Article
Pharmacology & Pharmacy
Chong Yin, Ye Tian, Yang Yu, Dijie Li, Zhiping Miao, Peihong Su, Yipu Zhao, Xue Wang, Jiawei Pei, Kewen Zhang, Airong Qian
Summary: Osteoporosis, a threat to human health caused by aging and menopause, is associated with reduced osteoblast differentiation. Long non-coding RNAs (LncRNAs) may serve as potential therapeutic targets for osteoporosis. In this study, two LncRNAs (AK039312 and AK079370) were identified to inhibit osteoblast differentiation and bone formation by suppressing osteogenic transcription factors, providing new insights for osteoporosis therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yeuni Yu, Sohee Park, Hansong Lee, Eun Jung Kwon, Hae Ryoun Park, Yun Hak Kim, Seung-Geun Lee
Summary: This study aimed to develop potential biomarkers for rheumatoid arthritis (RA) by sequencing small non-coding RNA (sncRNA) in circulating exosomes. The expression levels of hsa-miR-335-5p and hsa-miR-486-5p were found to be higher in RA patients compared to healthy controls, while the expression of the SRSF4 gene was decreased. These findings suggest that circulating exosomal miRNAs and SRSF4 could serve as valuable biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Qi Xu, Jia-Lin Xu, Wen-Quan Chen, Wen-Xiu Xu, Yu-Xin Song, Wen-Juan Tang, Di Xu, Meng-Ping Jiang, Jinhai Tang
Summary: miR-195-5p, as a noncoding RNA, plays an important regulatory role in cancer by affecting various pathways and behaviors of tumor cells. Through studying its expression and mechanisms in different tumors, we believe that miR-195-5p may serve as a novel diagnostic biomarker and therapeutic target for cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Qiang Zhuang, Zhenlin Jin, Xiangkuo Zheng, Ting Jin, Lina Xiang
Summary: The study found that LINC00460 was significantly upregulated in the serum of patients with AML, especially those with CN-AML, and its higher expression was associated with FAB classification and cytogenetics. ROC curve analysis showed that serum LINC00460 could differentiate patients with AML from healthy individuals, suggesting its potential as a diagnostic and prognostic biomarker for AML. The study also revealed that LINC00460 may exert its effects, at least partly, via the miR-320b/PBX3 axis in AML.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Xin Wang, Hongtao Liu, Qing Zhang, Xueying Zhang, Yue Qin, Guangzhao Zhu, Jinghan Dang, Feng Wang, Xiangxiang Yang, Ruitai Fan
Summary: Long non-coding RNA LINC00514 plays a critical role in esophageal squamous cell carcinoma by regulating lipogenesis-related proteins to promote cell proliferation and invasion. Targeting the LINC00514/miR-378a-5p/SPHK1 signaling axis may be a novel therapeutic strategy for ESCC patients.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiali Wu, Shuxin Sun, Wei Liao, Enni Chen, Xiaonan Wang, Yunda Song, Fangting Duan, Wuguo Deng, Shengping Li
Summary: LINC00460 is up-regulated in pancreatic ductal adenocarcinoma (PDAC) and is associated with poor clinical outcomes. Functional experiments showed that knockdown of LINC00460 inhibited cell proliferation and migration, while also leading to cell cycle blockage and enhanced apoptosis. Mechanistic investigations revealed that LINC00460 directly binds to and attenuates the tumor suppressor miR-491-5p, promoting the aggressiveness of PDAC.
JOURNAL OF GENE MEDICINE
(2021)
Article
Environmental Sciences
Qingqi Hong, Peishan Mai, Bin Wu, Haibin Wang, Mingzhe Xiao, Jun You
Summary: This study found that long non-coding RNA TDRG1 is upregulated in colorectal cancer cells and plays an important role in cell stemness. Additionally, TDRG1 binds to miR-873-5p, downregulating its level, and thereby increasing the expression of PRKAR2. This study reveals a novel signaling pathway in CRC progression.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wei Huang, Yifan Zhao, Zhengyi Xu, Xiaoyue Wu, Mingxin Qiao, Zhou Zhu, Zhihe Zhao
Summary: MicroRNAs (miRNAs) are small non-coding RNAs approximately 22 nucleotides in length, and dysregulation of miRNAs has been extensively studied in tumorigenesis, providing biomarkers for cancer diagnosis and prognosis. The miR-574-5p, located on human chromosome 4p14, is highly correlated with a high incidence of human cancers. This review systematically summarizes the regulatory role of miR-574-5p in tumorigenesis and progression, discusses its clinical applications as a diagnostic and prognostic biomarker, and explores its potential as a therapeutic target.
Article
Medicine, Research & Experimental
Tao Xu, Xiangrong Xu, Yuankui Chu, Dan Jiang, Guangxian Xu
Summary: The study investigated the role of lncRNA GAS in macrophage autophagy, showing that GAS5 overexpression can enhance autophagic body formation and promote autophagy by sponging miR-181c-5p and miR-1192 to upregulate ATG5 and ATG12.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Jie Song, Jiaguan Sun, Yuqing Wang, Yuehe Ding, Shengrong Zhang, Xiuzhen Ma, Fengxia Chang, Bingdong Fan, Hongjuan Liu, Chenglan Bao, Weimin Meng
Summary: This study aims to analyze the regulatory non-coding RNAs and identify novel diagnostic biomarkers in tuberculosis (TB) patients. The study conducted a longitudinal analysis in 5 newly diagnosed pulmonary TB patients, collected blood samples before and after 6 months of anti-TB treatment. Whole transcriptome sequencing was performed, and differentially expressed RNAs (DE RNAs) were identified using specific criteria. Functional annotation and pathway analysis were conducted to understand the biological processes involved. The study also established a competitive endogenous RNA (ceRNA) regulatory network. The findings suggest potential diagnostic biomarkers in TB.
Article
Cell Biology
Mi Zhou, Hui Hu, Yineng Han, Jie Li, Yang Zhang, Song Tang, Yu Yuan, Xiaonan Zhang
Summary: In this study, we found that LINC01126 is upregulated in periodontitis-induced hypoxia, suppressing proliferation, promoting apoptosis and inflammation of hPDLCs by sponging miR-518a-5p. Additionally, HIF-1 alpha was identified as a direct target of miR-518a-5p in hPDLCs, and LINC01126 promotes periodontitis pathogenesis by regulating the miR-518a-5p/HIF-1 alpha/MAPK pathway.
CELL PROLIFERATION
(2021)
Article
Oncology
Ji Huang, Qiu-Ming He, Qi Wu, Wei-Min Zhou, Chao Hao, Gong-Xian Wang, Xin-Hua Tu
Summary: The long non-coding RNA 00858 (LINC00858) is found to be upregulated in bladder cancer tissues and cell lines, and its knockdown inhibits proliferation, migration, and invasion of bladder cancer cells by regulating the miR-3064-5p/CTGF axis.
Article
Oncology
Mirko Minini, Alice Senni, Xingkang He, Sara Proietti, Domenico Liguoro, Angela Catizone, Alessandro Giuliani, Rita Mancini, Andrea Fuso, Alessandra Cucina, Yihai Cao, Mariano Bizzarri
Summary: Myo-Inositol inhibits the PI3K/Akt pathway, particularly effective in triple-negative breast cancer cells, but not in hormone-responsive breast cancer cells unless estrogen effects are counteracted. This novel axis involving miR-125a-5p downregulating IP(6)K1 gene could be activated as a molecular target therapy in breast cancer, inhibiting metastasis and tumor progression.
Article
Biochemistry & Molecular Biology
Liying Chen, Juntao Lu, Xiaoxu Li, Xinhao Wang, Ruoyang Qiao, Wei Guo, Qian Ren
Summary: This study found that KTN1-AS1 promotes the progression of ESCC by binding to miR-885-5p and regulating STRN3 expression and the Hippo pathway, suggesting it as a potential therapeutic target for ESCC.
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)