Journal
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
Volume 193, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2020.172928
Keywords
Psychopharmacotherapy; Acute and chronic stress; Animal model; Mental illness; Environmental enrichment
Funding
- Zebrafish Platform Construction funds from the School of Pharmacy of the Southwest University (Chongqing, China)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS) [18/2551-0000-493-6, 19/2551-0001-873-8]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (Brazil) [303263/2018-0]
- FAPERGS [17/2551-0001-269-0]
- Russian Science Foundation (RSF) [19-15-00053]
- Russian Foundation for Basic Research (RFBR) [18-34-00996]
- Special Rector's Fellowship for SPSU PhD Students
- RSF [20-65-46006]
- Institute of Physiology and Basic Medicine (Novosibirsk, Russia) [AAAA-A16-116021010228-0]
- Russian Science Foundation [20-65-46006] Funding Source: Russian Science Foundation
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Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psycho-pathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
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