Article
Cardiac & Cardiovascular Systems
Yi-Xin Wang, Lidia Minguez-Alarcon, Audrey J. Gaskins, Liang Wang, Ming Ding, Stacey A. Missmer, Janet W. Rich-Edwards, JoAnn E. Manson, Jorge E. Chavarro
Summary: The aim of this study was to investigate the association between pregnancy loss (PL) and cardiovascular disease (CVD), and to examine the role of subsequent metabolic disorders in mediating this relationship. The results showed that PL was associated with a higher risk of CVD, independent of the development of metabolic disorders.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zolt Arany, Denise Hilfiker-Kleiner, S. Ananth Karumanchi
Summary: Cardiovascular complications during pregnancy, such as preeclampsia and peripartum cardiomyopathy, have become a major cause of maternal mortality and have long-term effects on maternal cardiovascular health. However, the causes and mechanisms underlying these complications are not well understood, and treatment options are limited. Preclinical models have played an important role in advancing our understanding of these diseases.
CIRCULATION RESEARCH
(2022)
Article
Medicine, General & Internal
Clare Oliver-Williams, David Stevens, Rupert A. Payne, Ian B. Wilkinson, Gordon C. S. Smith, Angela Wood
Summary: This study compared the risk of cardiovascular disease outcomes for women with and without a history of gestational hypertension and pre-eclampsia using national hospital admissions data in England. The results showed that women with previous gestational hypertension or pre-eclampsia had a greater risk of various cardiovascular outcomes, including stroke, coronary heart disease, cardiomyopathy, and peripheral arterial disease. The associations were consistent across different cardiovascular disease subtypes and increased with the number of affected pregnancies.
Article
Medicine, General & Internal
Pietro Bortoletto, Emma S. Lucas, Pedro Melo, Ioannis D. Gallos, Adam J. Devall, Tom Bourne, Siobhan Quenby, Phillip R. Bennett, Arri Coomarasamy, Jan J. Brosens
Summary: After embryo implantation, the endometrium transforms into a robust decidual matrix to support the fetal placenta. Circulating NK cells and BM-MSC play a crucial role in decidual homeostasis and expansion in early pregnancy. Pathological signals that interfere with the recruitment or activity of extrauterine cells at the maternal-fetal interface may be linked to miscarriage and subsequent adverse pregnancy outcomes.
Article
Public, Environmental & Occupational Health
Sara Hallum, Thomas Alexander Gerds, Thomas Steen Gyldenstierne Sehested, Marianne Antonius Jakobsen, Anne Tjonneland, Mads Kamper-Jorgensen
Summary: The presence of male-origin microchimerism in women is associated with a reduced rate of later ischemic heart disease (IHD) development, but not ischemic stroke. This suggests a potential role of microchimerism in women's cardiovascular health, although further studies are needed to confirm these findings.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Monil Majmundar, Rajkumar Doshi, Kunal N. Patel, Harshvardhan Zala, Ashish Kumar, Ankur Kalra
Summary: This study analyzed the prevalence, trends, and outcomes of cardiovascular diseases (CVDs) in hospitalized pregnant patients in the USA from 2010 to 2019. The prevalence of CVDs increased over the years, but the in-hospital mortality rate decreased. CVDs were associated with higher rates of 6-week postpartum all-cause readmission, myocardial infarction, and stroke.
EUROPEAN HEART JOURNAL
(2023)
Article
Education & Educational Research
Benjamin Maxner, Barinder Hansra, Diana Sibai, Sheikh Moinul, Leslie Panella, Jeannine Jeha, Catherine Fiore, Tina Dumont, Julianne Lauring, Gerard Aurigemma, Colleen M. Harrington, Lara C. Kovell
Summary: A dedicated curriculum was developed to improve cardiology fellows' knowledge and confidence in recognizing and treating cardiovascular disease during pregnancy. The curriculum resulted in increased fellows' knowledge and confidence, although there was still a lack of exposure to pregnant women with cardiovascular disease.
BMC MEDICAL EDUCATION
(2022)
Article
Cardiac & Cardiovascular Systems
Gnanaraj Justin Paul, Steaphen Anne Princy, Surendran Anju, Susikar Anita, Majella Cecily Mary, Ganesan Gnanavelu, Kandasamy Kanmani, Mahalingam Meena, Mohanan Nandakumaran, Swaminathan Ramya, Govindarajulu Ravishankar, Gunasingh Shaanthi, Somasundaram Shoba, Venkatesan Sangareddi, Subramanian Vijaya, M PAC Investigators
Summary: This study aims to evaluate the outcomes of pregnant women with heart disease in Tamil Nadu, India, identify predictors of adverse outcomes, and assess the applicability of the modified WHO classification. It found that maternal mortality is high in these women, particularly in those with prosthetic heart valves, pulmonary hypertension, and left ventricular systolic dysfunction. The mWHO classification may need further adaptation and validation in India.
EUROPEAN HEART JOURNAL
(2023)
Article
Obstetrics & Gynecology
Gayathree Murugappan, Stephanie A. Leonard, Leslie Farland, Emily S. Lau, Aladdin H. Shadyab, Robert A. Wild, Peter Schnatz, Suzan L. Carmichael, Marcia L. Stefanick, Nisha Parikh
Summary: This study investigated the association of infertility with atherosclerotic cardiovascular disease (ASCVD) among postmenopausal women. The results showed that women with a history of infertility had a moderately higher risk of ASCVD compared to those without infertility. Additionally, nulliparous infertile women and nulliparous infertile women with a pregnancy loss had even higher ASCVD risks.
FERTILITY AND STERILITY
(2022)
Article
Public, Environmental & Occupational Health
Maria C. Magnus, Abigail Fraser, Janet W. Rich-Edwards, Per Magnus, Deborah A. Lawlor, Siri E. Haberg
Summary: The study found that both women and men with prolonged time-to-pregnancy have a slightly increased risk of cardiovascular disease. Further research is needed to investigate the clinical significance of this phenomenon and the underlying causes of the increased risk of CVD associated with prolonged TTP.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Obstetrics & Gynecology
E. G. Mulder, S. de Haas, Z. Mohseni, N. Schartmann, F. Abo Hasson, F. Alsadah, S. M. J. van Kuijk, J. van Drongelen, M. E. A. Spaanderman, C. Ghossein-Doha
Summary: During normotensive pregnancy, cardiac output gradually increases to its peak in early third trimester, while vascular resistance decreases until early third trimester before slightly increasing at term. In hypertensive pregnancies, initial increase in cardiac output is higher and vascular resistance remains stable throughout gestation compared to reference values. Monitoring haemodynamic changes in pregnancy can help identify women at risk for hypertensive complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Peripheral Vascular Disease
Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Summary: Women with a history of hypertensive disorders of pregnancy have higher rates of long-term cardiovascular events, and the American Heart Association calls for early identification and risk reduction by physicians. This review discusses the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Emily Aldridge, Maleesa Pathirana, Melanie Wittwer, Susan Sierp, Shalem Y. Leemaqz, Claire T. Roberts, Gustaaf A. Dekker, Margaret A. Arstall
Summary: The study investigates the prevalence of metabolic syndrome in women who experienced complications in pregnancy and found that a significant number of women already show signs of metabolic syndrome or multiple risk factors within 7 months postpartum.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sara Hallum, Saima Basit, Mads Kamper-Jorgensen, Thomas S. G. Sehested, Heather A. Boyd
Summary: Pre-eclampsia increases women's risk of cardiovascular disease, especially within a decade after delivery and for women aged 30-39 years. A history of pre-eclampsia can be used to identify women at increased risk of cardiovascular disease, and targeted interventions should be initiated soon after delivery.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Savine C. S. Minderhoud, Jolien W. Roos-Hesselink, Raluca G. Chelu, Lidia R. Bons, Allard T. van den Hoven, Suze-Anne Korteland, Annemien E. van den Bosch, Ricardo P. J. Budde, Jolanda J. Wentzel, Alexander Hirsch
Summary: This study compared the distribution of aortic wall shear stress (WSS) between patients with bicuspid aortic valve (BAV) and healthy controls, and found that the WSS angle was associated with aortic dilation in BAV patients. These findings are important for stratifying BAV patients at risk for aortic dilation.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Frederike Meccanici, Arjen L. Gokalp, Carlijn G. E. Thijssen, Mostafa M. Mokhles, Jos A. Bekkers, Roland van Kimmenade, Hence J. Verhagen, Jolien W. Roos-Hesselink, Johanna J. M. Takkenberg
Summary: This systematic review aimed to examine male-female differences in presentation, management, and outcomes in patients diagnosed with acute thoracic aortic dissection. While differences in patient and treatment characteristics were found, there were comparable early and overall mortality rates, and inconsistent outcome reporting. Further large prospective studies with standardized reporting are needed to improve understanding of these differences and guide individualized care.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Karishma P. Ramlakhan, Isabelle Malhame, Ariane Marelli, Tobias Rutz, Sorel Goland, Arie Franx, Karen Sliwa, Uri Elkayam, Mark R. Johnson, Roger Hall, Jerome Cornette, Jolien W. Roos-Hesselink
Summary: The study assessed the prevalence and outcomes of hypertensive disorders of pregnancy (HDP) and pre-eclampsia in women with heart disease, showing higher rates in those with cardiomyopathy, ischemic heart disease, and pulmonary arterial hypertension. Adverse outcomes were increased in women with HDP, particularly in those with pre-eclampsia.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Frederike Meccanici, Mathilda H. Schotte, Miranda Snoeren, Lidia R. Bons, Allard T. van den Hoven, Isabella Kardys, Ricardo P. J. Budde, Annemien E. van den Bosch, Anthonie L. Duijnhouwer, Jolien W. Roos-Hesselink
Summary: This study describes the prevalence of aortic dilation in women with Turner syndrome (TS) and identifies factors associated with this condition. The study also examines aortic growth over a 3-year period. The results show that aortic dilation is common in women with TS, and is associated with age, the presence of a bicuspid aortic valve, and systolic blood pressure. Aortic diameters remain stable over the 3-year follow-up period, except for a minor increase at the sinotubular junction.
Article
Cardiac & Cardiovascular Systems
Paul M. Hendriks, Robert M. Kauling, Laurie W. Geenen, Jannet A. Eindhoven, Jolien W. Roos-Hesselink, Karin A. Boomars, Annemien E. van den Bosch
Summary: This study investigated the prognostic value of ECG characteristics in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). It found that only a small percentage of patients had a normal ECG, which was associated with a favorable outcome. The ECG provided additional prognostic value to current clinical parameters and should be considered in risk prediction.
Article
Obstetrics & Gynecology
Karishma P. Ramlakhan, Johanna A. van Der Zande, Jolien W. Roos-Hesselink, Arie Franx, Jerome Cornette
Summary: The study assessed the long-term quality of life after obstetric ICU admission and found that it is associated with reductions in physical and mental health. The findings suggest the need for multidisciplinary rehabilitation and long-term psychosocial support.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
C. Pelosi, R. M. Kauling, J. A. A. E. Cuypers, A. E. van den Bosch, W. A. Helbing, E. M. W. J. Utens, J. S. Legerstee, J. W. Roos-Hesselink
Summary: Nowadays, a large number of adults with congenital heart disease (CHD) have attained adulthood, but there is limited knowledge about their psychosocial functioning. This longitudinal cohort study followed 204 patients who underwent surgery for CHD during childhood and found that despite lower education and employment rates, CHD patients had better health-related quality of life and emotional functioning compared to the general population.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Engineering, Biomedical
Amira Assaf, Dominic A. M. J. Theuns, Michelle Michels, Jolien Roos-Hesselink, Tamas Szili-Torok, Sing-Chien Yap
Summary: The 2018 ESC Syncope guidelines expanded the indications for an insertable cardiac monitor (ICM) to include patients with unexplained syncope and primary cardiomyopathy or inheritable arrhythmogenic disorders. This review article discusses the clinical evidence for using an ICM for risk stratification in different patient populations, including various cardiac conditions. The experts suggest that while there is limited data on the usefulness of ICMs in these populations, most studies demonstrate its early detection of clinically relevant arrhythmias. However, the impact of ICMs on prognosis is difficult to demonstrate in populations with rare diseases.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Review
Cardiac & Cardiovascular Systems
F. Meccanici, J. W. C. de Bruijn, J. S. Dommisse, J. J. M. Takkenberg, A. E. van den Bosch, J. W. Roos-Hesselink
Summary: This study aimed to systematically review the prevalence of aortic disease among women with Turner syndrome (TS). The results showed that ascending aortic dilatation is common in adult TS women, and there is an increased risk of aortic dissection.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jolien W. Roos-Hesselink, Johanna A. van der Zande, Mark R. Johnson
EUROPEAN HEART JOURNAL
(2023)
Review
Endocrinology & Metabolism
Anna G. W. Rosenberg, Veerle D. A. Dingemans, Anja G. Bos-Roubos, Sanne Luijks, Arianne B. Dessens, Ramon Dykgraaf, Jolien W. Roos-Hesselink, Elisabeth F. C. Van Rossum, Aart J. Van Der Lely, Laura C. G. De Graaff
Summary: Turner syndrome (TS) is a rare chromosomal disorder characterized by gonadal dysfunction, short stature, and heart defects. This study aimed to explore the association between fatigue and endocrine and non-endocrine comorbidities in women with TS. The results showed that liver enzyme disturbances, body mass index, and perceived stress were significantly associated with fatigue, while most endocrine and non-endocrine disorders were not. This suggests that fatigue in women with TS is only partly explained by somatic disorders, and TS-related neuropsychological processes may play an important role in its etiology. A practical algorithm for managing fatigue in women with TS is provided.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Feyza Memis, Carlijn G. E. Thijssen, Arjen L. Gokalp, Maximiliaan L. Notenboom, Frederike Meccanici, Mohammad Mostafa Mokhles, Roland R. J. van Kimmenade, Kevin M. Veen, Guillaume S. C. Geuzebroek, Jelena Sjatskig, Franciscus J. ter Woorst, Jos A. Bekkers, Johanna J. M. Takkenberg, Jolien W. Roos-Hesselink
Summary: This study aims to evaluate patient and procedural characteristics and compare the outcomes and mortality after surgery between elderly and non-elderly patients with ascending aortic aneurysm. The study found that elderly patients had larger aortic diameters and more cardiovascular risk factors. Short-term mortality was comparable between elderly and non-elderly patients, but the five-year survival rate was lower in elderly patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
J. A. van der Zande, G. Wander, K. P. Ramlakhan, J. W. Roos-Hesselink, M. R. Johnson
Summary: Due to improved survival rates in individuals with CHD, considering their reproductive health is important. This paper discusses fertility, sexuality, assisted reproductive technology (ART), and contraception in adults with CHD. The expert opinion suggests that timely counseling is necessary, and ART decisions are typically based on expert opinion with follow-up in an expert center recommended. Further research is needed to fill gaps in knowledge on the risks and frequency of complications of ART in adults with CHD, as well as differentiate relative risks in different types of CHD.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Gurleen Wander, Johanna A. van der Zande, Roshni R. Patel, Mark R. Johnson, Jolien Roos-Hesselink
Summary: This article provides an overview of common scenarios and management strategies for congenital heart disease (CHD) during pregnancy, including preconception counseling, antenatal management, and strategies to prevent maternal and fetal complications. Preconception counseling should start early and be offered to both men and women, addressing contraception choices, lifestyle modifications, cardiac optimization, chances of inherited cardiac lesions in the child, risks to the mother, and long-term prognosis. Pregnancy induces cardiovascular changes that may result in cardiac complications, and risk stratification is based on the underlying cardiac disease and data from studies. Women with lower-risk CHDs can be managed in secondary care, while complex CHD cases require expert counseling in tertiary centers. Those with high-risk conditions should avoid pregnancy, use effective contraception, and seek tertiary center management if pregnancy does occur.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Robert M. Kauling, Rienk Rienks, Judith A. A. E. Cuypers, Harald T. Jorstad, Jolien W. Roos-Hesselink
Summary: Conventionally, scuba diving has been discouraged for adult patients with congenital heart disease (ACHD) due to absence of high-quality diving-specific studies. However, as survival and quality of life in congenital heart disease (CHD) patients have improved, it is necessary to critically evaluate the applicability of this restrictive sports advice. This review provides a framework for the work-up for ACHD patients wishing to engage in scuba diving and proposes diving recommendations for specific CHD diagnostic groups.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)