Article
Medicine, General & Internal
Re- Chin, Ebunoluwa E. Otegbeye, Kylie H. Kang, Su-Hsin Chang, Scott McHenry, Amit Roy, William C. Chapman, Lauren E. Henke, Shahed N. Badiyan, Katrina Pedersen, Benjamin R. Tan, Sean C. Glasgow, Matthew G. Mutch, Pamela P. Samson, Hyun Kim
Summary: This study compared the cost-effectiveness of SCRT-TNT and LCCRT in the treatment of patients with locally advanced rectal cancer. The results showed that SCRT-TNT had lower costs and improved quality-adjusted life years (QALYs) compared to conventional LCCRT.
Article
Surgery
Jingqing Ren, Shaojie Liu, Huixing Luo, Bailin Wang, Fan Wu
Summary: There was no significant difference in short-term efficacy between TaTME and LaTME for low rectal cancer, but TaTME had a longer operation time and a greater circumferential resection margin distance.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Ziwei Zeng, Zhihang Liu, Shuangling Luo, Zhenxing Liang, Liang Huang, Lei Ruan, Junji Chen, Haiqing Jie, Wenfeng Liang, Huashan Liu, Liang Kang
Summary: There were no significant differences in the 3-year local recurrence rate between the taTME and laTME groups. Additionally, the disease-free survival and overall survival rates within 3 years after surgery were also similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Andrea Cercek, Melissa Lumish, Jenna Sinopoli, Jill Weiss, Jinru Shia, Michelle Lamendola-Essel, Imane H. El Dika, Neil Segal, Marina Shcherba, Ryan Sugarman, Zsofia Stadler, Rona Yaeger, J. Joshua Smith, Benoit Rousseau, Guillem Argiles, Miteshkumar Patel, Avni Desai, Leonard B. Saltz, Maria Widmar, Krishna Iyer, Janie Zhang, Nicole Gianino, Christopher Crane, Paul B. Romesser, Emmanouil P. Pappou, Philip Paty, Julio Garcia-Aguilar, Mithat Gonen, Marc Gollub, Martin R. Weiser, Kurt A. Schalper, Luis A. Diaz
Summary: This study found that mismatch repair-deficient, locally advanced rectal cancer is highly sensitive to PD-1 blockade. Additionally, no adverse events of grade 3 or higher have been reported, and no cases of progression or recurrence have been observed. Longer follow-up is needed to assess the duration of response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Joana Vidal, David Casadevall, Beatriz Bellosillo, Carles Pericay, Rocio Garcia-Carbonero, Ferran Losa, Laia Layos, Vicente Alonso, Jaume Capdevila, Javier Gallego, Ruth Vera, Antonieta Salud, Marta Martin-Richard, Miguel Nogue, Elena Cillan, Joan Maurel, Iris Faull, Victoria Raymond, Carlos Fernandez-Martos, Clara Montagut
Summary: The study showed that in patients with LARC undergoing TNT, the detection of presurgery ctDNA identified individuals at high risk of systemic recurrence, with shorter disease-free survival and overall survival. This sets the foundation for future clinical trials using liquid biopsy to personalize treatment post TNT.
CLINICAL CANCER RESEARCH
(2021)
Article
Surgery
Toshiyuki Adachi, Daichi Kitaguchi, Koichi Teramura, Hiro Hasegawa, Koji Ikeda, Yuichiro Tsukada, Yuji Nishizawa, Takeshi Sasaki, Masaaki Ito
Summary: This retrospective study compared the short-term outcomes of transanal and laparoscopic total mesorectal excisions for low and middle rectal cancers. The transanal group had significantly shorter operative times, lower positive circumferential resection margins rates, and lower incidence of grade III and IV complications compared to the laparoscopic group. This demonstrates the safety and usefulness of transanal total mesorectal excision for middle and low rectal cancers.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Antonio Caycedo-Marulanda, Lawrence Lee, Sami A. Chadi, Chris P. Verschoor, Jordan Crosina, Shady Ashamalla, Carl J. Brown
Summary: The study found that transanal TME performed by experienced surgeons had a low incidence of local recurrence and systemic recurrence, suggesting it may be an acceptable approach for rectal cancer management.
Article
Surgery
Vicente Simo, Patricia Tejedor, Luis Miguel Jimenez, Cristina Hernan, Jaime Zorilla, Jorge Arrredondo, Fernando Lapuente, Carlos Pastor
Summary: This study evaluated the mid-term oncological impact of TaTME for treating rectal cancer and showed positive outcomes at 2 years of follow-up. However, there is a lack of evidence in the literature regarding TaTME and oncological outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Jose Tomas Larach, Amrish K. S. Rajkomar, Philip J. Smart, Jacob J. McCormick, Alexander G. Heriot, Satish K. Warrier
Summary: The study suggests that implementation of taTME for resections beyond TME may be feasible and safe in a highly selected setting.
COLORECTAL DISEASE
(2021)
Article
Surgery
Ivy H. Gardner, Katherine A. Kelley, Walaa F. Abdelmoaty, Ahmed Sharata, Amanda V. Hayman, Mark H. Whiteford
Summary: This study retrospectively analyzed 44 patients with mid and low rectal cancer who underwent low anterior resection via taTME. The results showed that 91% of TME specimens were graded as complete or near complete, with a post-operative complication rate of 18.2% and a local recurrence rate of 4.5%. This indicates that using the taTME approach can yield comparably safe and effective outcomes to laparoscopic proctectomy in technically complex cases.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Ziwei Zeng, Zhihang Liu, Liang Huang, Huashan Liu, Haiqing Jie, Shuangling Luo, Xingwei Zhang, Liang Kang
Summary: The study compared the learning curves and outcomes of transanal total mesorectal excision with laparoscopic total mesorectal excision, finding that in different phases of the learning curve, operative time, intraoperative blood loss, and postoperative stay were significantly lower in the transanal group, with similar short-term and histopathologic outcomes between the two groups.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Surgery
Han Beol Jang, Sang-Bum Kang, Hyein Lee, Byung Jo Choi, Sang Chul Lee
Summary: The study found no significant differences in the occurrence of anastomotic leakage and chronic presacral sinus between Transanal Total Mesorectal Excision (taTME) and Laparoscopic TME (lapTME) in rectal cancer patients. Almost one-third of anastomotic leakages developed into chronic presacral sinus.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Srivishnu Saravanabavan, Mufaddal Kazi, Janesh Murugan, Tejas Vispute, Preeti Vijayakumaran, Ashwin Desouza, Avanish Saklani
Summary: This study retrospectively evaluated the surgical and survival outcomes of patients undergoing eTME and compared them with pelvic exenteration. The results suggest that eTME may be a safe alternative to pelvic exenteration.
COLORECTAL DISEASE
(2023)
Article
Surgery
Sapho Xenia Roodbeen, Antonino Spinelli, Willem A. Bemelman, Francesca Di Candido, Maylis Cardepont, Quentin Denost, Andre D'Hoore, Bert Houben, Joep J. Knol, Beatriz Martin-Perez, Eric Rullier, Dana Sands, Ilana Setton, Katrien Van de Steen, Pieter J. Tanis, Steven D. Wexner, Roel Hompes, Albert M. Wolthuis
Summary: This study aimed to determine the local recurrence (LR) rate and patterns after transanal total mesorectal excision (TaTME) for rectal cancer. The results showed good locoregional control after TaTME in selected cases from tertiary referral centers and did not indicate an inherent oncological risk of the surgical technique.
Article
Pathology
Susan D. Richman, Gemma Hemmings, Helen Roberts, Niall Gallop, Rachel Dodds, Lyndsay Wilkinson, Jonathan Davis, Rhian White, Emma Yates, Bharat Jasani, Louise Brown, Tim S. Maughan, Rachel Butler, Philip Quirke, Richard Adams
Summary: FOCUS4 trial is a successful umbrella trial for patients with advanced colorectal cancer, using molecular profiling for biomarker analysis.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Paul Jenkins, Indrajeet Mandal, Jim Zhong, Vicky Goh
Summary: Research in Clinical Radiology is facing challenges due to increased clinical demand, workforce shortages, and lack of funding and protected research time. The 2023 radiology specialty application process prioritizes other domains like audit over research, which is concerning considering the lack of research culture within the specialty. To strengthen research within radiology training, attracting bright candidates and ensuring research remains a priority is crucial for the future radiology workforce.
BRITISH JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. D. Turmezei, S. C. Shelmerdine, A. H. Ashok, V. Goh
Summary: This study surveyed past and current radiology academic clinical fellows (ACFs) to gather feedback on their experiences, academic achievements, challenges in balancing academic and clinical responsibilities, and suggestions for optimizing the fellowship program. The results showed that many ACFs continue their academic interests after training, with some achieving higher research degrees. Balancing clinical workload was identified as a challenge, requiring flexibility from supervisors.
CLINICAL RADIOLOGY
(2023)
Article
Oncology
Susanna Slater, Annette Bryant, Hsiang-Chi Chen, Ruwaida Begum, Isma Rana, Maria Aresu, Clare Peckitt, Oleg Zhitkov, Retchel Lazaro-Alcausi, Victoria Borja, Rachel Powell, David Lowery, Michael Hubank, Thereasa Rich, Gayathri Anandappa, Ian Chau, Naureen Starling, David Cunningham
Summary: This study aims to determine whether a de-escalation strategy using ctDNA to guide adjuvant chemotherapy is as effective as standard of care chemotherapy in patients with resected colorectal cancer. The primary endpoint is the difference in disease-free survival at 3 years between the trial arms. The study has the potential to reduce unnecessary chemotherapy and associated toxicity.
Article
Oncology
David K. Lau, Caroline Fong, Faten Arouri, Lillian Cortez, Hannah Katifi, Reyes Gonzalez-Exposito, Muhammad Bilal Razzaq, Su Li, Aislinn Macklin-Doherty, Monica Arenas Hernandez, Michael Hubank, Charlotte Fribbens, David Watkins, Sheela Rao, Ian Chau, David Cunningham, Naureen Starling
Summary: A retrospective study was conducted in a high volume cancer center in London to evaluate the impact of implementing DPYD variant testing for gastrointestinal cancer patients. The results showed that DPYD genotype testing prior to fluoropyrimidine chemotherapy ensured patient safety and the incidence of adverse events was similar to wild-type carriers.
Article
Oncology
Avani Athauda, Matthew Nankivell, Rupert Langer, Susan Pritchard, Ruth E. Langley, Katharina von Loga, Naureen Starling, Ian Chau, David Cunningham, Heike I. Grabsch
Summary: No definitive largescale data exist evaluating the role of pathologically defined regression changes within the primary tumour and lymph nodes (LN) of resected oesophagogastric (OG) adenocarcinoma following neoadjuvant chemotherapy and the impact on survival.
BRITISH JOURNAL OF CANCER
(2023)
Letter
Gastroenterology & Hepatology
Tim Meyer, Sevasti Galani, Andre Lopes, Arndt Vogel
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Janet E. Brown, Kara-Louise Royle, Walter Gregory, Christy Ralph, Anthony Maraveyas, Omar Din, Timothy Eisen, Paul Nathan, Tom Powles, Richard Griffiths, Robert Jones, Naveen Vasudev, Matthew Wheater, Abdel Hamid, Tom Waddell, Rhona McMenemin, Poulam Patel, James Larkin, Guy Faust, Adam Martin, Jayne Swain, Janine Bestall, Christopher McCabe, David Meads, Vicky Goh, Tze Min Wah, Julia Brown, Jenny Hewison, Peter Selby, Fiona Collinson
Summary: This study aimed to compare the non-inferiority of a tyrosine kinase inhibitor drug-free interval strategy with a conventional continuation strategy in the first-line treatment of advanced clear cell renal cell carcinoma. The results showed that non-inferiority between the two groups could not be concluded in terms of overall survival and quality-adjusted life-years (QALYs). However, treatment breaks might be a feasible and cost-effective option with lifestyle benefits for patients during tyrosine kinase inhibitor therapy in patients with renal cell carcinoma.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Vicky Goh
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Vicky Goh
Article
Cell Biology
Jan Moritz Niehues, Philip Quirke, Nicholas P. West, Heike I. Grabsch, Marko van Treeck, Yoni Schirris, Gregory P. Veldhuizen, Gordon G. A. Hutchins, Susan D. Richman, Sebastian Foersch, Titus J. Brinker, Junya Fukuoka, Andrey Bychkov, Wataru Uegami, Daniel Truhn, Hermann Brenner, Alexander Brobeil, Michael Hoffmeister, Jakob Nikolas Kather
Summary: Deep learning can predict microsatellite instability (MSI) from routine histopathology slides of colorectal cancer (CRC). It is unclear whether DL can also predict other biomarkers with high performance and whether DL predictions generalize to external patient populations.
CELL REPORTS MEDICINE
(2023)
Meeting Abstract
Oncology
J. Mencel, F. Turkes, L. Barber, B. Challoner, M. Buzzetti, A. Tran, H. Chen, N. McCafferty, A. Woolston, R. Crux, I. Rana, J. Thomas, V. Borja, R. Begum, E. Johnston, N. Fotiadis, M. Terlizzo, S. Rao, I. Chau, D. Cunningham, M. Gerlinger, N. Starling
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Do-Youn Oh, Maria Alsina Maqueda, David I. Quinn, Peter J. O'Dwyer, Ian Chau, Sun Young Kim, Ignacio Duran, Daniel Castellano, Jordan Berlin, Begona Mellado, Stephen K. Williamson, Keun-Wook Lee, Francisca Marti, Paul Mathew, Muhammad Wasif Saif, Ding Wang, Elizabeth Chong, Jacqueline Hilger-Rolfe, James P. Dean, Hendrik-Tobias Arkenau
Summary: This study evaluated the safety and efficacy of Ibrutinib combined with companion drugs for RCC, GC, and CRC, but did not observe clinically significant increases in efficacy compared to historical controls.
Article
Multidisciplinary Sciences
Sujath Abbas, Oriol A. Pich, Ginny Devonshire, Shahriar Zamani, Annalise Katz-Summercorn, Sarah Killcoyne, Calvin Cheah, Barbara Nutzinger, Nicola Grehan, Nuria Lopez-Bigas, Paul A. W. Edwards, Elwira M. Fidziukiewicz, Aisling Redmond, Adam C. Freeman, Elizabeth Smyth, Maria O'Donovan, Ahmad Miremadi, Shalini Malhotra, Monika Tripathi, Hannah Coles, Conor Flint, Matthew Eldridge, Sriganesh Jammula, Jim Davies, Charles Crichton, Nick H. Carroll, Richard Hardwick, Peter Safranek, Andrew Hindmarsh, Vijayendran J. Sujendran, Stephen Hayes, Yeng Ang, Andrew R. Sharrocks, Shaun Preston, Izhar Bagwan, Vicki Save, Richard J. E. R. Skipworth, Ted Hupp, J. Robert O'Neill, Olga Tucker, Andrew Beggs, Philippe Taniere, Sonia Puig, Gianmarco J. Contino, Timothy C. Underwood, Robert L. Walker, Ben Grace, Jesper Lagergren, James Gossage, Andrew Davies, Fuju Chang, Ula Mahadeva, Vicky D. Goh, Francesca Ciccarelli, Grant Sanders, Richard Berrisford, David Chan, Ed Cheong, Bhaskar Kumar, L. L. Sreedharan, Simon Parsons, Irshad Soomro, Philip Kaye, John Saunders, Laurence Lovat, Rehan Haidry, Michael Scott, Sharmila Sothi, Suzy B. Lishman, George J. Hanna, Christopher Peters, Krishna Moorthy, Anna Grabowska, Richard Turkington, Damian McManus, Helen D. Coleman, Russell Petty, Freddie C. Bartlett, Rebecca Fitzgerald, Maria Secrier
Summary: The mutational processes of oesophageal adenocarcinoma (OAC) progression from Barrett's Oesophagus have been characterized, with C[T > C/G]T substitution enriched signatures SBS17a/b being dominant. TP53 mutations, increased proliferation, genomic instability, and disease progression are associated with these mutations. Alterations in DNA damage repair pathways, including base excision repair deficiencies, are also linked to poor prognosis.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Neil McCafferty, Caroline Fong, Louise J. Barber, Andrew Woolston, Dimitrios Kleftogiannis, Taqia Rana, Susan Cromarty, Shannon Kidd, Ruwaida Begum, Ian Chau, Naureen Starling, David Cunningham, Marco Gerlinger