Organotypic culture assays for murine and human primary and metastatic-site tumors

MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

(2020) Renumathy Dhanasekaran et al.   eLife

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Twist1-induced epithelial dissemination requires Prkd1 signaling

(2019) Dan Georgess et al.   CANCER RESEARCH

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Myoepithelial cells are a dynamic barrier to epithelial dissemination

(2018) Orit Katarina Sirka et al.   JOURNAL OF CELL BIOLOGY

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

(2017) Tuomas Tammela et al.   NATURE

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2016) Minoru Takasato et al.   NATURE

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Organoid culture systems for prostate epithelial and cancer tissue

(2016) Jarno Drost et al.   Nature Protocols

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis

(2014) Q. Chen et al.   GENES & DEVELOPMENT

Twist1-induced dissemination preserves epithelial identity and requires E-cadherin

(2014) Eliah R. Shamir et al.   JOURNAL OF CELL BIOLOGY

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

(2013) Kevin J. Cheung et al.   CELL

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

(2013) Meritxell Huch et al.   EMBO JOURNAL

Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix

(2013) K.-V. NGUYEN-NGOC et al.   JOURNAL OF MICROSCOPY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

A functional CFTR assay using primary cystic fibrosis intestinal organoids

(2013) Johanna F Dekkers et al.   NATURE MEDICINE

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium

(2012) A. J. Ewald et al.   JOURNAL OF CELL SCIENCE

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

(2012) Jiri Kalabis et al.   Nature Protocols

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium

(2012) K.-V. Nguyen-Ngoc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K/mTOR signaling regulates prostatic branching morphogenesis

(2011) Susmita Ghosh et al.   DEVELOPMENTAL BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

(2010) Nick Barker et al.   Cell Stem Cell

Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues

(2009) Mathieu Unbekandt et al.   KIDNEY INTERNATIONAL

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE