summary: The study found that preoperative hyperglycemia was associated with myocardial injury after noncardiac surgery and 30-day mortality, while HbA1c levels were not. Immediate glucose control may be more crucial than long-term control in patients undergoing noncardiac surgery.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Immunology
Sangbin Han, Junhun Cho, Wongook Wi, Kyo Won Lee, Hyun Hwa Cha, Sanghoon Lee, Joong Hyun Ahn, Seonwoo Kim, Gyu Sung Choi, Jong Man Kim, Sang Yun Ha, Gaab Soo Kim, Jae-Won Joh
Summary: Females exhibit greater tolerance to hepatic ischemia-reperfusion injury compared to males, but only when they are under 40 years old and without macrosteatosis.
Article
Multidisciplinary Sciences
Jungchan Park, Seung-Hwa Lee, Jong-Hwan Lee, Jeong Jin Min, Ah Ran Oh, Kyunga Kim, Joonghyun Ahn
Summary: Despite the association between obesity and increased mortality in the general population, a paradoxical relationship is observed between obesity and mortality in surgery and some types of cancer. This study found that high BMI was associated with lower mortality after cancer surgery, especially in an Asian population. Overweight and obese individuals also had lower mortality compared to those with a normal BMI. However, this association was not observed in female patients and those undergoing breast and gynecological cancer surgery.
Article
Medicine, General & Internal
Ah Ran Oh, Jungchan Park, Jong-Hwan Lee, Dan-Cheong Choi, Kwangmo Yang, Jin-ho Choi, Joonghyun Ahn, Ji Dong Sung, Seunghwa Lee
Summary: This study aimed to evaluate the association between the Sequential Organ Failure Assessment (SOFA) score and outcomes in patients who stayed in the intensive care unit (ICU) for less than one day after non-cardiac surgery. The results showed that a higher initial SOFA score was associated with increased three-year mortality. Additionally, worsening of the SOFA score after surgery was associated with higher three-year mortality and complications. These findings suggest that the change in SOFA score should be considered at discharge from the ICU.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jung Hwa Lee, Yun Im Lee, Joonghyun Ahn, Jeong-Am Ryu
Summary: This study found that elevation of high-sensitivity troponin I (hs-TnI) is associated with in-hospital mortality and major adverse cardiac events (MACEs) in neurosurgical and neurocritically ill patients.
Article
Medicine, General & Internal
Yujin Heo, Hyun Suk Lee, Sungha Jung, Changhee Lee, Younghac Kim, Man Ki Chung, Han-Sin Jeong, Chung-Hwan Baek, Joong Hyun Ahn, Young-Ik Son, Nayeon Choi
Summary: In this study, we aimed to develop prediction models for the early detection of pharyngocutaneous fistula (PCF) after total laryngectomy (TL), which could prevent severe complications. We retrospectively analyzed clinical data from patients who underwent TL and found that factors such as fever, white blood cell count, C-reactive protein levels, neutrophil count, and neutrophil-to-lymphocyte ratio were significantly associated with PCF. By combining these factors, our predictive models showed improved diagnostic performance compared to fistulography alone.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Sang Hyun Lee, Eun Kyung Lee, Hyun Joo Ahn, Sangmin M. Lee, Jie Ae Kim, Mikyung Yang, Ji Won Choi, Jeayoun Kim, Heejoon Jeong, Seungmo Kim, Jinseo Kim, Joonghyun Ahn
Summary: Current guidelines recommend delaying noncardiac surgery for 6 months after drug eluting stent implantation. However, a retrospective study found that early surgery within 6 months after coronary stent implantation did not increase the incidence of myocardial injury in patients with normal preoperative hs-cTnI. The study also showed no differences in secondary outcomes between early and late surgery groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Informatics
Junho Jung, Hyungjin Kim, Seung-Hwa Lee, Jungchan Park, Sungsoo Lim, Kwangmo Yang
Summary: This study examined public attitudes toward the secondary use of public data, revealing large discrepancies between public and private entities. Most participants were favorable toward data use by public agencies but disfavored use by private entities, particularly marketing and private insurance companies. Concerns were frequently noted regarding commercial use of data and data breaches.
HEALTHCARE INFORMATICS RESEARCH
(2023)
Article
Clinical Neurology
Yun Im Lee, Joonghyun Ahn, Jeong-Am Ryu
Summary: This study investigated the impact of hypernatremia on mortality in neurocritically ill patients. The results showed that moderate and severe hypernatremia were associated with poor clinical outcomes, while mild hypernatremia had similar prognosis to patients without hypernatremia.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haejung Kim, So Yeon Yang, Joong Hyun Ahn, Eun Young Ko, Eun Sook Ko, Boo-Kyung Han, Ji Soo Choi
Summary: This study compared the effectiveness of digital breast tomosynthesis (DBT) and magnetic resonance imaging (MRI) as adjunct methods for the preoperative evaluation of breast cancer. The results showed that regardless of breast density, DBT plus full-field digital mammography (FFDM) had a higher specificity than MRI plus FFDM, and may not result in a significant loss in the diagnosis of additional cancers.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Seung-Hwa Lee, Jungchan Park, Kwangmo Yang, Jeongwon Min, Jinwook Choi
Summary: This study evaluated the accuracy of current cloud-based speech recognition (SR) open APIs for medical term recognition in Korean. The results showed that Naver Clova SR had the highest accuracy among the three APIs tested, followed by Amazon Transcribe and Google Speech-to-Text. The accuracy of longer words did not differ significantly between the APIs.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Ah Ran Oh, Jungchan Park, Ji Seon Jeong, Jin Young Lee, Ji Won Choi, Hara Kim, Woo Seog Sim
Summary: This study investigated the factors associated with repeated use of epidural blood patches (EBPs) for the treatment of intracranial hypotension. The results showed that in patients with spontaneous intracranial hypotension (SIH), both the international normalized ratio (INR) and cerebrospinal fluid (CSF) leakage on myelographies were significantly associated with repeated EBPs. However, these factors did not show a difference in repeated EBPs in patients with iatrogenic injury.
KOREAN JOURNAL OF PAIN
(2022)