Article
Oncology
Sonya Youngju Park, Eun Kyoung Choi, Jin Kyoung Oh, Joo Hyun Oh, Ie Ryung Yoo, Yong An Chung
Summary: This study compared the survival of breast cancer patients with and without BAT activity on FDG PET/CT. The results showed that patients with BAT activity had longer progression-free survival, with a more significant difference observed in premenopausal women.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Pavan Brahmbhatt, Fatemeh Ataei, Ephraim E. Parent, Akash Sharma
Summary: Brown fat activation with increased radiotracer localization on FDG PET/CT studies is a well-known phenomenon. This case reports an atypically intense, multilobular FDG uptake in activated brown adipose tissue, likely caused by the patient's use of mirabegron, a known activator of brown fat. More information is needed on pharmacologic causes of increased brown fat uptake to improve interpretation of PET/CT studies.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Xilan Yao, Xiaohong Ou
Summary: A 50-year-old man presented with right chest pain and increased parathyroid hormone levels after parathyroidectomy. PET/CT scans revealed an osteolytic lesion on the right sixth rib, which was confirmed to be a brown tumor upon subsequent biopsy.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sameer Taywade, Tanisha Gupta, Rajesh Kumar, Rahul Choudhary, Deepak Kumar
Summary: Nuclear imaging plays a crucial role in evaluating cardiac diseases of infective, inflammatory, innervation, and infiltrative origins. We report a case of persistent pyrexia after percutaneous transluminal coronary angioplasty in a patient with a history of inferior wall myocardial infarction. Molecular imaging techniques, such as F-18-FDG PET/CT and Tc-99m-MIBI myocardial perfusion study, helped in narrowing the differentials and eventually diagnosing the patient with Dressler syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Bing Zhang, Qiao He, Yali Long, Yuying Zhang, Xiaoyan Wang, Zhifeng Chen, Jianbo Liu, Xiangsong Zhang
Summary: This study compared the diagnostic efficacies of F-18-FDG PET/CT and Ga-68-DOTANOC PET/CT in patients with EAS. The results showed that Ga-68-DOTANOC PET/CT imaging may be more suitable for identifying the primary tumor, while F-18-FDG PET/CT may be more advantageous for patients with suspected metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Astrid Geysen, Koen Van Laere, Raf Verscuren
Summary: A 27-year-old male undergoing kidney transplant was found to have bone lesions and parathyroid issues, confirmed by PET/CT and histopathology as a parathyroid adenoma.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Joseph A. Frankl, Yu An, Amber Sherwood, Guiyang Hao, Feng-Yun Huang, Pawan Thapa, Deborah J. Clegg, Xiankai Sun, Philipp E. Scherer, Orhan K. Oz
Summary: Obesity is a leading cause of preventable death and morbidity. This study finds that imaging BAT with the radioiodinated fatty acid analogue BMIPP yields more physiologically relevant data than FDG-PET/CT and may be a pivotal tool for evaluating BAT in both mice and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Fagart, Thomas Quemeneur, Guillaume Collet, Franck Demailly, Clementine Rousselin
Summary: VEXAS syndrome is an adult-onset autoinflammatory disease caused by somatic UBA1 mutations. Most patients meet clinical criteria for an inflammatory syndrome or a hematologic condition, or both. We described abnormalities in marrow recruitment, presenting as a leopard man appearance on FDG PET/CT in a 70-year-old man with VEXAS syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Takashi Norikane, Yuka Yamamoto, Hanae Arai-Okuda, Hiroaki Dobashi, Yoshihiro Nishiyama
Summary: Pulmonary vasculitis is an uncommon type of vasculitis that may cause pulmonary artery stenosis and ischemic damage to lung tissue. Tc-99m-macroaggregated albumin scintigraphy and iodine lung perfusion mapping are useful for assessing lung perfusion, while F-18-FDG PET/CT is used for evaluating vasculitis activity but does not provide perfusion information.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tina Nazerani Hooshmand, Birgit Pernthaler, Kinga Szurian, Mauro Pau, Reingard Maria Aigner
Summary: Hyperparathyroidism-jaw-tumor syndrome (HPT-JTS) is a rare autosomal dominant disorder characterized by the association of jaw ossifying fibroma with primary hyperparathyroidism. Due to its rarity and diverse manifestations, diagnosis can be challenging.
CLINICAL NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Suzanne J. M. Tol, Friso M. van der Zant, Remco J. J. Knol, Maurits Wondergem, Wouter A. M. Broos
Summary: This article reports a case of Lofgren syndrome, which was visualized by F-18-FDG PET/CT showing typical thoracic lymphadenopathy, subcutaneous lesions, and periarticular FDG accumulation. The importance of recognizing and discriminating Lofgren syndrome from classic sarcoidosis is emphasized.
CLINICAL NUCLEAR MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Miju Cheon, Jang Yoo, Kyu-Bok Kang
Summary: Gorlin-Goltz syndrome is a rare autosomal dominant inherited disorder characterized by early-onset basal cell carcinomas. It also presents with keratocystic odontogenic tumors, palmar and plantar pitting, and skeletal abnormalities. The clinical findings of the syndrome are diverse and many symptoms appear during a certain period of life.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Niklas Lohaus, Jan Schaab, Dominik Schaer, Stefan Balabanov, Martin W. Huellner
Summary: A 77-year-old man presented with symptoms of weight loss and recurrent subfebrile temperatures for 6 months. CT revealed lung infiltrate and despite antibiotic treatment, inflammation markers remained high. The patient developed eczematous skin changes, uveitis, and macrocytic anemia. Further examination with FDG PET/CT showed metabolically active foci in various tissues, and bone marrow aspiration confirmed a UBA1 mutation indicative of VEXAS syndrome.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Francesco Dondi, Domenico Albano, Barbara Paghera, Francesco Bertagna, Raffaele Giubbini
Summary: Balint syndrome is a rare neurological disorder characterized by simultanagnosia, optic ataxia, and ocular apraxia, with diverse etiology. Diagnosis relies on neuropsychological evaluation and imaging studies. In this study, F-18-FDG PET/CT was found to be helpful in diagnosis and follow-up of Balint syndrome in two patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
David R. Spigel, Corinne Faivre-Finn, Jhanelle E. Gray, David Vicente, David Planchard, Luis Paz-Ares, Johan F. Vansteenkiste, Marina C. Garassino, Rina Hui, Xavier Quantin, Andreas Rimner, Yi-Long Wu, Mustafa Ozguroglu, Ki H. Lee, Terufumi Kato, Maike de Wit, Takayasu Kurata, Martin Reck, Byoung C. Cho, Suresh Senan, Jarushka Naidoo, Helen Mann, Michael Newton, Piruntha Thiyagarajah, Scott J. Antonia
Summary: The study examined the efficacy of consolidation durvalumab in patients with non-small-cell lung cancer, showing significant improvements in overall survival and progression-free survival, with manageable safety. The 5-year follow-up data continued to demonstrate the positive effects of durvalumab on survival and disease progression.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wendy Harris, Ellen Yorke, Henry Li, Christian Czmielewski, Mohit Chawla, Robert P. Lee, Alexandra Hotca-Cho, Dominique McKnight, Andreas Rimner, D. Michael Lovelock
Summary: This study evaluated the efficacy of using bronchoscopically implanted anchored electromagnetic transponders (EMTs) as surrogates for tumor position and repeatability of lung inflation during deep-inspiration breath-hold (DIBH) lung radiotherapy. The results showed that EMTs can serve as good surrogates for tumor position and are reliable for maintaining tumor position during DIBH treatment, as long as the tumor size and shape remain stable. However, large differences in registration between EMTs and spine indicate that lung inflation achieved during simulation is often not reproduced during treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Karina Knorr, So Won Oh, Markus Kroenke, Alexander Wurzer, Calogero D'Alessandria, Michael Herz, Wolfgang Weber, Hans-Jurgen Wester, Matthias Eiber, Nahid Yusufi, Stephan Nekolla
Summary: This study compared the radiation dosimetry and human biodistribution of two prostate-specific membrane antigen (PSMA) ligands. The results showed that both agents had favorable radiation dosimetry and similar human biodistribution. However, F-18-rhPSMA-7.3 showed lower bladder uptake and higher tumor uptake compared to F-18-rhPSMA-7.
Review
Chemistry, Medicinal
Zohreh Varasteh, Wolfgang A. Weber, Christoph Rischpler
Summary: Molecular imaging technologies play a vital role in the detection and treatment of cardiovascular disease, providing unique insights into pathobiological processes and enabling personalized therapy.
Article
Oncology
Carolin Kitzberger, Rebekka Spellerberg, Yang Han, Kathrin A. Schmohl, Christina Stauss, Christian Zach, Roland E. Kaelin, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Rainer Glass, Wolfgang A. Weber, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Summary: In this study, genetically engineered MSCs carrying the NIS gene were injected into mice to treat experimental glioblastoma. The results showed that NIS-MSCs successfully homed to the tumor and expressed the NIS gene, and subsequent treatment with therapeutically effective radioiodide (131I) significantly delayed tumor growth and prolonged mouse survival.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Ishita Chen, Abraham J. Wu, Andrew Jackson, Purvi Patel, Lian Sun, Angela Ng, Aditi Iyer, Aditya Apte, Andreas Rimner, Daniel Gomez, Joseph O. Deasy, Maria Thor
Summary: Pulmonary toxicity is a limiting factor in SBRT for tumors near PBT, esophagus, or other mediastinal structures. Published models of pulmonary toxicity were explored in an independent cohort of patients. Seven NTCP models were identified and the Dmax model best described pulmonary toxicity in this cohort.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Review
Urology & Nephrology
Robert Seifert, Louise Emmett, Steven P. Rowe, Ken Herrmann, Boris Hadaschik, Jeremie Calais, Frederik L. Giesel, Robert Reiter, Tobias Maurer, Matthias Heck, Andrei Gafita, Michael J. Morris, Stefano Fanti, Wolfgang A. Weber, Thomas A. Hope, Michael S. Hofman, Wolfgang Peter Fendler, Matthias Eiber
Summary: This study proposes the PROMISE V2 framework for standardized interpretation and reporting of PSMA-PET findings, aiming to improve communication between imaging experts and uro-oncologists. The framework integrates an updated miTNM system, improved assessment of local disease, and a slightly modified PSMA-expression score for clinical routine and research.
Article
Oncology
Andreas Rimner, Zachary R. Moore, Stephanie Lobaugh, Alexander Geyer, Daphna Y. Gelblum, Raja-Elie E. Abdulnour, Annemarie F. Shepherd, Narek Shaverdian, Abraham J. Wu, John Cuaron, Jamie E. Chaft, Marjorie G. Zauderer, Juliana Eng, Gregory J. Riely, Charles M. Rudin, Nicholas Vander Els, Mohit Chawla, Megan McCune, Henry Li, David R. Jones, Dennis M. Sopka, Charles B. Simone, Raymond Mak, Gerald L. Weinhouse, Zhongxing Liao, Daniel R. Gomez, Zhigang Zhang, Paul K. Paik
Summary: The purpose of the study was to investigate the efficacy and safety of nintedanib added to a prednisone taper in reducing pulmonary exacerbations in patients with radiation pneumonitis. The results showed that the addition of nintedanib to the treatment had a significant effect in reducing pulmonary exacerbations in RP patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Wolfgang A. Weber, Henryk Barthel, Frank Bengel, Matthias Eiber, Ken Herrmann, Michael Schaefers
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Volker Morath, Corinna Brandt, Friedrich-Christian Deuschle, Claudia T. Mendler, Birgit Blechert, Dominik Summer, Cyril Barinka, Clemens Decristoforo, Wolfgang A. Weber, Markus Schwaiger, Arne Skerra
Summary: Anticalin proteins targeting PSMA with tailored plasma half-life using PASylation technology are promising radioligands for PET imaging of xenograft tumors in mice. PET imaging using the FsC radiochelator is superior to Dfo radiochelator and adjusting the plasma half-life of Anticalin radioligands using PASylation technology can increase radioisotope accumulation within the tumor.
MOLECULAR PHARMACEUTICS
(2023)
Article
Hematology
Ashley Aaroe, Razelle Kurzrock, Gaurav Goyal, Aaron M. Goodman, Harsh Patel, Gordon Ruan, Gary Ulaner, Jason Young, Ziyi Li, Derek Dustin, Ronald S. Go, Eli L. Diamond, Filip Janku
Summary: ECD and RDD are rare non-LCHs with limited therapeutic options. The activation of the MAPK pathway through BRAFV600E mutation or other genomic alterations is a characteristic of histiocytosis and shows a positive response to BRAF inhibitors and the MEK inhibitor cobimetinib. This study retrospectively analyzed the outcomes of 26 adult patients treated with orally administered trametinib and found that the drug was effective in managing the diseases at low doses. The response rate was 71% in evaluable patients, including those without the detectable BRAFV600E mutation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Borjana Bogdanovic, Esteban L. Solari, Alberto Villagran Asiares, Sandra van Marwick, Sylvia Schachoff, Matthias Eiber, Wolfgang A. Weber, Stephan G. Nekolla
Summary: This study aimed to determine the effects of different PSMA PET timing on signal kinetics and its correlation with patients' PSA and Gleason scores. The results showed that the detection of tumors remained unchanged in static and dynamic scans. The activity concentration trend of lesions in pelvic lymph nodes and bones was mostly negative, while lesions in the prostate and prostatic fossa showed a positive trend. The correlation between dynamic parameters and PSA varied depending on the radiotracer used.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)
Article
Oncology
Carolin Kitzberger, Khuram Shehzad, Volker Morath, Rebekka Spellerberg, Julius Ranke, Katja Steiger, Roland E. Kaelin, Gabriele Multhoff, Matthias Eiber, Franz Schilling, Rainer Glass, Wolfgang A. Weber, Ernst Wagner, Peter J. Nelson, Christine Spitzweg
Summary: New treatment strategies are urgently needed for glioblastoma (GBM) due to its resistance to standard treatment and poor prognosis. In this study, mesenchymal stem cells (MSCs) were engineered to express the sodium/iodide symporter (NIS) in response to interleukin-6 (IL-6) activation, and were successfully used to deliver NIS deep into the GBM tumor microenvironment. This novel tumor-targeted gene therapy approach resulted in enhanced radiotracer uptake, delayed tumor growth, and improved survival in mice with GBM.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Computer Science, Interdisciplinary Applications
Aditi Iyer, Aditya P. Apte, Ethan Bendau, Maria Thor, Ishita Chen, Jacob Shin, Abraham Wu, Daniel Gomez, Andreas Rimner, Ellen Yorke, Joseph O. Deasy, Andrew Jackson
Summary: This study developed an open-source software tool for radiotherapy prescriptions that can help healthcare providers determine prescriptions based on personalized dose-response curves, providing various functions including visualizing predicted tumor control and normal tissue complications, batch-mode tools, etc.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
