Article
Oncology
Nethanel Asher, Noa Israeli-Weller, Ronnie Shapira-Frommer, Guy Ben-Betzalel, Jacob Schachter, Tomer Meirson, Gal Markel
Summary: The study on advanced melanoma patients treated with immunotherapy revealed that patients with non-complete response and those treated in the advanced-line setting should be treated for longer periods. Elective discontinuation should not take place prior to 18 months.
Article
Oncology
Marco Rubatto, Paolo Fava, Ignazio Stanganelli, Simone Ribero, Jacopo Pigozzo, Anna Maria Di Giacomo, Laura Ridolfi, Maria Chiara Tronconi, Claudia Trojaniello, Melissa Bersanelli, Mattia Garutti, Alice Indini, Ivana De Risi, Michele De Tursi, Barbara Merelli, Francesca Morgese, Marcella Occelli, Gian Carlo Antonini Cappellini, Stefano Poletto, Dahlia Fedele, Sonia Brugnara, Michela Frisinghelli, Luigi Formisano, Raffaele Conca, Marco Tucci, Michelangelo Russillo, Luca Ceroni, Paola Queirolo, Giada Targato, Sabino Strippoli, Mario Mandala, Michele Guida, Pietro Quaglino
Summary: This study aims to evaluate the progression-free survival (PFS) in patients with metastatic melanoma who interrupted anti-PD-1 treatment. The study found that long-lasting clinical responses can be maintained even after discontinuation of anti-PD-1 therapy, with approximately 70.6% of patients who did not achieve complete remission experiencing recurrence after treatment discontinuation.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Rebecca Pokorny, Jordan P. McPherson, Benjamin Haaland, Kenneth F. Grossmann, Carolyn Luckett, Benjamin Newell Voorhies, Daniel S. Sageser, Jocelyn Wallentine, Zachary Tolman, Siwen Hu-Lieskovan, Umang Swami
Summary: In this study, data of patients with metastatic melanoma treated with PD-1 inhibitors was reviewed to find that the majority of patients remained without disease progression on long-term follow-up after discontinuation of therapy at 1 year. Even patients with residual disease on imaging had a low risk of disease progression.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Michiel C. T. van Zeijl, Alfons J. M. van den Eertwegh, Michel W. J. M. Wouters, Liesbeth C. de Wreede, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jan-Willem B. de Groot, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Rozemarijn S. van Rijn, Karijn P. M. Suijkerbuijk, Albert J. ten Tije, Astrid A. M. van Der Veldt, Gerard Vreugdenhil, Jacobus J. M. van Der Hoeven, John B. A. G. Haanen
Summary: There is no consensus on the optimal treatment duration of anti-PD-1 for advanced melanoma. Our study aimed to gain insight into the outcomes of anti-PD-1 discontinuation, the association of treatment duration with progression, and re-treatment with anti-PD-1 in relapsing patients. The results showed that patients with partial or complete response to anti-PD-1 treatment can have durable remissions even after discontinuation.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Biochemistry & Molecular Biology
Beatriz Henriques, Fernando Mendes, Diana Martins
Summary: Breast cancer is the second most common cause of cancer death among women worldwide, and immunotherapy has emerged as a significant treatment strategy, leading to significant advances in treatment. While various immunotherapy approaches have been approved, some patients do not respond to treatment, or experience relapse or progression, mainly due to complex resistance mechanisms.
Review
Oncology
Z. Eroglu, T. O. Topcu, H. M. Yu, K. A. Margolin
Summary: Brain metastases are a common and deadly complication of advanced melanoma. Recent advancements in systemic treatment and radiation therapy have greatly improved the outcomes for patients with brain metastases. Highly active systemic therapy has shown significant benefits, despite concerns about its ability to cross the blood-brain barrier. Factors such as neurologic symptoms, number and size of brain metastases, extracranial disease status, and BRAF mutation status should be considered when determining the best treatment approach.
Review
Biochemistry & Molecular Biology
Mai-Huong Thi Nguyen, Yueh-Hsia Luo, An-Lun Li, Jen-Chieh Tsai, Kun-Lin Wu, Pei-Jung Chung, Nianhan Ma
Summary: Immune checkpoint inhibitors show promise in cancer treatment, but resistance in melanoma patients hinders their effectiveness. Recent studies explore the role of miRNAs in immune response and tumor microenvironment, suggesting their potential as key players in immunotherapy.
Article
Oncology
Eva Ellebaek, Aimilia Schina, Rikke Andersen, Helle Westergren Hendel, Inge Marie Svane, Marco Donia
Summary: This study found that patients with metastatic melanoma who obtain an early response and early discontinue immunotherapy have an excellent prognosis, especially in the absence of FDG-PET avid lesions when discontinuing treatment. These findings support the option of early discontinuation, reducing the risk of overtreatment and toxicity, and improving resource utilization efficiency.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Dermatology
Lauren Skudalski, Reid Waldman, Philip E. Kerr, Jane M. Grant-Kels
Summary: This article presents practical advice on how and when to incorporate various noninvasive melanoma detection techniques into clinical practice, in response to the increasing rates of melanoma worldwide. The aim is to facilitate early detection of melanoma and reduce unnecessary biopsies of benign pigmented lesions.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Henner Stege, Maximilian Haist, Michael Schultheis, Maria Isabel Fleischer, Peter Mohr, Friedegund Meier, Dirk Schadendorf, Selma Ugurel, Elisabeth Livingstone, Lisa Zimmer, Rudolf Herbst, Claudia Pfoehler, Katharina Kaehler, Michael Weichenthal, Patrick Terheyden, Dorothee Nashan, Dirk Debus, Martin Kaatz, Fabian Ziller, Sebastian Haferkamp, Andrea Forschner, Ulrike Leiter, Alexander Kreuter, Jens Ulrich, Johannes Kleemann, Fabienne Bradfisch, Stephan Grabbe, Carmen Loquai
Summary: The introduction of BRAF/MEK-directed targeted therapy has significantly improved the management of BRAF-V600-mutant melanoma patients. Some patients achieve durable complete response to the therapy, but it is unclear whether it is safe to discontinue treatment. Further studies are needed to determine the safety and efficacy of treatment cessation in these patients.
Article
Oncology
Geoffrey T. Gibney, Jacob Zaemes, Shelly Shand, Neil J. Shah, David Swoboda, Kellie Gardner, Arash Radfar, Vesna Petronic-Rosic, Michael J. Reilly, Waddah B. Al-Refaie, Suthee Rapisuwon, Michael B. Atkins
Summary: A retrospective study of 122 patients with advanced melanoma treated with anti PD-1 therapy found that discontinuation of treatment after 12 months when no active disease is observed on imaging or biopsy may have low rates of disease relapse. Biopsy of residual disease may frequently lead to a change in management.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Luc Ollivier, Charles Orione, Paul Bore, Laurent Misery, Delphine Legoupil, Jean-Christophe Leclere, Anne Coste, Gilles Girault, Iona Sicard-Cras, Clemence Kacperek, Francois Lucia, Dinu Stefan, Francois Thillays, Emmanuel Rio, Paul Lesueur, Christian Berthou, Dominique Heymann, Stephane Champiat, Stephane Supiot, Loig Vaugier
Summary: This retrospective study investigated the incidence of abscopal response (AR) in patients with metastatic melanoma who received palliative radiotherapy. The study found that AR is highly prognostic of overall survival, although it is a rare phenomenon. Multiple concurrent treatments with radiotherapy and immunotherapy, as well as acute inflammatory events such as infection, may promote AR.
Article
Immunology
Huiyu Yan, Aimin Jiang, Yinong Huang, Jun Zhang, Wenguang Yang, Wei Zhang, Tianya Liu
Summary: Exercise can function as a hypoxia modulator to improve the tumor immune microenvironment, thereby promoting anti-tumor efficacy and facilitating biologically safe sensitization of PD-1/PD-L1 immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Peter Kok-Ting Wan, Ricardo A. Fernandes, Leonard W. Seymour
Summary: Oncolytic viruses (OVs) have the potential to selectively kill tumor cells while amplifying the therapeutic agent within the tumor. Combination therapies, particularly with checkpoint inhibitor antibodies, have shown greater success than single agent treatments. This review examines the efficacy of encoding the antibodies within the OV genome versus administering them separately alongside OV treatments, and discusses key parameters influencing the superiority of these approaches.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Mona O. Mohsen, Matthew Heath, Matthias F. Kramer, Thalia Carreno Velazquez, Alan Bullimore, Murray A. Skinner, Daniel E. Speiser, Martin F. Bachmann
Summary: Intratumoral injections of nanoparticles can activate tumor antigen-specific T cells, providing local tumor control and systemic protection. This universal immunotherapy does not require patient-specific tumor antigen identification and is well tolerated and affordable.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
G. V. Long, A. Arance, L. Mortier, P. Lorigan, C. Blank, P. Mohr, J. Schachter, J. -J. Grob, M. Lotem, M. R. Middleton, B. Neyns, N. Steven, A. Ribas, E. Walpole, M. S. Carlino, C. Lebbe, M. Sznol, E. Jensen, M. A. Leiby, N. Ibrahim, C. Robert
Summary: Ipilimumab and BRAF +/- MEK inhibitors have antitumor activity as the first subsequent therapy after pembrolizumab in patients with advanced melanoma.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Dirk Schadendorf, Reinhard Dummer, Caroline Robert, Antoni Ribas, Ryan J. Sullivan, Timothy Panella, Meredith McKean, Edgardo S. Santos, Kimberli Brill, Anna Polli, Alessandra di Pietro, Paolo A. Ascierto
Summary: Despite significant progress in the treatment of BRAF-mutant melanoma, there are still limitations in terms of efficacy. This study aims to evaluate the efficacy and safety of combined targeted therapy and immunotherapy to further improve patient outcomes.
Article
Medicine, Research & Experimental
Paolo A. Ascierto, Allison Betof Warner, Christian Blank, Corrado Caraco, Sandra Demaria, Jeffrey E. Gershenwald, Nikhil I. Khushalani, Georgina V. Long, Jason J. Luke, Janice M. Mehnert, Caroline Robert, Piotr Rutkowski, Hussein A. Tawbi, Iman Osman, Igor Puzanov
Summary: The Great Debate session at the 2021 Melanoma Bridge virtual congress featured expert opinions on seven important issues in melanoma, covering various treatment options and techniques.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Sami Antoun, Emilie Lanoy, Samy Ammari, Siham Farhane, Lisa Martin, Caroline Robert, David Planchard, Emilie Routier, Anne Laure Voisin, Sabine Messayke, Stephane Champiat, Jean Marie Michot, Salim Laghouati, Olivier Lambotte, Aurelien Marabelle, Vickie Baracos
Summary: The association between high body mass index (BMI) and longer survival in patients on immune checkpoint inhibitors (ICIs) is inconsistent. This study found that the 'obesity paradox' disappeared when accounting for confounders such as cancer type and manifestations of depletion. Weight loss and reduced skeletal muscle mass were observed in patients across all BMI categories, and weight loss was associated with shorter survival in both melanoma and non-small cell lung cancer (NSCLC) patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Franck Carbonnel, Emilie Routier, Thierry Lazure, Charlotte Mussini, Christophe Bellanger, Carine Merklen, Bakhtiar Bejou, Anthony Buisson, Aurelien Amiot, Antoine Meyer, Catherine Dong, Caroline Robert
Summary: This study provides the first systematic description of colitis caused by dual blockade of BRAF and MEK kinases in the treatment of melanoma. The study found that severe colitis characterized by ulcerations of the right colon can occur, leading to symptoms such as diarrhea, rectal bleeding, abdominal pain, and intestinal obstruction. In some cases, the colitis was associated with ischemic changes and inflammation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Caroline Robert, Celeste Lebbe, Thierry Lesimple, Eija Lundstrom, Valerie Nicolas, Bruno Gavillet, Philippa Crompton, Barouyr Baroudjian, Emilie Routier, Ferdy J. Lejeune
Summary: This study evaluated the safety and efficacy of combined treatment with GnRH agonist triptorelin and nivolumab in male melanoma patients resistant to anti-PD-1. The results showed that this combination therapy effectively controlled the disease, with a disease control rate of 42.8% according to RECIST criteria. However, evidence for thymus rejuvenation was limited.
CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Rym Sfaxi, Biswendu Biswas, Galina Boldina, Mandy Cadix, Nicolas Servant, Huimin Chen, Daniel R. Larson, Martin Dutertre, Caroline Robert, Stephan Vagner
Summary: The recognition of polyadenylation signals (PAS) in eukaryotic pre-mRNAs is usually coupled to transcription termination, occurring while pre-mRNA is chromatin-bound. However, for some pre-mRNAs, this 3'-end processing occurs post-transcriptionally, i.e., through a co-transcriptional cleavage (CoTC) event downstream of the PAS, leading to chromatin release and subsequent PAS cleavage in the nucleoplasm. These findings indicate that CoTC-type cleavage of pre-mRNAs, followed by PAS cleavage in the nucleoplasm, allows certain pre-mRNAs to escape 3'-end processing inhibition in response to UV-induced DNA damage.
Letter
Oncology
Marie Boileau, Emilie Routier, Arnaud Pouvelle, Olivier Lambotte, Caroline Robert
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Julia Lai-Kwon, Sarah Jacques, Matteo Carlino, Naima Benannoune, Caroline Robert, Clara Allayous, Barouyr Baroudjian, Celeste Lebbe, Lisa Zimmer, Zeynep Eroglu, Turkan Ozturk Topcu, Florentia Dimitriou, Andrew Haydon, Serigne N. Lo, Alexander M. Menzies, Georgina Long
Summary: This study investigates the efficacy of a combination therapy strategy involving low-dose ipilimumab (IPI) and an anti-PD1 antibody in advanced melanoma. The results show that the majority of patients who progress following low-dose IPI and subsequently receive IPI 3 mg/kg (IPI3) have a positive response to this treatment. This suggests that the dosage of IPI is critical for certain patients.
EUROPEAN JOURNAL OF CANCER
(2023)
Letter
Oncology
Antoine Moya-Plana, Carine Ngo, Emilie Lanoy, Stephan Vagner, Caroline Robert
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Caroline Robert, Matteo S. Carlino, Catriona Mcneil, Antoni Ribas, Jean-Jacques Grob, Jacob Schachter, Marta Nyakas, Damien Kee, Teresa M. Petrella, Arnold Blaustein, Michal Lotem, Ana Arance, Adil I. Daud, Omid Hamid, James Larkin, James Anderson, Clemens Krepler, Dmitri Grebennik, Georgina V. Long
Summary: Clinical trials often have multiple end points that mature at different times. Clinical Trial Updates provide a platform to publish additional results from studies where the primary end point has already been reported. This article presents the 7-year follow-up and efficacy results of pembrolizumab in advanced melanoma patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Celine Boutros, Djaouida Belkadi-Sadou, Antoine Marchand, Severine Roy, Emilie Routier, Caroline Robert
Summary: Immune checkpoint inhibitors (ICIs) have shown robust antitumor activity and tolerable safety in advanced melanoma. Long-term outcomes of patients who benefitted from this therapy and remain progression-free despite ICI discontinuation are now available. This review discusses the characteristics of long-term responders to ICIs and addresses the question of cure.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Andrey A. Yurchenko, Fatemeh Rajabi, Tirzah Braz-Petta, Hiva Fassihi, Alan Lehmann, Chikako Nishigori, Jinxin Wang, Ismael Padioleau, Konstantin Gunbin, Leonardo Panunzi, Fanny Morice-Picard, Pierre Laplante, Caroline Robert, Patricia L. Kannouche, Carlos F. M. Menck, Alain Sarasin, Sergey I. Nikolaev
Summary: Xeroderma pigmentosum (XP) is a rare genetic disorder associated with an increased risk of skin cancer. In this study, the authors analyze skin cancer genomes from five different XP groups, revealing genetic and molecular factors related to the mutational profile and UV-induced mutagenesis in XP.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Yi Pu, Lu Li, Haoning Peng, Lunxu Liu, Dominique Heymann, Caroline Robert, Francois Vallette, Shensi Shen
Summary: Drug-tolerant persister (DTP) cell populations have been discovered in antibiotic-resistant bacterial biofilms and have also been identified in cancer cells. They are linked with treatment resistance and targeting these cells may offer new treatment opportunities.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Oncology
Krisztian Homicsko, Reinhard Dummer, Christoph Hoeller, Jedd D. Wolchok, F. Stephen Hodi, James Larkin, Paolo A. Ascierto, Victoria Atkinson, Caroline Robert, Michael A. Postow, Sandra Re, David Paulucci, Darin Dobler, Olivier Michielin
Summary: This retrospective analysis examined the impact of proton pump inhibitors (PPIs) on the efficacy of immune checkpoint inhibitors (ICIs) in patients with advanced melanoma. The results showed insufficient evidence to support a meaningful association between PPI use and ICI efficacy.