Article
Immunology
Sha-Sha Wang, Dan Chen, Jun-Jun He, Wen-Bin Zheng, Ai-Ling Tian, Guang-Hui Zhao, Hany M. Elsheikha, Xing-Quan Zhu
Summary: This study used RNA-seq to analyze the changes in expression of mRNAs, miRNAs, lncRNAs, and circRNAs in goat peripheral blood mononuclear cells treated with Fasciola gigantica ESPs. The results indicated that Fasciola gigantica ESPs altered the expression of genes associated with host immune response, receptor signaling, disease, and metabolism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Mengwei Zheng, Xuelian Jiang, Xinping Kong, Yanfeng Guo, Weiyu Zhang, Wenda Di
Summary: The study identifies the components of FgESP involved in the interaction between F. gigantica and buffaloes during different periods, and suggests their potential as vaccine and drug targets.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Benjamin Hamid, Friederike Ebner, Lalita Bechtold, Arkadi Kundik, Sebastian Rausch, Susanne Hartmann
Summary: The study found that the relative frequencies of DC subsets in porcine blood differ, with A. suum E/S showing differential modulation on different DC subsets, suppressing pDC and cDC1 while upregulating cDC2.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Zhuo Lan, Xiao-Lei Liu, Qing-Bo Lv, Min-Hao Zeng, Jun-Feng Gao, Qiao-Cheng Chang, Yuan-Yuan Chen, Chun-Ren Wang
Summary: This study identified differences in proteins present during different periods of Fasciola hepatica infection, providing valuable data for the diagnosis of fasciolosis and understanding of host-pathogen interactions.
Article
Immunology
Xuefang Mei, Yaoyao Zhang, Chenyu Quan, Yiying Liang, Weiyi Huang, Wei Shi
Summary: This study provides detailed histological, biochemical, and immunological indices in Kunming (KM) mice infected with Fasciola gigantica. The infected mice showed liver damage, anemia, and weight loss. The levels of aspartate aminotransferase and alanine aminotransferase in the serum increased, while albumin levels decreased. The parasite-specific IgG antibody levels increased and were positively correlated with the average parasite burdens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Xiangxiang Yuan, Xiaoge Han, Xinping Kong, Linjing Hou, Kelong Wei, Mingtang Chen, Weiyu Zhang, Wenda Di
Summary: The 22nd component (F22) of Fasciola gigantica's excretory-secretory products (FgESP) has better diagnostic value than FgESP. The study examines the immunomodulatory function and potential as a molecular vaccine candidate of F22, and identifies 216 components of F22. Results show that F22 significantly decreases the proliferation of stimulated PBMCs. Further studies are needed to investigate F22's immunomodulatory function in the adaptive immune response, and its components can be studied as potential vaccine candidate molecules.
Article
Parasitology
Abel Villa-Mancera, Jaime Olivares-Perez, Agustin Olmedo-Juarez, Alejandro Reynoso-Palomar
Summary: Immunizing sheep with E/S products and cathepsin L mimotopes from Fasciola hepatica showed significant reduction in fluke burden and egg output, as well as induction of specific humoral and cellular immune responses. The vaccination induced a mixed Th1/Th2 immune response, with higher levels of IFN-gamma and lower levels of IL-4 in vaccinated animals compared to controls. Specific amino acid sequences in the cathepsin L1 mimotope were associated with significant protection against the liver flukes.
VETERINARY PARASITOLOGY
(2021)
Article
Parasitology
Lingqin Wu, Wenhui Yin, Jutai Wen, Shuying Wang, Huihui Li, Xiaoli Wang, Weixiao Zhang, Shuyao Duan, Qiuyu Zhu, Erhe Gao, Shili Wu, Bin Zhan, Rui Zhou, Xiaodi Yang
Summary: The study showed that treatment with Ts-AES significantly improved cardiac function and ventricular remodeling, reduced pathological damage and mortality in mice with MI. This was associated with decreased pro-inflammatory cytokine levels, increased regulatory cytokine expression, and promotion of macrophage polarization from M1 to M2 type in MI mice.
PARASITES & VECTORS
(2023)
Review
Immunology
Samantha Nadeau, Gislaine A. Martins
Summary: Blimp1 plays important roles in the immune system, including regulating the differentiation and function of lymphocytes and immune cells. Recent studies have also revealed its important roles in innate immune cells and its association with chronic inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Haoxuan Wang, Yingying Zhu, Meichen Li, Jingdan Pan, Dan Li, Wen-Ping Guo, Guangcheng Xie, Luanying Du
Summary: The expression of 2,860 genes in A549 cells was altered by ML-ESPs, with 1,634 upregulated and 1,226 downregulated. GO and KEGG analysis revealed that the differentially expressed genes were mainly associated with cancer pathways and metabolic processes. Among the downregulated genes in the metabolic process interaction network, genes involved in glucose metabolism such as PFKM, PFKL, ENO2, LDHB, 6PGL, PRE, TKT, and TALDO1 were suppressed by ML-ESPs, while TCA-related genes including PDP1, PDP2, ACO1, and OGDH were upregulated.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Parasitology
Muhammad Ehsan, Rui-Si Hu, Jun-Ling Hou, Hany M. Elsheikha, Xiao-Dong Li, Pan-Hong Liang, Xing-Quan Zhu
Summary: The study demonstrates the immunomodulatory effects of a recombinant tegumental calcium-binding EF-hand protein 4 of F. gigantica (rFg-CaBP4) on goat monocytes through various experiments, showing an increase in cytokine transcription levels and major histocompatibility complex (MHC) class-II molecule expression. This sheds light on the roles of calcium-binding EF-hand proteins in host-parasite interaction and the strategies used by F. gigantica to evade host immune responses.
PARASITES & VECTORS
(2021)
Article
Parasitology
Jing Wang, Bin Tang, Xihuo You, Xuepeng Cai, Wanzhong Jia, Xiaolei Liu, Mingyuan Liu, Xuemin Jin, Jing Ding
Summary: This study investigated the effects of Trichinella spiralis' excretory/secretory products (ESP) on the functions of immune cells. The results revealed the evasion and regulation mechanisms employed by the parasite, providing insights into its strategies to manipulate host immunity.
PARASITES & VECTORS
(2023)
Article
Immunology
Alison Ricafrente, Hieu Nguyen, Nham Tran, Sheila Donnelly
Summary: Investigating how Fasciola hepatica regulates host immune response through miRNA and discovering the redundancy of miRNA in regulating immune cell activation provides evidence for the universal management of host immunology by this parasite.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Valeria Morales-Ruiz, Dina Lopez-Recinos, Maria Gracia Castaneda, Adrian Guevara-Salinas, Cristina Parada-Colin, Sandra Gomez-Fuentes, Clara Espitia-Pinzon, Marisela Hernandez-Gonzalez, Laura Adalid-Peralta
Summary: The study aims to identify and characterize the excretion/secretion products (ESPs) of Taenia crassiceps cysticerci that are linked to the induction of regulatory T cells (Tregs). ESPs were obtained from parasite cultures and inoculated in mice to measure Treg levels. Proteins in ESPs were analyzed and categorized as either differential or conserved. Only 4 out of 10 ESPs induced Tregs, with proteins involved in catalytic activity and immune processes being predominant.
PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Xianmin Fan, Yue Zhang, Renhui Ouyang, Bo Luo, Lizhu Li, Wei He, Meichen Liu, Nan Jiang, Fengjiao Yang, Lingjun Wang, Biying Zhou
Summary: The excretory secretory antigens (ESAs) of Cysticercus cellulosae induced imbalanced CD4(+)/CD8(+) T-cell proportions, increased CD4(+)Foxp3(+) and CD8(+)Foxp3(+) T-cell frequencies, and induced Th2-type immune responses in piglets.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Melanie R. Neeland, Wei Shi, Catherine Collignon, Nadine Taubenheim, Els N. T. Meeusen, Arnaud M. Didierlaurent, Michael J. de Veer
JOURNAL OF IMMUNOLOGY
(2016)
Article
Infectious Diseases
Xiao-Xuan Zhang, Wei Shi, Nian-Zhang Zhang, Kun Shi, Jian-Ming Li, Peng Xu, Quan Zhao, Rui Du
INFECTION GENETICS AND EVOLUTION
(2017)
Article
Parasitology
Wei Shi, Zhi-Yong Wei, Hany M. Elsheikha, Fu-Kai Zhang, Zhao-An Sheng, Ke-Jing Lu, Dong-Ying Wang, Wei-Yi Huang, Xing-Quan Zhu
PARASITES & VECTORS
(2017)
Article
Immunology
M. R. Neeland, W. Shi, C. Collignon, E. N. T. Meeusen, A. M. Didierlaurent, M. J. de Veer
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2018)
Article
Parasitology
Zhao-An Sheng, Jun Li, Dong-Ying Wang, Yang-Qun Kang, Zhi-Yong Wei, Fu-Kai Zhang, Xing-Quan Zhu, Hong-Lin Luo, Wei-Yi Huang
VETERINARY PARASITOLOGY
(2019)
Article
Parasitology
Xue-Fang Mei, Wei Shi, Yao-Yao Zhang, Bin Zhu, Yu-Rui Wang, Lin-Jing Hou, Wen-Ping Zhao, Jian Li, Dong-Ying Wang, Hong-Lin Luo, Wei-Yi Huang
PARASITES & VECTORS
(2019)
Article
Immunology
Yaoyao Zhang, Xuefang Mei, Yiying Liang, Bin Zhu, Zhaoan Sheng, Wei Shi, Dongying Wang, Weiyi Huang
MICROBIAL PATHOGENESIS
(2020)
Article
Infectious Diseases
Wei Shi, Jun-Jun He, Xue-Fang Mei, Ke-Jing Lu, Zi-Xuan Zeng, Yao-Yao Zhang, Zhao-An Sheng, Hany M. Elsheikha, Wei-Yi Huang, Xing-Quan Zhu
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Nanoscience & Nanotechnology
Shenxia Xie, Xiaoqiong Hou, Wei Yang, Wei Shi, Xiaomei Yang, Siliang Duan, Fengzhen Mo, Aiqun Liu, Wu Wang, Xiaoling Lu
Summary: This study demonstrates the enhancement of antitumor effect by modifying PD-1 silenced T cells with aptamer-based immunoliposomes and activating them with DC/tumor FCs. The surface modification resulted in a stronger antitumor outcome by inhibiting tumor growth and prolonging animal survival, highlighting a promising strategy for improving immunotherapeutic outcomes in cancer ACT.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Letter
Biochemistry & Molecular Biology
Xiao-mei Yang, Xuan-dong Lin, Wei Shi, Shen-xia Xie, Xia-ning Huang, Shi-hua Yin, Xiao-bing Jiang, Bruce D. Hammock, Zhi Ping Xu, Xiao-ling Lu
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Nutrition & Dietetics
Lichao Yang, Xiaojing Cheng, Wei Shi, Hui Li, Qi Zhang, Shiping Huang, Xuejing Huang, Sha Wen, Ji Gan, Zhouxiang Liao, Junming Sun, Jinning Liang, Yiqiang Ouyang, Min He
Summary: This study established Vasn knockout mice and found that Vasn deficiency resulted in decreased body and liver weight, abnormal liver function, liver injury, and aberrant activation of hepatocyte autophagy. It was also observed that Vasn deletion upregulated hepatocyte autophagy through the mTOR-ULK1 signaling pathway. These findings provide new insight into the role of Vasn in liver functionality.