Journal
MOVEMENT DISORDERS
Volume 35, Issue 9, Pages 1509-1531Publisher
WILEY
DOI: 10.1002/mds.28097
Keywords
integrated care; meta-analysis; multidisciplinary team; Parkinson's disease
Categories
Funding
- DST-SERB
- Michael J. Fox Foundation
- All India Institute of Medical Sciences, New Delhi
- Netherlands Organization for Scientific Research
- UCB
- AbbVie
- Stichting Parkinson Fonds
- Hersenstichting Nederland
- Parkinson's Foundation
- Verily Life Sciences
- Horizon 2020
- Topsector Life Sciences and Health
- Gatsby Foundation
- Parkinson Vereniging
- Civitas Therapeutics
- Parkinson Canada
- Ontario Brain Institute
- PSI Foundation
- Parkinson Research Consortium
- uOBMRI
- CIHR
- Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]
- NKFIH [EFOP3.6.2-16-2017-00008, SNN125143]
- Higher Education Institutional Excellence Programme of the Ministry for Innovation and Technology in Hungary, within University of Pecs
- AbbVie Pharmaceuticals
- DongA
- Pharma2B
- Impax
- Theravance
- Park Nicolet Foundation
- Biotie Therapies
- DBT
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Background Quality of life in Parkinson's disease (PD) is affected by motor and nonmotor symptoms, necessitating an integrated care approach. Existing care models vary considerably in numerous domains. The objectives of this study were to perform a systematic review and meta-analysis of PD integrated care models and develop recommendations for a representative model. Methods We conducted a systematic review of published integrated care models and a meta-analysis of randomized, controlled trials examining integrated care versus standard care. The primary outcome was health-related quality of life using a validated PD scale. We evaluated levels of care integration using the Rainbow Model of Integrated Care. Results Forty-eight publications were identified, including 8 randomized, controlled trials with health-related quality of life data (n = 1,149 total PD patients). Qualitative evaluation of individual care model integration guided by the Rainbow Model of Integrated Care revealed frequent clinical and professional integration, but infrequent organizational and population-based integration elements. Meta-analysis of randomized, controlled trials revealed significant heterogeneity (I-2 = 90%,P< 0.0001). Subgroup analysis including only outpatient care models (n = 5) indicated homogeneity of effects (I-2 = 0%,P= 0.52) and improved health-related quality of life favoring integrated care, with a small effect size (standardized mean difference [SMD], -0.17; 95% CI, -0.31 to -0.03;P= 0.02). Conclusions Outpatient integrated PD care models may improve patient-reported health-related quality of life compared with standard care; however, because of variable methodological approaches and a high risk of bias related to inherent difficulties in study design (eg, blinding of participants and interventionists), generalizability of these results are difficult to establish. The Rainbow Model of Integrated Care is a promising method of evaluating elements and levels of integration from individual patient care to population health in a PD context. (c) 2020 The Authors.Movement Disorderspublished by Wiley Periodicals, LLC. on behalf of International Parkinson and Movement Disorder Society.
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