Article
Infectious Diseases
Sundaram Muthukrishnan, Paranivasakam Prakathi, Thangavel Sivakumar, Muthu Thiruvengadam, Bindhu Jayaprakash, Venkidasamy Baskar, Maksim Rebezov, Marina Derkho, Gokhan Zengin, Mohammad Ali Shariati
Summary: Endophytic fungi residing in medicinal plants have the potential to produce various bioactive compounds. In this study, three endophytic fungi were isolated from different medicinal plants and their intra- and extracellular products were analyzed. The analysis revealed the presence of bioactive metabolites and phytochemicals, and the extracts exhibited strong antibacterial and antioxidant activity. Molecular docking analysis also suggested the potential anticancer activity of certain compounds. These findings highlight the importance of endophytic fungi in natural drug development and reducing the environmental burden of synthetic drugs.
Article
Chemistry, Multidisciplinary
Y. Huang, L. Chen, B. He, S. Y. Liu, D. Q. Zeng, Y. H. Wang, L. W. Du, W. W. Tang
Summary: The residue of traditional Chinese medicine contains many nutrients and active substances that can be processed into organic fertilizer for soil fertility improvement. In this study, it was found that Brucea javanica residue has herbicidal activity, with certain compounds showing potential herbicidal effects against common weeds.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Microbiology
Tharuka Wijesekara, Baojun Xu
Summary: The study examines the intricate relationship between plants and the endophytic fungi inhabiting their tissues. These fungi coexist with plants, forming a symbiotic connection that has potential implications for plant health and growth. The bioactive compounds produced by these fungi hold promise for human health.
Article
Microbiology
Longfeng Wei, Qinyu Zhang, Ailin Xie, Yang Xiao, Kun Guo, Shuzhen Mu, Yudan Xie, Zhu Li, Tengxia He
Summary: This study explored the bioactive compounds of Aspergillus niger and evaluated their antibacterial activity against three plant pathogens. The results showed that compound 4 exhibited the strongest antibacterial activity against Ralstonia solanacearum, suggesting its potential as a biocontrol agent.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meysam Firoozbahr, Peter Kingshott, Enzo A. Palombo, Bita Zaferanloo
Summary: Wound care is a significant health issue globally, causing a financial burden of nearly $96.8 billion annually in the USA alone. Chronic non-healing wounds are especially problematic, and new and more efficient wound dressings are needed. The misuse of antibiotics and the lack of novel antibacterial agents have led to an increase in antimicrobial resistance, making the development of new antibacterial additives in wound dressings urgent. Natural products, particularly those derived from plants and endophytic fungi, show great potential in wound dressing applications as antibacterial agents.
Article
Chemistry, Multidisciplinary
Piergiorgio Cianciullo, Viviana Maresca, Sergio Sorbo, Adriana Basile
Summary: Global health problems such as increased risks of oxidative stress-related diseases and antibiotic resistance are serious concerns. Bryophytes synthesize a large number of secondary metabolites that have potential therapeutic and nutraceutical applications. Some of these compounds have shown promising antibacterial activities and antioxidant potential in vitro.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Jiao Wu, Bingjun Han, Xiaoyu Chen, Jinglin Gao, Shan Zhao, Liping Sun, Shijie Wang
Summary: In this study, the quality of Malaysian stingless bee honeys was assessed based on physicochemical characteristics, phenolic compounds, and organic acids. The dominant phenolic compounds were chlorogenic acid and myricetin, while gluconic acid and trans-cinnamic acid were the major organic acids. The microbial community analysis indicated that Lactobacillus was the predominant bacterium in stingless bee honeys. Furthermore, the antibacterial activity of these honeys was examined to demonstrate their potential health benefits.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agronomy
Raphael Mota Garrido, Franck Emmanuel Dayan, Rosana Marta Kolb
Summary: Weeds cause significant yield loss and increase production costs for farmers globally. Natural extracts, such as smoke water, have the potential to be alternatives to synthetic herbicides or sources for discovering new pesticides. This study found that smoke water solutions inhibited germination and initial growth of various weeds, demonstrating their potential as herbicides. Field tests are necessary to confirm their effectiveness.
Article
Food Science & Technology
Jiao Wu, Bingjun Han, Shan Zhao, Yihai Zhong, Wensu Han, Jinglin Gao, Shijie Wang
Summary: This study evaluated the chemical composition, microbial community, and activity of honey produced by different bee species in Hainan province, China. The results showed that the honey from Lepidotrigona flavibasis had the highest antioxidant and antimicrobial activity.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Microbiology
Martin Muthee Gakuubi, Madhaiyan Munusamy, Zhao-Xun Liang, Siew Bee Ng
Summary: Fungi have long served as repositories of bioactive secondary metabolites and the demand for new drugs is increasing. Exploring understudied and specialized microbes is a promising way to discover potential new drug lead compounds. Plant-associated fungi known as endophytes, with unique bioactive compounds, have emerged as an important source for drug discovery.
Article
Chemistry, Applied
Md. Saddam Hossain, Md. Shahiduzzaman, Mohammad Abdur Rahim, Methun Paul, Rajib Sarkar, Farjana Showline Chaity, Md. Najem Uddin, G. M. Masud Rana, Mst. Sarmina Yeasmin, Amena Kibria, Saiful Islam
Summary: Studies are being carried out to achieve high-quality garlic through various approaches. In Bangladesh, new garlic varieties have been developed through artificial selection to enhance their quality. This study evaluated the bioactive properties and organosulfur compounds content of these varieties and compared them with other accessible varieties. The findings showed that the new variety, BARI-3, had the highest antioxidant activity and contained a potent blood pressure-lowering agent at an unprecedented level. However, the local variety exhibited greater inhibitory properties against tested pathogens. This study highlights the potential of these garlic varieties for further utilization and development.
Article
Microbiology
Senthuran Sureshkumar, Iniya Merlin, Jiwan R. Prasai, Pandy Rajapriya, Mohan Pandi
Summary: This study focuses on the antioxidant, antibacterial, phytochemical potential, and cytotoxicity of secondary metabolites from four fungi. Among them, A. arborescens shows higher antioxidant and antibacterial activity, as well as significant cytotoxicity against cancer cells.
JOURNAL OF BASIC MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rodion Khotimchenko, Igor Bryukhovetskiy, Maksim Khotimchenko, Yuri Khotimchenko
Summary: The study reviews the outcomes of screening studies of natural compounds with high anti-glioma activity, emphasizing the potential for greater diversity of marine compounds and likelihood of finding effective molecules. It covers the main problems of glioma chemotherapy and provides information on at least 15 classes of organic compounds with their chemical formulas and pharmacokinetic profiles. The taxonomic diversity of marine species containing bioactives with antiglioma activity is analyzed, noting cytotoxicity indicators and comparing them to similar indicators of antitumor agents for clinical use.
Article
Biochemistry & Molecular Biology
Giusy Rita Caponio, Mirella Noviello, Francesco Maria Calabrese, Giuseppe Gambacorta, Gianluigi Giannelli, Maria De Angelis
Summary: Grape pomace is a byproduct rich in phenolic compounds and secondary metabolites, with potential health benefits. This study evaluated the antioxidant and antimicrobial activity of grape pomace extracts using two different extraction methods, finding that aqueous extracts showed increased antioxidant activity after gastrointestinal digestion, while hydroalcoholic extracts decreased.
Article
Plant Sciences
Robert W. Schumacher, Amanda L. Waters, Jiangnan Peng, Richard A. Schumacher, Ailish Bateman, Josie Thiele, Andrew J. Mitchell, Samuel G. Miller, Arthur Goldberg, Siddharth K. Tripathi, Ameeta K. Agarwal, Yike Zou, Yeun-Mun Choo, Mark T. Hamann
Summary: Two new lactone lipids, scoriosin (1) and its methyl ester (2), with unique structures were isolated from Scorias spongiosa, showing potent antimicrobial activities and potential utility in combination therapies for treating cryptococcal infections.
JOURNAL OF NATURAL PRODUCTS
(2022)
