Journal
NEUROBIOLOGY OF AGING
Volume 91, Issue -, Pages 36-44Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2020.03.006
Keywords
Alzheimer's disease; Dementia; Hippocampus; Hippocampal subfields; Preclinical dementia
Categories
Funding
- UK Alzheimer's Society [178, 264]
- US Alzheimer's Association [TriBEKa-17e519007]
- Cambridge NIHR Biomedical Research Centre Dementia theme
- Alzheimer's Research UK [ARUK-SRF2017B-1]
- Alzheimer's Society Junior fellowship [RG96111]
Ask authors/readers for more resources
The hippocampus is one of the first regions to demonstrate atrophy during the prodromal stage of Alzheimer's disease. Volumetric analysis of its individual subflelds could provide biomarkers with higher sensitivity than whole hippocampal volume during an earlier disease stage. We quantified the hippocampal subflelds volume in a large cohort comprising healthy participants (aged 40-59) with dementia family history (FH) and controls (without FH), examined at 2 time points across 2 years. Subfield volumes were quantified using both a T1-weighted and a high-resolution T2 hippocampal magnetic resonance imaging acquisition with Freesurfer. The participants were stratified based on dementia FH, APOE genotype, and CAIDE (Cardiovascular Risk Factors, Aging and Dementia) risk score. Whole hippocampal volume did not differ between the groups. The volume of the molecular layer was lower in participants with an APOE epsilon 4 genotype, but there were no differences between subjects with and without dementia FH or with an increasing CAIDE score. The molecular layer may be the first hippocampal region to demonstrate volumetric alterations in subjects at risk of dementia. (C) 2020 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available