The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer
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Title
The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer
Authors
Keywords
Breast cancer, Gene expression, Cancer stem cells, Cancer treatment, Pluripotency, RNA sequencing, Small interfering RNA, Statins
Journal
PLoS One
Volume 15, Issue 7, Pages e0236187
Publisher
Public Library of Science (PLoS)
Online
2020-07-22
DOI
10.1371/journal.pone.0236187
References
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Note: Only part of the references are listed.- Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells
- (2019) Andy Göbel et al. Cell Death & Disease
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- (2016) Nina Akrap et al. Stem Cell Reports
- Mevalonate metabolism in cancer
- (2015) Georg Gruenbacher et al. CANCER LETTERS
- Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm
- (2013) Ferdinando Mannello BMC Medicine
- Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients
- (2013) M. J. Engstrøm et al. BREAST CANCER RESEARCH AND TREATMENT
- The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells
- (2013) JAVIER MENENDEZ et al. CELL CYCLE
- Extensive regulation of the non-coding transcriptome by hypoxia: role of HIF in releasing paused RNApol2
- (2013) Hani Choudhry et al. EMBO REPORTS
- Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
- (2013) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Thomas W. Owens et al. Frontiers in Physiology
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- (2012) William A. Freed-Pastor et al. CELL
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- (2012) W. A. Freed-Pastor et al. GENES & DEVELOPMENT
- A Detailed Mammosphere Assay Protocol for the Quantification of Breast Stem Cell Activity
- (2012) Frances L. Shaw et al. JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Targeting tumor cell metabolism with statins
- (2012) J W Clendening et al. ONCOGENE
- Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target
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- Cancer metabolism: current perspectives and future directions
- (2012) C Muñoz-Pinedo et al. Cell Death & Disease
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- (2011) Kornelia Polyak JOURNAL OF CLINICAL INVESTIGATION
- Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study
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- (2010) Anders Ståhlberg et al. NUCLEIC ACIDS RESEARCH
- Dysregulation of the mevalonate pathway promotes transformation
- (2010) J. W. Clendening et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
- (2009) Balazs Györffy et al. BREAST CANCER RESEARCH AND TREATMENT
- Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature
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- Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery
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