Identification of BLNK and BTK as mediators of rituximab‐induced programmed cell death by CRISPR screens in GCB‐subtype diffuse large B‐cell lymphoma

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

(2020) Lionel Rougé et al.   SCIENCE

High CXCR4 expression impairs rituximab response and the prognosis of R-CHOP-treated diffuse large B-cell lymphoma patients

(2019) Maria Bach Laursen et al.   Oncotarget

Genetic alterations and their clinical implications in DLBCL

(2019) Yi Miao et al.   Nature Reviews Clinical Oncology

Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies

(2019) Annarita Scialdone et al.   EXPERIMENTAL HEMATOLOGY

Rituximab primarily targets an intra-clonal BCR signaling proficient CLL subpopulation characterized by high CD20 levels

(2018) Gabriela Pavlasova et al.   LEUKEMIA

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

(2018) James D. Phelan et al.   NATURE

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma

(2018) Roland Schmitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach

(2018) Mathilde R. W. de Jong et al.   PLoS One

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

(2018) Beata Pyrzynska et al.   OncoImmunology

Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities

(2018) Kendall R. Sanson et al.   Nature Communications

Inactivation of CREBBP expands the germinal center B cell compartment, down-regulates MHCII expression and promotes DLBCL growth

(2017) Hind Hashwah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

(2017) Joseph Rosenbluh et al.   Nature Communications

A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment

(2017) Aradhana Awasthi et al.   Oncotarget

Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4/SDF-1 axis

(2016) G. Pavlasova et al.   BLOOD

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

(2016) S. H. Swerdlow et al.   BLOOD

Dissection of CD20 regulation in lymphoma using RNAi

(2016) M Słabicki et al.   LEUKEMIA

CD20-Targeting Immunotherapy Promotes Cellular Senescence in B-Cell Lymphoma

(2016) J. H. M. Da britz et al.   MOLECULAR CANCER THERAPEUTICS

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

(2015) Sidi Chen et al.   CELL

Interactions between Ibrutinib and Anti-CD20 Antibodies: Competing Effects on the Outcome of Combination Therapy

(2015) M. Skarzynski et al.   CLINICAL CANCER RESEARCH

Localized Store-Operated Calcium Influx Represses CD95-Dependent Apoptotic Effects of Rituximab in Non-Hodgkin B Lymphomas

(2015) Pierre Vacher et al.   JOURNAL OF IMMUNOLOGY

B-Cell Receptor Signaling in Diffuse Large B-Cell lymphoma

(2015) Ryan M. Young et al.   SEMINARS IN HEMATOLOGY

Prognostic factors for diffuse large B-cell lymphoma in the R(X)CHOP era

(2014) R. Vaidya et al.   ANNALS OF ONCOLOGY

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

B-cell receptor pathway inhibitors affect CD20 levels and impair antitumor activity of anti-CD20 monoclonal antibodies

(2014) K Bojarczuk et al.   LEUKEMIA

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies

(2014) Magdalena Winiarska et al.   mAbs

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

(2012) C Visco et al.   LEUKEMIA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

Escape mechanisms from antibody therapy to lymphoma cells: Downregulation of CD20 mRNA by recruitment of the HDAC complex and not by DNA methylation

(2009) Takumi Sugimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rituximab inhibits B-cell receptor signaling

(2009) S. Kheirallah et al.   BLOOD

CD20 deficiency in humans results in impaired T cell–independent antibody responses

(2009) Taco W. Kuijpers et al.   JOURNAL OF CLINICAL INVESTIGATION

Amelioration of Psoriasis by Anti-TNF-α RNAi in the Xenograft Transplantation Model

(2009) Maria Jakobsen et al.   MOLECULAR THERAPY

Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels

(2008) M. S. Czuczman et al.   CLINICAL CANCER RESEARCH

CD20 Homo-oligomers Physically Associate with the B Cell Antigen Receptor

(2008) Maria J. Polyak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Cytosolic Calcium Flux by CD20 Is Dependent upon B Cell Antigen Receptor Signaling

(2008) Claire A. Walshe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY