Article
Radiology, Nuclear Medicine & Medical Imaging
Yining Wang, Zijun Chen, Yinjie Zhu, Haitao Zhao, Lianghua Li, Gang Huang, Wei Xue, Ruohua Chen, Jianjun Liu
Summary: The purpose of this study was to assess whether total-body [(68) Ga]Ga-PSMA-11 PET/CT could improve the detection rate compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT in patients with biochemical recurrent prostate cancer. The results showed that total-body [(68) Ga]Ga-PSMA-11 PET/CT had better objective evaluation in terms of background noise, lesion prominence, liver SD, SNR, and lesion SUVmax compared with conventional [(68) Ga]Ga-PSMA-11 PET/CT. Overall, total-body [(68) Ga]Ga-PSMA-11 PET/CT had a significantly higher detection rate for biochemical recurrent prostate cancer compared to conventional [(68) Ga]Ga-PSMA-11 PET/CT. Rating: 9/10.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaomei Gao, Yongxiang Tang, Minfeng Chen, Jian Li, Hongling Yin, Yu Gan, Xiongbin Zu, Yi Cai, Shuo Hu
Summary: This study compared [Ga-68]Ga-RM26 PET/CT and [Ga-68]Ga-PSMA-617 PET/CT for diagnosing prostate cancer, and found that [Ga-68]Ga-PSMA-617 PET/CT had superior accuracy in detecting clinically significant PCa, while [Ga-68]Ga-RM26 PET/CT showed an advantage for imaging low-risk PCa.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Oncology
Ruizhe Huang, Yizhen Li, Haowen Wu, Boyi Liu, Xuanjun Zhang, Zhongxi Zhang
Summary: The aim of this study was to compare the diagnostic efficacy of Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI in patients with biochemically recurrent prostate cancer. A meta-analysis and systematic review were conducted, analyzing 37 studies involving 8409 patients. The results showed that Ga-68-PSMA-11 PET/CT and Ga-68-PSMA-11 PET/MRI had similar detection rates for biochemically recurrent prostate cancer. However, larger prospective studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Wen, Yinjie Zhu, Lianghua Li, Jianjun Liu, Yumei Chen, Ruohua Chen
Summary: Dynamic total-body PET imaging in patients with prostate cancer showed that 6 minutes post-injection was the optimal time for imaging, avoiding interference from bladder activity and detecting lesions with relatively low PSMA uptake. Additionally, imaging at 35-59 minutes post-injection could also yield similar results to imaging at 60 minutes post-injection.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuheng Liu, Lianghua Li, Yanyu Qin, Zijun Chen, Haitao Zhao, Xinlu Wang, Ruohua Chen
Summary: The objective of this study was to compare the diagnostic performance and image quality of total-body PET/CT imaging using half-dose of [(68) Ga]Ga-PSMA radiotracer to conventional PET/CT imaging using full dose of [(68) Ga]Ga-PSMA. The results showed that total-body PET/CT with half-dose of [(68) Ga]Ga-PSMA yielded comparable image quality and diagnostic performance to conventional PET/CT, while reducing radiation exposure for the subjects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Wenxiao Yu, Ming Zhao, Yingjun Deng, Shengjing Liu, Guanchao Du, Bin Yan, Ziwei Zhao, Ning Sun, Jun Guo
Summary: This study compared the diagnostic value of (18) F-PSMA-1007 PET/CT, (18) F-FDG PET/CT, and Ga-68-PSMA PET/CT in prostate cancer. The results showed that both (18) F-PSMA-1007 PET/CT and Ga-68 PSMA PET/CT demonstrated higher diagnostic efficacy compared to (18) F-FDG PET/CT.
Article
Medicine, General & Internal
Manuela A. Hoffmann, Jonas Mueller-Huebenthal, Florian Rosar, Nicolas Fischer, Finn Edler von Eyben, Hans-Georg Buchholz, Helmut J. Wieler, Mathias Schreckenberger
Summary: This study compared the performance of [F-18]PSMA-1007 and [Ga-68]Ga-PSMA-11 positron emission tomography/computed tomography in the initial staging of prostate cancer patients. The results showed that both methods were able to detect PSMA-avid lesions with high concordance to histopathologically proven cancer. There was no superior advantage of either method in diagnosing prostate cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wojciech Cytawa, Stefan Kircher, Hubert Kuebler, Rudolf A. Werner, Simon Weber, Philipp Hartrampf, Tomasz Bandurski, Piotr Lass, Wojciech Polom, Marcin Matuszewski, Hans-Juergen Wester, Constantin Lapa, Andreas Rosenwald, Anna Katharina Seitz, Andreas K. Buck
Summary: The purpose of this study was to validate the expression of primary tumor PSMA in prostate cancer patients using [Ga-68]Ga-PSMA PET/CT imaging. The results showed that among PSMA-positive patients, about one-third had lymph node metastases, which were associated with PSMA expression and tumor volume. In contrast, only 1 out of 7 PET-negative patients had lymph node involvement. These results suggest that PSMA-positive prostate cancer may have a higher risk of aggressiveness and distant metastasis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
David A. Pattison, Maciej Debowski, Brook Gulhane, Evyn G. Arnfield, Anita M. Pelecanos, Peter L. Garcia, Melissa J. Latter, Charles Y. Lin, Matthew J. Roberts, Stuart C. Ramsay, Paul A. Thomas
Summary: This study aimed to compare the concordance of [F-18]PSMA-1007 and [(68)Ga]Ga-PSMA-11 in TNM diagnosis and tracer uptake. The results showed differences in tracer uptake in most physiological sites, but high consistency in overall AJCC prognostic stage.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Yee Ling Ng, Xinlan Yang, Yinjie Zhu, Lianghua Li, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Total-body parametric imaging of [(68) Ga]Ga-PSMA-11 improved lesion contrast and detectability compared to SUV images, which may serve as an imaging biomarker and theranostic tool for precise diagnosis and treatment evaluation in prostate cancer patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guochang Wang, Linlin Li, Jie Zang, Haiyan Hong, Lin Zhu, Hank F. Kung, Zhaohui Zhu
Summary: This study compared the diagnostic performance of Ga-68-P16-093 and Ga-68-PSMA-617 PET/CT in primary prostate cancer patients. The results showed that Ga-68-P16-093 PET/CT detected more positive tumors and had higher tumor uptake and better tumor detection capability than Ga-68-PSMA-617 PET/CT.
CLINICAL NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jiayu Cai, Weizhi Xu, Tinghua Meng, YiZhen Pang, Haojun Chen
Summary: Mixed neuroendocrine carcinoma-acinar carcinoma is a rare type of neuroendocrine prostate cancer and has rarely been reported in de novo cases. In this case, we present the PET/CT findings of Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG in the de novo form of mixed large-cell neuroendocrine carcinoma-acinar adenocarcinoma of the prostate. Different levels of radiotracer uptake were observed in metastatic sites on Ga-68-PSMA, Ga-68-FAPI, and F-18-FDG PET/CT. This case demonstrates the potential use of a multitracer PET/CT strategy for noninvasive detection of intermetastatic heterogeneity in metastatic neuroendocrine prostate cancer.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaan Akcay, Ali Kibar, Onur Erdem Sahin, Muhammet Demirbilek, Gamze Beydagi, Sertac Asa, Fuad Aghazada, Turkay Toklu, Nalan Alan Selcuk, Bulent Onal, Levent Kabasakal
Summary: The study retrospectively reviewed 147 patient records and found that [(68) Ga]Ga-PSMA-11 PET/CT imaging has potential value in diagnosing clinically significant prostate cancer. PRIMARY scoring was more reliable than PIRADS scoring in diagnosing significant prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Vishal Sharma, Harjeet Singh, Ritambhra Nada, Amanjit Bal, Manish Rohilla, Harmandeep Singh, Surinder S. Rana
Summary: The study aimed to differentiate malignant and benign pancreatic lesions by evaluating PSMA expression and comparing Ga-68 PSMA-PET/CT and F-18 FDG-PET/CT. Ga-68 PSMA-PET/CT showed higher specificity and accuracy in pre-operatively diagnosing primary pancreatic malignancy compared to FDG-PET/CT.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Daniel Groener, Jennifer Wichert, Magdalena Adams, Nicolai Mader, Konrad Klimek, Christina Nguyen Ngoc, Justus Baumgarten, Christian Happel, Philipp Mandel, Felix K. H. Chun, Nikolaos Tselis, Frank Gruenwald, Amir Sabet
Summary: This study aims to assess the change in uptake to reference organs, including the liver, parotid, and salivary glands after radioligand therapy (RLT) with [Lu-177]Lu-PSMA-617 in relation to pretreatment imaging metrics. The results showed that RLT has a significant impact on salivary gland uptake, while the changes in liver uptake are burden-dependent.
Letter
Rheumatology
Anthony M. Sammel, Edward Hsiao, Katherine Nguyen, Geoffrey Schembri, Rodger Laurent
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dasantha T. Jaymanne, Sneha Kaushal, David Chan, Geoff Schembri, David Brazier, Dale Bailey, Helen Wheeler, Michael Back
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2018)
Article
Oncology
George Hruby, Thomas Eade, Louise Emmett, Bao Ho, Ed Hsiao, Geoff Schembri, Linxin Guo, Carolyn Kwong, Julia Hunter, Keelan Byrne, Andrew Kneebone
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Endocrinology & Metabolism
Matti L. Gild, Nikita Naik, Jeremy Hoang, Edward Hsiao, Rachel T. McGrath, Mark Sywak, Stan Sidhu, Leigh Walter Delbridge, Bruce Gregory Robinson, Geoff Schembri, Roderick John Clifton-Bligh
CLINICAL ENDOCRINOLOGY
(2018)
Article
Oncology
Keelan Byrne, Thomas Eade, Andrew Kneebone, Linxin Guo, Ed Hsiao, Geoff Schembri, Carolyn Kwong, Julia Hunter, Louise Emmett, George Hruby
RADIOTHERAPY AND ONCOLOGY
(2018)
Article
Medicine, General & Internal
Daniel Wong, Peter Veitch, Geoff Schembri
INTERNAL MEDICINE JOURNAL
(2018)
Article
Clinical Neurology
David L. Chan, Edward Hsiao, Geoff Schembri, Dale L. Bailey, Paul J. Roach, Adrian Lee, Dasantha Jayamanne, Mehrdad Ghasemzadeh, Aimee Hayes, Raymond Cook, Jonathon Parkinson, James P. Drummond, Imogen Ibbett, Helen R. Wheeler, Michael Back
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Imogen Ibbett, Geoff Schembri, Raymond Cook, Jonathon Parkinson
WORLD NEUROSURGERY
(2019)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Rueben Ganeshalingam, Paul Roach, Geoffrey Paul Schembri
CLINICAL NUCLEAR MEDICINE
(2019)
Article
Rheumatology
Anthony M. Sammel, Edward Hsiao, Geoffrey Schembri, Katherine Nguyen, Janice Brewer, Leslie Schrieber, Beatrice Janssen, Peter Youssef, Clare L. Fraser, Elizabeth Bailey, Dale L. Bailey, Paul Roach, Rodger Laurent
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Endocrinology & Metabolism
Ayanthi Wijewardene, Jeremy Hoang, Aung Min Maw, Matti Gild, Lyndal Tacon, Paul Roach, Geoffrey Schembri, David Chan, Roderick Clifton-Bligh
Summary: In this study, a new scoring system (I-PET) combining whole body scan (WBS) and FDG findings was proposed to identify patients who are refractory to radioactive iodine in thyroid cancer. The results showed that patients with I-PET [3B] were more likely to receive multikinase inhibitor therapy and had a higher mortality rate.
CLINICAL ENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
D. Chan, P. Roach, E. Bernard, N. Pavlakis, S. Clarke, D. Bailey, G. Schembri
NEUROENDOCRINOLOGY
(2019)
Meeting Abstract
Endocrinology & Metabolism
Matti Gild, Jeremy Hoang, Edward Hsiao, Geoffrey Schembri, Roderick Clifton-Bligh
CLINICAL ENDOCRINOLOGY
(2018)
Article
Surgery
Dasantha Jayamanne, Helen Wheeler, Raymond Cook, Charles Teo, David Brazier, Geoff Schembri, Marina Kastelan, Linxin Guo, Michael F. Back
ANZ JOURNAL OF SURGERY
(2018)
Article
Oncology
Aimee R. Hayes, Dasantha Jayamanne, Edward Hsiao, Geoffrey P. Schembri, Dale L. Bailey, Paul J. Roach, Mustafa Khasraw, Allison Newey, Helen R. Wheeler, Michael Back
PRACTICAL RADIATION ONCOLOGY
(2018)
