Journal
ORGANIC LETTERS
Volume 22, Issue 14, Pages 5656-5660Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02026
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Funding
- Uehara Memorial Foundation
- Nagase Science and Technology Foundation
- Basis for Supporting Innovative Drug Discovering and Life Science Research (BINDS) from Japan Agency for Medical Research and Development (AMED)
- [19H03353]
- [18K06585]
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Asymmetric dearomatizing fluorocyclization of indole derivatives was investigated using a dicarboxylate phase-transfer catalyst. This reaction proceeds under mild reaction conditions to provide fluoropyrroloindoline derivatives in a highly enantioselective manner. Various substitution patterns on the indole ring are well tolerated. To facilitate the reaction and ensure reproducibility, the addition of water is essential, and its possible role is discussed.
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