Article
Nanoscience & Nanotechnology
Jianhang Li, Guanbin Gao, Xintong Tang, Meng Yu, Meng He, Taolei Sun
Summary: The chemical and physical properties of nanobio interfaces can significantly impact the conformational transitions of adjacent biomolecules. This study investigates the isomeric effect of nanobio interfaces on the misfolding, aggregation, and fibrillation of A beta(40) using three different isomeric AuNCs. The results show that the inhibition efficiency of o-MBA-AuNCs is higher than that of m-MBA-AuNCs and p-MBA-AuNCs, providing insights for structure-based nanodrug design targeting Alzheimer's disease and other protein conformational diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke, Chunying Chen, Yuliang Zhao
Summary: Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology that focus on nano-bio interface, with shared goals and challenges. In recent years, the relationship between the two fields has become closer, and their joint development can bring greater benefits to human health and environmental safety.
Review
Chemistry, Multidisciplinary
Bo Li, Jiahui Mao, Jiawei Wu, Kerou Mao, Yangrui Jia, Fulin Chen, Jing Liu
Summary: This review introduces the biological characteristics of biofilm and discusses the interactions between biofilm and nanomaterials. The focus is on nanomaterials-based antibacterial strategies, including biofilm targeting, preventing biofilm formation, enhancing biofilm penetration, disrupting the mature biofilm, and acting as drug delivery systems. The current advances in nanomaterials for antibacterial nanomedicines via biofilm targeting are also summarized.
Article
Engineering, Biomedical
Chenyang Yin, Yuqing Li, Ziyu Liao, Zekun Wang, Chunxue Dai, Weiyun Wang, Endong Yang, Feng Guo, India R. Wright, Lisandra L. Martin, Dongdong Sun
Summary: A functionalized, smart nanosonosensitizer, Bac@ARS, based on Au-RuO2 nanoparticles and selenium nanoparticles, was developed. Bac@ARS exhibited highly efficient ROS-producing activity and optimized sonosensitivity. It was able to remodel the tumor microenvironment and generate excess reactive oxygen species (ROS) for improved tumor treatment.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Multidisciplinary
Jieying Liang, Kang Liang
Summary: Metal-organic frameworks (MOFs) have made significant progress in the field of bio-interface engineering, expanding the applications of biotechnology. Through design and integration with various biomacromolecules and living systems, MOFs exhibit unique interfacial interactions and application potential.
Article
Chemistry, Physical
Dillon R. McCarthy, Jacob M. Remington, Jonathon B. Ferrell, Severin T. Schneebeli, Jianing Li
Summary: DNA nanostructures are promising nanomedical tools due to their biocompatibility and adjustability. Recent research focuses on the interaction between DNA nanocages decorated with organic dendrimers and human serum albumin (HSA). The study reveals the fuzzy interactions between these structures and provides insights for the design of next-generation DNA nanomedicines.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Review
Engineering, Biomedical
Lucia Abarca-Cabrera, Paula Fraga-Garcia, Sonja Berensmeier
Summary: This paper critically reviews experimental studies on the interactions between low cost IONPs and biomolecules, emphasizing on the driving forces and unique structural characteristics of biomolecular classes at the solid-liquid interface. Future work is needed to improve nanoparticles' targeting capabilities in complex systems and to facilitate multipurpose recognition and bioseparation processes.
BIOMATERIALS RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Jie Li, Na Lu, Suping Han, Xuemei Li, Mengqin Wang, Mengchao Cai, Zisheng Tang, Min Zhang
Summary: Nanomaterials with enzyme-like activity, or nanozymes, have attracted significant interest for a wide range of applications. This study focused on understanding the interactions between nanozymes and common biomolecules, and explored the construction of bio-nano interfaces for modulating catalytic activities. The research also developed strategies for precise protein identification, colorimetric detection of GSH, and investigated factors influencing the interactions at bio-nano interfaces, offering new opportunities for utilizing nanozymes in bioanalysis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Ni-Yuan Zhang, Da-Yong Hou, Xing-Jie Hu, Jian-Xiao Liang, Man-Di Wang, Zhang-Zhi Song, Li Yi, Zhi-Jia Wang, Hong-Wei An, Wanhai Xu, Hao Wang
Summary: Reported here is an intracellular fabricated Nano-PROTACs modality with a center-spoke degradation network, which achieves efficient dose-dependent protein degradation in tumor. Nano-PROTACs are self-assembled by intermolecular hydrogen bond interactions triggered by higher GSH concentrations inside tumor cells, forming fibrous structures that can form effective polynary complexes and E3 ligases degradation network. Nano-PROTACs demonstrate dose-dependent protein degradation of variable proteins of interest (POI) in vitro, with a degradation rate of 95% and long-lasting potency up to 72 h. In vivo, Nano-PROTACs achieve dose-dependent protein degradation up to 79% and tumor growth inhibition in xenograft mouse models.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Carlos Sanchez-Cano, Ramon A. Alvarez-Puebla, John M. Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N. Chapman, Chunying Chen, Bruce E. Cohen, Andre L. C. Conceicao, David P. Cormode, Daxiang Cui, Kenneth A. Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni, Claus-C Glueer, Florian Gruener, Moustapha Hassan, Yong Hu, Yalan Huang, Samuel Huber, Nils Huse, Yanan Kang, Ali Khademhosseini, Thomas F. Keller, Christian Koernig, Nicholas A. Kotov, Dorota Koziej, Xing-Jie Liang, Beibei Liu, Sijin Liu, Yang Liu, Ziyao Liu, Luis M. Liz-Marzan, Xiaowei Ma, Andres Machicote, Wolfgang Maison, Adrian P. Mancuso, Saad Megahed, Bert Nickel, Ferdinand Otto, Cristina Palencia, Sakura Pascarelli, Arwen Pearson, Oula Penate-Medina, Bing Qi, Joachim Raedler, Joseph J. Richardson, Axel Rosenhahn, Kai Rothkamm, Michael Rubhausen, Milan K. Sanyal, Raymond E. Schaak, Heinz-Peter Schlemmer, Marius Schmidt, Oliver Schmutzler, Theo Schotten, Florian Schulz, A. K. Sood, Kathryn M. Spiers, Theresa Staufer, Dominik M. Stemer, Andreas Stierle, Xing Sun, Gohar Tsakanova, Paul S. Weiss, Horst Weller, Fabian Westermeier, Ming Xu, Huijie Yan, Yuan Zeng, Ying Zhao, Yuliang Zhao, Dingcheng Zhu, Ying Zhu, Wolfgang J. Parak
Summary: X-ray-based analytics are widely used in physics, chemistry, materials science, and engineering, but their full potential in life sciences and medicine has not been fully utilized. Current and upcoming advances in applying these techniques to investigate the nano-bio interface are discussed, along with addressing current limitations and potential strategies for future in vivo use.
Article
Environmental Sciences
Nelofer Jan, Neelofar Majeed, Muneeb Ahmad, Waseem Ahmad Lone, Riffat John
Summary: Nanoparticles are highly diverse in quality and sources of emission. The lack of rules and regulations has led to severe impacts on the environment and human health, with only a few studies assessing their toxic effects. Further research is needed to determine the actual impacts of nanoparticles on the environment and human health.
Review
Pharmacology & Pharmacy
Khatereh Khorsandi, Sepehr Fekrazad, Farshid Vahdatinia, Abbas Farmany, Reza Fekrazad
Summary: This study evaluates the potential therapeutic effects of Nano antiviral photodynamic therapy on COVID-19, based on data extracted from various published studies. While studies indicate that aPDT and Nano-based aPDT may be useful in viral pulmonary complications, there is a lack of direct research on SARS-Cov-2. Recent findings suggest that Nano-based aPDT could play a role in controlling the stages of viral infections, highlighting the need for further investigation in utilizing nanomedicine for COVID-19 management.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Chemistry, Multidisciplinary
Panagiota Papadopoulou, Rianne van der Pol, Niek van Hilten, Winant L. van Os, Roy Pattipeiluhu, Gabriela Arias-Alpizar, Renzo Aron Knol, Willem Noteborn, Mohammad-Amin Moradi, Maria Joao Ferraz, Johannes Maria Franciscus Gerardus Aerts, Nicolaas Antonius Johannes Maria Sommerdijk, Frederick Campbell, Herre Jelger Risselada, Geert Jan Agur Sevink, Alexander Kros
Summary: The membrane-protein interface on lipid-based nanoparticles has an impact on their behavior in vivo. Understanding how lipids and proteins interact can improve targeted drug delivery. This study investigates the changes in composition and morphology of phase-separated liposomes induced by lipases and reveals the mechanism by which lipases recognize and bind to these particles. The findings demonstrate the selective degradation of phase-separated lipid droplets by lipases and the preferential binding of lipases to the particles due to lipid packing defects induced by phase separation. The study also shows how phase separation can be used to generate mRNA-LNPs that selectively target specific cells and deliver mRNA for protein expression in zebrafish embryos. Overall, these findings contribute to our understanding of selective nanoparticle-protein communications and in vivo behavior, which can help improve control over lipid-based nanoparticles.
ADVANCED MATERIALS
(2023)
Article
Engineering, Mechanical
Xueshen Liu, Xincong Zhou, Chaozhen Yang, Jian Huang, Peng Wang
Summary: This paper investigates the interaction between nano-SiO2 and NBR and its effect on the tribological properties of water-lubricated NBR-based composites. The results show that the strength of the interface bonding affects the wear mechanism and friction performance of NBR. Surface-modified SiO2(TESPT) particles have stronger interface bonding with the matrix, which improves the wear resistance of NBR but also increases the friction coefficient of the composite.
Article
Polymer Science
Hai-Xiao Wan, Duo Xu, Xue-Wei Dong, Kai Yang, Li-Tang Yan
Summary: The development of biopolymers for biomedical applications has traditionally focused on new chemistries, but it is now recognized that the physical properties of biomaterials also play a role in regulating biological responses. This review article explores how computer simulations and theoretical analysis can be used to understand the physicochemical principles of biopolymer cellular interactions. The findings and correlations between theoretical results and experiments are summarized, and the future prospects for this field are discussed.
CHINESE JOURNAL OF POLYMER SCIENCE
(2023)
