Article
Hematology
Pengpeng Xu, Rui Guo, Jianhua You, Shu Cheng, Jian Li, Huijuan Zhong, Chenwei Sun, Haoping Xu, Hengye Huang, Biao Li, Weili Zhao
Summary: F-18-FDG PET/CT plays an important role in predicting the prognosis of ENKTL, helping to predict overall survival and progression-free survival. The study found that mid-SUVmax, as well as DS at the middle and end of treatment, were significant predictors of PFS.
ANNALS OF HEMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui Guo, Xiaobin Hu, Haoming Song, Pengpeng Xu, Haoping Xu, Axel Rominger, Xiaozhu Lin, Bjoern Menze, Biao Li, Kuangyu Shi
Summary: The study developed a WSDL method that utilized incomplete survival data to predict the prognosis of ENKTL based on F-18-FDG PET/CT results. PSI showed excellent performance in predicting PFS, and the WSDL method was more effective than the CDL method. Multivariate analysis confirmed PSI as an independent significant predictor of PFS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yue Zhang, Liqian Yu, Rang Wang, Minggang Su
Summary: A 69-year-old man with a history of extranodal NK/T-Cell lymphoma, nasal type (ENKTL-NT), underwent an interim F-18-FDG PET/CT scan for response evaluation. The scan revealed intense focal uptake at the penile glans, initially suspected as urinary contamination. However, the patient reported redness and swelling of the penis, leading to a highly suspected diagnosis of ENKTL-NT recurrence at the penile glans. This diagnosis was confirmed by percutaneous biopsy.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yun Chen, Shan Zheng, Zenan Wu, Yanmin Lin, Weibing Miao
Summary: A 76-year-old man with yellowish discoloration of sclera and skin for 2 months was referred for F-18-FDG PET/CT to characterize a mass in the pancreas. PET/CT images showed intense FDG uptake in the head of the pancreas, with a lymph nodal mass in the hepatic hilar region, consistent with pancreatic malignancy. Histopathologic findings confirmed diffuse large B-cell lymphoma with no evidence of adenocarcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Hongyan Li, Guozhu Shao, Yajing Zhang, Xiaomin Chen, Chengcheng Du, Kun Wang, Zairong Gao
Summary: This study developed nomograms incorporating pretreatment SUVmax and clinical parameters for individualized prognostication of both PFS and OS in patients with newly diagnosed ENKTL. The nomograms showed good prediction accuracies, outperforming the traditional IPI and KPI prognostic indices in terms of predictive accuracy for PFS and OS.
Review
Oncology
Domenico Albano, Giorgio Treglia, Francesco Dondi, Anna Calabro, Alessio Rizzo, Salvatore Annunziata, Luca Guerra, Silvia Morbelli, Alessandra Tucci, Francesco Bertagna
Summary: The new biomarker Dmax, which measures the maximal distance between the two farthest hypermetabolic PET lesions, has shown high accuracy as a prognostic factor in lymphoma patients. Most studies have demonstrated the significant predictive value of Dmax in predicting progression-free survival and overall survival.
Article
Medicine, General & Internal
Shengbing Zang, Lei Liu, Junjie Bao, Min Xiong, Yumo Zhao, Suxia Lin, Xiaoping Lin
Summary: This study investigated the clinicopathologic features, F-18-FDG PET/CT findings, and outcomes for patients with primary thymic MALT lymphoma. The results showed no correlation between SUVmax and Ki-67 index.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chae Hong Lim, Sang Eun Yoon, Seok Jin Kim, Junhun Cho, Young Hyeh Ko, Kyung-Han Lee, Won Seog Kim
Summary: This study investigated the capability of FDG PET/CT in discerning ENKTL TIME subtypes and found that metabolic features were associated with different TIME subtypes, and patients with IS subtype had worse prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Hongyan Li, Min Wang, Yajing Zhang, Fan Hu, Kun Wang, Chenyang Wang, Zairong Gao
Summary: This study investigated the utility of a new PET parameter in predicting progression-free survival and pathologic grade in follicular lymphoma. The results showed that high D-max, high TLG, and elevated serum lactate dehydrogenase were independent predictors of progression-free survival. A scoring system based on these factors effectively stratified patients into different risk categories. Additionally, SUVmax showed some value in distinguishing different grades of lymphoma.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
Chunli Yang, Wanchun Wu, Huijie Zhou, Sha Zhao, Rong Tian, Maya Xiang, Liqun Zou
Summary: This study investigated the role of F-18-2-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (F-18-FDG PET/CT) in evaluating bone marrow involvement (BMI) among patients with extranodal natural killer/T-cell lymphoma (ENKTL). The results showed that PET/CT has the potential to replace bone marrow biopsy (BMB) as the initial staging method for early-stage ENKTL patients, but it is not accurate enough for BMI evaluation in advanced-stage patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dan Cohen, Chava Perry, Shir Hazut-Krauthammer, Mikhail Kesler, Yair Herishanu, Efrat Luttwak, Einat Even-Sapir, Irit Avivi
Summary: This paper summarizes the experience in assessing the extent and metabolic characteristics of MALT lymphomas using [F-18]FDG PET-CT. It reveals that PET-CT has a high detection rate for extranodal lesions located in tissues with low/homogeneous physiologic [F-18]FDG uptake, and increased [F-18]FDG uptake in extranodal lesions predicts worse disease progression.
Article
Oncology
Clement Bouron, Clara Mathie, Valerie Seegers, Olivier Morel, Pascal Jezequel, Hamza Lasla, Camille Guillerminet, Sylvie Girault, Marie Lacombe, Avigaelle Sher, Franck Lacoeuille, Anne Patsouris, Aude Testard
Summary: The aim of this study was to evaluate PET/CT parameters for determining different prognostic groups in triple-negative breast cancer (TNBC). The study found that MTV, TLG, and entropy could be of interest in predicting the prognostic outcome of TNBC patients. Textural features associated with metabolic and volumetric parameters of baseline [F-18]FDG PET/CT have a prognostic value for identifying high-relapse-risk groups in early TNBC patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Ding, Jiangdong Qiu, Zhixin Hao, Hua Huang, Qiaofei Liu, Wenjing Liu, Chao Ren, Marcus Hacker, Taiping Zhang, Wenming Wu, Xiang Li, Li Huo
Summary: This study evaluated the performance of [(68) Ga]Ga-FAPI-04 and [F-18]F-FDG PET/CT on the disease staging and prognostic value of patients with localized PDAC. The results showed that [(68) Ga]Ga-FAPI-04 was more sensitive and accurate than [F-18]F-FDG, and could be used for staging and prognostic evaluation of PDAC, providing a non-invasive guide for clinical management.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
I-Lun Shih, Rouh-Fang Yen, Chi-An Chen, Wen-Fang Cheng, Bang-Bin Chen, Yu-Hsuan Chang, Mei-Fang Cheng, Tiffany Ting-Fang Shih
Summary: PET/MRI biomarkers of cervical cancer are associated with tumor stage and survival. SUVmax and ADCmin are independent predictors of PFS and OS, respectively.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Clinical Neurology
Chin-Hsien Lin, Chin-Hao Chang, Chun-Hwei Tai, Mei-Fang Cheng, Yi-Chieh Chen, Ying-Ting Chao, Tse-Le Huang, Ruoh-Fang Yen, Ruey-Meei Wu
Summary: Evidence suggests that lovastatin may slow the progression of motor symptoms in patients with early-stage PD, especially in the striatal region. The treatment was generally well tolerated, indicating the potential benefits of lovastatin in PD management.
MOVEMENT DISORDERS
(2021)
Article
Oncology
Yu-Sen Huang, Jenny Ling-Yu Chen, Hsin-Ming Chen, Li-Hao Yeh, Jin-Yuan Shih, Ruoh-Fang Yen, Yeun-Chung Chang
Summary: The study shows that MR-PET parameters are strongly correlated with serum angiogenesis-related biomarkers in NSCLC patients, and higher values are associated with advanced-stage disease. Patients with high values of these parameters may benefit from angiogenesis inhibitor therapy and have longer overall survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pei-Ju Chuang, Hsiu-Po Wang, Yu-Jen Lin, Chieh-Chang Chen, Yu-Wen Tien, Min-Shu Hsieh, Shih-Hung Yang, Ruoh-Fang Yen, Chi-Lun Ko, Yen-Wen Wu, Mei-Fang Cheng
Summary: This study found that preoperative 2-[F-18]FDG PET-CT imaging in patients with ampullary carcinoma undergoing pancreaticoduodenectomy provided independent prognostic value, with lymphovascular invasion, involved margin in pathology, and tumor retention index from the dual-phase PET being associated with disease-free survival (DFS), and involved margin, post-recurrence chemotherapy, and metabolic tumor volume (MTV) being associated with overall survival (OS).
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Chieh-Kai Chan, Yi-Yao Chang, Yi-Chun Tsai, Zheng-Wei Chen, Chun-Yi Wu, Wei-Chieh Huang, I-Weng Yen, Kuo-Hsin Wu, Vin-Cent Wu, Yen-Hung Lin
Summary: This study aims to update information on internationally acceptable standards and clinical practice recommendations for the management of patients with primary aldosteronism. The Taiwan Society of Aldosteronism Task Force reached a group consensus on the management of patients with aldosterone-producing adenoma, recommending unilateral adrenalectomy and the use of mineralocorticoid receptor antagonists.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Hsin-Hsi Tsai, Marco Pasi, Li-Kai Tsai, Chi-Ching Huang, Ya-Fang Chen, Bo-Ching Lee, Ruoh-Fang Yen, M. Edip Gurol, Jiann-Shing Jeng
Summary: The prevalence of high-degree perivascular spaces in the centrum semiovale (CSO) is similar between cerebral amyloid angiopathy-related intracerebral hemorrhage (CAA-ICH) and non-CAA-ICH patients in an Asian cohort. However, the severity of CSO-perivascular spaces may be associated with higher brain amyloid deposition in CAA-ICH patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kuan-Yin Ko, Ruoh-Fang Yen, Chi-Lun Ko, Shu-Wei Chou, Hsiu-Hao Chang, Yung-Li Yang, Shiann-Tarng Jou, Wen-Ming Hsu, Meng-Yao Lu
Summary: This study found that midtreatment FDG and FDOPA PET/CT could serve as prognostic markers in stage 3-4 neuroblastoma patients. The interim tumor FDG/FDOPA SUVmax and interim FDOPA whole-body metabolic burden scores were significantly associated with overall survival (OS).
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Surgery
Ying-Sheng Lin, Chia-Ju Liu
Summary: This study analyzed the intraoperative findings of lymphatic ducts in patients who had undergone lymphovenous anastomosis (LVA), aiming to find predictive factors for the severity of lymphosclerosis. The results showed that location in a lower extremity and more advanced Taiwan lymphoscintigraphy stage were associated with more severe lymphosclerosis. In lower limb lymphedema, higher BMI and older age also contributed to more severe lymphosclerosis.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2022)
Article
Cell Biology
Sheng-Nan Chang, Jien-Jiun Chen, Jo-Hsuan Wu, Yao-Te Chung, Jin-Wun Chen, Chu-Hsuan Chiu, Chia-Ju Liu, Meng-Tsun Liu, Yi-Cheng Chang, Chin Li, Jou-Wei Lin, Juey-Jen Hwang, Wen-Pin Lien
Summary: The study identified specific exosomal miRNAs that may serve as biomarkers for coronary artery disease (CAD).
Article
Biochemical Research Methods
Mei-Fang Cheng, Tsun-Jen Cheng, Yue Leon Guo, Ching-Hung Chiu, Hung-Ming Wu, Ruoh-Fang Yen, Ya-Yao Huang, Wen-Sheng Huang, Chyng-Yann Shiue
Summary: This study developed a simplified automated synthesis method and high-performance liquid chromatography purification method to successfully produce high-quality, high-yield, and reproducible [F-18]FEPPA tracer. The tracer showed promising results in PET imaging of PM2.5-exposed rats and can be potentially used in various clinical or preclinical studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ching-Chu Lu, Chien-Jung Chen, Kang-Yung Peng, Jeff S. Chueh, Chin-Chen Chang, Ruoh-Fang Yen, Vin-Cent Wu
Summary: This study aimed to evaluate the feasibility of using MTO PET for lateralization in patients with primary aldosteronism (PA) and explore its correlation with other lateralization methods and its usefulness in predicting treatment outcomes. The results showed a high discordance rate between MTO PET and other lateralization methods, but it was able to predict the biochemical and clinical outcomes of patients. This suggests that MTO PET may be a useful imaging biomarker for predicting the treatment outcome of PA patients.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Peripheral Vascular Disease
Vin-Cent Wu, Chieh-Kai Chan, Wan-Chen Wu, Kang-Yung Peng, Yuan-Shian Chang, Fang-Yu Yeh, Jiun-Yang Chiang, Yuan-Ju Lee, Kao-Lang Liu, Shuo-Meng Wang, Yen-Hung Lin, Jeff S. Chueh, TAIPAI Grp
Summary: This study aimed to investigate the effect of cortisol levels on incident new-onset type 2 diabetes mellitus in patients with primary aldosteronism. The results showed that a cortisol level ≥2.65μg/dL after 1-mg DST was a risk factor for developing new-onset type 2 diabetes mellitus. This risk was more pronounced in patients with other factors such as a higher BMI, lower estimated glomerular filtration rate, longer hypertension duration, and higher waist-to-hip ratio.
HYPERTENSION RESEARCH
(2023)
Article
Clinical Neurology
Bo-Ching Lee, Hsin-Hsi Tsai, Chia-Ju Liu, Ya-Fang Chen, Li-Kai Tsai, Jiann-Shing Jeng, Ruoh-Fang Yen
Summary: This study found that cerebral venous reflux (CVR) is more closely associated with cerebral amyloid angiopathy (CAA) than hypertensive microangiopathy in intracerebral hemorrhage (ICH) survivors. The results suggest that venous drainage dysfunction potentially plays a role in CAA and cerebral amyloid deposition.
Article
Medicine, Research & Experimental
Meng-Ting Chiang, Jann-Tay Wang, Wan-Yu Lin, Ruoh-Fang Yen, Jei-Yie Huang, Ching-Chu Lu
Summary: This study compared the occurrence of hypermetabolic lymphadenopathy (HLN) on F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) after virus-vector and mRNA vaccines for COVID-19. The mRNA-1273 COVID-19 vaccine was found to be associated with higher glucose hypermetabolism in regional lymph nodes within the first 4 weeks compared with the virus-vector vaccine, as indicated by the presence of HLN on FDG PET/CT. The degree of glucose hypermetabolism was comparable between the two vaccines.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
