Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB

Properties of FDA-approved small molecule protein kinase inhibitors

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials

(2018) Fabrice Carles et al.   MOLECULES

PubChem 2019 update: improved access to chemical data

(2018) Sunghwan Kim et al.   NUCLEIC ACIDS RESEARCH

VSPrep: A General KNIME Workflow for the Preparation of Molecules for Virtual Screening

(2017) José-Manuel Gally et al.   Molecular Informatics

Assessing Scaffold Diversity of Kinase Inhibitors Using Alternative Scaffold Concepts and Estimating the Scaffold Hopping Potential for Different Kinases

(2017) et al.   MOLECULES

Trastuzumab in the Treatment of Breast Cancer

(2016) Sofia Maximiano et al.   BIODRUGS

The ChEMBL database in 2017

(2016) Anna Gaulton et al.   NUCLEIC ACIDS RESEARCH

Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Current kinase inhibitors cover a tiny fraction of fragment space

(2015) Hongtao Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ten things you should know about protein kinases: IUPHAR Review 14

(2015) Doriano Fabbro et al.   BRITISH JOURNAL OF PHARMACOLOGY

Better Informed Distance Geometry: Using What We Know To Improve Conformation Generation

(2015) Sereina Riniker et al.   Journal of Chemical Information and Modeling

What does the aromatic ring number mean for drug design?

(2014) Simon E Ward et al.   Expert Opinion on Drug Discovery

Immune diseases caused by mutations in kinases and components of the ubiquitin system

(2014) Philip Cohen   NATURE IMMUNOLOGY

Quinazoline-based multi-tyrosine kinase inhibitors: Synthesis, modeling, antitumor and antiangiogenic properties

(2013) Maria Teresa Conconi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Significance of Chirality in Drug Design and Development

(2011) W. H. Brooks et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Rule-Based Classification of Chemical Structures by Scaffold

(2011) Ansgar Schuffenhauer et al.   Molecular Informatics

Dissecting the role of mTOR: Lessons from mTOR inhibitors

(2009) Ryan J.O. Dowling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents

(2009) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE