Article
Neurosciences
Dongting Tian, Shin-Ichi Izumi
Summary: Results of this study suggest that 20Hz rTMS induces a reliable interhemispheric facilitatory effect, with a significant increase in single-pulse MEP and paired-pulse intracortical facilitation (ICF) in the non-stimulated hemisphere after rTMS intervention. Intracortical inhibition in the unstimulated hemisphere also increased following rTMS.
Article
Biochemistry & Molecular Biology
Kevin Pacheco-Barrios, Danielle Carolina Pimenta, Anne Victorio Pessotto, Felipe Fregni
Summary: The clinical correlates of transcranial magnetic stimulation (TMS) measures, such as resting motor threshold (MT), motor-evoked potential (MEP), short intracortical inhibition (SICI), and intracortical facilitation (ICF), in fibromyalgia syndrome (FMS) patients were investigated. It was found that SICI was associated with sleepiness, comorbidities, disease duration, and anxiety, while ICF showed a positive correlation with pain levels and a negative correlation with body mass index (BMI). These findings suggest that SICI and ICF metrics may serve as potential phenotyping biomarkers in FMS.
Article
Neurosciences
Takuya Matsumoto, Tatsunori Watanabe, Takayuki Kuwabara, Keisuke Yunoki, Xiaoxiao Chen, Nami Kubo, Hikari Kirimoto
Summary: Our study found that SICI in the ipsi-M1 is decreased during visually guided finger movements compared to rest condition. Additionally, both SICI and LICI were smaller in the right M1 compared to the left M1, regardless of task conditions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Neurosciences
Danny Adrian Spampinato, Jaime Ibanez, Lorenzo Rocchi, John Rothwell
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used to study the human brain. One outcome measure of TMS is the motor-evoked potential (MEP), which estimates changes in corticospinal excitability. This article summarizes the neural pathways and circuits contributing to MEP generation, discusses factors to consider when interpreting MEP amplitude in motor processing and neurological conditions, and explores how emerging technologies can enhance understanding of neural substrates influencing MEPs.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Neurosciences
George M. Opie, Wei-Yeh Liao, John G. Semmler
Summary: Research indicates that interactions between the cerebellum and primary motor cortex are crucial for effective motor function. A review of emerging literature on this topic offers valuable insights into the nature of these interactions.
Article
Behavioral Sciences
Qian Ding, Huiting Cai, Manfeng Wu, Guiyuan Cai, Hongying Chen, Wanqi Li, Tuo Lin, Yinghua Jing, Tifei Yuan, Guangqing Xu, Yue Lan
Summary: This study systematically investigated the relationship between resting-state intracortical inhibition or facilitation and inhibitory control, finding a positive correlation between short intracortical facilitation and poorer inhibitory control. This suggests that short intracortical facilitation may serve as a potential physiological biomarker for motor-inhibitory control and have clinical implications for disorders associated with inhibitory control deficits.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Sonia Turrini, Francesca Fiori, Emilio Chiappini, Boris Lucero, Emiliano Santarnecchi, Alessio Avenanti
Summary: Transcranial magnetic stimulation (TMS) studies have shown that cortico-cortical paired associative stimulation (ccPAS) can strengthen connectivity between the ventral premotor cortex (PMv) and the primary motor cortex (M1) by modulating convergent input over M1 via Hebbian spike-timing-dependent plasticity (STDP). The authors tested 60 right-handed young healthy humans using dual coil TMS and ccPAS over the left PMv and M1 to probe and manipulate PMv-to-M1 connectivity, and found that ccPAS acts locally over M1 by gradually increasing motor-evoked potentials (MEPs) induced by paired PMv-M1 stimulation. Moreover, ccPAS reduced the magnitude of short-interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF), highlighting the physiological basis of ccPAS.
Article
Behavioral Sciences
Judith Bek, Merryn D. Constable, Matthew Hilchey, Timothy N. Welsh
Summary: Inhibition of return (IOR) refers to the phenomenon where response times are longer for stimuli presented at previously cued locations compared to uncued locations. While previous studies have implicated posterior parietal cortex (PPC) in IOR effects, the role of primary motor cortex (M1) has not been directly tested. This study investigated the effects of transcranial magnetic stimulation (TMS) over M1 on manual IOR and found that TMS significantly affected IOR, suggesting the need for further research on the involvement of the motor system in manual IOR effects.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Ronan A. Mooney, Amy J. Bastian, Pablo A. Celnik
Summary: Learning similar motor skills in close succession is limited by interference due to unstable motor memories, which compete for neural resources. Prolonged training at the asymptote of an initial motor skill reduces interference when acquiring a second skill, with downregulation of excitatory neurotransmission in the primary motor cortex being a potential marker of online motor memory stabilization.
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Behavioral Sciences
Max Loomes, Dominic M. D. Tran, Nahian S. Chowdhury, Damian P. Birney, Justin A. Harris, Evan J. Livesey
Summary: Recent research using TMS has found a correlation between the speed of stopping an action and GABAergic inhibitory activity in the motor system. This study aimed to replicate this correlation and investigate its generalization to other measures of inhibitory control and working memory. The results showed a specific relationship between SICI and SSRT, indicating the role of local inhibitory networks mediated by GABAA.
Article
Substance Abuse
Yuyu Song, Yanling Pi, Xiaoying Tan, Xue Xia, Yu Liu, Jian Zhang
Summary: By conducting three transcranial magnetic stimulation (TMS) experiments, the researchers measured the modulatory mechanisms in the primary motor cortex (M1) of smokers when they actively approached or avoided smoking-related cues. The results showed that smokers had faster reaction times, increased excitability of corticospinal pathways and intracortical facilitation effects when approaching smoking-related cues. On the other hand, they exhibited stronger short-interval intracortical inhibition effects when avoiding these cues.
Article
Multidisciplinary Sciences
Maximilian J. Wessel, Chang-hyun Park, Elena Beanato, Estelle A. Cuttaz, Jan E. Timmermann, Robert Schulz, Takuya Morishita, Philipp J. Koch, Friedhelm C. Hummel
Summary: The study found that multisession motorcortical stimulation is beneficial for skill acquisition, while monofocal cerebellar stimulation or sequential multifocal motorcortico-cerebellar stimulation did not show additional effects. Baseline task performance and structural integrity of the bilateral superior cerebellar peduncle are the most influential predictors of training success.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Janine Kesselheim, Mitsuaki Takemi, Lasse Christiansen, Anke Ninija Karabanov, Hartwig Roman Siebner
Summary: This study investigated whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. The results showed that multipulse TMSHAND at individual peak latency and trough latency facilitated MEP amplitudes and reduced resting motor threshold (RMT). This facilitation may be related to I-wave periodicity and slower-conducting indirect pyramidal tract projections, respectively.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Review
Neurosciences
George M. Opie, Wei-Yeh Liao, John G. Semmler
Summary: Research indicates that interactions between the cerebellum and primary motor cortex are crucial for effective motor function. A review of emerging literature on this topic offers valuable insights into the nature of these interactions.
Article
Physiology
Brodie J. Hand, George M. Opie, Simranjit K. Sidhu, John G. Semmler
Summary: The study found that endurance-trained cyclists had longer movement times, increased M1 plasticity, but no effect on visuomotor skill acquisition in a sequential visuomotor task.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ryoki Sasaki, John G. Semmler, George M. Opie
Summary: The study found that there was no relationship between the magnitude of C-SICI and TT-SICI, but there was a positive relationship between the slope of inhibition recorded with C-SICI and TT-SICI under a PA current; C-SICI measures were unrelated to TEP amplitude, while TT-SICI was predicted by the P30 generated with AP stimulation.
Article
Multidisciplinary Sciences
Wei-Yeh Liao, Ryoki Sasaki, John G. Semmler, George M. Opie
Summary: This study aimed to assess the impact of the cerebellum on the neuroplasticity of early and late I-wave circuits. The findings suggest that stimulation of the cerebellum has a disruptive effect on the excitatory response in the primary motor cortex, but the specific effect depends on the current direction.
Article
Multidisciplinary Sciences
Andris Cerins, Daniel Corp, George Opie, Michael Do, Bridgette Speranza, Jason He, Pamela Barhoun, Ian Fuelscher, Peter Enticott, Christian Hyde
Summary: Transcranial magnetic stimulation (TMS) is used to investigate neurobiological dysfunctions in neurological disorders. Short-interval intracortical inhibition (SICI) is a promising biomarker but its variability can be influenced by inter-individual differences in excitatory neural populations activated by TMS.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Brodie J. Hand, George M. Opie, Simranjit K. Sidhu, John G. Semmler
Summary: Previous research has shown that regular exercise increases plasticity in primary motor cortex (M1) and a single session of aerobic exercise can also increase M1 plasticity in untrained individuals. This study found that the effect of acute exercise on M1 plasticity is greater in endurance-trained cyclists compared to untrained individuals. Exercise history is an important factor in exercise-induced cortical plasticity.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Claire Bradley, Jessica Elliott, Samuel Dudley, Genevieve A. Kieseker, Jason B. Mattingley, Martin Sale
Summary: This study investigated the role of slow-oscillatory transcranial alternating current stimulation (tACS) in modulating synaptic homeostasis in awake humans. The results suggest that slow-oscillatory tACS does not appear to modulate synaptic homeostasis in the motor system of awake humans under the conditions tested.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ryoki Sasaki, Brodie J. Hand, John G. Semmler, George M. Opie
Summary: This study aimed to investigate the effects of repetitive paired-pulse transcranial magnetic stimulation (iTMS) at different time intervals on the plasticity of specific I-wave circuits. The results showed that iTMS increased motorevoked potentials (MEPs) produced by transcranial magnetic stimulation (TMS) and had a facilitatory effect on short-interval intracortical facilitation (SICF).
Article
Sport Sciences
Cameron Little, Andrew P. Lavender, Cobie Starcevich, Christopher Mesagno, Tim Mitchell, Rodney Whiteley, Hanieh Bakhshayesh, Darren Beales
Summary: Fear is a factor that affects the return to sports after an ACL injury. This study qualitatively and quantitatively assessed the responses of ACL-injured individuals to videos depicting threat to knee stability. The results showed a direct relationship between the level of threat in the videos and the reported fear and distress.
Article
Neurosciences
Wei-Yeh Liao, George M. Opie, Ulf Ziemann, John G. Semmler
Summary: Previous research has shown that the connectivity between dorsal premotor cortex (PMd) and motor cortex (M1) weakens with age. However, the influence of PMd on specific indirect wave circuits within M1 and its effect on age are unclear. This study investigates the influence of PMd on early and late I-wave excitability in M1 of young and older adults.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Editorial Material
Geriatrics & Gerontology
Ann-Maree Vallence, Rachael D. Seidler, Mitchell Ryan Goldsworthy, John G. Semmler, George M. Opie
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Gabriel Tillman, Evita March, Andrew P. Lavender, Taylor A. Braund, Christopher Mesagno
Summary: Disordered social media use may indirectly predict depression and perceived stress through fear of COVID-19. The study indicates that the COVID-19 pandemic has a significant impact on the physical, psychological, and emotional health of individuals worldwide, and this impact may be exacerbated by disordered use of social media.
BEHAVIORAL SCIENCES
(2023)
Article
Neurosciences
R. Sasaki, B. J. Hand, W. Y. Liao, N. C. Rogasch, L. Fernandez, J. G. Semmler, G. M. Opie
Summary: This study investigated the utility of combining electroencephalography (EEG) with transcranial magnetic stimulation (TMS) to measure the response to cerebellar-brain inhibition (CBI). The results showed that both F8 and DC coils suppressed TMS-evoked EEG potentials (TEPs) in the motor cortex, and the TEP produced by CBI stimulation was related to the motor inhibitory response to CBI. These findings suggest that TMS-EEG can be used to measure the response to CBI.
Article
Psychology, Multidisciplinary
Ashley Humphrey, Evita March, Andrew P. Lavender, Kyle J. Miller, Marlies Alvarenga, Christopher Mesagno
Summary: Social connections and resilience play an important mediating role between fear of COVID-19 and psychological wellbeing.
BEHAVIORAL SCIENCES
(2022)
Article
Education & Educational Research
Daniel Jolley, Melissa Davis, Andrew P. Lavender, Lynne Roberts
Summary: This study assessed the impact of an online critical thinking course on personal trainers' misconceptions and critical thinking ability. The results showed that the intervention led to reduced endorsement of misconceptions and increased trust in reliable information. Additionally, both the intervention and control groups showed improved critical thinking ability.
STUDIES IN CONTINUING EDUCATION
(2022)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)