Journal
NATURAL PRODUCT RESEARCH
Volume 36, Issue 2, Pages 595-600Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1795855
Keywords
Portulaca oleraceaL; alkaloid; isolation; anti-inflammatory
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Funding
- National Natural Science Foundation of China [81573546]
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A novel alkaloid, portulacatone A, was identified from Portulaca oleracea. It was found to significantly inhibit the inflammatory factor IL-1β.
A novel alkaloid identified as methyl 8,9-dihydroxy-11-oxo-6,11-dihydro-5H-benzo[d]pyrrolo[1,2-a]azepine-3-carboxylate, named portulacatone A (1) with six known compounds Oleracein E (2), 6,7-dihdroxy-3,4-dihydro-2H-isoquinolin-1-one (3),N-trans-p-coumaroytyramine (4), 9H-carbazole (5), isoaspergin (6) and flavoglaucin (7) were obtained fromPortulaca oleraceaL., while compounds (5-7) were isolated from the plant for the first time. The new structure was identified by using UHPLC-ESI-Q-TOF/MS, 1D, 2D NMR and the others were proved by(1)H-NMR and(13)C NMR that comparing with previous reports. It was suggested that the portulacatone A (1) can significantly inhibit the inflammatory factor, interleukin-1 beta (IL-1 beta) in the RAW 264.7 cells induced by LPS.
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